HUE033007T2 - Gyógyszer, terápiás nukleinsavak és funkcionális nukleinsavak célzott szolgáltatása emlõs sejtekhez sértetlen elölt bakteriális sejtek útján - Google Patents
Gyógyszer, terápiás nukleinsavak és funkcionális nukleinsavak célzott szolgáltatása emlõs sejtekhez sértetlen elölt bakteriális sejtek útján Download PDFInfo
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- HUE033007T2 HUE033007T2 HUE13191266A HUE13191266A HUE033007T2 HU E033007 T2 HUE033007 T2 HU E033007T2 HU E13191266 A HUE13191266 A HU E13191266A HU E13191266 A HUE13191266 A HU E13191266A HU E033007 T2 HUE033007 T2 HU E033007T2
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1228—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K16/1235—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia from Salmonella (G)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Claims (3)
- QYÓGYS2B*, TERÁPIÁS NUKUciNSAVAK &S PUNK£K5NAMS NUKtlINSAY&K CÉLZOTT ÍIÖIÍAÍÍÁtISA g»í§| SEdTEKHEE Sé^TgltEN SlŐLT 8AKTSRtÁUS SSoTEK ÜT MN S2ABAÍ3ALW IGÉNYPONTOK 1 Kompoféié apglmaxlpká lyféegtnégek tcszet&sébeo, ahol a kompozioiá a következőket tartalmazza fpí sédélód (loféci} eidt (Mied) bakteriális seffék sokasága. «ha* sí wféett sokaság egyes elolt báieelfs sejtje! rendelkeznek sédé® sejtíaíto; ésoggy seitwnlxtVtoah és tartalmaznak olyas genetikai anyagot. amely attaogán a baienlíía laioz (species). as a kompoz® leiómii (encompassi a következőket' (··} agy tempi? nukteinsav, sandy olyan terméke; kódol mit egy pópád. pokpepíid vsgy féhége, arosiyoek termese kívánatos egy célsejtben (target call};, p) egy gyógyszer (drog), ahol a?, agy féiöfcg-siieg vagy íetmakológiallag aktly anyag, amely kialakít egy kívánt helyi vagy szisztémás hatást emtbsékbao és sfabstekben, vagy (kit agy fcnkcsorOit nekfensav molekula. amely: ibevezéiskot' sgy geadatteltfcs. fajlagosa·: intetté t& agy fehegs expresszijével. #1 §|íVgyás?stlag efogaclaato norcfézc· ehhez., és (é) feispooíftkas tigsmSam, amely rögződik as egyes sértéséi előtt bsktanaks sejtekhez.
- 2. Ko?n&o?:vO dkatrf'.azSsra betegségek kezaiásében. also; a bropozfcté a következőket tartalmazza- {a; sédszen (snittet; éléit bakted® $φά· sokasága. ahol as említett sokaság egyes elothbakteoeks se$es rendelkeznek sértetten se-tlallat ifévagy: btferadrármai. és férialsnazíták eiyert generates anyagot. smely endogén a bakteriális (speoesh és a kompók® Isloíel; fénsoofasg a következőket' (g egy terápiás öokisinsp· \&®φ olyan lármákéi kódol, miatepy pepiid, pokpsptkl vagy led®;:sme|yoek le?tnoléso klyánalos egy céktsilbsn fíápt^ly; ||| f|y:|yógysoa? ásol ez egy ífésoiógssösg vagy tarmssotögs'síiag aktív anyag, amely kialakít egy kivárd hesy; vagy aáspvnás halM erofősökhee es ernkterekhen, vagy: pl· egy fonkefénsls nektélnsav rootetcola, antety beééaiéskp' egy