HUP0003351A3 - 2-substituted 4,5-diaryl imidazoles, process for producing them, pharmaceutical compositions containing them and their use - Google Patents

2-substituted 4,5-diaryl imidazoles, process for producing them, pharmaceutical compositions containing them and their use

Info

Publication number: HUP0003351A3
Authority: HU; Hungary
Prior art keywords: substituted; producing; pharmaceutical compositions; compositions containing; diaryl
Prior art date: 1997-06-30

Application number

HU0003351A

Other languages

English (en)

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-06-30

Filing date

1998-06-26

Publication date

2002-01-28

1998-06-26 Application filed by Novartis Ag filed Critical Novartis Ag

2001-06-28 Publication of HUP0003351A2 publication Critical patent/HUP0003351A2/hu

2002-01-28 Publication of HUP0003351A3 publication Critical patent/HUP0003351A3/hu

Links

239000008194 pharmaceutical composition Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Transplantation (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Steroid Compounds (AREA)

HU0003351A 1997-06-30 1998-06-26 2-substituted 4,5-diaryl imidazoles, process for producing them, pharmaceutical compositions containing them and their use HUP0003351A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9713726.9A GB9713726D0 (en)	1997-06-30	1997-06-30	Organic compounds
PCT/EP1998/003930 WO1999001449A1 (en)	1997-06-30	1998-06-26	2-substituted 4,5-diaryl imidazoles

Publications (2)

Publication Number	Publication Date
HUP0003351A2 HUP0003351A2 (hu)	2001-06-28
HUP0003351A3 true HUP0003351A3 (en)	2002-01-28

Family

ID=10815101

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU0003351A HUP0003351A3 (en)	1997-06-30	1998-06-26	2-substituted 4,5-diaryl imidazoles, process for producing them, pharmaceutical compositions containing them and their use

Country Status (28)

Country	Link
US (1)	US6300347B1 (hu)
EP (2)	EP0993456B1 (hu)
JP (1)	JP3704362B2 (hu)
KR (1)	KR20010013215A (hu)
CN (1)	CN1261885A (hu)
AR (1)	AR014886A1 (hu)
AT (1)	ATE275557T1 (hu)
AU (1)	AU744411B2 (hu)
BR (1)	BR9810955A (hu)
CA (1)	CA2291758A1 (hu)
CO (1)	CO4940462A1 (hu)
DE (1)	DE69826127T2 (hu)
ES (1)	ES2226164T3 (hu)
GB (1)	GB9713726D0 (hu)
HU (1)	HUP0003351A3 (hu)
ID (1)	ID23385A (hu)
IL (1)	IL133034A0 (hu)
NO (1)	NO996429D0 (hu)
NZ (1)	NZ501275A (hu)
PE (1)	PE99999A1 (hu)
PL (1)	PL337057A1 (hu)
PT (1)	PT993456E (hu)
RU (1)	RU2214408C2 (hu)
SK (1)	SK186599A3 (hu)
TR (1)	TR199903278T2 (hu)
TW (1)	TW429258B (hu)
WO (1)	WO1999001449A1 (hu)
ZA (1)	ZA985656B (hu)

