HUE039948T2 - Csökkent oxidációjú készítmények - Google Patents

Csökkent oxidációjú készítmények

Info

Publication number
HUE039948T2
HUE039948T2 HUE14773506A HUE14773506A HUE039948T2 HU E039948 T2 HUE039948 T2 HU E039948T2 HU E14773506 A HUE14773506 A HU E14773506A HU E14773506 A HUE14773506 A HU E14773506A HU E039948 T2 HUE039948 T2 HU E039948T2
Authority
HU
Hungary
Prior art keywords
formulations
reduced oxidation
oxidation
reduced
Prior art date
Application number
HUE14773506A
Other languages
English (en)
Inventor
Sreedhara Alavattam
Mary Mallaney
Parbir Grewal
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HUE039948T2 publication Critical patent/HUE039948T2/hu

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591Stabilisation, fragmentation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
HUE14773506A 2013-03-13 2014-03-13 Csökkent oxidációjú készítmények HUE039948T2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361780845P 2013-03-13 2013-03-13
US201361909813P 2013-11-27 2013-11-27

Publications (1)

Publication Number Publication Date
HUE039948T2 true HUE039948T2 (hu) 2019-02-28

Family

ID=51625442

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE14773506A HUE039948T2 (hu) 2013-03-13 2014-03-13 Csökkent oxidációjú készítmények

Country Status (25)

Country Link
EP (1) EP2968466B1 (hu)
JP (3) JP6389236B2 (hu)
KR (1) KR102237885B1 (hu)
CN (2) CN110075293A (hu)
AU (3) AU2014243700B2 (hu)
BR (1) BR112015022484A2 (hu)
CA (2) CA3113172A1 (hu)
DK (1) DK2968466T3 (hu)
ES (1) ES2688895T3 (hu)
HK (1) HK1211219A1 (hu)
HR (1) HRP20181504T1 (hu)
HU (1) HUE039948T2 (hu)
IL (2) IL269947B (hu)
LT (1) LT2968466T (hu)
MX (2) MX369671B (hu)
MY (1) MY174679A (hu)
NZ (1) NZ711566A (hu)
PL (1) PL2968466T3 (hu)
PT (1) PT2968466T (hu)
RS (1) RS57813B1 (hu)
RU (1) RU2707092C2 (hu)
SG (2) SG10201705525VA (hu)
SI (1) SI2968466T1 (hu)
WO (1) WO2014160495A1 (hu)
ZA (2) ZA201506876B (hu)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR095398A1 (es) 2013-03-13 2015-10-14 Genentech Inc Formulaciones con oxidación reducida
US10653779B2 (en) 2013-03-13 2020-05-19 Genentech, Inc. Formulations with reduced oxidation
HUE049707T2 (hu) * 2013-03-13 2020-11-30 Hoffmann La Roche Csökkent oxidációjú kiszerelések
EP3909985A1 (en) 2016-06-27 2021-11-17 MorphoSys AG Anti-cd19 antibody formulations
BR112021002130A2 (pt) * 2018-08-08 2021-05-04 Genentech, Inc. formulação líquida, artigo de fabricação ou kit e método para reduzir a oxidação de um polipeptídeo

