HRP20191932T1 - Sinteza boronatnih soli i njihove uporabe - Google Patents
Sinteza boronatnih soli i njihove uporabe Download PDFInfo
- Publication number
- HRP20191932T1 HRP20191932T1 HRP20191932TT HRP20191932T HRP20191932T1 HR P20191932 T1 HRP20191932 T1 HR P20191932T1 HR P20191932T T HRP20191932T T HR P20191932TT HR P20191932 T HRP20191932 T HR P20191932T HR P20191932 T1 HRP20191932 T1 HR P20191932T1
- Authority
- HR
- Croatia
- Prior art keywords
- optionally substituted
- compound
- alkyl
- formula
- group
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical class OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 22
- 125000000217 alkyl group Chemical group 0.000 claims 9
- 125000001072 heteroaryl group Chemical group 0.000 claims 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 7
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims 6
- 125000006710 (C2-C12) alkenyl group Chemical group 0.000 claims 5
- 125000006711 (C2-C12) alkynyl group Chemical group 0.000 claims 5
- 238000000034 method Methods 0.000 claims 4
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 238000006243 chemical reaction Methods 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 125000003107 substituted aryl group Chemical group 0.000 claims 3
- 101001043818 Mus musculus Interleukin-31 receptor subunit alpha Proteins 0.000 claims 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims 2
- 239000008139 complexing agent Substances 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims 1
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 claims 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 claims 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims 1
- 229910052782 aluminium Inorganic materials 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 150000001768 cations Chemical class 0.000 claims 1
- 229910052744 lithium Inorganic materials 0.000 claims 1
- 229910052700 potassium Inorganic materials 0.000 claims 1
- 239000011591 potassium Substances 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- ZMANZCXQSJIPKH-UHFFFAOYSA-O triethylammonium ion Chemical compound CC[NH+](CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-O 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N55/00—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
- A01N55/08—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur containing boron
Claims (13)
1. Spoj formule (I)
ili njegova sol, u kojem:
n je 0 ili 1;
Y1 je O ili N+R5R6;
Y2 je O ili NR10;
R1 i R2 su neovisno izabrani iz grupe koja se sastoji od H, izborno supstituiranog fenila i izborno supstituiranog C1-4 alkila, ili R1 i R2 zajedno s atomima za koje su vezani, formiraju =O;
R3 je izabran iz grupe koja se sastoji od H, izborno supstituiranog fenila i izborno supstituiranog C1-4 alkila, ili R3 i R5, zajedno s atomima za koje su vezani, formiraju heteroaril prsten; ili R3 i R4 zajedno s atomima za koje su vezani, formiraju =O;
R4, R5, R6, i R10 su neovisno izabrani iz grupe koja se sastoji od H, izborno supstituiranog fenila i izborno supstituiranog C1-4 alkila; i
R9 je izabran iz grupe koja se sastoji od izborno supstituiranog C1-C12 alkila, izborno supstituiranog C3-C8 cikloalkila, izborno supstituiranog C2-C12 alkenila, izborno supstituiranog C2-C12 alkinila, izborno supstituiranog arila i izborno supstituiranog heteroarila.
2. Spoj u skladu s patentnim zahtjevom 1, naznačen time što Y1 je O.
3. Spoj u skladu s patentnim zahtjevom 1, naznačen time što Y1 je N+R5R6.
4. Spoj u skladu s patentnim zahtjevom 1, naznačen time što Y2 je O.
5. Spoj u skladu s patentnim zahtjevom 1, naznačen time što Y2 je NR10.
6. Spoj u skladu s patentnim zahtjevom 1, naznačen time što R1 i R2 su oba H.
7. Spoj u skladu s patentnim zahtjevom 1, naznačen time što R1 i R2 zajedno s atomima za koje su vezani, formiraju =O i gdje R3 i R4 zajedno s atomima za koje su vezani, formiraju =O.
