SG10201601349XA - Bacterially derived, intact minicells for delivery of therapeutic agents to brain tumors - Google Patents
Bacterially derived, intact minicells for delivery of therapeutic agents to brain tumorsInfo
- Publication number
- SG10201601349XA SG10201601349XA SG10201601349XA SG10201601349XA SG10201601349XA SG 10201601349X A SG10201601349X A SG 10201601349XA SG 10201601349X A SG10201601349X A SG 10201601349XA SG 10201601349X A SG10201601349X A SG 10201601349XA SG 10201601349X A SG10201601349X A SG 10201601349XA
- Authority
- SG
- Singapore
- Prior art keywords
- delivery
- therapeutic agents
- brain tumors
- bacterially derived
- intact minicells
- Prior art date
Links
- 208000003174 Brain Neoplasms Diseases 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229940124597 therapeutic agent Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1084—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being a hybrid immunoglobulin
- A61K51/109—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being a hybrid immunoglobulin immunoglobulins having two or more different antigen-binding sites or multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/1203—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules in a form not provided for by groups A61K51/1206 - A61K51/1296, e.g. cells, cell fragments, viruses, virus capsides, ghosts, red blood cells, viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
- A61K9/5068—Cell membranes or bacterial membranes enclosing drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Botany (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161569907P | 2011-12-13 | 2011-12-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201601349XA true SG10201601349XA (en) | 2016-03-30 |
Family
ID=48611925
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201601349XA SG10201601349XA (en) | 2011-12-13 | 2012-12-12 | Bacterially derived, intact minicells for delivery of therapeutic agents to brain tumors |
SG11201403062YA SG11201403062YA (en) | 2011-12-13 | 2012-12-12 | Bacterially derived, intact minicells for delivery of therapeutic agents to brain tumors |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201403062YA SG11201403062YA (en) | 2011-12-13 | 2012-12-12 | Bacterially derived, intact minicells for delivery of therapeutic agents to brain tumors |
Country Status (23)
Country | Link |
---|---|
US (3) | US9844598B2 (en) |
EP (1) | EP2790668B1 (en) |
JP (2) | JP6522340B2 (en) |
KR (2) | KR102046042B1 (en) |
CN (2) | CN109125286A (en) |
AU (2) | AU2012351743B2 (en) |
CA (1) | CA2858315C (en) |
CY (1) | CY1123824T1 (en) |
DK (1) | DK2790668T3 (en) |
ES (1) | ES2843402T3 (en) |
HK (1) | HK1201473A1 (en) |
HR (1) | HRP20201930T1 (en) |
HU (1) | HUE052136T2 (en) |
IL (1) | IL233031B (en) |
LT (1) | LT2790668T (en) |
MX (1) | MX359410B (en) |
PT (1) | PT2790668T (en) |
RS (1) | RS61161B1 (en) |
RU (1) | RU2664698C2 (en) |
SG (2) | SG10201601349XA (en) |
SI (1) | SI2790668T1 (en) |
TW (1) | TWI627966B (en) |
WO (1) | WO2013088250A1 (en) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1583562B1 (en) * | 2003-01-06 | 2011-06-15 | Angiochem Inc. | Angiopep-1, related compounds, and uses thereof |
US9365634B2 (en) * | 2007-05-29 | 2016-06-14 | Angiochem Inc. | Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues |
PT2279008T (en) | 2008-04-18 | 2019-05-20 | Angiochem Inc | Pharmaceutical compositions of paclitaxel, paclitaxel analogs or paclitaxel conjugates and related methods of preparation and use |
RU2531591C2 (en) | 2008-10-15 | 2014-10-20 | Ангиокем Инк. | Etoposide and doxorubicin conjugates for drug delivery |
CA2740316A1 (en) | 2008-10-15 | 2010-04-22 | Angiochem Inc. | Conjugates of glp-1 agonists and uses thereof |
CN102307904A (en) | 2008-12-05 | 2012-01-04 | 安吉奥开米公司 | Conjugates of neurotensin or neurotensin analogs and uses thereof |
CN102300987A (en) | 2008-12-17 | 2011-12-28 | 安吉奥开米公司 | Membrane Type-1 Matrix Metalloprotein Inhibitors And Uses Thereof |