Family Cites Families (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE30985E (en) 1978-01-01 1982-06-29 Serum-free cell culture media
FR2413974A1 (fr) 1978-01-06 1979-08-03 David Bernard Sechoir pour feuilles imprimees par serigraphie
US4419446A (en) 1980-12-31 1983-12-06 The United States Of America As Represented By The Department Of Health And Human Services Recombinant DNA process utilizing a papilloma virus DNA as a vector
NZ201705A (en) 1981-08-31 1986-03-14 Genentech Inc Recombinant dna method for production of hepatitis b surface antigen in yeast
US4601978A (en) 1982-11-24 1986-07-22 The Regents Of The University Of California Mammalian metallothionein promoter system
US4560655A (en) 1982-12-16 1985-12-24 Immunex Corporation Serum-free cell culture medium and process for making same
US4657866A (en) 1982-12-21 1987-04-14 Sudhir Kumar Serum-free, synthetic, completely chemically defined tissue culture media
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
DD266710A3 (de) 1983-06-06 1989-04-12 Ve Forschungszentrum Biotechnologie Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase
US4767704A (en) 1983-10-07 1988-08-30 Columbia University In The City Of New York Protein-free culture medium
US4965199A (en) 1984-04-20 1990-10-23 Genentech, Inc. Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
US4879231A (en) 1984-10-30 1989-11-07 Phillips Petroleum Company Transformation of yeasts of the genus pichia
GB8516415D0 (en) 1985-06-28 1985-07-31 Celltech Ltd Culture of animal cells
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US6548640B1 (en) 1986-03-27 2003-04-15 Btg International Limited Altered antibodies
US4927762A (en) 1986-04-01 1990-05-22 Cell Enterprises, Inc. Cell culture medium with antioxidant
GB8610600D0 (en) 1986-04-30 1986-06-04 Novo Industri As Transformation of trichoderma
DE68925971T2 (de) 1988-09-23 1996-09-05 Cetus Oncology Corp Zellenzuchtmedium für erhöhtes zellenwachstum, zur erhöhung der langlebigkeit und expression der produkte
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
KR0184860B1 (ko) 1988-11-11 1999-04-01 메디칼 리써어치 카운실 단일영역 리간드와 이를 포함하는 수용체 및 이들의 제조방법과 이용(법)
FR2646437B1 (fr) 1989-04-28 1991-08-30 Transgene Sa Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant
EP0402226A1 (en) 1989-06-06 1990-12-12 Institut National De La Recherche Agronomique Transformation vectors for yeast yarrowia
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
DE69029036T2 (de) 1989-06-29 1997-05-22 Medarex Inc Bispezifische reagenzien für die aids-therapie
US5959177A (en) 1989-10-27 1999-09-28 The Scripps Research Institute Transgenic plants expressing assembled secretory antibodies
US6075181A (en) 1990-01-12 2000-06-13 Abgenix, Inc. Human antibodies derived from immunized xenomice
DE69120146T2 (de) 1990-01-12 1996-12-12 Cell Genesys Inc Erzeugung xenogener antikörper
US6150584A (en) 1990-01-12 2000-11-21 Abgenix, Inc. Human antibodies derived from immunized xenomice
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
ES2246502T3 (es) 1990-08-29 2006-02-16 Genpharm International, Inc. Animales no humanos transgenicos capaces de producir anticuerpos heterologos.
US5122469A (en) 1990-10-03 1992-06-16 Genentech, Inc. Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
ES2113940T3 (es) 1990-12-03 1998-05-16 Genentech Inc Metodo de enriquecimiento para variantes de proteinas con propiedades de union alteradas.
US5571894A (en) 1991-02-05 1996-11-05 Ciba-Geigy Corporation Recombinant antibodies specific for a growth factor receptor
EP0586505A1 (en) 1991-05-14 1994-03-16 Repligen Corporation Heteroconjugate antibodies for treatment of hiv infection
GB9114948D0 (en) 1991-07-11 1991-08-28 Pfizer Ltd Process for preparing sertraline intermediates
US7018809B1 (en) 1991-09-19 2006-03-28 Genentech, Inc. Expression of functional antibody fragments
DK0605522T3 (da) 1991-09-23 2000-01-17 Medical Res Council Fremgangsmåde til fremstilling af humaniserede antistoffer
US5587458A (en) 1991-10-07 1996-12-24 Aronex Pharmaceuticals, Inc. Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof
WO1993008829A1 (en) 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions that mediate killing of hiv-infected cells
US5667988A (en) 1992-01-27 1997-09-16 The Scripps Research Institute Methods for producing antibody libraries using universal or randomized immunoglobulin light chains
AU675929B2 (en) 1992-02-06 1997-02-27 Curis, Inc. Biosynthetic binding protein for cancer marker
ATE149570T1 (de) 1992-08-17 1997-03-15 Genentech Inc Bispezifische immunoadhesine
CA2149329C (en) 1992-11-13 2008-07-15 Darrell R. Anderson Therapeutic application of chimeric and radiolabeled antibodies to human b lymphocyte restricted differentiation antigen for treatment of b cell lymphoma
