HRP20161766T1 - Antitijela protiv cd38 za liječenje multiplog mijeloma - Google Patents
Antitijela protiv cd38 za liječenje multiplog mijeloma Download PDFInfo
- Publication number
- HRP20161766T1 HRP20161766T1 HRP20161766TT HRP20161766T HRP20161766T1 HR P20161766 T1 HRP20161766 T1 HR P20161766T1 HR P20161766T T HRP20161766T T HR P20161766TT HR P20161766 T HRP20161766 T HR P20161766T HR P20161766 T1 HRP20161766 T1 HR P20161766T1
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- Croatia
- Prior art keywords
- antibody
- lymphoma
- cell
- leukemia
- human
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Classifications
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Claims (25)
1. Antitijelo koje se vezuje za ljudski CD38 (SEQ ID NO:31) i koje se ne vezuje za mutirani ljudski CD38, pri čemu je ostatak serina na položaju 274 supstituiran s ostatkom fenilanina (SEQ ID No:34) u istoj mjeri u kojoj se vezuje za ljudski CD38 (SEQ ID No:31) i koji se ne vezuje za mutirani ljudski CD38, pri čemu je mutirani ostatak glutamina na položaju 272 supstituiran s ostatkom arginina (SEQ ID No:33) u istoj mjeri u kojoj se vezuje za ljudski CD38 (SEQ ID No:31), i pri čemu antitijelo prepoznaje motive KRN i VQTL ljudskog CD38 (SEQ ID No:31).
2. Antitijelo prema zahtjevu 1, naznačeno time, što se spomenuto antitijelo vezuje za mutirani ljudski CD38 pri čemu je ostatak teorina na položaju 237 supstituiran s ostatkom alanina (SEQ ID No:32) u istoj mjeri u kojoj se vezuje za ljudski CD38 (SEQ ID No:31).
3. Antitijelo prema bilo kojem od prethodnih zahtjeva, naznačeno time, što antitijelo sadrži VH CDR3 koji ima sekvencu kao što je navedeno u SEQ ID No:20.
4. Antitijelo prema bilo kojem od prethodnih zahtjeva, koje je ljudsko monoklonalno antitijelo.
5. Antitijelo prema bilo kojem od prethodnih zahtjeva, naznačeno time, što je IgG1, IgG2, IgG3, IgG4, IgD, IgA, IgE ili IgM antitijelo pune dužine, kao što je IgG1 antitijelo, poželjno IgG1,K antitijelo ili IgM antitijelo, poželjno IgM,K antitijelo.
6. Antitijelo prema bilo kojem od prethodnih zahtjeva, koje je fragment antitijela ili jednolančano antitijelo.
7. Antitijelo prema bilo kojem zahtjevu od 1 do 6, koje dodatno sadrži poveznika kelatora za priključivanje radioaktivnog izotopa.
8. Antitijelo prema bilo kojem zahtjevu od 1 do 7, koje se nalazi u suštinski izoliranom obliku.
9. Izolirana nukleinska kiselina koja kodira antitijelo prema bilo kojem zahtjevu od 1 do 8.
10. Vektor ekspresije koji sadrži sekvencu nukleinske kiseline koja kodira antitijelo prema bilo kojem zahtjevu od 1 do 8.
11. Vektor ekspresije prema zahtjevu 10, koji dodatno sadrži sekvencu nukleotida koja kodira konstantnu regiju lakog lanca, teškog lanca ili i lakog i teškog lanca ljudskog antitijela.
12. Eukariotska ili prokariotska stanica domaćina koja proizvodi antitijelo prema bilo kojem zahtjevu od 1 do 8.
13. Imunokonjugat koji sadrži antitijelo prema bilo kojem zahtjevu od 1 do 8 povezan s citotoksičnim sredstvom, radioaktivnim izotopom ili lijekom.
14. Bispecifična ili multispecifična molekula koja sadrži antitijelo prema bilo kojem zahtjevu od 1 do 8 i specifičnosti vezivanja za ljudsku efektorsku stanicu.
15. Bispecifična ili multispecifična molekula prema zahtjevu 14, koja sadrži antitijelo prema bilo kojem zahtjevu od 1 do 8 i specifičnost vezivanja za CD3, CD4, CD138, IL-15R, TNF-α vezan za membranu ili vezan za receptor, ljudski Fc receptor ili IL-15 vezan za membranu ili vezan za receptor.
16. Farmaceutski pripravak koji sadrži antitijelo prema bilo kojem zahtjevu od 1 do 8, imunokonjugat prema zahtjevu 13 ili bispecifičnu ili multispecifičnu molekulu prema zahtjevu 14 ili 15 te farmaceutski prihvatljiv nosač.
