HRP20171197T1 - Bifenilsulfonamidni antagonist receptora endotelina i angiotensina ii, namijenjen liječenju glomeruloskleroze - Google Patents
Bifenilsulfonamidni antagonist receptora endotelina i angiotensina ii, namijenjen liječenju glomeruloskleroze Download PDFInfo
- Publication number
- HRP20171197T1 HRP20171197T1 HRP20171197TT HRP20171197T HRP20171197T1 HR P20171197 T1 HRP20171197 T1 HR P20171197T1 HR P20171197T T HRP20171197T T HR P20171197TT HR P20171197 T HRP20171197 T HR P20171197T HR P20171197 T1 HRP20171197 T1 HR P20171197T1
- Authority
- HR
- Croatia
- Prior art keywords
- biphenylsulfonamide
- endothelin
- angiotensin
- receptor antagonist
- glomerulosclerosis
- Prior art date
Links
- 206010061989 glomerulosclerosis Diseases 0.000 title claims 3
- SBXDENYROQKXBE-UHFFFAOYSA-N 2-phenylbenzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=CC=C1C1=CC=CC=C1 SBXDENYROQKXBE-UHFFFAOYSA-N 0.000 title 1
- 102000002045 Endothelin Human genes 0.000 title 1
- 229940118365 Endothelin receptor antagonist Drugs 0.000 title 1
- 229940126317 angiotensin II receptor antagonist Drugs 0.000 title 1
- 239000002333 angiotensin II receptor antagonist Substances 0.000 title 1
- 239000002308 endothelin receptor antagonist Substances 0.000 title 1
- ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
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- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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Claims (2)
1. Spoj Formule I:
[image]
,
ili njegova farmaceutski prihvatljiva sol, naznačen time što je namijenjen upotrebi u liječenju glomeruloskleroze.
2. Upotreba spoja Formule I:
[image]
,
ili njegove farmaceutski prihvatljive soli, naznačena time što je spoj namijenjen proizvodnji medikamenta za liječenje glomeruloskleroze.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16544709P | 2009-03-31 | 2009-03-31 | |
| US16541909P | 2009-03-31 | 2009-03-31 | |
| EP14155459.2A EP2732818B1 (en) | 2009-03-31 | 2010-03-29 | A biphenylsulfonamide endothelin and angiotensin ii receptor antagonist to treat glomerulosclerosis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20171197T1 true HRP20171197T1 (hr) | 2017-10-20 |
Family
ID=42828649
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20171197TT HRP20171197T1 (hr) | 2009-03-31 | 2017-08-03 | Bifenilsulfonamidni antagonist receptora endotelina i angiotensina ii, namijenjen liječenju glomeruloskleroze |
| HRP20200665TT HRP20200665T1 (hr) | 2009-03-31 | 2020-04-24 | Bifenilsulfonamidni antagonist receptora za endotelin i angiotenzin ii za liječenje glomeruloskleroze i iga-inducirane nefropatije |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20200665TT HRP20200665T1 (hr) | 2009-03-31 | 2020-04-24 | Bifenilsulfonamidni antagonist receptora za endotelin i angiotenzin ii za liječenje glomeruloskleroze i iga-inducirane nefropatije |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US20140142149A1 (hr) |
| EP (4) | EP2732818B1 (hr) |
| JP (3) | JP2012522058A (hr) |
| CN (2) | CN102421434A (hr) |
| CY (2) | CY1119232T1 (hr) |
| DK (2) | DK3222277T3 (hr) |
| ES (2) | ES2811342T3 (hr) |
| HK (1) | HK1244687A1 (hr) |
| HR (2) | HRP20171197T1 (hr) |
| HU (2) | HUE049450T2 (hr) |
| LT (2) | LT3222277T (hr) |
| PL (2) | PL3222277T3 (hr) |
| PT (2) | PT3222277T (hr) |
| SI (2) | SI3222277T1 (hr) |
| WO (1) | WO2010114801A1 (hr) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103261225A (zh) | 2010-07-23 | 2013-08-21 | 波士顿大学董事会 | 作为用于抑制病理性血管生成和肿瘤细胞侵袭力的治疗剂以及用于分子成像和靶向递送的抗DEspR抑制剂 |
| AR083417A1 (es) * | 2010-10-14 | 2013-02-21 | Novartis Ag | Composiciones farmaceuticas que contienen un dgat1 inhibidor |
| US20130022551A1 (en) * | 2011-07-22 | 2013-01-24 | Trustees Of Boston University | DEspR ANTAGONISTS AND AGONISTS AS THERAPEUTICS |
| UA114412C2 (uk) * | 2011-10-17 | 2017-06-12 | Лексікон Фармасьютікалз, Інк. | Тверда дозована форма гіпурату (s)-2-аміно-3-(4-(2-аміно-6-((r)-1-(4-хлор-2-(3-метил-1h-піразол-1-іл)феніл)-2,2,2-трифторетокси)піримідин-4-іл)феніл)пропаноату |
| ES2790358T3 (es) | 2011-12-28 | 2020-10-27 | Global Blood Therapeutics Inc | Compuestos de heteroaril aldehído sustituido y métodos para su uso en el aumento de la oxigenación tisular |
| LT2797416T (lt) | 2011-12-28 | 2017-10-25 | Global Blood Therapeutics, Inc. | Pakeistieji benzaldehido junginiai ir jų panaudojimo būdai, didinant audinių aprūpinimą deguonimi |
| EP2875359A4 (en) | 2012-03-30 | 2015-08-19 | Charles R Drew University Of Medicine And Science | COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING METABOLISM SYNDROME DISEASES |
| US20140271923A1 (en) | 2013-03-14 | 2014-09-18 | Christopher Brian Reid | Compositions & formulations for preventing and treating chronic diseases that cluster in patients such as cardiovascular disease, diabetes, obesity, polycystic ovary syndrome, hyperlipidemia and hypertension, as well as for preventing and treating other diseases and conditions |
| AU2014237348C1 (en) | 2013-03-15 | 2019-02-07 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| MX2015011445A (es) | 2013-03-15 | 2016-04-20 | Global Blood Therapeutics Inc | Compuestos y usos de estos para la modulacion de la hemoglobina. |
| US9458139B2 (en) | 2013-03-15 | 2016-10-04 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| KR20150132146A (ko) | 2013-03-15 | 2015-11-25 | 글로벌 블러드 테라퓨틱스, 인크. | 헤모글로빈 조정을 위한 화합물 및 이의 용도 |
| US8952171B2 (en) | 2013-03-15 | 2015-02-10 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| NZ753904A (en) | 2013-06-13 | 2020-07-31 | Akebia Therapeutics Inc | Compositions and methods for treating anemia |
| EA201992707A1 (ru) | 2013-11-18 | 2020-06-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
| WO2015119848A1 (en) | 2014-02-05 | 2015-08-13 | Merck Sharp & Dohme Corp. | Tablet formulation for cgrp-active compounds |
| BR112015032160B1 (pt) | 2014-02-07 | 2021-11-30 | Global Blood Therapeutics, Inc | Ansolvato cristalino de composto, composição e composição farmacêutica |
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| US793898A (en) | 1905-03-01 | 1905-07-04 | William Mcintosh | Locomotive-tender frame. |
| US1395298A (en) | 1919-11-20 | 1921-11-01 | Walter H Richman | Container |
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| US6586438B2 (en) | 1999-11-03 | 2003-07-01 | Bristol-Myers Squibb Co. | Antidiabetic formulation and method |
| EP1237888B1 (en) * | 1999-12-15 | 2006-09-13 | Bristol-Myers Squibb Company | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists |
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