HRP20192059T1 - Protutijela protiv tau i njihova upotreba - Google Patents
Protutijela protiv tau i njihova upotreba Download PDFInfo
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- HRP20192059T1 HRP20192059T1 HRP20192059TT HRP20192059T HRP20192059T1 HR P20192059 T1 HRP20192059 T1 HR P20192059T1 HR P20192059T T HRP20192059T T HR P20192059TT HR P20192059 T HRP20192059 T HR P20192059T HR P20192059 T1 HRP20192059 T1 HR P20192059T1
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- Prior art keywords
- seq
- amino acid
- acid sequence
- monoclonal antibody
- given
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 12
- 108091033319 polynucleotide Proteins 0.000 claims 4
- 102000040430 polynucleotide Human genes 0.000 claims 4
- 239000002157 polynucleotide Substances 0.000 claims 4
- 229920001184 polypeptide Polymers 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 108020004414 DNA Proteins 0.000 claims 3
- 102000053602 DNA Human genes 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 210000004962 mammalian cell Anatomy 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 201000011240 Frontotemporal dementia Diseases 0.000 claims 1
- 101000891579 Homo sapiens Microtubule-associated protein tau Proteins 0.000 claims 1
- 208000000609 Pick Disease of the Brain Diseases 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 102000057063 human MAPT Human genes 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 201000002212 progressive supranuclear palsy Diseases 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- Y10S424/80—Antibody or fragment thereof whose amino acid sequence is disclosed in whole or in part
Claims (9)
1. Monoklonsko protutijelo koje se veže na ljudski tau, naznačeno time što sadrži varijabilno područje lakog lanca (LCVR) i varijabilno područje teškog lanca (HCVR), gdje aminokiselinski slijed LCVR je dan sa SEQ ID NO: 9, a aminokiselinski slijed HCVR je dan sa SEQ ID NO: 10.
2. Monoklonsko protutijelo u skladu s patentnim zahtjevom 1, naznačeno time što sadrži laki lanac (LC) i teški lanac (HC), gdje aminokiselinski slijed LC je dan sa SEQ ID NO: 1, a aminokiselinski slijed HC je dan sa SEQ ID NO: 2.
3. Molekula DNA koja sadrži polinukleotidni slijed koji kodira polipeptid koji ima aminokiselinski slijed sa SEQ ID NO: 1, te koja sadrži polinukleotidni slijed koji kodira polipeptid koji ima aminokiselinski slijed sa SEQ ID NO: 2.
4. Molekula DNA u skladu s patentnim zahtjevom 3, naznačena time što je polinukleotidni slijed koji kodira polipeptid koji ima aminokiselinski slijed sa SEQ ID NO: 1 dan sa SEQ ID NO: 11, a polinukleotidni slijed koji kodira polipeptid koji ima aminokiselinski slijed sa SEQ ID NO: 2 je dan sa SEQ ID NO: 12.
5. Sisavačka stanica koja sadrži molekulu DNA u skladu s patentnim zahtjevom 3 ili patentnim zahtjevom 4, naznačena time što stanica može eksprimirati monoklonsko protutijelo koje sadrži laki lanac koji ima aminokiselinski slijed sa SEQ ID NO: 1 i teški lanac koji ima aminokiselinski slijed sa SEQ ID NO: 2.
6. Postupak proizvodnje monoklonskog protutijela koje sadrži laki lanac koji ima aminokiselinski slijed sa SEQ ID NO: 1 i teški lanac koji ima aminokiselinski slijed sa SEQ ID NO: 2, naznačen time što se postupak sastoji u uzgoju sisavačke stanica u skladu s patentnim zahtjevom 5 u takvim uvjetima da se monoklonsko protutijelo eksprimira, te u prikupljanju eksprimiranog monoklonskog protutijela.
7. Farmaceutski pripravak, naznačen time što sadrži monoklonsko protutijelo u skladu s bilo kojim od patentnog zahtjeva 1 ili patentnog zahtjeva 2, kao i jedan ili više farmaceutski prihvatljivih nosačima, razrjeđivačima ili pomoćnim tvarima.
8. Monoklonsko protutijelo u skladu s patentnim zahtjevom 1 ili patentnim zahtjevom 2, naznačeno time što je namijenjeno upotrebi u terapiji.
9. Monoklonsko protutijelo u skladu s patentnim zahtjevom 1 ili patentnim zahtjevom 2, naznačeno time što je namijenjeno upotrebi u liječenju bolesti koju se bira između Alzheimerove bolesti, progresivne supranuklearne paralize i Pickove bolesti.