17. Farmaceutski pripravak prema zahtjevu 16 koji sadrži jedno ili više terapeutskih sredstava.
18. Antitijelo prema bilo kojem zahtjevu od 1 do 8, imunokonjugat prema zahtjevu 13, bispecifična ili multispecifična molekula prema zahtjevu 14 ili 15, farmaceutski pripravak prema zahtjevu 16 ili 17 ili vektor ekspresije prema zahtjevu 10 ili 11 za upotrebu kao lijek.
19. Antitijelo prema bilo kojem zahtjevu od 1 do 8, imunokonjugat prema zahtjevu 13, bispecifična ili multispecifična molekula prema zahtjevu 14 ili 15, farmaceutski pripravak prema zahtjevu 16 ili 17, vektor ekspresije prema zahtjevu 10 ili 11 za primjenu u metodi liječenja ili sprječavanja bolesti ili poremećaja koji uključuju ekspresiju CD38, pri čemu je bolest ili poremećaj odabran iz grupe koja obuhvaća: limfom / leukemiju B stanica uključujući limfoblastičnu leukemiju / limfom B stanica preteča ne-Hodgikov limfom B stanica; akutnu limfoblastičnu leukemiju (CLL) / limfom malih limfocita (SLL); akutnu limfocitnu leukemiju B stanica; prolimfocitnu leukemiju B stanica; limfoplazmacitni limfom; limfom stanica plašta (MCL); folikularni limfom (FL), uključujući folikularni limfom niskog stupnja, srednjeg stupnja i visokog stupnja; centralni folikularni limfom; limfom granične zone B stanica uključujući MALT tip, nodalni i slezenski tip; leukemiju vlasastih stanica; difuzni B velikostanični limfom; Bukrittov limfom; plazmacitomu; mijelom plazma stanica; leukemiju plazma stanica; limfoproliferativni poremaćaj nakon transplantacije; Waldenstormova makroglobulinemija; leukemije plazma stanica; anaplastični limfom velikih stanica (ALCL); multipli mijelom; Hodgkinov limfom; neoplazme zrelih T stanica i NK stanica uključujući prolimfocitnu leukemiju T stanica; velikostanična T granularna limfocitna leukemija; agresivna leukemija NK stanica; leukemija / limfom odraslih T stanica; ekstranodalni limfom NK / T stanica; limfom T stanica nazalnog ili enteropatskog tipa; hepatosplenični limfom T stanica; limfom T stanica sličan potkožno Panniculitisu; blastični limfom NK stanica; Mycosis fungoides / Sezaryjev sindrom; primarne kožne limfoproliferativne poremećaje T stanica pozitivnih na CD30 uključujući kožni anaplastični limfom velikih stanica C-ALCL, limfomatoidnu papulozu i granične lezije; angioimunoblastički limfom T stanica; nespecificirani periferni T-stanični limfom; anaplastični limfom velikih stanica; akutnu mijeloidnu leukemiju uključujući akutnu promijelocitnu leukemiju; i kronične mijeloproliferativne bolesti uključujući kroničnu mijeloidnu leukemiju.
20. Antitijelo, imunokonjugat, bispecifična ili multispecifična molekula, farmaceutski pripravak ili vektor ekspresije za primjenu prema zahtjevu 19, naznačen time, što je ne-Hodgkinov limfom B stanica odabran iz grupe koja se sastoji od limfomatoidne granulomatoze; primarnog efuzijskog limfoma; intravaskularnog velikostaničnog B limfoma; medijastinalnog velikostaničnog B limfoma; bolesti teškog lanca uključujući γ, μ i α bolest; limfoma izazvanih terapijom imunosupresivima uključujući limfom izazvan ciklosporinom; i limfoma izazvanog metotreksatom.
21. Antitijelo, imunokonjugat, bispecifična ili multispecifična molekula, farmaceutski pripravak ili vektor ekspresije za primjenu prema zahtjevu 19, naznačen time, što je bolest ili poremećaj multipli mijelom.
22. Antitijelo, imunokonjugat, bispecifična ili multispecifična molekula, farmaceutski pripravak ili vektor ekspresije za primjenu prema bilo kojem zahtjevu od 18 do 21, naznačen time, što se postupak sastoji od primjene jednog ili više dodatnih terapeutskih sredstava kod bolesnika.
23. Antitijelo, imunokonjugat, bispecifična ili multispecifična molekula, farmaceutski pripravak ili vektor ekspresije za primjenu prema zahtjevu 22, naznačen time, što je jedno ili više dodatnih terapeutskih sredstava odabrano iz kemoterapijskog sredstva, protuupalnog sredstva ili imunosupresiva i/ili imunomodulatora.
