HRP20192182T1 - Agrokemijski pripravci koji sadrže protutijela koja se vežu na sfingolipide - Google Patents

Agrokemijski pripravci koji sadrže protutijela koja se vežu na sfingolipide Download PDF

Info

Publication number
HRP20192182T1
HRP20192182T1 HRP20192182TT HRP20192182T HRP20192182T1 HR P20192182 T1 HRP20192182 T1 HR P20192182T1 HR P20192182T T HRP20192182T T HR P20192182TT HR P20192182 T HRP20192182 T HR P20192182T HR P20192182 T1 HRP20192182 T1 HR P20192182T1
Authority
HR
Croatia
Prior art keywords
seq
region
cdr1
cdr2
cdr3
Prior art date
Application number
HRP20192182TT
Other languages
English (en)
Inventor
Peter Verheesen
Chris De Jonghe
Inge Elodie VAN DAELE
Miguel Francesco Coleta De Bolle
João Filipe VELOSO VIEIRA
Karin Thevissen
Bruno Cammue
Original Assignee
Agrosavfe Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agrosavfe Nv filed Critical Agrosavfe Nv
Publication of HRP20192182T1 publication Critical patent/HRP20192182T1/hr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/14Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from fungi, algea or lichens
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • A01N37/46N-acyl derivatives
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/10Animals; Substances produced thereby or obtained therefrom
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/50Isolated enzymes; Isolated proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8279Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Claims (8)