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US201562121116P | 2015-02-26 | 2015-02-26 | |
PCT/US2016/018419 WO2016137811A1 (en) | 2015-02-26 | 2016-02-18 | Antibodies to tau and uses thereof |
EP16706741.2A EP3261720B1 (en) | 2015-02-26 | 2016-02-18 | Antibodies to tau and uses thereof |
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HRP20192059T1 true HRP20192059T1 (hr) | 2020-02-21 |
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HRP20192059TT HRP20192059T1 (hr) | 2015-02-26 | 2019-11-13 | Protutijela protiv tau i njihova upotreba |
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Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI669314B (zh) * | 2015-02-26 | 2019-08-21 | 美國禮來大藥廠 | 針對tau之抗體及其用途 |
TWI790642B (zh) | 2015-06-05 | 2023-01-21 | 美商建南德克公司 | 抗-tau抗體及使用方法 |
CN107849105B (zh) | 2015-07-06 | 2021-09-17 | Ucb生物制药有限责任公司 | Tau结合抗体 |
EP3496750A2 (en) * | 2016-08-09 | 2019-06-19 | Eli Lilly and Company | Combination therapy |
KR20230146126A (ko) | 2016-12-07 | 2023-10-18 | 제넨테크, 인크. | 항-타우 항체 및 이의 이용 방법 |
CN110248959B (zh) | 2016-12-07 | 2023-06-30 | 基因泰克公司 | 抗tau抗体和使用方法 |
CN110520440A (zh) | 2017-02-17 | 2019-11-29 | 戴纳立制药公司 | 抗τ抗体及其使用方法 |
TW202340244A (zh) | 2017-10-16 | 2023-10-16 | 日商衛材R&D企管股份有限公司 | 抗tau抗體及其用途 |
WO2019161384A1 (en) * | 2018-02-19 | 2019-08-22 | New York University | Tau single domain antibodies |
CA3107788A1 (en) * | 2018-07-31 | 2020-02-06 | Eli Lilly And Company | Combination of anti-tau antibody and oga inhibitor for treatment of diseases characterized by aberrant tau aggregation |
US20220017611A1 (en) * | 2018-12-13 | 2022-01-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | New anti tau svqivykpv epitope single domain antibody |
CA3142040A1 (en) * | 2019-05-27 | 2020-12-03 | The University Of British Columbia | Conformation-specific epitopes in tau, antibodies thereto and methods related thereof |
EP4001305A4 (en) * | 2019-07-15 | 2022-10-12 | Adel Inc. | ANTI-TAU ANTIBODIES AND ITS USE |
MX2022004311A (es) | 2019-10-15 | 2022-05-10 | Lilly Co Eli | Estirpes celulares de mamiferos con deficiencia de lipasa/esterasa modificadas geneticamente de manera recombinante. |
Family Cites Families (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5811310A (en) | 1986-09-30 | 1998-09-22 | Albert Einstein College Of Medicine Of Yeshiva Univ. | The Alz-50 monoclonal antibody and diagnostic assay for alzheimer's disease |
JPS63132355U (hr) | 1987-02-20 | 1988-08-30 | ||
AT500379B8 (de) | 2001-02-02 | 2009-08-15 | Axon Neuroscience | Tau-proteine |
US7161060B1 (en) | 2002-07-16 | 2007-01-09 | Albert Einstein College Of Medicine Of Yeshiva University | Transgenic mice comprising a genomic human tau transgene |
JP4393382B2 (ja) | 2002-08-14 | 2010-01-06 | 三菱化学株式会社 | 中枢性タウ蛋白質特異的抗体 |
US7238788B2 (en) | 2004-02-18 | 2007-07-03 | University Of Iowa Foundation | Antibodies to phosphorylated tau, methods of making and methods of use |
US20070218491A1 (en) | 2006-02-08 | 2007-09-20 | Oligomerix, Inc. | Oligomerization of amyloid proteins |
US8012936B2 (en) | 2006-03-29 | 2011-09-06 | New York University | Tau fragments for immunotherapy |
US20080220449A1 (en) | 2007-02-08 | 2008-09-11 | Oligomerix, Inc. | Biomarkers and assays for Alzheimer's disease |
UA107571C2 (xx) | 2009-04-03 | 2015-01-26 | Фармацевтична композиція | |
DE102009016515A1 (de) | 2009-04-08 | 2010-10-14 | Voith Patent Gmbh | Dynamoelektrische Maschine |
US8609097B2 (en) | 2009-06-10 | 2013-12-17 | Hoffmann-La Roche Inc. | Use of an anti-Tau pS422 antibody for the treatment of brain diseases |
CA2765099A1 (en) | 2009-06-10 | 2010-12-16 | New York University | Phosphorylated tau peptide for use in the treatment of tauopathy |