24. Antitijelo, imunokonjugat, bispecifična ili multispecifična molekula, farmaceutski pripravak ili vektor ekspresije za primjenu prema zahtjevu 22, naznačen time, što je jedno ili više dodatnih terapeutskih sredstava odabrano iz grupe koja sadrži cisplatin, gefitinib, cetuksimab, rituksimab, bevacizumab, erlotinib, bortezomib, talidomid, pamidronat, zolendronatnu kiselinu, klodronat, risendronat, ibandronat, etidronat, alendronat, tiludronat, arsen trioksid, lenalidomid, filgrastim, pegfilgrastim, sargramostim, suberoilanilid hidroksamsku kiselinu i SCIO-469.
25. In vitro način za otkrivanje prisutnosti CD38 antigena ili stanica koje izražavaju CD38 u uzorku koji se sastoji od:
a) kontaktiranja uzorka antitijelom prema bilo kojem zahtjevu od 1 do 8 u uvjetima koji omogućavaju formiranje kompleksa između antitijela i CD38; i
b) otkrivanja formiranja kompleksa.
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EP06722861.9A EP1866338B1 (en) | 2005-03-23 | 2006-03-23 | Antibodies against cd38 for treatment of multiple myeloma |
PCT/DK2006/000166 WO2006099875A1 (en) | 2005-03-23 | 2006-03-23 | Antibodies against cd38 for treatment of multiple myeloma |
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HRP20191768TT HRP20191768T1 (hr) | 2005-03-23 | 2019-09-30 | Antitijela protiv cd38 za liječenje multiplog mijeloma |
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Families Citing this family (225)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ534399A (en) | 2002-01-25 | 2008-08-29 | G2 Therapies Ltd | Monoclonal antibodies against extracellular loops of C5aR |
US9200061B2 (en) | 2004-02-06 | 2015-12-01 | Morpho Sys AG | Generation and profiling of fully human HuCAL gold®-derived therapeutic antibodies specific for human CD3i |
AU2005235811B2 (en) * | 2004-02-06 | 2011-11-03 | Morphosys Ag | Anti-CD38 human antibodies and uses therefor |
SG10201912554TA (en) | 2005-03-23 | 2020-02-27 | Genmab As | Antibodies against cd38 for treatment of multiple myeloma |
TWI428444B (zh) | 2005-10-12 | 2014-03-01 | Morphosys Ag | 由全長人類HuCAL GOLD-衍生之對人類CD38有特異性之治療抗體之產生及鑑定 |
BRPI0619460A2 (pt) * | 2005-12-06 | 2011-11-08 | Domantis Ltd | ligando, uso do ligando, composição, dispositivo de dispensação de medicamento, ácido nucléico isolado ou recombinante, vetor, célula hospedeira, e, método para produzir um ligando |
EP2046383B1 (en) | 2006-07-04 | 2014-11-19 | Genmab A/S | Cd20 binding molecules for the treatment of copd |
US20090029904A1 (en) * | 2006-07-21 | 2009-01-29 | Sean Oldham | Compositions and methods for treatment of insulin-resistance diseases |
WO2008033571A2 (en) * | 2006-09-15 | 2008-03-20 | Memorial Sloan Kettering Cancer Center | Methods of diagnosing, treating, or preventing plasma cell disorders |
SI2081595T1 (sl) | 2006-09-26 | 2019-10-30 | Genmab As | Anti-cd38 plus kortikosteroidi plus ne-kortikosteroidni kemoterapevtik za zdravljenje tumorjev |
WO2008040348A2 (en) * | 2006-10-03 | 2008-04-10 | Genmab A/S | High througput methods for characterization of antibodies |
EP1914242A1 (en) * | 2006-10-19 | 2008-04-23 | Sanofi-Aventis | Novel anti-CD38 antibodies for the treatment of cancer |
AU2013209322A1 (en) * | 2006-10-19 | 2013-08-15 | Sanofi-Aventis | Novel anti-cd38 antibodies for the treatment of cancer |
US8143014B2 (en) * | 2007-10-02 | 2012-03-27 | Mayo Foundation For Medical Education And Research | CD38 and obesity |
CN101952315B (zh) | 2007-12-26 | 2015-04-01 | 生物测试股份公司 | 靶向cd138的试剂及其应用 |