1. Agrokemijski pripravak za zaštitu ili tretiranje biljke ili dijela navedene biljke od infekcije ili druge biološke interakcije s biljnom patogenom gljivom, koji sadrži najmanje jedan VHH, koji se specifično veže na glukozilceramid biljne patogene gljive, ili njegov ulomak pri čemu zadržava specifičnost vezanja izvornog VHH, naznačen time što se koncentracija navedenog najmanje jednog VHH u agrokemijskom pripravku kreće u rasponu od 0,001 do 50 masenih%.
2. Agrokemijski pripravak prema patentnom zahtjevu 1, naznačen time što nadalje sadrži agrokemijski prihvatljiv nosač i/ili jednu ili više prikladnih pomoćnih tvari.
3. Agrokemijski pripravak prema patentnom zahtjevu 1, naznačen time što je rod navedene biljne patogene gljive odabran iz skupine koja sadrži rodove Alternaria, Ascochyta, Botrytis, Cercospora, Colletotrichum, Diplodia, Erysiphe, Fusarium, Leptosphaeria, Gaeumanomyces, Helminthosporium, Macrophomina, Nectria, Penicillium, Peronospora, Phoma, Phymatotrichum, Phytophthora, Plasmopara, Podosphaera, Puccinia, Pyrenophora, Pyricularia, Pythium, Rhizoctonia, Scerotium, Sclerotinia, Septoria, Thielaviopsis, Uncinula, Venturia, Verticillium, Magnaporthe, Blumeria, Mycosphaerella, Ustilago, Melampsora, Phakopsora, Monilinia, Mucor, Rhizopus, i Aspergillus.
4. Agrokemijski pripravak prema bilo kojem od patentnih zahtjeva 1 do 3, naznačen time što navedeni najmanje jedan VHH sadrži jednu ili više kombinacija odabranih iz skupine koja sadrži: CDR1 regiju koja ima SEQ ID NO: 85, CDR2 regiju koja ima SEQ ID NO: 169, i CDR3 regiju koja ima SEQ ID NO: 253, i/ili CDR1 regiju koja ima SEQ ID NO: 86, CDR2 regiju koja ima SEQ ID NO: 170, i CDR3 regiju koja ima SEQ ID NO: 254, i/ili CDR1 regiju koja ima SEQ ID NO: 87, CDR2 regiju koja ima SEQ ID NO: 171, i CDR3 regiju koja ima SEQ ID NO: 255, i/ili CDR1 regiju koja ima SEQ ID NO: 88, CDR2 regiju koja ima SEQ ID NO: 172, i CDR3 regiju koja ima SEQ ID NO: 256, i/ili CDR1 regiju koja ima SEQ ID NO: 89, CDR2 regiju koja ima SEQ ID NO: 173, i CDR3 regiju koja ima SEQ ID NO: 257, i/ili CDR1 regiju koja ima SEQ ID NO: 90, CDR2 regiju koja ima SEQ ID NO: 174, i CDR3 regiju koja ima SEQ ID NO: 258, i/ili CDR1 regiju koja ima SEQ ID NO: 91, CDR2 regiju koja ima SEQ ID NO: 175, i CDR3 regiju koja ima SEQ ID NO: 259, i/ili CDR1 regiju koja ima SEQ ID NO: 92, CDR2 regiju koja ima SEQ ID NO: 176, i CDR3 regiju koja ima SEQ ID NO: 260, i/ili CDR1 regiju koja ima SEQ ID NO: 93, CDR2 regiju koja ima SEQ ID NO: 177, i CDR3 regiju koja ima SEQ ID NO: 261, i/ili CDR1 regiju koja ima SEQ ID NO: 94, CDR2 regiju koja ima SEQ ID NO: 178, i CDR3 regiju koja ima SEQ ID NO: 262, i/ili CDR1 regiju koja ima SEQ ID NO: 95, CDR2 regiju koja ima SEQ ID NO: 179, i CDR3 regiju koja ima SEQ ID NO: 263, i/ili CDR1 regiju koja ima SEQ ID NO: 96, CDR2 regiju koja ima SEQ ID NO: 180, i CDR3 regiju koja ima SEQ ID NO: 264, i/ili CDR1 regiju koja ima SEQ ID NO: 97, CDR2 regiju koja ima SEQ ID NO: 181, i CDR3 regiju koja ima SEQ ID NO: 265, i/ili CDR1 regiju koja ima SEQ ID NO: 98, CDR2 regiju koja ima SEQ ID NO: 182, i CDR3 regiju koja ima SEQ ID NO: 266, i/ili CDR1 regiju koja ima SEQ ID NO: 99, CDR2 regiju koja ima SEQ ID NO: 183, i CDR3 regiju koja ima SEQ ID NO: 267, i/ili CDR1 regiju koja ima SEQ ID NO: 100, CDR2 regiju koja ima SEQ ID NO: 184, i CDR3 regiju