HUP0004037A2 - Új dihidronaftalin-származékok és eljárás az előállításukra - Google Patents

Új dihidronaftalin-származékok és eljárás az előállításukra

Info

Publication number
HUP0004037A2
HUP0004037A2 HU0004037A HUP0004037A HUP0004037A2 HU P0004037 A2 HUP0004037 A2 HU P0004037A2 HU 0004037 A HU0004037 A HU 0004037A HU P0004037 A HUP0004037 A HU P0004037A HU P0004037 A2 HUP0004037 A2 HU P0004037A2
Authority
HU
Hungary
Prior art keywords
group
inhibitory activity
compounds
cancer
branched
Prior art date
Application number
HU0004037A
Other languages
English (en)
Inventor
Rolf Wolfgang Hartmann
Yoshikazu Ikeda
Masamichi Nakakoshi
Shin Nomoto
Bertil Wachall
Makoto Yoshihama
Original Assignee
Yukijirushi Nyugyo Kabushiki Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yukijirushi Nyugyo Kabushiki Kaisha filed Critical Yukijirushi Nyugyo Kabushiki Kaisha
Publication of HUP0004037A2 publication Critical patent/HUP0004037A2/hu
Publication of HUP0004037A3 publication Critical patent/HUP0004037A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

A találmány kiváló 17a-hidroxiláz/C17-20-liáz gátló aktivitással,tromboxán A2 szintézis gátló aktivitással és aromatáz gátlóaktivitással rendelkező, általános képletű új dihidronaftalinvegyületekre és sóikra vonatkozik, ahol R1 hidrogénatomot,hidroxilcsoportot vagy egyenes vagy elágazó szénláncú, C1-C6alkiloxicsoportot jelent; R2 hidrogénatomot, egyenes vagy elágazószénláncú, C1-C6 alkilcsoportot, fenil- vagy aralkilcsoportot képviselés R3 jelentése piridil- vagy imidazolilcsoport. Ezek a vegyületekkülönböző férfi és női nemi hormon függő megbetegedések, mint aprosztatarák, prosztatamegnagyobbodás, elférfiasodás, mellrák,masztopátia, petefészekrák, endometriozis, méhnyakrák, valamintszívizominfarktus, angina pectoris és hörgőasztma megelőző és/vagyterápiás kezelésére használhatók. Ó
HU0004037A 1997-10-02 1998-10-01 Novel dihydronaphthalene compounds and process for producing the same HUP0004037A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP28426397 1997-10-02
PCT/JP1998/004426 WO1999018075A1 (fr) 1997-10-02 1998-10-01 Nouveaux composes a base de dihydronaphtalene et leur procede de production

Publications (2)

Publication Number Publication Date
HUP0004037A2 true HUP0004037A2 (hu) 2001-10-28
HUP0004037A3 HUP0004037A3 (en) 2002-03-28

Family

ID=17676271

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0004037A HUP0004037A3 (en) 1997-10-02 1998-10-01 Novel dihydronaphthalene compounds and process for producing the same

Country Status (17)