US9173891B2 (en) | 2009-04-20 | 2015-11-03 | Angiochem, Inc. | Treatment of ovarian cancer using an anticancer agent conjugated to an angiopep-2 analog |
US9161988B2 (en) | 2009-07-02 | 2015-10-20 | Angiochem Inc. | Multimeric peptide conjugates and uses thereof |
WO2012019168A2 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
CA2821992A1 (en) | 2010-10-01 | 2012-04-05 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
CA2831613A1 (en) | 2011-03-31 | 2012-10-04 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
ES2911677T3 (en) | 2011-10-03 | 2022-05-20 | Modernatx Inc | Nucleosides, nucleotides and modified nucleic acids, and their uses |
SG10201601349XA (en) * | 2011-12-13 | 2016-03-30 | Engeneic Molecular Delivery Pty Ltd | Bacterially derived, intact minicells for delivery of therapeutic agents to brain tumors |
DE12858350T1 (en) | 2011-12-16 | 2021-10-07 | Modernatx, Inc. | MODIFIED MRNA COMPOSITIONS |
US10501512B2 (en) | 2012-04-02 | 2019-12-10 | Modernatx, Inc. | Modified polynucleotides |
EP3501550A1 (en) | 2012-04-02 | 2019-06-26 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins associated with human disease |
US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
US9597380B2 (en) | 2012-11-26 | 2017-03-21 | Modernatx, Inc. | Terminally modified RNA |
EP2971010B1 (en) | 2013-03-14 | 2020-06-10 | ModernaTX, Inc. | Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions |
US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
EP3041938A1 (en) | 2013-09-03 | 2016-07-13 | Moderna Therapeutics, Inc. | Circular polynucleotides |
WO2015034928A1 (en) | 2013-09-03 | 2015-03-12 | Moderna Therapeutics, Inc. | Chimeric polynucleotides |
US10023626B2 (en) | 2013-09-30 | 2018-07-17 | Modernatx, Inc. | Polynucleotides encoding immune modulating polypeptides |
EP3052521A1 (en) | 2013-10-03 | 2016-08-10 | Moderna Therapeutics, Inc. | Polynucleotides encoding low density lipoprotein receptor |
EA032740B1 (en) * | 2013-10-04 | 2019-07-31 | Энджинеик Молекьюлар Деливери Пти Лтд | Method for treating a tumor in a subject and kit for carrying out the method |
EP3169326B1 (en) * | 2014-07-15 | 2021-03-31 | The Johns Hopkins University | Suppression of myeloid derived suppressor cells and immune checkpoint blockade |
AU2015289583A1 (en) | 2014-07-16 | 2017-02-02 | Modernatx, Inc. | Chimeric polynucleotides |
EP3171895A1 (en) | 2014-07-23 | 2017-05-31 | Modernatx, Inc. | Modified polynucleotides for the production of intrabodies |
JP7029957B2 (en) | 2014-10-03 | 2022-03-04 | エンジーンアイシー モレキュラー デリバリー ピーティーワイ リミテッド | Improved filling of small molecule compounds in intact bacterial vesicles |
JP6823055B2 (en) | 2015-06-15 | 2021-01-27 | アンジオケム インコーポレーテッド | How to treat soft meningeal carcinomatosis |
PL3394093T3 (en) | 2015-12-23 | 2022-05-16 | Modernatx, Inc. | Methods of using ox40 ligand encoding polynucleotides |
US20190241658A1 (en) | 2016-01-10 | 2019-08-08 | Modernatx, Inc. | Therapeutic mRNAs encoding anti CTLA-4 antibodies |
CA3063723A1 (en) | 2017-05-18 | 2018-11-22 | Modernatx, Inc. | Polynucleotides encoding tethered interleukin-12 (il12) polypeptides and uses thereof |
DE102018220892A1 (en) * | 2018-12-04 | 2020-06-04 | Robert Bosch Gmbh | Device and method for generating label objects for the surroundings of a vehicle |
WO2020123569A1 (en) * | 2018-12-10 | 2020-06-18 | Flagship Pioneering Innovations Vi, Llc | Achromosomal dynamic active systems |
US20230139944A1 (en) * | 2019-06-21 | 2023-05-04 | Board Of Regents, The University Of Texas System | Targeting alpha3beta1 integrin for treatment of cancer and other diseases |
CN111001014B (en) * | 2019-12-12 | 2022-04-22 | 四川大学华西医院 | Anti-tumor drug based on immobilized bacteria as carrier and application thereof |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0222340Y2 (en) | 1986-11-18 | 1990-06-15 | ||
US6962702B2 (en) | 1998-06-22 | 2005-11-08 | Immunomedics Inc. | Production and use of novel peptide-based agents for use with bi-specific antibodies |
EP1169064B1 (en) * | 1999-04-02 | 2004-03-03 | Center For Molecular Medicine And Immunology | Method of detecting endometriosis |