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US7301021B2 (en)	1997-07-02	2007-11-27	Smithkline Beecham Corporation	Substituted imidazole compounds
WO2000019824A1 (en)	1998-10-07	2000-04-13	Smithkline Beecham Corporation	Novel treatment for stroke management
EP1143957A3 (en) *	1998-12-16	2002-02-27	Warner-Lambert Company	Treatment of arthritis with mek inhibitors
ATE425142T1 (de) *	1999-04-23	2009-03-15	Vertex Pharma	Inhibitoren von c-jun n-terminal kinasen (jnk)
PL351148A1 (en) *	1999-04-23	2003-03-24	Takeda Chemical Industries Ltd	5-pyridyl-1,3-azole compounds, process for producing the same and use thereof
US6291457B1 (en)	1999-07-01	2001-09-18	Merck & Co., Inc.	Compounds having cytokine inhibitory activity
US7122666B2 (en)	1999-07-21	2006-10-17	Sankyo Company, Limited	Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses
ATE311385T1 (de) *	1999-10-27	2005-12-15	Novartis Pharma Gmbh	Thiazol und imidazo(4,5-b)pyridin verbindungen und ihre verwendung als pharmazeutika
AU784484B2 (en) *	1999-11-10	2006-04-13	Ortho-Mcneil Pharmaceutical, Inc.	Substituted 2-aryl-3(heteroaryl)-imidazo(1,2-a) pyrimidines, and related pharmaceutical compositions and methods
US6808902B1 (en)	1999-11-12	2004-10-26	Amgen Inc.	Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules
DE60037597T2 (de)	1999-11-22	2008-12-11	Smithkline Beecham P.L.C., Brentford	Imidazol- Derivate
DE60015599T2 (de)	1999-11-23	2005-11-03	Smithkline Beecham Corp.	3,4-DIHYDRO-(1H)CHINAZOLIN-2-ON-VERBINDUNGEN ALS CSBP/p38-KINASE-INHIBITOREN
US7612065B2 (en)	2000-04-21	2009-11-03	Vertex Pharmaceuticals Incorporated	Inhibitors of c-JUN N-terminal kinases (JNK)
DE60210755T2 (de)	2001-03-09	2006-11-16	Pfizer Products Inc., Groton	Triazolopyridine als entzündungshemmende mittel
WO2002072576A1 (en)	2001-03-09	2002-09-19	Pfizer Products Inc.	Benzimidazole anti-inflammatory compounds
ES2247271T3 (es)	2001-04-04	2006-03-01	Pfizer Products Inc.	Nuevos benzotriazoles como compuestos antiinflamatorios.
EP3492100B1 (en)	2001-06-26	2021-12-08	Amgen Inc.	Antibodies to opgl
PL210470B1 (pl) *	2001-10-22	2012-01-31	Mitsubishi Tanabe Pharma Corp	Związki 4-imidazolin-2-onu i jego zastosowanie
AR039241A1 (es)	2002-04-04	2005-02-16	Biogen Inc	Heteroarilos trisustituidos y metodos para su produccion y uso de los mismos
DE10222103A1 (de) *	2002-05-17	2003-11-27	Merckle Gmbh Chem Pharm Fabrik	2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie
EP1534282B1 (en)	2002-07-09	2006-12-27	Boehringer Ingelheim Pharma GmbH & Co.KG	Pharmaceutical compositions of anticholinergics and p38 kinase inhibitors in the treatment of respiratory diseases
US6949652B2 (en)	2002-08-30	2005-09-27	Pfizer, Inc.	Crystalline forms of 3-isopropyl-6-[4-(2,5-difluoro-phenyl)-oxazol-5-yl]-[1,2,4]triazolo-[4,3-A]pyridine
US7037923B2 (en)	2002-08-30	2006-05-02	Pfizer, Inc.	Alkyl-[4-(trifluorophenyl)-oxazol-5-yl]-triazolo-pyridines
US7012143B2 (en)	2002-08-30	2006-03-14	Dombroski Mark A	Cycloalkyl-[4-(difluorophenyl)-oxazol-5-yl]-triazolo-pyridines
US7005523B2 (en)	2002-08-30	2006-02-28	Pfizer Inc.	Cycloalkyl-[4-(trifluorophenyl)-oxazol-5yl]-triazolo-pyridines
PA8579601A1 (es)	2002-08-30	2004-05-07	Pfizer Prod Inc	Compuestos antiinflamatorios de di y trifloruro-triazolo-piridinas
UA80295C2 (en)	2002-09-06	2007-09-10	Biogen Inc	Pyrazolopyridines and using the same
WO2004053107A2 (en) *	2002-12-06	2004-06-24	Scios Inc.	Methods for treating diabetes
DE60331367D1 (de)	2002-12-30	2010-04-01	Angiotech Int Ag	Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung
AU2004225887A1 (en) *	2003-04-03	2004-10-14	Merck & Co., Inc.	4-ring imidazole derivatives as modulators of metabotropic glutamate receptor-5
US7553827B2 (en) *	2003-08-13	2009-06-30	Depuy Spine, Inc.	Transdiscal administration of cycline compounds
US20040229878A1 (en) *	2003-05-13	2004-11-18	Depuy Spine, Inc.	Transdiscal administration of specific inhibitors of P38 kinase
US8273347B2 (en) *	2003-05-13	2012-09-25	Depuy Spine, Inc.	Autologous treatment of degenerated disc with cells