US5789199A (en) 1994-11-03 1998-08-04 Genentech, Inc. Process for bacterial production of polypeptides
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US5840523A (en) 1995-03-01 1998-11-24 Genetech, Inc. Methods and compositions for secretion of heterologous polypeptides
US5641870A (en) 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
US5869046A (en) 1995-04-14 1999-02-09 Genentech, Inc. Altered polypeptides with increased half-life
ES2304786T3 (es) 1995-04-27 2008-10-16 Amgen Fremont Inc. Anticuerpos anti-il-8 humanos, derivados a partir de xenoratones inmunizados.
EP0823941A4 (en) 1995-04-28 2001-09-19 Abgenix Inc HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENO MOUSES
AU729039C (en) 1996-08-30 2001-08-02 Upfront Chromatography A/S Isolation of immunoglobulins
DK1500329T3 (da) 1996-12-03 2012-07-09 Amgen Fremont Inc Humane antistoffer, der specifikt binder TNF-alfa
US20080318254A9 (en) 1997-03-10 2008-12-25 The Regents Of The University Of California PSCA antibodies and hybridomas producing them
US20020173629A1 (en) 1997-05-05 2002-11-21 Aya Jakobovits Human monoclonal antibodies to epidermal growth factor receptor
US6040498A (en) 1998-08-11 2000-03-21 North Caroline State University Genetically engineered duckweed
US6610833B1 (en) 1997-11-24 2003-08-26 The Institute For Human Genetics And Biochemistry Monoclonal human natural antibodies
ATE531812T1 (de) 1997-12-05 2011-11-15 Scripps Research Inst Humanisierung von nager-antikörpern
JP2000247903A (ja) * 1999-03-01 2000-09-12 Chugai Pharmaceut Co Ltd 長期安定化製剤
DE60039596D1 (de) 1999-03-30 2008-09-04 Japan Tobacco Inc Verfahren zur herstellung von monoklonalen antikörpern
AU782626B2 (en) 1999-10-04 2005-08-18 Medicago Inc. Method for regulating transcription of foreign genes
US7125978B1 (en) 1999-10-04 2006-10-24 Medicago Inc. Promoter for regulating expression of foreign genes
JP4683810B2 (ja) * 2000-02-29 2011-05-18 中外製薬株式会社 長期安定化製剤
EP1367998A4 (en) * 2000-09-15 2004-03-17 Scripps Research Inst METHODS AND COMPOSITIONS RELATING TO HYDROGEN PEROXIDE AND THE PRODUCTION OF SUPEROXIDE BY ANTIBODIES
US6933123B2 (en) * 2001-04-05 2005-08-23 Yao Xiong Hu Peptides from the E2, E6, and E7 proteins of human papilloma viruses 16 and 18 for detecting and/or diagnosing cervical and other human papillomavirus associated cancers
WO2002092017A2 (en) 2001-05-16 2002-11-21 Albert Einstein College Of Medicine Of Yeshiva University Human antipneumococcal antibodies from non-human animals
JP4359503B2 (ja) 2001-08-23 2009-11-04 ゲンマブ エー/エス インターロイキン15(il−15)に特異的なヒト抗体
US7682608B2 (en) * 2001-08-29 2010-03-23 Chugai Seiyaku Kabushiki Kaisha Stabilized preparations containing antibody
US20040116350A1 (en) * 2001-09-17 2004-06-17 Paul Wentworth Jr Methods and compositions relating to hydrogen peroxide and superoxide production by antibodies
CA2513308A1 (en) 2003-01-17 2004-08-05 Josef Michl Pancreatic cancer associated antigen, antibody thereto, and diagnostic and treatment methods
US7871607B2 (en) 2003-03-05 2011-01-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
US20060104968A1 (en) 2003-03-05 2006-05-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
AU2004270103B2 (en) 2003-05-21 2012-02-23 E. R. Squibb & Sons, L.L.C. Human monoclonal antibodies against Bacillusanthracis protective antigen
US7741071B2 (en) * 2003-12-18 2010-06-22 The Scripps Research Institute Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells
WO2007095288A2 (en) * 2006-02-13 2007-08-23 Nektar Therapeutics Methionine-containing protein or peptide compositions and methods of making and using
CN101438158A (zh) * 2006-03-06 2009-05-20 阿穆尼克斯股份有限公司 遗传包和其应用
JP2007319124A (ja) * 2006-06-02 2007-12-13 Nippon Tablet Kk 健康食品
MY154869A (en) * 2007-01-16 2015-08-14 Ipintl Llc Composition for treating metabolic syndrome
CA2719658C (en) * 2008-04-01 2019-10-01 Antipodean Pharmaceuticals, Inc. Compositions and methods for skin care
US8980254B2 (en) * 2008-08-21 2015-03-17 Alvine Pharmaceuticals, Inc. Formulation for oral administration of proteins
JP5705115B2 (ja) * 2008-09-10 2015-04-22 ジェネンテック, インコーポレイテッド 蛋白質の酸化的分解の予防のための組成物および方法
BRPI0917888A2 (pt) 2008-09-19 2014-02-25 Pfizer Formulação de anticorpo líquida estável
CA2802756C (en) * 2010-06-24 2021-05-04 Genentech, Inc. Compositions and methods for stabilizing protein-containing formulations
RU2447448C1 (ru) * 2010-08-30 2012-04-10 Государственное образовательное учреждение высшего профессионального образования "Оренбургский государственный университет" Способ стабилизации антител в водных растворах
EP2717698A4 (en) * 2011-06-09 2015-01-07 Requis Pharmaceuticals Inc ANTIHISTAMINES COMBINED WITH FOOD SUPPLEMENTS TO IMPROVE HEALTH
CN103649105A (zh) * 2011-06-28 2014-03-19 白血球保健股份有限公司 防止(多)肽解折叠和/或诱导(多)肽(再)折叠的方法