koja ima SEQ ID NO: 268, i/ili CDR1 regiju koja ima SEQ ID NO: 101, CDR2 regiju koja ima SEQ ID NO: 185, i CDR3 regiju koja ima SEQ ID NO: 269, i/ili CDR1 regiju koja ima SEQ ID NO: 102, CDR2 regiju koja ima SEQ ID NO: 186, i CDR3 regiju koja ima SEQ ID NO: 270, i/ili CDR1 regiju koja ima SEQ ID NO: 103, CDR2 regiju koja ima SEQ ID NO: 187, i CDR3 regiju koja ima SEQ ID NO: 271, i/ili CDR1 regiju koja ima SEQ ID NO: 104, CDR2 regiju koja ima SEQ ID NO: 188, i CDR3 regiju koja ima SEQ ID NO: 272, i/ili CDR1 regiju koja ima SEQ ID NO: 105, CDR2 regiju koja ima SEQ ID NO: 189, i CDR3 regiju koja ima SEQ ID NO: 273, i/ili CDR1 regiju koja ima SEQ ID NO: 106, CDR2 regiju koja ima SEQ ID NO: 190, i CDR3 regiju koja ima SEQ ID NO: 274, i/ili CDR1 regiju koja ima SEQ ID NO: 107, CDR2 regiju koja ima SEQ ID NO: 191, i CDR3 regiju koja ima SEQ ID NO: 275, i/ili CDR1 regiju koja ima SEQ ID NO: 108, CDR2 regiju koja ima SEQ ID NO: 192, i CDR3 regiju koja ima SEQ ID NO: 276, i/ili CDR1 regiju koja ima SEQ ID NO: 109, CDR2 regiju koja ima SEQ ID NO: 193, i CDR3 regiju koja ima SEQ ID NO: 277, i/ili CDR1 regiju koja ima SEQ ID NO: 110, CDR2 regiju koja ima SEQ ID NO: 194, i CDR3 regiju koja ima SEQ ID NO: 278, i/ili CDR1 regiju koja ima SEQ ID NO: 111, CDR2 regiju koja ima SEQ ID NO: 195, i CDR3 regiju koja ima SEQ ID NO: 279, i/ili CDR1 regiju koja ima SEQ ID NO: 112, CDR2 regiju koja ima SEQ ID NO: 196, i CDR3 regiju koja ima SEQ ID NO: 280, i/ili CDR1 regiju koja ima SEQ ID NO: 113, CDR2 regiju koja ima SEQ ID NO: 197, i CDR3 regiju koja ima SEQ ID NO: 281, i/ili CDR1 regiju koja ima SEQ ID NO: 114, CDR2 regiju koja ima SEQ ID NO: 198, i CDR3 regiju koja ima SEQ ID NO: 282, i/ili CDR1 regiju koja ima SEQ ID NO: 115, CDR2 regiju koja ima SEQ ID NO: 199, i CDR3 regiju koja ima SEQ ID NO: 283, i/ili CDR1 regiju koja ima SEQ ID NO: 116, CDR2 regiju koja ima SEQ ID NO: 200, i CDR3 regiju koja ima SEQ ID NO: 284, i/ili CDR1 regiju koja ima SEQ ID NO: 117, CDR2 regiju koja ima SEQ ID NO: 201, i CDR3 regiju koja ima SEQ ID NO: 285, i/ili CDR1 regiju koja ima SEQ ID NO: 118, CDR2 regiju koja ima SEQ ID NO: 202, i CDR3 regiju koja ima SEQ ID NO: 286, i/ili CDR1 regiju koja ima SEQ ID NO: 119, CDR2 regiju koja ima SEQ ID NO: 203, i CDR3 regiju koja ima SEQ ID NO: 287, i/ili CDR1 regiju koja ima SEQ ID NO: 120, CDR2 regiju koja ima SEQ ID NO: 204, i CDR3 regiju koja ima SEQ ID NO: 288, i/ili CDR1 regiju koja ima SEQ ID NO: 121, CDR2 regiju koja ima SEQ ID NO: 205, i CDR3 regiju koja ima SEQ ID NO: 289, i/ili CDR1 regiju koja ima SEQ ID NO: 122, CDR2 regiju koja ima SEQ ID NO: 206, i CDR3 regiju koja ima SEQ ID NO: 290, i/ili CDR1 regiju koja ima SEQ ID NO: 123, CDR2 regiju koja ima SEQ ID NO: 207, i CDR3 regiju koja ima SEQ ID NO: 291, i/ili CDR1 regiju koja ima SEQ ID NO: 124, CDR2 regiju koja ima SEQ ID NO: 208, i CDR3 regiju koja ima SEQ ID NO: 292, i/ili CDR1 regiju koja ima SEQ ID NO: 125, CDR2 regiju koja ima SEQ ID NO: 209, i CDR3 regiju koja ima SEQ ID NO: 293, i/ili CDR1 regiju koja ima SEQ ID NO: 126, CDR2 regiju koja ima SEQ ID NO: 210, i CDR3 regiju koja ima SEQ ID NO: 294, i/ili CDR1 regiju koja ima SEQ ID NO: 127, CDR2 regiju koja ima SEQ ID NO: 211, i CDR3 regiju koja ima SEQ ID NO: 295, i/ili CDR1 regiju koja ima SEQ ID NO: 128, CDR2 regiju koja ima SEQ ID NO: 212, i CDR3 