8. Spoj u skladu s patentnim zahtjevom 1, naznačen time što R3 i R4 su oba H.
9. Spoj u skladu s patentnim zahtjevom 1, koji ima strukturu izabranu iz grupe koja se sastoji od:
i
gdje:
M+ je kation izabran iz grupe koja se sastoji od litija, natrija, kalija, kalcija, amonija, trietilamonija i aluminija.
10. Postupak za pripremu spoja formule (I), ili njegove soli, koji sadrži korake:
(a) zaštite hidroksi grupe spoja formule (A):
da bi se formirao spoj formule (B):
(b) reakcije spoja formule (B) sa spojem formule (C):
da bi se formirao spoj formule (D):
(c) uklanjanja zaštitne grupe spoja formule (D) da bi se formirao spoj formule (E):
(d) reakcije spoja formule (E) s kompleksirajućim sredstvom formule (F):
da bi se formirao spoj formule (I):
gdje:
PG je hidroksil zaštitna grupa;
n je 0 ili 1;
Y1 je O ili N+R5R6
Y2 je O ili NR10;
R1 i R2 su neovisno izabrani iz grupe koja se sastoji od H, izborno supstituiranog fenila i izborno supstituiranog C1-4 alkila, ili R1 i R2 zajedno s atomima za koje su vezani, formiraju =O;
R3 je izabran iz grupe koja se sastoji od H, izborno supstituiranog fenila i izborno supstituiranog C1-4alkila ili R1 i R3 zajedno s atomima za koje su vezani formiraju aril ili heteroaril prsten; ili
R3 i R4 zajedno s atomima za koje su vezani, formiraju =O;
R4, R5, R6, i R10 su neovisno izabrani iz grupe koja se sastoji od H, izborno supstituiranog fenila i izborno supstituiranog C1-4 alkila;
R9 je izborno supstituirani C1-C12 alkil, izborno supstituirani C3-C8 cikloalkil, izborno supstituirani C2-C12 alkenil, izborno supstituirani C2-C12 alkinil, izborno supstituirani aril ili izborno supstituirani heteroaril;
R11 je izabran iz grupe koja se sastoji od supstituiranih ili nesupstituiranih varijanti od sljedećih: C1-C12 alkil, C2-C12 alkenil, C2-C12 alkinil, C3-C12 cikloalkil, C3-C12 cikloalkenil, C3-C12 cikloalkinil, C3-C12 heterociklil, aril, heteroaril, arilalkil, heteroarilalkil i (cikloalkil)alkil, i
X je izabran iz grupe koja se sastoji od supstituiranih ili nesupstituiranih varijanti od sljedećih: C1-C4 alkil, C2-C4 alkenil i C2-C4 alkinil; i
R12 je izabran iz grupe koja se sastoji od supstituiranih ili nesupstituiranih varijanti od sljedećih: C1-C12 alkil, C2-C12 alkenil, C2-C12 alkinil, C3-C12 cikloalkil, C3-C12 cikloalkenil, C3-C12 cikloalkinil, C3-C12 heterociklil, aril, heteroaril, arilalkil, heteroarilalkil i (cikloalkil)alkil.
11. Postupak u skladu s patentnim zahtjevom 10, naznačen time što R9 je izborno supstituirani C1-C12 alkil.
12. Postupak za pripremu spoja formule (I), ili njegove soli, koji sadrži korake: reakcije spoja formule (E):
s kompleksirajućim sredstvom formule (F):
da bi se formirao spoj formule (I):
gdje
n je 0 ili 1,
Y1 je O ili N+R5R6
Y2 = O ili NR10,
R1, R2, R3, R4, R5, R6, i R10 su neovisno izabrani iz grupe koja se sastoji od H, izborno supstituiranog fenila i izborno supstituiranog C1-4 alkila; ili
pri čemu neovisno dva geminalna R1, R2, R3, R4 zajedno s atomima za koje su vezani, formiraju =O; i
pri čemu R9 je izborno supstituirani C1-C12 alkil, izborno supstituirani C3-C8 cikloalkil, izborno supstituirani C2-C12 alkenil, izborno supstituirani C2-C12 alkinil, izborno supstituirani aril ili izborno supstituirani heteroaril.