Country Link
EP (1) EP1028110B1 (hu)
KR (1) KR20000069426A (hu)
CN (1) CN1117732C (hu)
AT (1) ATE264304T1 (hu)
AU (1) AU743405B2 (hu)
CA (1) CA2298527A1 (hu)
DE (1) DE69823222T2 (hu)
DK (1) DK1028110T3 (hu)
ES (1) ES2218853T3 (hu)
FI (1) FI20000207A (hu)
HU (1) HUP0004037A3 (hu)
IL (1) IL133483A0 (hu)
NO (1) NO315044B1 (hu)
NZ (1) NZ501822A (hu)
RU (1) RU2203890C2 (hu)
WO (1) WO1999018075A1 (hu)
ZA (1) ZA988954B (hu)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100287366B1 (ko) 1997-11-24 2001-04-16 윤순조 엠피이지 방식을 이용한 휴대용 음향 재생장치 및 방법
US7001926B2 (en) 2000-03-10 2006-02-21 Oxigene, Inc. Tubulin binding agents and corresponding prodrug constructs
TWI283669B (en) * 1999-06-10 2007-07-11 Allergan Inc Compounds and method of treatment having agonist-like activity selective at alpha 2B or 2B/2C adrenergic receptors
US6849656B1 (en) 1999-09-17 2005-02-01 Baylor University Indole-containing and combretastatin-related anti-mitotic and anti-tubulin polymerization agents
JP4616454B2 (ja) * 1999-10-22 2011-01-19 武田薬品工業株式会社 １−置換フェニル−１−（１ｈ−イミダゾール−４−イル）アルコール類、その製造法および用途
DE60027034T2 (de) 1999-10-22 2006-11-09 Takeda Pharmaceutical Co. Ltd. 1-substituierte-phenyl-1-(1h-imidazol-4-yl)alkohole, verfahren zu deren herstellung sowie deren verwendung
JP4520012B2 (ja) * 1999-10-22 2010-08-04 武田薬品工業株式会社 １−置換−１−（１ｈ−イミダゾール−４−イル）メタノール類
JP2004505888A (ja) 2000-03-10 2004-02-26 ベイラー・ユニバーシテイ チューブリン結合リガンドおよび対応するプロドラッグ構造
US7091240B2 (en) 2000-03-10 2006-08-15 Oxigene, Inc. Tubulin binding ligands and corresponding prodrug constructs
MY134929A (en) 2000-11-17 2008-01-31 Takeda Pharmaceutical Novel imidazole derivatives, production method thereof and use thereof
ATE502030T1 (de) 2000-11-20 2011-04-15 Takeda Pharmaceutical Imidazolderivate, verfahren zu deren herstellung und deren verwendung
DE60139639D1 (de) 2000-12-08 2009-10-01 Takeda Pharmaceutical Substituierte thiazolderivate mit 3-pyridylgruppen, verfahren zu deren herstellung und deren verwendung
WO2004073602A2 (en) * 2002-01-25 2004-09-02 Pharmacia Corporation Aldosterone blocker therapy to prevent or treat inflammation-related disorders
US7456214B2 (en) 2004-05-03 2008-11-25 Baylor University Chromene-containing compounds with anti-tubulin and vascular targeting activity
UA105794C2 (uk) 2009-06-26 2014-06-25 Новартіс Аг 1,3-ДИЗАМІЩЕНІ ПОХІДНІ ІМІДАЗОЛІДИН-2-ОНУ ЯК ІНГІБІТОРИ Cyp17
WO2012018948A2 (en) 2010-08-04 2012-02-09 Pellficure Pharmaceuticals, Inc. Novel treatment of prostate carcinoma
JP2013537210A (ja) 2010-09-16 2013-09-30 ノバルティス アーゲー １７α−ヒドロキシラーゼ／Ｃ１７，２０−リアーゼ阻害剤
JP6002210B2 (ja) 2011-04-28 2016-10-05 ノバルティス アーゲー １７α−ヒドロキシラーゼ／Ｃ１７，２０−リアーゼ阻害剤
EP2968219B1 (en) 2013-03-14 2019-04-24 Pellficure Pharmaceuticals, Inc. Novel therapy for prostate carcinoma
US10093620B2 (en) 2014-09-12 2018-10-09 Pellficure Pharmaceuticals, Inc. Compositions and methods for treatment of prostate carcinoma
AU2017350690A1 (en) 2016-10-24 2019-06-13 Pellficure Pharmaceuticals Inc. Pharmaceutical compositions of 5-hydroxy-2-methylnaphthalene-1, 4-dione

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5681566A (en) * 1979-12-05 1981-07-03 Yoshitomi Pharmaceut Ind Ltd Imidazole derivative
ZA825413B (en) * 1981-08-26 1983-06-29 Pfizer Thromboxane synthetase inhibitors, processes for their production, and pharmaceutical compositions comprising them
US4540705A (en) * 1983-03-14 1985-09-10 Sterling Drug Inc. Antidepressant imidazolines and related compounds
PH22076A (en) * 1983-08-25 1988-05-20 Daiichi Seiyaku Co Benzocycloalkane derivative
JPS61186348A (ja) * 1985-02-14 1986-08-20 Dai Ichi Seiyaku Co Ltd ナフタレン誘導体
DE3508905A1 (de) * 1985-03-13 1986-09-18 Hoechst Ag, 6230 Frankfurt Neue imidazolylverbindungen und verfahren zu ihrer herstellung
JPH06166674A (ja) * 1992-12-01 1994-06-14 Tokyo Tanabe Co Ltd テトラリン化合物
JP3338905B2 (ja) * 1993-05-13 2002-10-28 帝国臓器製薬株式会社 ６位置換ステロイド誘導体
HUT75871A (en) * 1993-09-30 1997-05-28 Yamanouchi Co Azole derivatives and pharmaceutical compositions thereof
FR2787451B1 (fr) * 1998-12-18 2001-01-26 Adir Nouveaux composes imidazoliniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
DE69823222D1 (de) 2004-05-19
HUP0004037A3 (en) 2002-03-28
EP1028110A1 (en) 2000-08-16
FI20000207A (fi) 2000-02-01
NZ501822A (en) 2001-12-21
AU9281098A (en) 1999-04-27
ATE264304T1 (de) 2004-04-15
CN1268120A (zh) 2000-09-27
CN1117732C (zh) 2003-08-13
ZA988954B (en) 1999-04-12
DE69823222T2 (de) 2005-04-14
CA2298527A1 (en) 1999-04-15
WO1999018075A1 (fr) 1999-04-15
NO20001289L (no) 2000-03-10
NO20001289D0 (no) 2000-03-10
NO315044B1 (no) 2003-06-30
EP1028110A4 (en) 2001-05-23
DK1028110T3 (da) 2004-07-19
ES2218853T3 (es) 2004-11-16
KR20000069426A (ko) 2000-11-25
IL133483A0 (en) 2001-04-30
EP1028110B1 (en) 2004-04-14
RU2203890C2 (ru) 2003-05-10
AU743405B2 (en) 2002-01-24

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