ES2570135T3 - Sal y solvatos de un derivado de tetrahidroisoquinolina - Google Patents
Sal y solvatos de un derivado de tetrahidroisoquinolinaInfo
- Publication number
- ES2570135T3 ES2570135T3 ES11740973T ES11740973T ES2570135T3 ES 2570135 T3 ES2570135 T3 ES 2570135T3 ES 11740973 T ES11740973 T ES 11740973T ES 11740973 T ES11740973 T ES 11740973T ES 2570135 T3 ES2570135 T3 ES 2570135T3
- Authority
- ES
- Spain
- Prior art keywords
- solvates
- salt
- tetrahydroisoquinoline derivative
- tetrahydroisoquinoline
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Sal de sodio del ácido (S)-2-(difenilacetil)-1,2,3,4-tetrahidro-6-metoxi-5-(fenilmetoxi)-3-isoquinolin-carboxílico y solvatos del mismo, en forma amorfa o en forma de un solvato cristalino.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36636710P | 2010-07-21 | 2010-07-21 | |
PCT/GB2011/001096 WO2012010843A1 (en) | 2010-07-21 | 2011-07-21 | Salt and solvates of a tetrahydroisoquinoline derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2570135T3 true ES2570135T3 (es) | 2016-05-17 |
Family
ID=44386640
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES11740973T Active ES2570135T3 (es) | 2010-07-21 | 2011-07-21 | Sal y solvatos de un derivado de tetrahidroisoquinolina |
Country Status (19)
Country | Link |
---|---|
US (3) | US8614227B2 (es) |
EP (2) | EP2595960B1 (es) |
JP (3) | JP5948326B2 (es) |
CN (2) | CN103003244B (es) |
AU (3) | AU2011281381B2 (es) |
CA (1) | CA2803699C (es) |
DK (1) | DK2595960T3 (es) |
ES (1) | ES2570135T3 (es) |
HK (1) | HK1224290A1 (es) |
HR (1) | HRP20160540T1 (es) |
HU (1) | HUE028620T2 (es) |
ME (1) | ME02407B (es) |
NZ (2) | NZ605444A (es) |
PL (1) | PL2595960T3 (es) |
PT (1) | PT2595960E (es) |
SI (1) | SI2595960T1 (es) |
SM (1) | SMT201600171B (es) |
WO (1) | WO2012010843A1 (es) |
ZA (1) | ZA201300169B (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2595960B1 (en) * | 2010-07-21 | 2016-02-24 | Novartis AG | Salt and solvates of a tetrahydroisoquinoline derivative |
US9320530B2 (en) * | 2013-03-13 | 2016-04-26 | The Spectranetics Corporation | Assisted cutting balloon |
PL3019477T3 (pl) * | 2013-07-08 | 2021-11-22 | Novartis Ag | Związki heterocykliczne i sposoby ich stosowania |
JP6667551B2 (ja) | 2015-01-13 | 2020-03-18 | ノバルティス アーゲー | アンジオテンシンii2型拮抗薬としてのピロリジン誘導体 |
ES2898635T3 (es) | 2015-03-12 | 2022-03-08 | Novartis Ag | Compuestos heterocíclicos y métodos para su uso |
CN106478502B (zh) * | 2015-08-29 | 2021-04-27 | 上海翰森生物医药科技有限公司 | 1,2,3,4-四氢异喹啉衍生物、其制备方法和应用 |
EP3475261A1 (en) | 2016-06-27 | 2019-05-01 | ratiopharm GmbH | Crystalline calcium salt of (s)-2-(diphenylacetyl)-1,2,3,4-tetrahydro-6-methoxy-5-(phenylmethoxy)-3-isoquinoline carboxylic acid |
JP2019514862A (ja) * | 2017-03-23 | 2019-06-06 | ノバルティス アーゲー | (s)−2−(ジフェニルアセチル)−1,2,3,4−テトラヒドロ−6−メトキシ−5−(フェニルメトキシ)−3−イソキノリンカルボン酸ナトリウムの無水結晶形 |
WO2018224037A1 (zh) * | 2017-06-09 | 2018-12-13 | 南京明德新药研发股份有限公司 | 作为at2r受体拮抗剂的羧酸衍生物 |
WO2020012266A1 (en) | 2018-07-12 | 2020-01-16 | Novartis Ag | Biocatalytic synthesis of olodanrigan (ema401) from 3-(2-(benzyloxy)-3-methoxyphenyl)propenoic acid with phenylalanine ammonia lyase |