13. Postupak u skladu s patentnim zahtjevom 12, naznačen time što R1 i R2 zajedno s atomima za koje su vezani, formiraju =O i naznačen time da R3 i R4 zajedno s atomima za koje su vezani, formiraju =O.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461988690P | 2014-05-05 | 2014-05-05 | |
PCT/US2015/028613 WO2015171430A1 (en) | 2014-05-05 | 2015-04-30 | Synthesis of boronate salts and uses thereof |
EP15788682.1A EP3140310B1 (en) | 2014-05-05 | 2015-04-30 | Synthesis of boronate salts and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20191932T1 true HRP20191932T1 (hr) | 2020-01-24 |
Family
ID=54392864
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20191932TT HRP20191932T1 (hr) | 2014-05-05 | 2019-10-23 | Sinteza boronatnih soli i njihove uporabe |
Country Status (14)
Country | Link |
---|---|
US (2) | US10385074B2 (hr) |
EP (3) | EP3140310B1 (hr) |
CY (1) | CY1122222T1 (hr) |
DK (1) | DK3140310T3 (hr) |
ES (1) | ES2750805T3 (hr) |
FI (1) | FI3604316T3 (hr) |
HR (1) | HRP20191932T1 (hr) |
HU (1) | HUE046836T2 (hr) |
LT (2) | LT3604316T (hr) |
PL (2) | PL3604316T3 (hr) |
PT (1) | PT3140310T (hr) |
RS (1) | RS59488B1 (hr) |
SI (1) | SI3140310T1 (hr) |
WO (1) | WO2015171430A1 (hr) |
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2015
- 2015-04-30 DK DK15788682.1T patent/DK3140310T3/da active
- 2015-04-30 RS RS20191368A patent/RS59488B1/sr unknown
- 2015-04-30 PL PL19186092.3T patent/PL3604316T3/pl unknown
- 2015-04-30 WO PCT/US2015/028613 patent/WO2015171430A1/en active Application Filing
- 2015-04-30 EP EP15788682.1A patent/EP3140310B1/en active Active
- 2015-04-30 EP EP19186092.3A patent/EP3604316B1/en active Active
- 2015-04-30 US US15/305,954 patent/US10385074B2/en active Active
- 2015-04-30 LT LTEP19186092.3T patent/LT3604316T/lt unknown
- 2015-04-30 SI SI201530973T patent/SI3140310T1/sl unknown
- 2015-04-30 EP EP23214076.4A patent/EP4356736A2/en active Pending
- 2015-04-30 FI FIEP19186092.3T patent/FI3604316T3/fi active
- 2015-04-30 LT LT15788682T patent/LT3140310T/lt unknown
- 2015-04-30 PL PL15788682T patent/PL3140310T3/pl unknown
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2019
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- 2019-11-01 CY CY20191101140T patent/CY1122222T1/el unknown
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PL3604316T3 (pl) | 2024-04-29 |
SI3140310T1 (sl) | 2020-01-31 |
FI3604316T3 (fi) | 2024-02-29 |
DK3140310T3 (da) | 2019-10-21 |
EP3140310B1 (en) | 2019-08-07 |
US20170057979A1 (en) | 2017-03-02 |
EP3140310A4 (en) | 2017-12-13 |
CY1122222T1 (el) | 2020-11-25 |
EP4356736A2 (en) | 2024-04-24 |
PL3140310T3 (pl) | 2020-01-31 |
LT3140310T (lt) | 2019-11-25 |
EP3140310A1 (en) | 2017-03-15 |
EP3604316B1 (en) | 2023-12-06 |
US10385074B2 (en) | 2019-08-20 |
RS59488B1 (sr) | 2019-12-31 |
US20200031851A1 (en) | 2020-01-30 |
EP3604316A1 (en) | 2020-02-05 |
US10669292B2 (en) | 2020-06-02 |
PT3140310T (pt) | 2019-11-18 |
LT3604316T (lt) | 2024-02-26 |
HUE046836T2 (hu) | 2020-03-30 |
ES2750805T3 (es) | 2020-03-27 |
WO2015171430A1 (en) | 2015-11-12 |
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