Also Published As

Publication number Publication date
NZ711566A (en) 2020-06-26
RU2015143548A (ru) 2017-04-20
LT2968466T (lt) 2018-10-10
CA2904166C (en) 2021-05-18
RU2707092C2 (ru) 2019-11-22
MX2015011432A (es) 2016-04-27
NZ751543A (en) 2020-09-25
EP2968466A1 (en) 2016-01-20
JP2020164531A (ja) 2020-10-08
CN104968362B (zh) 2018-12-14
ES2688895T3 (es) 2018-11-07
SI2968466T1 (sl) 2018-10-30
IL269947A (hu) 2019-12-31
CA3113172A1 (en) 2014-10-02
IL240933B (en) 2019-10-31
JP6389236B2 (ja) 2018-09-12
WO2014160495A1 (en) 2014-10-02
KR102237885B1 (ko) 2021-04-07
ZA201906057B (en) 2022-04-28
PT2968466T (pt) 2018-10-22
ZA201506876B (en) 2019-12-18
KR20150130397A (ko) 2015-11-23
HK1211219A1 (en) 2016-05-20
AU2021201366A1 (en) 2021-03-18
CA2904166A1 (en) 2014-10-02
SG11201507043SA (en) 2015-10-29
SG10201705525VA (en) 2017-08-30
RS57813B1 (sr) 2018-12-31
JP2018150317A (ja) 2018-09-27
AU2019202464B2 (en) 2020-12-10
AU2014243700A1 (en) 2015-10-08
CN104968362A (zh) 2015-10-07
AU2014243700B2 (en) 2019-01-24
AU2019202464A1 (en) 2019-05-02
HRP20181504T1 (hr) 2018-11-02
EP2968466B1 (en) 2018-07-25
CN110075293A (zh) 2019-08-02
DK2968466T3 (en) 2018-10-22
BR112015022484A2 (pt) 2017-07-18
EP2968466A4 (en) 2016-10-26
MY174679A (en) 2020-05-06
MX369671B (es) 2019-11-15
PL2968466T3 (pl) 2018-11-30
JP2016520521A (ja) 2016-07-14
MX2019013560A (es) 2020-01-20
IL240933A0 (en) 2015-11-30
IL269947B (en) 2022-08-01

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