EP2238169A1 (en) | 2007-12-26 | 2010-10-13 | Biotest AG | Method of decreasing cytotoxic side-effects and improving efficacy of immunoconjugates |
CA2710483C (en) * | 2007-12-26 | 2018-05-08 | Biotest Ag | Methods and agents for improving targeting of cd138 expressing tumor cells |
DK2242772T3 (en) | 2007-12-26 | 2015-01-05 | Biotest Ag | Immunoconjugates that targets CD138, and uses thereof |
US8268972B2 (en) | 2008-02-20 | 2012-09-18 | G2 Inflammation Pty Ltd | Humanized anti-C5aR antibodies |
GB0808350D0 (en) * | 2008-05-09 | 2008-06-18 | Airbus Uk Ltd | Self-cleaning surfaces |
US20110076723A1 (en) * | 2008-05-23 | 2011-03-31 | Samsung Electronics Co., Ltd. | Antibody-peptide fused synergibody |
US8188235B2 (en) * | 2008-06-18 | 2012-05-29 | Pfizer Inc. | Antibodies to IL-6 and their uses |
EP2191842A1 (en) * | 2008-11-28 | 2010-06-02 | Sanofi-Aventis | Antitumor combinations containing antibodies recognizing specifically CD38 and cytarabine |
EP2191843A1 (en) * | 2008-11-28 | 2010-06-02 | Sanofi-Aventis | Antitumor combinations containing antibodies recognizing specifically CD38 and cyclophosphamide |
EP2191841A1 (en) | 2008-11-28 | 2010-06-02 | Sanofi-Aventis | Antitumor combinations containing antibodies recognizing specifically CD38 and vincristine |
EP2191840A1 (en) * | 2008-11-28 | 2010-06-02 | Sanofi-Aventis | Antitumor combinations containing antibodies recognizing specifically CD38 and melphalan |
KR101725170B1 (ko) | 2009-05-06 | 2017-04-10 | 바이오테스트 아게 | Cd138을 표적으로 하는 면역접합체의 용도 |
AU2013201618B2 (en) * | 2009-05-06 | 2016-06-02 | Biotest Ag | Uses of immunoconjugates targeting CD138 |
WO2011047228A1 (en) | 2009-10-16 | 2011-04-21 | Cornell University | Measuring subcellular concentrations in vivo |
WO2011063131A1 (en) * | 2009-11-18 | 2011-05-26 | Nohands, Llc | Method and system for preventing virus-related obesity and obesity related diseases |
SI2580243T1 (sl) * | 2010-06-09 | 2020-02-28 | Genmab A/S | Protitelesa proti humanemu CD38 |
RU2595839C2 (ru) | 2010-09-27 | 2016-08-27 | МорфоСис АГ | Антитело к cd38 и леналидомид или бортезомиб для лечения множественной миеломы и nhl |
UA112170C2 (uk) * | 2010-12-10 | 2016-08-10 | Санофі | Протипухлинна комбінація, що містить антитіло, яке специфічно розпізнає cd38, і бортезоміб |
JOP20210044A1 (ar) | 2010-12-30 | 2017-06-16 | Takeda Pharmaceuticals Co | الأجسام المضادة لـ cd38 |
DK3798230T3 (en) * | 2011-06-06 | 2022-10-31 | Novo Nordisk As | Terapeutiske antistoffer |
WO2013004841A1 (en) | 2011-07-06 | 2013-01-10 | Genmab A/S | Modulation of complement-dependent cytotoxicity through modifications of the c-terminus of antibody heavy chains |
UA117901C2 (uk) | 2011-07-06 | 2018-10-25 | Ґенмаб Б.В. | Спосіб посилення ефекторної функції вихідного поліпептиду, його варіанти та їх застосування |
LT2771364T (lt) | 2011-10-27 | 2019-09-10 | Genmab A/S | Heterodimerinių baltymų gamyba |
KR102037541B1 (ko) | 2011-10-28 | 2019-10-29 | 테바 파마슈티컬즈 오스트레일리아 피티와이 엘티디 | 폴리펩티드 구축물 및 이의 용도 |
WO2013075740A1 (en) | 2011-11-23 | 2013-05-30 | Sanofi | Antibody purification method |
RU2632108C2 (ru) | 2011-12-08 | 2017-10-02 | Биотест Аг | Применения иммуноконъюгатов, мишенью которых является cd138 |
US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
EP2861622A4 (en) * | 2012-06-15 | 2016-06-01 | Sinomab Bioscience Ltd | Anti-idiotypic anti-CD22 antibodies and uses thereof |
