HRP20221329T1 - Automatski injektor s kontrolom temperature - Google Patents

Automatski injektor s kontrolom temperature Download PDF

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Publication number
HRP20221329T1
HRP20221329T1 HRP20221329TT HRP20221329T HRP20221329T1 HR P20221329 T1 HRP20221329 T1 HR P20221329T1 HR P20221329T T HRP20221329T T HR P20221329TT HR P20221329 T HRP20221329 T HR P20221329T HR P20221329 T1 HRP20221329 T1 HR P20221329T1
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piston lever
cartridge
automatic injector
mixing
piston
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HRP20221329TT
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Per Mølgaard PEDERSEN
Steen Jensen
Henrik EGESBORG
Bjørn Knud ANDERSEN
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Ascendis Pharma A/S
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2066—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31566—Means improving security or handling thereof
    • A61M5/31573—Accuracy improving means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321—Means for protection against accidental injuries by used needles
    • A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
    • A61M5/326—Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2403—Ampoule inserted into the ampoule holder
    • A61M2005/2411—Ampoule inserted into the ampoule holder from the front
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M2005/31588—Constructional features or modes of drive mechanisms for piston rods electrically driven
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321—Means for protection against accidental injuries by used needles
    • A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
    • A61M5/326—Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user
    • A61M2005/3267—Biased sleeves where the needle is uncovered by insertion of the needle into a patient's body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/332—Force measuring means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3368—Temperature
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A61M2205/502—User interfaces, e.g. screens or keyboards
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/60—General characteristics of the apparatus with identification means
    • A61M2205/6063—Optical identification systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/82—Internal energy supply devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/82—Internal energy supply devices
    • A61M2205/8206—Internal energy supply devices battery-operated

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  • Heart & Thoracic Surgery (AREA)
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  • Vascular Medicine (AREA)
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  • Environmental & Geological Engineering (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Exhaust-Gas Circulating Devices (AREA)
  • Electrical Control Of Air Or Fuel Supplied To Internal-Combustion Engine (AREA)

Claims (26)