CN112672989A (zh) * | 2018-07-12 | 2021-04-16 | 科德克希思公司 | 工程化苯丙氨酸氨裂合酶多肽 |
CN111620816B (zh) * | 2020-05-27 | 2023-06-02 | 上海赛默罗生物科技有限公司 | 螺桨烷类衍生物、其制备方法、药物组合物和用途 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5246943A (en) * | 1992-05-19 | 1993-09-21 | Warner-Lambert Company | Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties |
US5236934A (en) | 1992-08-26 | 1993-08-17 | E. I. Du Pont De Nemours And Company | 1,2,3,4-tetrahydroisoquinolines useful in the treatment of CNS disorders |
JP2002504498A (ja) * | 1998-02-25 | 2002-02-12 | メルク エンド カムパニー インコーポレーテッド | アンギオテンシンii受容体拮抗薬を用いてqt分散を低下させる、または、qt分散の進行を阻害する方法 |
JP4966202B2 (ja) * | 2004-12-24 | 2012-07-04 | スピニフェクス ファーマシューティカルズ ピーティーワイ リミテッド | 治療または予防のための方法 |
JP5230595B2 (ja) | 2006-03-20 | 2013-07-10 | スピニフェクス ファーマシューティカルズ ピーティーワイ リミテッド | 炎症性疼痛の治療または予防の方法 |
NZ601383A (en) * | 2010-01-19 | 2014-07-25 | Spinifex Pharm Pty Ltd | Methods and compositions for improved nerve conduction velocity |
EP2595960B1 (en) * | 2010-07-21 | 2016-02-24 | Novartis AG | Salt and solvates of a tetrahydroisoquinoline derivative |
-
2011
- 2011-07-21 EP EP11740973.0A patent/EP2595960B1/en active Active
- 2011-07-21 SI SI201130804A patent/SI2595960T1/sl unknown
- 2011-07-21 CN CN201180035468.9A patent/CN103003244B/zh not_active Expired - Fee Related
- 2011-07-21 JP JP2013520203A patent/JP5948326B2/ja not_active Expired - Fee Related
- 2011-07-21 PT PT117409730T patent/PT2595960E/pt unknown
- 2011-07-21 US US13/187,882 patent/US8614227B2/en not_active Expired - Fee Related
- 2011-07-21 HU HUE11740973A patent/HUE028620T2/en unknown
- 2011-07-21 NZ NZ605444A patent/NZ605444A/en not_active IP Right Cessation
- 2011-07-21 ES ES11740973T patent/ES2570135T3/es active Active
- 2011-07-21 EP EP15200360.4A patent/EP3081557A1/en not_active Withdrawn
- 2011-07-21 DK DK11740973.0T patent/DK2595960T3/en active
- 2011-07-21 ME MEP-2016-98A patent/ME02407B/me unknown
- 2011-07-21 CA CA2803699A patent/CA2803699C/en not_active Expired - Fee Related
- 2011-07-21 WO PCT/GB2011/001096 patent/WO2012010843A1/en active Application Filing
- 2011-07-21 PL PL11740973.0T patent/PL2595960T3/pl unknown
- 2011-07-21 AU AU2011281381A patent/AU2011281381B2/en not_active Ceased
- 2011-07-21 NZ NZ708529A patent/NZ708529A/en not_active IP Right Cessation
- 2011-07-21 CN CN201610152658.3A patent/CN105777636A/zh active Pending
-
2013
- 2013-01-08 ZA ZA2013/00169A patent/ZA201300169B/en unknown
- 2013-07-03 HK HK16112556.3A patent/HK1224290A1/zh unknown
- 2013-11-18 US US14/083,391 patent/US8927575B2/en not_active Expired - Fee Related
-
2014
- 2014-12-17 US US14/573,774 patent/US9162985B2/en not_active Expired - Fee Related
-
2015
- 2015-10-06 AU AU2015238774A patent/AU2015238774A1/en not_active Abandoned
-
2016
- 2016-04-11 JP JP2016078656A patent/JP2016164178A/ja active Pending
- 2016-05-20 HR HRP20160540TT patent/HRP20160540T1/hr unknown
- 2016-06-15 SM SM201600171T patent/SMT201600171B/it unknown
-
2017
- 2017-05-15 AU AU2017203236A patent/AU2017203236A1/en not_active Abandoned
- 2017-08-14 JP JP2017156436A patent/JP2017214415A/ja active Pending
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