EP3632462A1 (en) | 2012-07-06 | 2020-04-08 | Genmab B.V. | Dimeric protein with triple mutations |
AU2013285355A1 (en) | 2012-07-06 | 2015-01-29 | Genmab B.V. | Dimeric protein with triple mutations |
CA2885792C (en) * | 2012-09-25 | 2021-09-28 | Jan Endell | Pharmaceutical combination of an anti-cd38 antibody and melphalan for treating multiple myeloma |
DK2914302T3 (en) | 2012-11-05 | 2017-04-10 | Morphosys Ag | RADIOACTIVALLY MARKED ANTIBODY AND USES OF IT |
JP6374392B2 (ja) * | 2012-11-05 | 2018-08-15 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | Xbp1、cd138およびcs1ペプチド、該ペプチドを含有する薬学的組成物、ならびにかかるペプチドおよび組成物を使用する方法 |
US10342869B2 (en) | 2012-12-07 | 2019-07-09 | The Regents Of The University Of California | Compositions comprising anti-CD38 antibodies and lenalidomide |
UA118255C2 (uk) * | 2012-12-07 | 2018-12-26 | Санофі | Композиція, яка містить антитіло до cd38 і леналідомід |
EA201500741A1 (ru) * | 2013-01-10 | 2016-01-29 | Генмаб Б.В. | ВАРИАНТЫ Fc-ОБЛАСТИ IGG1 ЧЕЛОВЕКА И ИХ ПРИМЕНЕНИЕ |
CN103103197A (zh) * | 2013-01-30 | 2013-05-15 | 百奇生物科技(苏州)有限公司 | 抗cd138单克隆抗体可变区序列及其制备方法和应用 |
ES2800630T3 (es) | 2013-03-12 | 2021-01-04 | Molecular Templates Inc | Proteínas citotóxicas que comprenden regiones de unión de reconocimiento celular y regiones de la subunidad A de la toxina Shiga para la eliminación selectiva de tipos de células específicas |
FR3003171B1 (fr) * | 2013-03-15 | 2015-04-10 | Lab Francais Du Fractionnement | Nouveaux medicaments comprenant une composition d'anticorps enrichie en isoforme de charge majoritaire |
US11117975B2 (en) | 2013-04-29 | 2021-09-14 | Teva Pharmaceuticals Australia Pty Ltd | Anti-CD38 antibodies and fusions to attenuated interferon alpha-2B |
EA033115B1 (ru) | 2013-04-29 | 2019-08-30 | Тева Фармасьютикалз Острэйлиа Пти Лтд. | АНТИТЕЛА ПРОТИВ CD38 И СЛИТЫЕ БЕЛКИ С ОСЛАБЛЕННЫМ ИНТЕРФЕРОНОМ АЛЬФА-2b |
HUE057119T2 (hu) | 2013-05-06 | 2022-04-28 | Sanofi Sa | Folyamatos többlépéses eljárás antitestek tisztítására |
AU2014290186A1 (en) * | 2013-07-15 | 2016-02-04 | The Board Of Trustees Of The Leland Stanford Junior University | Medical uses of CD38 agonists |
CA2927099A1 (en) | 2013-10-31 | 2015-05-07 | Sanofi | Specific anti-cd38 antibodies for treating human cancers |
EP3176185A1 (en) | 2013-11-04 | 2017-06-07 | Glenmark Pharmaceuticals S.A. | Production of t cell retargeting hetero-dimeric immunoglobulins |
EP3092049A1 (en) | 2014-01-08 | 2016-11-16 | Flodesign Sonics Inc. | Acoustophoresis device with dual acoustophoretic chamber |
EP3099704B1 (en) | 2014-01-27 | 2021-03-17 | Molecular Templates, Inc. | Mhc class i epitope delivering polypeptides |
US10675352B2 (en) * | 2014-02-14 | 2020-06-09 | Centrose, Llc | Extracellular targeted drug conjugates |
US9732154B2 (en) * | 2014-02-28 | 2017-08-15 | Janssen Biotech, Inc. | Anti-CD38 antibodies for treatment of acute lymphoblastic leukemia |
US9603927B2 (en) * | 2014-02-28 | 2017-03-28 | Janssen Biotech, Inc. | Combination therapies with anti-CD38 antibodies |
EP3872090A1 (en) * | 2014-03-11 | 2021-09-01 | Molecular Templates, Inc. | Proteins comprising amino-terminal proximal shiga toxin a subunit effector regions and cell-targeting immunoglobulin-type binding regions |
JP6935195B2 (ja) * | 2014-03-11 | 2021-09-15 | モレキュラー テンプレーツ, インク.Molecular Templates, Inc. | 結合領域、志賀毒素aサブユニットのエフェクター領域、及びカルボキシ末端小胞体局在化シグナルモチーフを含むタンパク質 |
US11142584B2 (en) | 2014-03-11 | 2021-10-12 | Molecular Templates, Inc. | CD20-binding proteins comprising Shiga toxin A subunit effector regions for inducing cellular internalization and methods using same |