1. Automatski injektor (4) za davanje lijeka, te automatski injektor sadrži: kućište (6); prijemnik uloška (300) konfiguriran za prihvat uloška (700) koji sadrži prvi graničnik (708) i odjeljak uloška (702) koji sadrži lijek, pri čemu odjeljak uloška (702) ima prvi pododjeljak uloška (704) koji sadrži koji sadrži prvu komponentu lijeka (792) za lijek i drugi pododjeljak uloška (706) koji sadrži koji sadrži drugu komponentu lijeka (794) za lijek; polugu klipa (400); pogonski modul (500) spojen radi pomicanja poluge klipa (400) između uvučenog položaja poluge klipa i ispruženog položaja poluge klipa, te je poluga klipa (400) konfigurirana za pomicanje prvog graničnika (708); a temperaturni senzor (32) konfiguriran za davanje temperaturnog signala koji ukazuje na temperaturu lijeka u ulošku (700) kada je primljen u prijemnik uloška (300); jedinicu za obradu (20) spojenu na temperaturni senzor (32) i pogonski modul (500); jedinica za obradu (20) je konfigurirana za: - primanje temperaturnog signala; - upravljanje pogonskim modulom (500) za pomicanje poluge klipa (400) iz prvog položaja poluge klipa u položaj poluge klipa za miješanje s brzinom poluge klipa za miješanje, pri čemu je položaj poluge klipa za miješanje odabran za postavljanje prvog graničnika (708) u položaj u kojem je prva komponenta lijeka (792) pomiješana s drugom komponentom lijeka (794), te pri čemu se kretanje od prvog položaja poluge klipa do položaja poluge klipa za miješanje temelji na signalu temperature; - upravljanje pogonskim modulom (500) za pomicanje poluge klipa (400) iz položaja poluge klipa za miješanje u drugi položaj poluge klipa nakon što je proteklo vrijeme rekonstitucije od završetka pomicanja poluge klipa (400) do položaja poluge klipa za miješanje, pri čemu je prvi položaj poluge klipa položaj poluge klipa za prethodno miješanje, a položaj poluge klipa za prethodno miješanje je odabran da postavlja prvi graničnik (708) u položaj u kojem još nije uspostavljena komunikacija fluida između prvog pododjeljka uloška (704) i drugog pododjeljka uloška (706), i pri čemu je drugi položaj poluge klipa glavni položaj poluge klipa, te je glavni položaj poluge klipa odabran da postavlja prvi graničnik (708) u položaj u kojem je zrak u odjeljku za uložak (702) smanjen na količinu prikladnu za ubrizgavanje.
2. Automatski injektor (4) prema patentnom zahtjevu 1 naznačen time što se vrijeme rekonstitucije temelji na signalu temperature.
3. Automatski injektor (4) prema bilo kojem od prethodnih patentnih zahtjeva naznačen time što se prvi položaj poluge klipa i/ili položaj poluge klipa za miješanje temelji na signalu temperature.
4. Automatski injektor (4) prema bilo kojem od prethodnih patentnih zahtjeva naznačen time što se brzina klipa za miješanje temelji na signalu temperature.
5. Automatski injektor (4) prema bilo kojem od prethodnih patentnih zahtjeva, naznačen time što je prijemnik uloška (300) konfiguriran za primanje sklopa uloška (600) koji sadrži uložak (700) i značajku koda uloška (1000), a automatski injektor (4) sadrži senzor koda (24) konfiguriran za čitanje značajke koda uloška (1000), te pri čemu je jedinica za obradu (20) spojena na senzor koda (24) i dalje konfigurirana za primanje od senzora koda (24) kodiranog signala koji indicira značajku koda uloška (1000), i pri čemu se kretanje od prvog položaja poluge klipa do položaja mix poluge klipa za miješanje temelji na kodiranom signalu.
6. Automatski injektor (4) prema patentnom zahtjevu 5 naznačen time što se vrijeme rekonstitucije temelji na kodiranom signalu.
7. Automatski injektor (4) prema bilo kojem od patentnih zahtjeva 5-6, naznačen time što se prvi položaj poluge klipa i/ili položaj poluge klipa za miješanje temelji na kodiranom signalu.
8. Automatski injektor (4) prema bilo kojem od patentnih zahtjeva 5-7 naznačen time što se brzina klipa za miješanje temelji na kodiranom signalu.
9. Automatski injektor (4) prema bilo kojem od prethodnih patentnih zahtjeva koji sadrži senzor orijentacije (22) konfiguriran da daje signal orijentacije koji ukazuje na orijentaciju uloška (700) kada se primi u prijemnik uloška (300), te pri čemu je jedinica za obradu (20) spojena je na senzor orijentacije (22) i dalje konfigurirana za primanje signala orijentacije, te pri čemu se kretanje od prvog položaja poluge klipa do položaja poluge klipa za miješanje temelji na signalu orijentacije.
10. Automatski injektor (4) prema patentnom zahtjevu 9 naznačen time što se vrijeme rekonstitucije temelji na signalu orijentacije.
11. Automatski injektor (4) prema bilo kojem od patentnih zahtjeva 9-10 naznačen time što se brzina klipa za miješanje temelji na signalu orijentacije.