regiju koja ima SEQ ID NO: 296, i/ili CDR1 regiju koja ima SEQ ID NO: 129, CDR2 regiju koja ima SEQ ID NO: 213, i CDR3 regiju koja ima SEQ ID NO: 297, i/ili CDR1 regiju koja ima SEQ ID NO: 130, CDR2 regiju koja ima SEQ ID NO: 214, i CDR3 regiju koja ima SEQ ID NO: 298, i/ili CDR1 regiju koja ima SEQ ID NO: 131, CDR2 regiju koja ima SEQ ID NO: 215, i CDR3 regiju koja ima SEQ ID NO: 299, i/ili CDR1 regiju koja ima SEQ ID NO: 132, CDR2 regiju koja ima SEQ ID NO: 216, i CDR3 regiju koja ima SEQ ID NO: 300, i/ili CDR1 regiju koja ima SEQ ID NO: 133, CDR2 regiju koja ima SEQ ID NO: 217, i CDR3 regiju koja ima SEQ ID NO: 301, i/ili CDR1 regiju koja ima SEQ ID NO: 134, CDR2 regiju koja ima SEQ ID NO: 218, i CDR3 regiju koja ima SEQ ID NO: 302, i/ili CDR1 regiju koja ima SEQ ID NO: 135, CDR2 regiju koja ima SEQ ID NO: 219, i CDR3 regiju koja ima SEQ ID NO: 303, i/ili CDR1 regiju koja ima SEQ ID NO: 136, CDR2 regiju koja ima SEQ ID NO: 220, i CDR3 regiju koja ima SEQ ID NO: 304, i/ili CDR1 regiju koja ima SEQ ID NO: 137, CDR2 regiju koja ima SEQ ID NO: 221, i CDR3 regiju koja ima SEQ ID NO: 305, i/ili CDR1 regiju koja ima SEQ ID NO: 138, CDR2 regiju koja ima SEQ ID NO: 222, i CDR3 regiju koja ima sekvencu aminokiseline NRY, i/ili CDR1 regiju koja ima SEQ ID NO: 139, CDR2 regiju koja ima SEQ ID NO: 223, i CDR3 regiju koja ima SEQ ID NO: 306, i/ili CDR1 regiju koja ima SEQ ID NO: 140, CDR2 regiju koja ima SEQ ID NO: 224, i CDR3 regiju koja ima SEQ ID NO: 307, i/ili CDR1 regiju koja ima SEQ ID NO: 141, CDR2 regiju koja ima SEQ ID NO: 225, i CDR3 regiju koja ima SEQ ID NO: 308, i/ili CDR1 regiju koja ima SEQ ID NO: 142, CDR2 regiju koja ima SEQ ID NO: 226, i CDR3 regiju koja ima SEQ ID NO: 309, i/ili CDR1 regiju koja ima SEQ ID NO: 143, CDR2 regiju koja ima SEQ ID NO: 227, i CDR3 regiju koja ima SEQ ID NO: 310, i/ili CDR1 regiju koja ima SEQ ID NO: 144, CDR2 regiju koja ima SEQ ID NO: 228, i CDR3 regiju koja ima SEQ ID NO: 311, i/ili CDR1 regiju koja ima SEQ ID NO: 145, CDR2 regiju koja ima SEQ ID NO: 229, i CDR3 regiju koja ima SEQ ID NO: 312, i/ili CDR1 regiju koja ima SEQ ID NO: 146, CDR2 regiju koja ima SEQ ID NO: 230, i CDR3 regiju koja ima SEQ ID NO: 313, i/ili CDR1 regiju koja ima SEQ ID NO: 147, CDR2 regiju koja ima SEQ ID NO: 231, i CDR3 regiju koja ima SEQ ID NO: 314, i/ili CDR1 regiju koja ima SEQ ID NO: 148, CDR2 regiju koja ima SEQ ID NO: 232, i CDR3 regiju koja ima SEQ ID NO: 315, i/ili CDR1 regiju koja ima SEQ ID NO: 149, CDR2 regiju koja ima SEQ ID NO: 233, i CDR3 regiju koja ima SEQ ID NO: 316, i/ili CDR1 regiju koja ima SEQ ID NO: 150, CDR2 regiju koja ima SEQ ID NO: 234, i CDR3 regiju koja ima SEQ ID NO: 317, i/ili CDR1 regiju koja ima SEQ ID NO: 151, CDR2 regiju koja ima SEQ ID NO: 235, i CDR3 regiju koja ima SEQ ID NO: 318, i/ili CDR1 regiju koja ima SEQ ID NO: 152, CDR2 regiju koja ima SEQ ID NO: 236, i CDR3 regiju koja ima SEQ ID NO: 319, i/ili CDR1 regiju koja ima SEQ ID NO: 153, CDR2 regiju koja ima SEQ ID NO: 237, i CDR3 regiju koja ima SEQ ID NO: 320, i/ili CDR1 regiju koja ima SEQ ID NO: 154, CDR2 regiju koja ima SEQ ID NO: 238, i CDR3 regiju koja ima SEQ ID NO: 321, i/ili CDR1 regiju koja ima SEQ ID NO: 155, CDR2 regiju koja ima SEQ ID NO: 239, i CDR3 regiju koja ima SEQ ID NO: 322, i/ili CDR1 regiju koja ima SEQ ID NO: 156, CDR2 regiju koja ima SEQ ID NO: 