UA119352C2 (uk) | 2014-05-01 | 2019-06-10 | Тева Фармасьютикалз Острейліа Пті Лтд | Комбінація леналідоміду або помалідоміду і конструкції анти-cd38 антитіло-атенуйований інтерферон альфа-2b та спосіб лікування суб'єкта, який має cd38-експресуючу пухлину |
EP3137488B1 (en) | 2014-06-11 | 2019-01-02 | Molecular Templates, Inc. | Protease-cleavage resistant, shiga toxin a subunit effector polypeptides and cell-targeting molecules comprising the same |
US10106620B2 (en) | 2014-06-16 | 2018-10-23 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Blocking CD38 using anti-CD38 F(ab′)2 to protect NK cells |
WO2015195555A1 (en) * | 2014-06-16 | 2015-12-23 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Blocking cd38 using anti-cd38 antibody conjugated to protein g to protect nk cells |
ME03678B (me) * | 2014-06-17 | 2020-10-20 | Univ California | Unapređena alfa-v beta-8 antitela |
WO2016011210A2 (en) | 2014-07-15 | 2016-01-21 | Juno Therapeutics, Inc. | Engineered cells for adoptive cell therapy |
JP6132074B2 (ja) * | 2014-08-22 | 2017-05-24 | 株式会社村田製作所 | 触覚提示装置 |
WO2016040294A2 (en) * | 2014-09-09 | 2016-03-17 | Janssen Biotech, Inc. | Combination therapies with anti-cd38 antibodies |
IL251822B2 (en) | 2014-10-29 | 2023-03-01 | Teva Pharmaceuticals Australia Pty Ltd | Variants of interferon alpha-2-b |
MA40894A (fr) * | 2014-11-04 | 2017-09-12 | Glenmark Pharmaceuticals Sa | Immunoglobulines hétéro-dimères reciblant des lymphocytes t cd3/cd38 et leurs procédés de production |
US11773166B2 (en) | 2014-11-04 | 2023-10-03 | Ichnos Sciences SA | CD3/CD38 T cell retargeting hetero-dimeric immunoglobulins and methods of their production |
SG11201704390PA (en) * | 2014-12-04 | 2017-06-29 | Janssen Biotech Inc | Anti-cd38 antibodies for treatment of acute myeloid leukemia |
MX2017010072A (es) | 2015-02-05 | 2017-11-09 | Molecular Templates Inc | Moleculas multivalentes que se enlazan a cd20, las cuales comprenden regiones efectoras de la subunidad a de la toxina shiga, y composiciones enriquecidas de las mismas. |
MA41555A (fr) * | 2015-02-17 | 2017-12-26 | Millennium Pharm Inc | Polythérapie pour le traitement du cancer |
WO2016164656A1 (en) * | 2015-04-08 | 2016-10-13 | Sorrento Therapeutics, Inc. | Antibody therapeutics that bind cd38 |
US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
CA2984464C (en) | 2015-05-13 | 2023-10-10 | Morphosys Ag | Treatment for multiple myeloma (mm) |
BR112017024877A2 (pt) * | 2015-05-20 | 2019-09-17 | Janssen Biotech, Inc. | anticorpo anti-cd38 e seu uso no tratamento de amiloidose de cadeia leve e outras malignidades hematológicas positivas para cd38 |
MY188049A (en) | 2015-05-29 | 2021-11-12 | Bristol Myers Squibb Co | Antibodies against ox40 and uses thereof |
KR20240038121A (ko) * | 2015-05-30 | 2024-03-22 | 몰레큘러 템플레이츠, 인코퍼레이션. | 탈면역된 시가 독소 a 서브유닛 스캐폴드 및 이를 포함하는 세포-표적화 분자 |
CA2990406A1 (en) | 2015-06-22 | 2016-12-29 | Janssen Biotech, Inc. | Combination therapies for heme malignancies with anti-cd38 antibodies and survivin inhibitors |
US20160376373A1 (en) * | 2015-06-24 | 2016-12-29 | Janssen Biotech, Inc. | Immune Modulation and Treatment of Solid Tumors with Antibodies that Specifically Bind CD38 |
US20170044265A1 (en) | 2015-06-24 | 2017-02-16 | Janssen Biotech, Inc. | Immune Modulation and Treatment of Solid Tumors with Antibodies that Specifically Bind CD38 |