US10266585B2 (en) | 2009-08-28 | 2019-04-23 | The Board Of Regents Of The Univerity Of Texas System | Methods of treating brain injury |
JP6124591B2 (ja) | 2009-08-28 | 2017-05-10 | ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム | タウオリゴマーに結合する抗体 |
US8771693B2 (en) | 2009-10-27 | 2014-07-08 | Beth Israel Deaconess Medical Center, Inc. | Methods and compositions for the generation and use of conformation-specific antibodies |
WO2011109112A2 (en) | 2010-03-05 | 2011-09-09 | Albert Einstein College Of Medicine Of Yeshiva University | Method of detecting tau protein and tau fragments in serum |
CN103502272B (zh) | 2010-10-07 | 2016-06-15 | Ac免疫有限公司 | 识别Tau的磷酸化特异抗体 |
SI2627672T1 (sl) | 2010-10-11 | 2018-10-30 | Biogen International Neuroscience Gmbh | Človeška protitelesa anti-tau |
CA2826286C (en) | 2011-01-31 | 2021-09-21 | Intellect Neurosciences Inc. | Treatment of tauopathies |
US8697076B2 (en) | 2011-04-27 | 2014-04-15 | Northwestern University | Antibodies selective for pathological tau dimers and prefibrillar pathological tau oligomers and their uses in treatment, diagnosis and monitoring of tauopathies |
GB201112056D0 (en) | 2011-07-14 | 2011-08-31 | Univ Leuven Kath | Antibodies |
AU2012311234B2 (en) * | 2011-09-19 | 2017-09-28 | Axon Neuroscience Se | Protein-based therapy and diagnosis of tau-mediated pathology in Alzheimer's disease |
EP3135689B1 (en) | 2011-10-07 | 2018-12-19 | AC Immune S.A. | Phosphospecific antibodies recognising tau |
WO2013059786A1 (en) | 2011-10-21 | 2013-04-25 | The Ohio State University | Methylated peptides derived from tau protein and their antibodies for diagnosis and therapy of alzheimer's disease |
MY186066A (en) | 2011-12-20 | 2021-06-18 | Janssen Biotech Inc | Anti-phf-tau antibodies and their uses |
RU2644242C2 (ru) | 2012-04-05 | 2018-02-08 | Ац Иммуне С.А. | Гуманизированное тау-антитело |
RU2018132044A (ru) | 2012-07-03 | 2018-10-19 | Вашингтон Юниверсити | Антитела против тау |
WO2014016737A1 (en) | 2012-07-24 | 2014-01-30 | Pfizer Inc. | Novel chicken monoclonal antibodies against human phosphorylated tau and uses thereof |
BR112015003326A2 (pt) | 2012-08-16 | 2017-07-04 | Ipierian Inc | métodos de tratamento de uma tauopatia |
US20140056901A1 (en) | 2012-08-21 | 2014-02-27 | The Institute For Molecular Medicine | Anti-tau antibodies and compositions for and methods of making and using in treatment, diagnosis and monitoring of tauopathies |
CA2885924C (en) | 2012-08-21 | 2022-12-13 | Institute For Molecular Medicine, Inc. | Compositions and methods related to diseases associated with deposits of amyloid, tau, and alpha-synuclein |
CA2887933A1 (en) * | 2012-10-12 | 2014-04-17 | Arizona Board Of Agents, On Behalf Of Arizona State University | Antibody based reagents that specifically recognize toxic oligomeric forms of tau |
WO2014096321A1 (en) | 2012-12-21 | 2014-06-26 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Antibodies specific to tau phosphorylated at serine 422 and uses for the treatment and diagnosis of tauopathies |
PT2935326T (pt) * | 2012-12-21 | 2020-09-14 | Biogen Ma Inc | Anticorpos anti-tau humanos |
US8980270B2 (en) | 2013-01-18 | 2015-03-17 | Ipierian, Inc. | Methods of treating a tauopathy |
PE20152004A1 (es) | 2013-03-13 | 2016-02-07 | Prothena Biosciences Ltd | Inmunoterapia tau |
US9688747B2 (en) * | 2013-03-15 | 2017-06-27 | Beth Israel Deaconess Medical Center, Inc. | Methods and compositions for the generation and use of conformation-specific antibodies |
ES2800827T3 (es) | 2013-06-10 | 2021-01-04 | Ipierian Inc | Procedimientos de tratamiento de una tauopatía |
TWI669314B (zh) * | 2015-02-26 | 2019-08-21 | 美國禮來大藥廠 | 針對tau之抗體及其用途 |
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