JP4926320B2 (en) * | 1999-04-28 | 2012-05-09 | ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム | Compositions and methods for cancer treatment by selective inhibition of VEGF |
FR2793684B1 (en) | 1999-05-17 | 2001-08-10 | Ethypharm Lab Prod Ethiques | USE OF BIODEGRADABLE MICROSPHERES RELEASING ANTI-CANCER AGENT FOR THE TREATMENT OF GLIOBLASTOMA, PROCESS FOR PREPARING SUCH MICROSPHERES AND SUSPENSION CONTAINING THEM |
US20030194798A1 (en) * | 2001-05-24 | 2003-10-16 | Surber Mark W. | Minicell compositions and methods |
US20030203411A1 (en) | 2001-06-05 | 2003-10-30 | Sabbadini Roger A. | Methods of minicell-based delivery |
ES2380612T3 (en) * | 2001-10-15 | 2012-05-16 | Engeneic Molecular Delivery Pty Ltd. | Intact mini cells as vectors for DNA transfer and gene therapy in vitro and in vivo |
US7332585B2 (en) * | 2002-04-05 | 2008-02-19 | The Regents Of The California University | Bispecific single chain Fv antibody molecules and methods of use thereof |
US20040005700A1 (en) * | 2002-05-28 | 2004-01-08 | Surber Mark W. | Poroplasts |
DE60331827D1 (en) | 2002-05-29 | 2010-05-06 | Immunomedics Inc | COMPOSITIONS FOR THE RADIOIMMUN THERAPY OF BRAIN TUMORS |
WO2004013180A2 (en) * | 2002-08-01 | 2004-02-12 | Immunomedics, Inc. | Alpha-fetoprotein immu31 antibodies and fusion proteins and methods of use thereof |
US7611885B2 (en) * | 2003-06-24 | 2009-11-03 | Engeneic Molecular Delivery Pty, Ltd. | Pharmaceutically compatible method for purifying intact bacterial minicells |
JP4332558B2 (en) | 2003-12-09 | 2009-09-16 | エンジーンアイシー モレキュラー デリバリー ピーティーワイ リミテッド | Targeted gene delivery to non-phagocytic mammalian cells via intact minicells from bacteria |
ME02251B (en) * | 2004-02-02 | 2015-12-31 | Engeneic Molecular Delivery Pty Ltd | Compositions and methods for targeted in vitro and in vivo drug delivery to mammalian cells via bacterially derived intact minicells |
US8772013B2 (en) | 2004-02-02 | 2014-07-08 | Engeneic Molecular Delivery Pty Ltd | Methods for targeted in vitro and in vivo drug delivery to mammalian cells via bacterially derived intact minicells |
US7837998B2 (en) | 2004-05-21 | 2010-11-23 | Nathaniel Lallatin | Anti-cancer activity of an anti-thymidine kinase monoclonal antibody |
US8691963B2 (en) * | 2004-08-26 | 2014-04-08 | Engeneic Molecular Delivery Pty. Ltd. | Delivering functional nucleic acids to mammalian cells via bacterially-derived, intact minicells |
WO2006099445A2 (en) | 2005-03-14 | 2006-09-21 | Massachusetts Institute Of Technology | Nanocells for diagnosis and treatment of diseases and disorders |
US8940871B2 (en) | 2006-03-20 | 2015-01-27 | The Regents Of The University Of California | Engineered anti-prostate stem cell antigen (PSCA) antibodies for cancer targeting |
PT2040725E (en) * | 2006-06-23 | 2014-04-24 | Engeneic Molecular Delivery Pty Ltd | Targeted delivery of drugs, therapeutic nucleic acids and functional nucleic acids to mammalian cells via intact killed bacterial cells |
US20100215581A1 (en) | 2006-10-25 | 2010-08-26 | Koninklijke Philips Electronics N.V. | Contrast agents for detecting prostate cancer |
PL2145002T3 (en) | 2007-03-30 | 2015-06-30 | Engeneic Molecular Delivery Pty Ltd | Bacterially-derived, intact minicells that encompass plasmid-free functional nucleic acid for in vivo delivery to mammalian cells |
CA2729545C (en) * | 2008-06-25 | 2019-07-09 | Vaxiion Therapeutics, Inc. | Regulated genetic suicide mechanism compositions and methods |
CN104174025B (en) * | 2008-12-05 | 2017-01-11 | 阿布拉西斯生物科学有限责任公司 | SPARC binding peptides and uses thereof |
SG10201800757TA (en) | 2010-04-20 | 2018-02-27 | Genmab As | Heterodimeric antibody fc-containing proteins and methods for production thereof |
AU2012217728B2 (en) * | 2011-02-15 | 2017-04-27 | Vaxiion Therapeutics, Llc | Therapeutic compositions and methods for antibody and Fc-containing targeting molecule-based targeted delivery of bioactive molecules by bacterial minicells |