MA42895A (fr) | 2015-07-15 | 2018-05-23 | Juno Therapeutics Inc | Cellules modifiées pour thérapie cellulaire adoptive |
JP2018522907A (ja) | 2015-08-11 | 2018-08-16 | セレクティスCellectis | Cd38抗原を標的とするためおよびcd38遺伝子を不活化するために操作された、免疫療法用の細胞 |
AR106188A1 (es) | 2015-10-01 | 2017-12-20 | Hoffmann La Roche | Anticuerpos anti-cd19 humano humanizados y métodos de utilización |
EA202190808A2 (ru) | 2015-11-03 | 2021-12-31 | Янссен Байотек, Инк. | Составы антител к cd38 для подкожного введения и их применение |
US10781261B2 (en) | 2015-11-03 | 2020-09-22 | Janssen Biotech, Inc. | Subcutaneous formulations of anti-CD38 antibodies and their uses |
AU2017226960B2 (en) * | 2016-03-04 | 2024-03-21 | Morphosys Ag | Clinical assessment of M-protein response in multiple myeloma |
SG10201601719RA (en) | 2016-03-04 | 2017-10-30 | Agency Science Tech & Res | Anti-LAG-3 Antibodies |
RU2764201C2 (ru) * | 2016-03-25 | 2022-01-14 | Биомюнё Фармасьютикалз | Связывающиеся с cd38 и pd-l1 молекулы |
US11214789B2 (en) | 2016-05-03 | 2022-01-04 | Flodesign Sonics, Inc. | Concentration and washing of particles with acoustics |
SG10201603721TA (en) | 2016-05-10 | 2017-12-28 | Agency Science Tech & Res | Anti-CTLA-4 Antibodies |
WO2018002181A1 (en) * | 2016-06-28 | 2018-01-04 | Umc Utrecht Holding B.V. | TREATMENT OF IgE-MEDIATED DISEASES WITH ANTIBODIES THAT SPECIFICALLY BIND CD38 |
CA3030834A1 (en) | 2016-07-15 | 2018-01-18 | Takeda Pharmaceutical Company Limited | Methods and materials for assessing response to plasmablast- and plasma cell-depleting therapies |
WO2018015498A1 (en) | 2016-07-20 | 2018-01-25 | Hybrigenics Sa | Combinations of inecalcitol with an anti-cd38 agent and their uses for treating cancer |
WO2018083126A1 (en) | 2016-11-01 | 2018-05-11 | Genmab B.V. | Polypeptide variants and uses thereof |
MX2019004621A (es) | 2016-11-02 | 2019-11-28 | Engmab Sarl | Anticuerpo biespecifico contra bcma y cd3 y un farmaco inmunologico para uso combinado en el tratamiento del mieloma multiple. |
EP3330712A1 (en) | 2016-12-01 | 2018-06-06 | imusyn GmbH & Co. KG | Analysis of anti-erythrocyte antibody in the presence of antibody directed against a surface-bound erythrocyte antigen |
KR102557126B1 (ko) | 2016-12-07 | 2023-07-18 | 몰레큘러 템플레이츠, 인코퍼레이션. | 부위 특이적 접합을 위한 시가 독소 a 서브유닛 작동체 폴리펩타이드, 시가 독소 작동체 스캐폴드, 및 세포-표적화 분자 |
WO2018104562A1 (en) * | 2016-12-09 | 2018-06-14 | Onkimmune Limited | Engineered natural killer cells and uses thereof |
IL267990B2 (en) | 2017-01-25 | 2024-04-01 | Molecular Templates Inc | Cell-targeted molecules containing Shiga toxin A subunit activators and nonimmune CD8 T-cell epitopes |
US20190048055A1 (en) * | 2017-03-31 | 2019-02-14 | Altor Bioscience Corporation | Alt-803 in combination with anti-cd38 antibody for cancer therapies |
CN111051344B (zh) | 2017-06-08 | 2023-10-27 | 黑带医疗有限公司 | Cd38调节抗体 |
CA3066555A1 (en) | 2017-06-08 | 2018-12-13 | Black Belt Therapeutics Limited | Cd38 modulating antibody |
PL3538645T3 (pl) | 2017-06-20 | 2021-11-08 | Institut Curie | Komórki odpornościowe z defektem suv39h1 |
CA3072296A1 (en) | 2017-08-16 | 2019-02-21 | Black Belt Therapeutics Limited | Cd38 antibody |
WO2019035938A1 (en) | 2017-08-16 | 2019-02-21 | Elstar Therapeutics, Inc. | MULTISPECIFIC MOLECULES BINDING TO BCMA AND USES THEREOF |
WO2019034752A1 (en) | 2017-08-16 | 2019-02-21 | Tusk Therapeutics Ltd | CD38 MODULATOR ANTIBODY |