US7344716B2 (en) *	2003-05-13	2008-03-18	Depuy Spine, Inc.	Transdiscal administration of specific inhibitors of pro-inflammatory cytokines
US8361467B2 (en)	2003-07-30	2013-01-29	Depuy Spine, Inc.	Trans-capsular administration of high specificity cytokine inhibitors into orthopedic joints
CA2533824A1 (en) *	2003-07-31	2005-02-10	Irm, Llc	Bicyclic compounds and compositions as pdf inhibitors
WO2005030151A2 (en) *	2003-10-02	2005-04-07	Irm Llc	Compounds and compositions as protein kinase inhibitors
US8895540B2 (en) *	2003-11-26	2014-11-25	DePuy Synthes Products, LLC	Local intraosseous administration of bone forming agents and anti-resorptive agents, and devices therefor
WO2005063716A1 (en)	2003-12-22	2005-07-14	Janssen Pharmaceutica, N.V.	Imidazoles and their use cck-1 receptor modulators
US20060035893A1 (en)	2004-08-07	2006-02-16	Boehringer Ingelheim International Gmbh	Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders
US7713998B2 (en)	2004-11-10	2010-05-11	Ono Pharmaceutical Co., Ltd.	Nitrogenous heterocyclic compound and pharmaceutical use thereof
PE20060777A1 (es)	2004-12-24	2006-10-06	Boehringer Ingelheim Int	Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
EP1853581B1 (en) *	2005-02-28	2010-06-02	Merckle Gmbh	2-sulfinyl- and 2-sulfonyl-substituted imidazole derivatives and their use as cytokine inhibitors
EP1932840B1 (en)	2005-10-03	2014-04-09	Ono Pharmaceutical Co., Ltd.	Nitrogen-containing heterocyclic compound and pharmaceutical application thereof
AU2006306991A1 (en)	2005-10-28	2007-05-03	Takeda Pharmaceutical Company Limited	Heterocyclic amide compound and use thereof
ES2301380B1 (es)	2006-08-09	2009-06-08	Laboratorios Almirall S.A.	Nuevos derivados de 1,7-naftiridina.
ES2320955B1 (es)	2007-03-02	2010-03-16	Laboratorios Almirall S.A.	Nuevos derivados de 3-((1,2,4)triazolo(4,3-a)piridin-7-il)benzamida.
ES2329639B1 (es)	2007-04-26	2010-09-23	Laboratorios Almirall S.A.	Nuevos derivados de 4,8-difenilpoliazanaftaleno.
EP1992344A1 (en)	2007-05-18	2008-11-19	Institut Curie	P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation
MX2009013176A (es) *	2007-06-05	2011-03-02	Western States Biopharmaceuticals Inc	Moleculas superficiales que inducen citosinas de celulas t y metodos de uso.
US20090162351A1 (en) *	2007-12-21	2009-06-25	Depuy Spine, Inc.	Transdiscal administration of inhibitors of p38 MAP kinase
US8986696B2 (en) *	2007-12-21	2015-03-24	Depuy Mitek, Inc.	Trans-capsular administration of p38 map kinase inhibitors into orthopedic joints
EP2108641A1 (en)	2008-04-11	2009-10-14	Laboratorios Almirall, S.A.	New substituted spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one derivatives and their use as p38 mitogen-activated kinase inhibitors
EP2113503A1 (en)	2008-04-28	2009-11-04	Laboratorios Almirall, S.A.	New substituted indolin-2-one derivatives and their use as p39 mitogen-activated kinase inhibitors
TWI435874B (zh)	2008-10-31	2014-05-01	Toray Industries	環己烷衍生物及其醫藥用途
EP2322176A1 (en)	2009-11-11	2011-05-18	Almirall, S.A.	New 7-phenyl-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives
EP2516668B1 (en) *	2009-12-22	2016-04-06	Csir	Inhibition of the activity of kinase and synthetase enzymes
JP2013523766A (ja) *	2010-03-31	2013-06-17	グラクソグループリミテッド	キナーゼ阻害剤としてのイミダゾリル‐イミダゾール
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US6251914B1 (en)	1997-07-02	2001-06-26	Smithkline Beecham Corporation	Cycloalkyl substituted imidazoles
AR016294A1 (es)	1997-07-02	2001-07-04	Smithkline Beecham Corp	Compuesto de imidazol sustituido, composicion farmaceutica que la contiene, su uso en la fabricacion de un medicamento y procedimiento para supreparacion
TW517055B (en)	1997-07-02	2003-01-11	Smithkline Beecham Corp	Novel substituted imidazole compounds
FR2772377B1 (fr)	1997-12-12	2000-01-07	Synthelabo	Derives de 1-(1-h-imidazol-2-yl)pyrrolidines et 1-(1-h-imidazol-2-ylpiperidines), leur preparation et leur application en therapeutique