SG10201601349XA (en) | 2011-12-13 | 2016-03-30 | Engeneic Molecular Delivery Pty Ltd | Bacterially derived, intact minicells for delivery of therapeutic agents to brain tumors |
SG11202100507PA (en) | 2018-07-23 | 2021-02-25 | Engeneic Molecular Delivery Pty Ltd | Compositions comprising bacterially derived minicells and methods of using the same |
-
2012
- 2012-12-12 SG SG10201601349XA patent/SG10201601349XA/en unknown
- 2012-12-12 MX MX2014006967A patent/MX359410B/en active IP Right Grant
- 2012-12-12 KR KR1020197019600A patent/KR102046042B1/en active IP Right Grant
- 2012-12-12 SI SI201231862T patent/SI2790668T1/en unknown
- 2012-12-12 CA CA2858315A patent/CA2858315C/en active Active
- 2012-12-12 LT LTEP12857452.2T patent/LT2790668T/en unknown
- 2012-12-12 SG SG11201403062YA patent/SG11201403062YA/en unknown
- 2012-12-12 AU AU2012351743A patent/AU2012351743B2/en active Active
- 2012-12-12 PT PT128574522T patent/PT2790668T/en unknown
- 2012-12-12 US US13/711,848 patent/US9844598B2/en active Active
- 2012-12-12 DK DK12857452.2T patent/DK2790668T3/en active
- 2012-12-12 JP JP2014546670A patent/JP6522340B2/en active Active
- 2012-12-12 CN CN201811227385.XA patent/CN109125286A/en active Pending
- 2012-12-12 ES ES12857452T patent/ES2843402T3/en active Active
- 2012-12-12 RS RS20201489A patent/RS61161B1/en unknown
- 2012-12-12 WO PCT/IB2012/002950 patent/WO2013088250A1/en active Application Filing
- 2012-12-12 RU RU2014128338A patent/RU2664698C2/en active
- 2012-12-12 HU HUE12857452A patent/HUE052136T2/en unknown
- 2012-12-12 EP EP12857452.2A patent/EP2790668B1/en active Active
- 2012-12-12 KR KR1020147019228A patent/KR20140102294A/en active Application Filing
- 2012-12-12 CN CN201280069592.1A patent/CN104114153A/en active Pending
- 2012-12-13 TW TW101147186A patent/TWI627966B/en active
-
2014
- 2014-06-09 IL IL233031A patent/IL233031B/en active IP Right Grant
-
2015
- 2015-03-02 HK HK15102092.6A patent/HK1201473A1/en unknown
-
2017
- 2017-08-22 JP JP2017158959A patent/JP6594383B2/en active Active
- 2017-10-05 AU AU2017239542A patent/AU2017239542B2/en active Active
- 2017-10-23 US US15/790,885 patent/US10994014B2/en active Active
-
2020
- 2020-11-13 CY CY20201101075T patent/CY1123824T1/en unknown
- 2020-12-03 HR HRP20201930TT patent/HRP20201930T1/en unknown
-
2021
- 2021-03-25 US US17/212,995 patent/US11964021B2/en active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1201473A1 (en) | Bacterially derived, intact minicells for delivery of therapeutic agents to brain tumors | |
HK1192758A1 (en) | Phosphoramidate derivatives of 5-fluoro-2-deoxyuridine for use in the treatment of cancer 5--2- | |
EP2842049A4 (en) | Secure administration of virtual machines | |
PL2643004T3 (en) | Oligosaccharide composition for treating skin diseases | |
IL228112A0 (en) | Protein nanocarriers for topical delivery | |
EP2666475A4 (en) | Therapeutic agent for alopecia | |
IL232530B (en) | Combination of agents for treatment of cancer | |
ZA201404655B (en) | Methods for improving medical therapies | |
EP2752198A4 (en) | Vaccine preparation for cancer treatment | |
GB201114212D0 (en) | Therapeutic agents | |
MY168300A (en) | Pharmaceutical Composition for Inhalation | |
IL227558A0 (en) | Therapeutic agent for tumor | |
GB201119401D0 (en) | Therapeutic agents | |
EP2709670A4 (en) | Targeted delivery of proteins across the blood brain barrier | |
EP2671565A4 (en) | External preparation for skin | |
EP2717901A4 (en) | He4 based therapy for malignant disease | |
EP2709661A4 (en) | Therapeutic anti-igf1r combinations | |
EP2753398A4 (en) | System for providing targeted electrical stimulation to tissue | |
ZA201502595B (en) | Therapeutic methods | |
PL2723330T3 (en) | Vasoconstrictor-containing agent for combination therapy | |
EP2925332A4 (en) | Placental vaccination therapy for cancer | |
EP2688566A4 (en) | Anticancer therapeutic agents | |
IL230479A0 (en) | Method for treating cancer by combined use of drugs | |
EP2742970A4 (en) | System for stimulating hair growth | |
SG11201402226PA (en) | Therapeutic agent for arthrosis |