HUE054448T2 - CGRP receptor antagonistaként alkalmas 3-metil-pirrolidin-2,5-dion származékok - Google Patents

CGRP receptor antagonistaként alkalmas 3-metil-pirrolidin-2,5-dion származékok

Info

Publication number
HUE054448T2
HUE054448T2 HUE18727529A HUE18727529A HUE054448T2 HU E054448 T2 HUE054448 T2 HU E054448T2 HU E18727529 A HUE18727529 A HU E18727529A HU E18727529 A HUE18727529 A HU E18727529A HU E054448 T2 HUE054448 T2 HU E054448T2
Authority
HU
Hungary
Prior art keywords
pyrrolidine
methyl
receptor antagonists
derivatives useful
cgrp receptor
Prior art date
Application number
HUE18727529A
Other languages
English (en)
Inventor
Jennifer Anne McMahon
Miles Goodman Siegel
Russell Dean Stucky
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of HUE054448T2 publication Critical patent/HUE054448T2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
HUE18727529A 2017-05-15 2018-05-08 CGRP receptor antagonistaként alkalmas 3-metil-pirrolidin-2,5-dion származékok HUE054448T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762506204P 2017-05-15 2017-05-15

Publications (1)

Publication Number Publication Date
HUE054448T2 true HUE054448T2 (hu) 2021-09-28

Family

ID=62245454

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE18727529A HUE054448T2 (hu) 2017-05-15 2018-05-08 CGRP receptor antagonistaként alkalmas 3-metil-pirrolidin-2,5-dion származékok

Country Status (18)

Country Link
US (1) US10336726B2 (hu)
EP (1) EP3625221B1 (hu)
JP (1) JP6794583B2 (hu)
CN (1) CN110662741B (hu)
AR (1) AR111665A1 (hu)
CA (1) CA3061762C (hu)
CY (1) CY1124032T1 (hu)
DK (1) DK3625221T3 (hu)
ES (1) ES2870325T3 (hu)
HR (1) HRP20210655T1 (hu)
HU (1) HUE054448T2 (hu)
LT (1) LT3625221T (hu)
PL (1) PL3625221T3 (hu)
PT (1) PT3625221T (hu)
RS (1) RS61657B1 (hu)
SI (1) SI3625221T1 (hu)
TW (1) TW201904955A (hu)
WO (1) WO2018213059A1 (hu)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3061653C (en) 2017-05-15 2022-09-06 Eli Lilly And Company Cgrp receptor antagonists
CA3161236A1 (en) * 2019-12-12 2021-06-17 Mark Donald Chappell Cgrp antigonists useful as tracer compounds for positron emission tomography
CN115704811B (zh) * 2022-12-26 2023-03-31 南京威凯尔生物医药科技有限公司 一种高效液相色谱法检测乌布吉泮及其对映体和非对映体杂质的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6680387B2 (en) 2000-04-24 2004-01-20 Aryx Therapeutics Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis
EP2846798B1 (en) 2012-05-09 2018-04-04 Merck Sharp & Dohme Corp. Aliphatic spirolactam cgrp receptor antagonists
TWI636041B (zh) * 2015-08-12 2018-09-21 美國禮來大藥廠 Ｃｇｒｐ受體拮抗劑
TW201718574A (zh) 2015-08-12 2017-06-01 美國禮來大藥廠 Ｃｇｒｐ受體拮抗劑

Also Published As

Publication number Publication date
CY1124032T1 (el) 2022-05-27
PL3625221T3 (pl) 2021-08-23
RS61657B1 (sr) 2021-04-29
EP3625221B1 (en) 2021-03-03
CA3061762A1 (en) 2018-11-22
AR111665A1 (es) 2019-08-07
HRP20210655T1 (hr) 2021-05-28
SI3625221T1 (sl) 2021-04-30
LT3625221T (lt) 2021-04-26
JP6794583B2 (ja) 2020-12-02
DK3625221T3 (da) 2021-04-19
TW201904955A (zh) 2019-02-01
EP3625221A1 (en) 2020-03-25
JP2020519686A (ja) 2020-07-02
PT3625221T (pt) 2021-04-15
US10336726B2 (en) 2019-07-02
US20180327384A1 (en) 2018-11-15
CA3061762C (en) 2021-11-09
WO2018213059A1 (en) 2018-11-22
CN110662741A (zh) 2020-01-07
ES2870325T3 (es) 2021-10-26
CN110662741B (zh) 2022-08-16

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