1997
- 1997-06-30 GB GBGB9713726.9A patent/GB9713726D0/en active Pending
1998
- 1998-06-11 TW TW087109301A patent/TW429258B/zh active
- 1998-06-25 CO CO98036362A patent/CO4940462A1/es unknown
- 1998-06-26 CA CA002291758A patent/CA2291758A1/en not_active Abandoned
- 1998-06-26 CN CN98806673A patent/CN1261885A/zh active Pending
- 1998-06-26 EP EP98939541A patent/EP0993456B1/en not_active Expired - Lifetime
- 1998-06-26 US US09/446,885 patent/US6300347B1/en not_active Expired - Fee Related
- 1998-06-26 JP JP50628899A patent/JP3704362B2/ja not_active Expired - Fee Related
- 1998-06-26 WO PCT/EP1998/003930 patent/WO1999001449A1/en not_active Application Discontinuation
- 1998-06-26 DE DE69826127T patent/DE69826127T2/de not_active Expired - Fee Related
- 1998-06-26 ID IDW991681A patent/ID23385A/id unknown
- 1998-06-26 EP EP03026996A patent/EP1396491A3/en not_active Withdrawn
- 1998-06-26 HU HU0003351A patent/HUP0003351A3/hu unknown
- 1998-06-26 TR TR1999/03278T patent/TR199903278T2/xx unknown
- 1998-06-26 ES ES98939541T patent/ES2226164T3/es not_active Expired - Lifetime
- 1998-06-26 RU RU2000101820/04A patent/RU2214408C2/ru not_active IP Right Cessation
- 1998-06-26 PT PT98939541T patent/PT993456E/pt unknown
- 1998-06-26 AU AU88015/98A patent/AU744411B2/en not_active Ceased
- 1998-06-26 SK SK1865-99A patent/SK186599A3/sk unknown
- 1998-06-26 IL IL13303498A patent/IL133034A0/xx unknown
- 1998-06-26 AR ARP980103093A patent/AR014886A1/es unknown
- 1998-06-26 NZ NZ501275A patent/NZ501275A/en unknown
- 1998-06-26 KR KR19997011203A patent/KR20010013215A/ko not_active Application Discontinuation
- 1998-06-26 BR BR9810955-3A patent/BR9810955A/pt not_active IP Right Cessation
- 1998-06-26 PL PL98337057A patent/PL337057A1/xx unknown
- 1998-06-26 PE PE1998000569A patent/PE99999A1/es not_active Application Discontinuation
- 1998-06-26 AT AT98939541T patent/ATE275557T1/de not_active IP Right Cessation
- 1998-06-29 ZA ZA985656A patent/ZA985656B/xx unknown
1999
- 1999-12-23 NO NO996429A patent/NO996429D0/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
EP0993456A1 (en)	2000-04-19
EP1396491A2 (en)	2004-03-10
RU2214408C2 (ru)	2003-10-20
US6300347B1 (en)	2001-10-09
PL337057A1 (en)	2000-07-31
HUP0003351A2 (hu)	2001-06-28
DE69826127D1 (de)	2004-10-14
ATE275557T1 (de)	2004-09-15
CN1261885A (zh)	2000-08-02
ES2226164T3 (es)	2005-03-16
SK186599A3 (en)	2000-06-12
ZA985656B (en)	1998-12-30
AU744411B2 (en)	2002-02-21
TR199903278T2 (en)	2000-07-21
WO1999001449A1 (en)	1999-01-14
JP3704362B2 (ja)	2005-10-12
CA2291758A1 (en)	1999-01-14
CO4940462A1 (es)	2000-07-24
GB9713726D0 (en)	1997-09-03
PE99999A1 (es)	1999-11-01
NZ501275A (en)	2002-04-26
IL133034A0 (en)	2001-03-19
PT993456E (pt)	2005-01-31
AR014886A1 (es)	2001-04-11
ID23385A (id)	2000-04-20
JP2001506280A (ja)	2001-05-15
AU8801598A (en)	1999-01-25
NO996429L (no)	1999-12-23
KR20010013215A (ko)	2001-02-26
EP1396491A3 (en)	2004-06-30
NO996429D0 (no)	1999-12-23
TW429258B (en)	2001-04-11
DE69826127T2 (de)	2005-09-29
BR9810955A (pt)	2000-09-26
EP0993456B1 (en)	2004-09-08

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