240, i CDR3 regiju koja ima SEQ ID NO: 323, i/ili CDR1 regiju koja ima SEQ ID NO: 157, CDR2 regiju koja ima SEQ ID NO: 241, i CDR3 regiju koja ima SEQ ID NO: 324, i/ili CDR1 regiju koja ima SEQ ID NO: 158, CDR2 regiju koja ima SEQ ID NO: 242, i CDR3 regiju koja ima SEQ ID NO: 325, i/ili CDR1 regiju koja ima SEQ ID NO: 159, CDR2 regiju koja ima SEQ ID NO: 243, i CDR3 regiju koja ima SEQ ID NO: 326, i/ili CDR1 regiju koja ima SEQ ID NO: 160, CDR2 regiju koja ima SEQ ID NO: 244, i CDR3 regiju koja ima SEQ ID NO: 327, i/ili CDR1 regiju koja ima SEQ ID NO: 161, CDR2 regiju koja ima SEQ ID NO: 245, i CDR3 regiju koja ima SEQ ID NO: 328, i/ili CDR1 regiju koja ima SEQ ID NO: 162, CDR2 regiju koja ima SEQ ID NO: 246, i CDR3 regiju koja ima SEQ ID NO: 329, i/ili CDR1 regiju koja ima SEQ ID NO: 163, CDR2 regiju koja ima SEQ ID NO: 247, i CDR3 regiju koja ima SEQ ID NO: 330, i/ili CDR1 regiju koja ima SEQ ID NO: 164, CDR2 regiju koja ima SEQ ID NO: 248, i CDR3 regiju koja ima SEQ ID NO: 331, i/ili CDR1 regiju koja ima SEQ ID NO: 165, CDR2 regiju koja ima SEQ ID NO: 249, i CDR3 regiju koja ima SEQ ID NO: 332, i/ili CDR1 regiju koja ima SEQ ID NO: 166, CDR2 regiju koja ima SEQ ID NO: 250, i CDR3 regiju koja ima SEQ ID NO: 333, i/ili CDR1 regiju koja ima SEQ ID NO: 167, CDR2 regiju koja ima SEQ ID NO: 251, i CDR3 regiju koja ima SEQ ID NO: 334, i/ili CDR1 regiju koja ima SEQ ID NO: 168, CDR2 regiju koja ima SEQ ID NO: 252, i CDR3 regiju koja ima SEQ ID NO: 335.
5. Upotreba agrokemijskog pripravka prema bilo kojem od patentnih zahtjeva 1 do 4 kao fungicidnog i/ili fungistatskog sredstva.
6. Postupak zaštite ili tretiranja biljke ili dijela navedene biljke od infekcije ili druge biološke interakcije s biljnom patogenom gljivom, koji obuhvaća barem korak primjene na navedenu biljku ili na dio navedene biljke, agrokemijskog pripravka prema bilo kojem od patentnih zahtjeva 1 do 4, pod uvjetima koji su učinkoviti za zaštitu ili tretiranje navedene biljke ili dijela navedene biljke od navedene infekcije ili biološke interakcije s navedenom biljnom patogenom gljivom.
7. Postupak tretmana nakon berbe za zaštitu ili tretiranje ubrane biljke ili ubranog dijela navedene biljke od infekcije ili druge biološke interakcije s biljnom patogenom gljivom, koji barem uključuje korak primjene na navedenu ubranu biljku ili na ubrani dio navedene biljke, agrokemijskog pripravka prema bilo kojem od patentnih zahtjeva 1 do 4, pod uvjetima koji su učinkoviti za zaštitu ili tretiranje navedene ubrane biljke ili ubranog dijela navedene biljke od navedene infekcije ili biološke interakcije s navedenom biljnom patogenom gljivom.
8. Postupak inhibicije ili ubijanja rasta biljne patogene gljive, naznačen time što obuhvaća barem korak primjene na biljku ili na dio navedene biljke, agrokemijskog pripravka prema bilo kojem od patentnih zahtjeva 1 do 4.
HRP20192182TT 2013-04-29 2019-12-04 Agrokemijski pripravci koji sadrže protutijela koja se vežu na sfingolipide HRP20192182T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361817170P 2013-04-29 2013-04-29
EP14725022.9A EP2992100B1 (en) 2013-04-29 2014-04-29 Agrochemical compositions comprising antibodies binding to sphingolipids
PCT/EP2014/058772 WO2014191146A1 (en) 2013-04-29 2014-04-29 Agrochemical compositions comprising antibodies binding to sphingolipids