gazdasajifee, íálagoaso mtaríerál egy tenetfe stress Jt|ávsl, Φ5 gyogyassaolag Gtogsdható hordozó ehhez, és Ü plpóilkas isgandom, amely rdgz&fck az agyas sanatleh* elél aakteóáiis sóiilékhoa. sh#tlkpikaipa® tártairGzzza s kaespozkvó bevezetőét egy s«ffcé& saovaflaa vagy ezervhez. ív ^PipoPiltsikalpazósra betegségek kezoleséPen egy hasznos Éltor olisép^k m vtvo. ahol o kompoz® a kóvetkezékékldaltnlMai ja) séflelen fintac?· alól pated) baktedéks sojiek sokasaga. élői sa emiatt sokasig ogpe éP:l boklenaks spli* rendetkaznek sértésén se|?Püi épvágy sdtn'omiö«s4kl. és üiáknaansk otyao geooitp agyagot, amely endogén a hakdnáiís f^ioz (spooled; és a köospozlcíö felöli (enoomps# s|| UmM fémet (payloady ssnety a koveíkoz^ közét választható ki; 11} egyfétápás nekinsov aomly opsovtofínáktít kOoog ^!?ί; egy pepii, ofélpeplid pgy féléik· anselynek íetotelése kívánatos egy eólsegbee (tmget zo;;}. K: sgy gyógyszer Itkog}. snoi ez egy ttápispapg veak formakoíépaíiag aktiari/ag. amely kmlakkegy kíván; helyrpgyéli-sziféáé fiiiomfééekhéít ás omberskpd. és Ψ) égy töök^jg^if· :.ítüi|ü|:i^i:: épély: ótyekólésfei; é|y §áPésé|tt>S::: 'isji8j|óSSR stttófeal egy kíéM ejtpreeszpávak fi .gyögyásza%:Éo^é»^M;etjm M u |llpeoikee ;:|ándtílt, ptsttli3ktena;;o sójféktsaz.. féiiroá® óélppfáriotlíépep hozását; a kompozfcióvsi. amelyet ^ iféíféöen. gi# :^r t::ibme02^8r,< és 9 (^tgdfévsot} köveféén i. WM&( # ktbocsátja a hasznos terhet (oayiood} a célsejtbe. '?«* Yhn 'kr'Jk^ -t' otu ' >setd wv,v ^ c; y -Xj y S ,ΐΐΐίξ. Ax 1-3 igénypontok Pmistytp szarini· pmpodsiA atPInmpsp pits; p jfeiMt glSI: Pkip|ts ssjmk isr^lmaspk toakoíooéils rmkynsayapt § A2 5 Igénypont azortmi kopoddo alkatrnaPsrs. ahol SAomiitsi PkcPaiis mydnsav pmPPneniss ? As § ρηνροί szörp PsosPA alPnn*psm:Pot as említeti iimksonaiis mjklelnsav orKAtea Rapt) Wlftln ^>ί?Ι« pap (^ase#g; :am^ ®l6s^|::a gyégysser-rpsásocp gátolja a.? apopfet (aepPl). lágy dosagíl agy psg|#i# {dsgnriaios} Potipusl. S. A ?. Igénypont szerinti ahol at emlttsti tuokdonailo nuklems#:$i8&&| ahRNS vagy miRhif, ahoi rnmmt^m eiosegítía gyopsrrsrmzspendai § A 7. Igénypont szerinti kompoddá mkaimnzam ahol az említeti tankdmdtis rsuxiefc^ P^iMpioiin; ®Α-2 vagy StDfM iiiPÉ ssíözss mery isi A ?. ígénypni psrM: kemps# alkalmazásig. psi az emíiiétl Ampopís Mpsspir SIRR-g, 8CR-A8L :STaS?i teAaáissssáíal lámdiipléríA pSfaAp^dAva! kpepiia (laagAPltaaértSlaíi) PlpdkioplgaiP^ npipilAípor' yppv XRCCi í: ERCC1. OSTPX mutáns ^'tubulin, yagy paveke#^íaklöf pel# ΡΙρκη mag. 11. A /. igénypont szerinh koapzimó alkalmazásra. ahol azemlíteti tpkdonllsngpiosgy egy őlyp fsshérje átiratai célozza sep amely gátolja ozeppiozmt tg. A f. lgPy^5Csaá?mtl kömpAtóóáAaimaa|s'a mmt ay pipi %Édöhs|s aiálaiissy Agy olyan pép áérsim sete'® mag, aplyePoglfégf áeopaszitkos térmíippt 13. A?, igénypniszehnti kompozícióalkalmazásra smaiy tarimmszfevátiéagy Sylgyepá 14. A13. igénypont ezerdll kompoddá dkelmszásm, almi az említeti pógymm? be van csomagolva py elolt eakmoáils piám