12. Automatski injektor (4) prema bilo kojem od prethodnih patentnih zahtjeva, naznačen time što je jedinica za obradu (20) dalje konfigurirana za određivanje prvog parametra kretanja na temelju kumulativnog kretanja automatskog injektora (4).
13. Automatski injektor (4) prema patentnom zahtjevu 12, naznačen time što se vrijeme rekonstitucije temelji na prvom parametru kretanja.
14. Automatski injektor (4) prema bilo kojem od patentnih zahtjeva 12-13, naznačen time što se brzina klipa za miješanje temelji na prvom parametru kretanja.
15. Automatski injektor (4) prema bilo kojem od patentnih zahtjeva 12-14, naznačen time što je prvi parametar kretanja pokazatelj broja inverzija automatskog injektora (4).
16. Automatski injektor (4) prema bilo kojem od patentnih zahtjeva 12-15, naznačen time što je prvi parametar pomicanja pokazatelj frekvencije pomicanja automatskog injektora (4).
17. Automatski injektor (4) prema bilo kojem od prethodnih patentnih zahtjeva, naznačen time što temperaturni senzor (32) sadrži infracrveni senzor.
18. Automatski injektor (4) prema bilo kojem od prethodnih patentnih zahtjeva naznačen time što nadalje sadrži jedinicu za kontrolu temperature (36) konfiguriranu da mijenja temperaturu uloška kada se primi u prijemnik uloška.
19. Automatski injektor (4) prema patentnom zahtjevu 18, naznačen time što je jedinica za kontrolu temperature (36) konfigurirana za podizanje temperature uloška (700).
20. Automatski injektor (4) prema patentnom zahtjevu 19, naznačen time što jedinica za kontrolu temperature (36) sadrži otporni grijaći element.
21. Automatski injektor (4) prema bilo kojem od patentnih zahtjeva 19-20, naznačen time što jedinica za kontrolu temperature (36) sadrži dielektrični grijaći element.
22. Automatski injektor (4) prema bilo kojem od patentnih zahtjeva 18-21, naznačen time što je jedinica za kontrolu temperature (36) konfigurirana da snižava temperaturu uloška (700).
23. Automatski injektor (4) prema bilo kojem od patentnih zahtjeva 18-22, naznačen time što jedinica za kontrolu temperature (36) sadrži termoelektrični element, kao što je Peltierov element.
24. Automatski injektor (4) prema bilo kojem od patentnih zahtjeva 18-23, naznačen time što jedinica za kontrolu temperature (36) sadrži kontaktni element (42) konfiguriran da bude u kontaktu s uloškom (700) kada se prihvaća u prijemnik uloška (300).
25. Automatski injektor (4) prema bilo kojem od patentnih zahtjeva 18-24, naznačen time što jedinica za kontrolu temperature (36) sadrži element zavojnice konfiguriran da okružuje cijeli perimetar uloška (700) kada se prihvaća u prijemnik uloška (300).
26. Postupak za pripremu lijeka i punjenje automatskog injektora (4), te automatski injektor (4) sadrži prijemnik uloška (300) konfiguriran da prihvaća uložak (700) koji sadrži prvi graničnik (708) i odjeljak za uložak (702) koji sadrži lijek, te odjeljak za uložak (702) ima prvi pododjeljak uloška (704) koji sadrži prvu komponentu lijeka (792) za lijek i drugi pododjeljak uloška (706) koji sadrži drugu komponentu lijeka (794) za lijek, polugu klipa (400) konfiguriranu za pomicanje prvog graničnika (708), i temperaturni senzor (32), te postupak obuhvaća: - primanje temperaturnog signala od temperaturnog senzora (32) koji pokazuje temperaturu lijeka kada je uložak (700) primljen u prijemnik uloška (300); - pomicanje poluge klipa (400) iz prvog položaja poluge klipa u položaj poluge klipa za miješanje s brzinom poluge klipa za miješanje, pri čemu je položaj poluge klipa za miješanje odabran za postavljanje prvog graničnika (708) u položaj pri čemu se prva komponenta lijeka (792) miješa sa drugom komponentom lijeka (794), te pri čemu pri čemu se kretanje od prvog položaja poluge klipa do položaja poluge klipa za miješanje temelji na signalu temperature; - pomicanje poluge klipa (400) iz položaja poluge klipa za miješanje u drugi položaj poluge klipa nakon što je proteklo vrijeme rekonstitucije od završetka pomicanja poluge klipa (400) u položaj poluge klipa za miješanje, pri čemu je drugi položaj poluge klipa glavni položaj poluge klipa, te je glavni položaj poluge klipa odabran tako da postavlja prvi graničnik u položaj pri čemu je zrak u odjeljku uloška smanjen na količinu prikladnu za ubrizgavanje.
HRP20221329TT 2015-12-30 2016-12-29 Automatski injektor s kontrolom temperature HRP20221329T1 (hr)

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PCT/EP2016/082857 WO2017114908A1 (en) 2015-12-30 2016-12-29 Auto injector with temperature control

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