Publications (1)

Publication Number Publication Date
HRP20192182T1 true HRP20192182T1 (hr) 2020-02-21

Family

ID=50736046

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20192182TT HRP20192182T1 (hr) 2013-04-29 2019-12-04 Agrokemijski pripravci koji sadrže protutijela koja se vežu na sfingolipide

Country Status (16)

Country Link
US (5) US9803003B2 (hr)
EP (3) EP2992100B1 (hr)
JP (4) JP6388917B2 (hr)
CN (4) CN116076508A (hr)
AU (3) AU2014273418B2 (hr)
BR (2) BR112015027192B1 (hr)
CA (2) CA2910632A1 (hr)
DK (1) DK2992100T3 (hr)
ES (2) ES2762151T3 (hr)
HR (1) HRP20192182T1 (hr)
HU (1) HUE047580T2 (hr)
PL (2) PL2992101T3 (hr)
PT (1) PT2992100T (hr)
TR (1) TR201819577T4 (hr)
WO (2) WO2014177595A1 (hr)
ZA (2) ZA201507758B (hr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8598081B2 (en) 2010-04-06 2013-12-03 Agrosavfe N.V. Specific delivery of agrochemicals
PT2992100T (pt) 2013-04-29 2019-12-16 Agrosavfe Nv Composições agroquímicas compreendendo anticorpos que se ligam a esfingolípidos
US20180222966A1 (en) * 2013-04-29 2018-08-09 Agrosavfe N.V. Transgenic plant comprising a polynucleotide encoding a variable domain of heavy-chain antibody
JP6376798B2 (ja) * 2014-03-27 2018-08-22 三菱重工業株式会社 洗濯排水生物処理製剤を用いた洗濯排水処理装置及び方法
JP7089877B2 (ja) 2014-11-05 2022-06-23 バイオタリス・エン・フェー 重鎖抗体の可変ドメインをコードするポリヌクレオチドを含むトランスジェニック植物
EP3415010A1 (en) * 2017-06-13 2018-12-19 Agrosavfe Nv Insect-controlling polypeptides and methods
EP3665303A4 (en) * 2017-08-09 2021-04-28 Orionis Biosciences, Inc. CLEC9A BINDING INGREDIENTS AND USES THEREOF
US10017560B1 (en) 2017-11-16 2018-07-10 King Saud University Nanobody against begomoviruses
US11896643B2 (en) 2018-02-05 2024-02-13 Orionis Biosciences, Inc. Fibroblast binding agents and use thereof
CN109081870B (zh) * 2018-09-21 2021-12-03 成都阿帕克生物科技有限公司 一种抗人促绒毛膜***β亚单位的纳米抗体及核酸分子和应用
WO2020210237A1 (en) * 2019-04-08 2020-10-15 Dna Twopointo Inc. Transposition of nucleic acid constructs into eukaryotic genomes with a transposase from amyelois
AU2020258365A1 (en) * 2019-04-13 2021-12-02 Flagship Pioneering Innovations Vi, Llc Plant messenger packs encapsulating polypeptides and uses thereof
CN110205252A (zh) * 2019-06-20 2019-09-06 江苏大学 喷雾干燥制备拮抗酵母固体制剂的方法
WO2021072312A1 (en) * 2019-10-11 2021-04-15 The Trustees Of The University Of Pennsylvania Compositions and methods for targeting cd13 and tim-3 with car t cells to treat acute myeloid leukemia
AU2020384953A1 (en) 2019-11-11 2022-06-23 Ibi-Ag Innovative Bio Insecticides Ltd. Insect control nanobodies and uses thereof
CA3178461A1 (en) * 2020-03-31 2021-10-07 Biotalys NV Anti-fungal polypeptides
US20230227577A1 (en) * 2020-05-05 2023-07-20 Oncorus, Inc. Anti-dll3 antibodies and methods of use
IL300173A (en) 2020-07-31 2023-03-01 Biotalys NV expression host
EP4015041A1 (en) * 2020-12-15 2022-06-22 Universidad De Zaragoza Treatment of fungal infections or diseases
CN113121692B (zh) * 2021-04-29 2022-12-06 中国科学技术大学 结合人rage胞外域的羊驼源抗体
WO2023148291A1 (en) 2022-02-02 2023-08-10 Biotalys NV Methods for genome editing
WO2023148301A1 (en) 2022-02-02 2023-08-10 Biotalys NV Modified microbial cells and uses thereof
WO2023172983A1 (en) * 2022-03-08 2023-09-14 Molecular Templates, Inc. Ctla-4 binding molecules comprising shiga toxin a subunit scaffolds and uses thereof
CN115043934B (zh) * 2022-03-31 2023-06-27 深圳市人民医院 靶向新冠病毒的纳米抗体及其制备方法和应用
CN117659194A (zh) * 2023-11-30 2024-03-08 科弈(浙江)药业科技有限公司 靶向egfr的纳米抗体、药物偶联物及其用途
CN117866903A (zh) * 2024-03-12 2024-04-12 北京贝来药业有限公司 单域抗体修饰的干细胞及其在疾病治疗中用途