- 15. Az t*U igénypontok olPolyAa. ssPdP kompoddá é®m említett Pmpsmííkes íipnOurn ísrídmaz egy adiiesmt vágy antitest fcspseftWOi, IS Az M5 igenypmok szemben bixpscmkus Panpm tartass» «gy*kö hi«1 fwno. Ofnaiy %(lagosssg&tAóp>í egy paktpáíís ptiáAMszpcs&oim. m agy mésrxiik kart, m$f íajlsgosságoi hantos agy nemPgodias inon-ppagoeytiC} emlős sa:t időiéi repfe®, 17 A 3 igéoyp-s«t S2srl«« kompozíció ahol o terápiás mAynsmí óevszáilsre egy gapanaps nstlasal yan &τφ$ AA immpiiisíiÁm, ámeiyeií M siísrgénoei vagy Pop éaé^ támoíp, és aéol a bf ps|§ atiepbP|l<P«éIP vagy ferPS; éSéhsl kpyeliP|yolÍ8íiáaPs rénPlPasséf:
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US81588306P | 2006-06-23 | 2006-06-23 | |
US90907807P | 2007-03-30 | 2007-03-30 |
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HUE13191266A HUE033007T2 (hu) | 2006-06-23 | 2007-06-20 | Gyógyszer, terápiás nukleinsavak és funkcionális nukleinsavak célzott szolgáltatása emlõs sejtekhez sértetlen elölt bakteriális sejtek útján |
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US (4) | US9878043B2 (hu) |
EP (2) | EP2040725B1 (hu) |
CN (1) | CN101505768B (hu) |
AU (1) | AU2007278899B2 (hu) |
CA (1) | CA2658058C (hu) |
CY (1) | CY1118437T1 (hu) |
DK (2) | DK2712618T3 (hu) |
ES (2) | ES2610703T3 (hu) |
HK (1) | HK1129845A1 (hu) |
HU (1) | HUE033007T2 (hu) |
LT (1) | LT2712618T (hu) |
PL (2) | PL2040725T3 (hu) |
PT (2) | PT2040725E (hu) |
SI (2) | SI2040725T1 (hu) |
WO (1) | WO2008012695A2 (hu) |
Families Citing this family (64)
Publication number | Priority date | Publication date | Assignee | Title |
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ES2380612T3 (es) * | 2001-10-15 | 2012-05-16 | Engeneic Molecular Delivery Pty Ltd. | Minicélulas intactas como vectores para transferencia de ADN y terapia génica in vitro e in vivo |
US7611885B2 (en) * | 2003-06-24 | 2009-11-03 | Engeneic Molecular Delivery Pty, Ltd. | Pharmaceutically compatible method for purifying intact bacterial minicells |
JP4332558B2 (ja) | 2003-12-09 | 2009-09-16 | エンジーンアイシー モレキュラー デリバリー ピーティーワイ リミテッド | 細菌由来のインタクトなミニ細胞を介した非食作用性哺乳動物細胞への標的化遺伝子送達 |
US8772013B2 (en) * | 2004-02-02 | 2014-07-08 | Engeneic Molecular Delivery Pty Ltd | Methods for targeted in vitro and in vivo drug delivery to mammalian cells via bacterially derived intact minicells |
ME02251B (me) | 2004-02-02 | 2015-12-31 | Engeneic Molecular Delivery Pty Ltd | Kompozicije i postupci in vitro i in vivo, ciljanog oslobađanja leka u ćelijama sisara, preko intaktnih minićelija izvedenih iz bakterija |
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