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02128697A (ja) * 1988-11-09 1990-05-17 Hoechst Japan Ltd 抗フコシルセラミドモノクローナル抗体
AU634186B2 (en) 1988-11-11 1993-02-18 Medical Research Council Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors
DK1087013T3 (da) 1992-08-21 2009-05-11 Univ Bruxelles Immunoglobuliner uden lette kæder
DK0698097T3 (da) 1993-04-29 2001-10-08 Unilever Nv Produktion af antistoffer eller (funktionaliserede) fragmenter deraf afledt af Camelidae-immunoglobuliner med tung kæde
FR2708622B1 (fr) 1993-08-02 1997-04-18 Raymond Hamers Vecteur recombinant contenant une séquence d'un gène de lipoprotéine de structure pour l'expression de séquences de nucléotides.
WO1996009398A1 (en) * 1994-09-19 1996-03-28 Rijkslandbouwuniversiteit Wageningen Gene constructs encoding crop-protecting agents, as well as transformed plants containing and expressing such constructs, and methods of controlling plague organisms and pathogens in crops
EP0739981A1 (en) 1995-04-25 1996-10-30 Vrije Universiteit Brussel Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes
ATE374248T1 (de) 1996-06-27 2007-10-15 Vlaams Interuniv Inst Biotech Antikörpermoleküle, die spezifisch mit dem aktiven zentrum oder dem aktiven spalt eines zielmoleküls interagieren
EP1051493A2 (en) 1998-01-26 2000-11-15 Unilever Plc Method for producing antibody fragments
AU5209399A (en) 1998-07-10 2000-02-01 Cornell Research Foundation Inc. Recombinant constructs and systems for secretion of proteins via type iii secretion systems
EP1123398B1 (en) 1998-10-16 2005-08-10 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Molecular pathogenicide mediated plant disease resistance
WO2000040968A1 (en) 1999-01-05 2000-07-13 Unilever Plc Binding of antibody fragments to solid supports
AU2291700A (en) 1999-01-19 2000-08-07 Unilever Plc Method for producing antibody fragments
WO2000065057A1 (en) 1999-04-22 2000-11-02 Unilever Plc Inhibition of viral infection using monovalent antigen-binding proteins
AU775233B2 (en) 1999-07-22 2004-07-22 National Institute Of Agrobiological Sciences Method for superrapid transformation of monocotyledon
US6479280B1 (en) 1999-09-24 2002-11-12 Vlaams Interuniversitair Institutuut Voor Biotechnologie Vzw Recombinant phages capable of entering host cells via specific interaction with an artificial receptor
ES2331051T3 (es) 1999-11-29 2009-12-21 Bac Ip B.V. Inmovilizacion de moleculas de union de antigenos de un dominio.
US7358096B1 (en) 1999-11-29 2008-04-15 Conopco, Inc. Immobilisation of proteins
EP1118669A3 (en) 1999-12-17 2001-08-29 Unilever Plc Production of camelid antibodies in plants
DE60138333D1 (de) 2000-03-14 2009-05-28 Unilever Nv Variabele Domänen der schweren Kette eines Antikörpers gegen menschliche Ernährungslipasen und deren Verwendungen
US20030190598A1 (en) 2000-05-26 2003-10-09 Jasmid Tanha Single-domain antigen-binding antibody fragments derived from llama antibodies
DK1360207T3 (da) 2000-12-13 2011-09-05 Bac Ip B V Proteinarray af variable domæner af tunge immunoglobulinkæder fra kameler
GB0110029D0 (en) * 2001-04-24 2001-06-13 Grosveld Frank Transgenic animal
US20060073141A1 (en) 2001-06-28 2006-04-06 Domantis Limited Compositions and methods for treating inflammatory disorders
EP1433793A4 (en) 2001-09-13 2006-01-25 Inst Antibodies Co Ltd METHOD FOR CREATING A CAMEL ANTIBODY LIBRARY
JP2005289809A (ja) 2001-10-24 2005-10-20 Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) 突然変異重鎖抗体
EP1456410A2 (en) 2001-12-11 2004-09-15 AlgoNomics N.V. Method for displaying loops from immunoglobulin domains in different contexts
CA2471116A1 (en) 2001-12-21 2003-07-03 Serge Muyldermans Method for cloning of variable domain sequences
JP2005517674A (ja) 2002-01-03 2005-06-16 フラームス・インテルウニフェルシタイル・インステイチュート・フォール・ビオテヒノロヒー・ヴェーゼットウェー 腫瘍の処置に有用な新規免疫コンジュゲート
WO2003089475A2 (en) 2002-04-22 2003-10-30 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Antibodies, recombinant antibodies, recombinant antibody fragments and fusions mediated plant disease resistance against fungi
DE10234116A1 (de) * 2002-07-26 2004-02-12 Land Rheinland-Pfalz vertreten durch die Staatliche Lehr- und Forschungsanstalt für Landwirtschaft, Weinbau und Gartenbau (SLFA) Verfahren zur Expression von gegen virale Proteine gerichtete scFv-Fragmenten in Pflanzen und deren Verwendung
WO2004041865A2 (en) 2002-11-08 2004-05-21 Ablynx N.V. Stabilized single domain antibodies
EP2267032A3 (en) 2002-11-08 2011-11-09 Ablynx N.V. Method of administering therapeutic polypeptides, and polypeptides therefor
CN101412759A (zh) 2003-01-10 2009-04-22 埃博灵克斯股份有限公司 治疗性多肽,其同源物、其片段及其在调节血小板介导的聚集方面的应用
JP4283127B2 (ja) * 2003-06-20 2009-06-24 独立行政法人科学技術振興機構 転写因子を転写抑制因子に変換するペプチド及びこれをコードするポリヌクレオチド、並びにその利用
US7563443B2 (en) 2004-09-17 2009-07-21 Domantis Limited Monovalent anti-CD40L antibody polypeptides and compositions thereof
US20080014192A1 (en) * 2006-05-23 2008-01-17 Poeta Maurizio D Methods For The Diagnosis And Treatment of Fungal Infections Caused By Microorganisms Producing Glucosylceramide
NZ580505A (en) 2007-04-20 2011-03-31 Hexima Ltd Modified plant defensin comprising a signal peptide, a mature domain from a Class I defensin and a C-terminal propeptide tail from a Class II plant defensin
EP2148889A4 (en) 2007-04-20 2010-06-23 Hexima Ltd MODIFIED PLANT DEFENSE
CU23688A1 (es) 2008-03-28 2011-07-11 Ct Ingenieria Genetica Biotech Secuencias de ácido nucleico y aminoácidos para el control de agentes patógenos
EP2143735A1 (en) * 2008-07-10 2010-01-13 Institut Pasteur Variable domains of camelid heavy-chain antibodies directed against glial fibrillary acidic proteins
CA2732882A1 (en) 2008-08-12 2010-02-18 Plant Health Care, Inc. Production, formulation, and uses of stable liquid harpin protein formulations
AU2009326075B2 (en) 2008-12-08 2014-06-05 Complix Nv Single-chain antiparallel coiled coil proteins
EP2435478A1 (en) * 2009-05-28 2012-04-04 Glaxo Group Limited Antigen-binding proteins
US20120042416A1 (en) 2009-08-24 2012-02-16 Fraunhofer-Gesellschaft zur Forderung der angewandten e.V. Antibody fusion-mediated plant resistance against Oomycota
WO2011085070A2 (en) 2010-01-06 2011-07-14 Virginia Tech Intellectual Properties, Inc. Methods and compositions to improve the health of plants, animals and microbes by manipulating protein entry into symbionts and their hosts
US8598081B2 (en) 2010-04-06 2013-12-03 Agrosavfe N.V. Specific delivery of agrochemicals
WO2012011396A1 (ja) * 2010-07-20 2012-01-26 国立大学法人東京大学 ナノ抗体を発現するトランスジェニックイネ
ES2634547T3 (es) 2010-08-26 2017-09-28 Agrosavfe N.V. Composiciones para el tratamiento de semillas
WO2012025602A1 (en) * 2010-08-26 2012-03-01 Vib Vzw Insect binding antibodies
CN103153044B (zh) 2010-10-08 2015-06-17 韩国生命工学研究院 源自巴西橡胶树的乳胶分泌组织特异性srpp启动子及其用途
JP2012157315A (ja) * 2011-02-02 2012-08-23 Gekkeikan Sake Co Ltd ラクダ科動物抗体の重鎖可変ドメイン(vhh)の生産方法
EP2763529A1 (en) 2011-10-06 2014-08-13 Agrosavfe N.V. Manufacturing of specifically targeting microcapsules
PT2992100T (pt) 2013-04-29 2019-12-16 Agrosavfe Nv Composições agroquímicas compreendendo anticorpos que se ligam a esfingolípidos
US20180222966A1 (en) 2013-04-29 2018-08-09 Agrosavfe N.V. Transgenic plant comprising a polynucleotide encoding a variable domain of heavy-chain antibody
JP7089877B2 (ja) 2014-11-05 2022-06-23 バイオタリス・エン・フェー 重鎖抗体の可変ドメインをコードするポリヌクレオチドを含むトランスジェニック植物

Also Published As

Publication number Publication date
AU2020205327B2 (en) 2023-02-23
CN105358699A (zh) 2016-02-24
AU2014261434A1 (en) 2015-11-12
US20190352379A1 (en) 2019-11-21
CA2910632A1 (en) 2014-12-04
EP3597758A1 (en) 2020-01-22
WO2014177595A1 (en) 2014-11-06
AU2020205327A1 (en) 2020-08-06
ES2703192T3 (es) 2019-03-07
US9803003B2 (en) 2017-10-31
TR201819577T4 (tr) 2019-01-21
BR112015027430B1 (pt) 2022-09-06
US20160145325A1 (en) 2016-05-26
US20210253677A1 (en) 2021-08-19
JP6720252B2 (ja) 2020-07-08
PT2992100T (pt) 2019-12-16
JP6967347B2 (ja) 2021-11-17
JP2016526015A (ja) 2016-09-01
HUE047580T2 (hu) 2020-05-28
ZA201507758B (en) 2017-01-25
US11028154B2 (en) 2021-06-08
CA2910874A1 (en) 2014-11-06
DK2992100T3 (da) 2019-12-09
JP6388917B2 (ja) 2018-09-12
EP2992101A1 (en) 2016-03-09
EP2992100B1 (en) 2019-09-04
WO2014191146A1 (en) 2014-12-04
EP2992101B1 (en) 2018-10-10
ZA201507757B (en) 2016-12-21
PL2992100T3 (pl) 2020-04-30
PL2992101T3 (pl) 2019-05-31
AU2014273418B2 (en) 2020-04-23
US20180022791A1 (en) 2018-01-25
JP2019178136A (ja) 2019-10-17
AU2014261434B2 (en) 2020-04-16
ES2762151T3 (es) 2020-05-22
CN114732017A (zh) 2022-07-12
CN105358698A (zh) 2016-02-24
JP2019014715A (ja) 2019-01-31
BR112015027430A2 (pt) 2017-07-25
AU2014273418A1 (en) 2015-11-05
JP2016522186A (ja) 2016-07-28
BR112015027192B1 (pt) 2022-05-10
CA2910874C (en) 2022-03-22
CN116076508A (zh) 2023-05-09
BR112015027430A8 (pt) 2019-12-24
US10400033B2 (en) 2019-09-03
EP2992100A1 (en) 2016-03-09
CN105358698B (zh) 2024-02-20
BR112015027192A2 (hr) 2017-07-25
US20160075769A1 (en) 2016-03-17

Similar Documents

Publication Publication Date Title
HRP20192182T1 (hr) Agrokemijski pripravci koji sadrže protutijela koja se vežu na sfingolipide
WO2016201388A3 (en) Anti-cd33 antibodies and methods of use thereof
WO2016201389A3 (en) Anti-cd33 antibodies and methods of use thereof
WO2017062672A3 (en) Anti-trem2 antibodies and methods of use thereof
WO2017152102A3 (en) Anti-trem1 antibodies and methods of use thereof
MA42542B1 (fr) Molécules se liant à pd-1 et méthodes d'utilisation correspondantes
WO2017075432A3 (en) Anti-siglec-9 antibodies and methods of use thereof
MY189159A (en) Multispecific antigen-binding molecules and uses thereof
EA202191580A1 (ru) Биспецифичные антитела анти-cd28 x анти-cd22 и их применение
WO2016033225A3 (en) Antibodies, compositions, and uses
EP3991748A3 (en) Anti-sortilin antibodies and methods of use thereof
PH12019502463A1 (en) Anti-cd33 antibodies and methods of use thereof
EA201792657A1 (ru) Связывающие lag-3 молекулы и способы их применения
PE20161032A1 (es) Anticuerpos anti-tau(ps422) humanizados y metodos de utilizacion
JP2014043446A5 (hr)
UA117901C2 (uk) Спосіб посилення ефекторної функції вихідного поліпептиду, його варіанти та їх застосування
EA201590627A1 (ru) Антитела, распознающие альфа-синуклеин
MX344971B (es) Anticuerpos anti-ctla4 humanizados.
EA201690167A1 (ru) Гуманизованные или химерные антитела к cd3
HK1207655A1 (en) Affinity matured anti-ccr4 humanized monoclonal antibodies and methods of use 4(ccr4)
PE20181054A1 (es) Anticuerpos anti-cd19 humano humanizados y metodos de utilizacion
WO2012156532A8 (en) Anti-human-her3 antibodies and uses thereof
JP2016512214A5 (hr)
UA113623C2 (uk) Моноклональне антитіло проти інгібітору шляху тканинного фактора (tfpi)
EA201300137A1 (ru) Комбинированная фармацевтическая композиция и способ лечения заболеваний или состояний, связанных с нейродегенеративными зоболеваниями