US20200207867A1 (en) | 2017-09-13 | 2020-07-02 | Teneobio, Inc. | Heavy chain antibodies binding to ectoenzymes |
US11945868B2 (en) * | 2017-10-02 | 2024-04-02 | Visterra, Inc. | Antibody molecules to CD138 and uses thereof |
BR112020007002A2 (pt) * | 2017-10-10 | 2020-11-17 | Sanofi | anticorpos anti-cd38 e métodos de uso |
MA50514A (fr) | 2017-10-31 | 2020-09-09 | Janssen Biotech Inc | Méthodes de traitement du myélome multiple à haut risque |
CN111902159A (zh) | 2017-11-01 | 2020-11-06 | 朱诺治疗学股份有限公司 | 对b细胞成熟抗原(bcma)具有特异性的嵌合抗原受体 |
BR112020008340A2 (pt) | 2017-11-01 | 2020-11-17 | Juno Therapeutics Inc | processo para gerar composições terapêuticas de células modificadas |
US11564946B2 (en) | 2017-11-01 | 2023-01-31 | Juno Therapeutics, Inc. | Methods associated with tumor burden for assessing response to a cell therapy |
US11623961B2 (en) | 2017-11-01 | 2023-04-11 | Juno Therapeutics, Inc. | Antibodies and chimeric antigen receptors specific for B-cell maturation antigen |
WO2019089858A2 (en) | 2017-11-01 | 2019-05-09 | Juno Therapeutics, Inc. | Methods of assessing or monitoring a response to a cell therapy |
US20210254000A1 (en) | 2017-11-01 | 2021-08-19 | Juno Therapeutics, Inc. | Process for producing a t cell composition |
JP2021501587A (ja) | 2017-11-03 | 2021-01-21 | ソレント・セラピューティクス・インコーポレイテッドSorrento Therapeutics, Inc. | Cd38指向性キメラ抗原受容体構築物 |
CN107936110B (zh) * | 2017-11-07 | 2021-06-22 | 潍坊医学院 | 突变基因Nasp在狼疮性模型小鼠自身免疫病发病中的作用及机制 |
DK3720883T3 (da) | 2017-12-05 | 2023-07-24 | Medical Res Infrastructure & Health Services Fund Tel Aviv Medical Ct | T-celler omfattende kimære anti-cd38- og anti-cd138-antigenreceptorer og anvendelser deraf |
US20210128616A1 (en) | 2017-12-08 | 2021-05-06 | Juno Therapeutics, Inc. | Phenotypic markers for cell therapy and related methods |
SG11202005272SA (en) | 2017-12-08 | 2020-07-29 | Juno Therapeutics Inc | Process for producing a composition of engineered t cells |
WO2019113556A1 (en) | 2017-12-08 | 2019-06-13 | Juno Therapeutics, Inc. | Serum-free media formulation for culturing cells and methods of use thereof |
BR112020009889A2 (pt) | 2017-12-14 | 2020-11-03 | Flodesign Sonics, Inc. | acionador e controlador de transdutor acústico |
EP3694546A1 (en) | 2018-01-30 | 2020-08-19 | Cellectis | Combination comprising allogeneic immune cells deficient for an antigen present on both t-cells and pathological cells and therapeutic antibody against said antigen |
JP6648171B2 (ja) * | 2018-02-02 | 2020-02-14 | テバ・ファーマシューティカルズ・オーストラリア・ピーティワイ・リミテッド | 抗cd38抗体及び弱毒化インターフェロンアルファ−2bとの融合物 |
CN110144008B (zh) * | 2018-02-12 | 2021-03-19 | 杭州尚健生物技术有限公司 | Cd38蛋白抗体及其应用 |
US20210040224A1 (en) * | 2018-03-13 | 2021-02-11 | Trillium Therapeutics Inc. | Cd47 blockade therapy with cd38 antibody |
WO2019186273A1 (en) * | 2018-03-28 | 2019-10-03 | Takeda Pharmaceutical Company Limited | Subcutaneous dosing of anti-cd38 antibodies |
CN108593912A (zh) * | 2018-04-09 | 2018-09-28 | 北京大学深圳研究生院 | 一种可溶性cd38浓度的检测方法 |
MX2019009726A (es) | 2018-04-17 | 2020-02-05 | Molecular Templates Inc | Moleculas con direccion hacia her2 que comprenden andamiajes de la sub-unidad a de la toxina shiga desinmunizados. |
CA3100118A1 (en) | 2018-05-16 | 2019-11-21 | Janssen Biotech, Inc. | Bcma/cd3 and gprdc5d/cd3 bispecific antibodies for use in cancer therapy |
EP3820890A1 (en) | 2018-07-13 | 2021-05-19 | Genmab A/S | Trogocytosis-mediated therapy using cd38 antibodies |
SG11202012993SA (en) | 2018-07-13 | 2021-02-25 | Genmab As | Variants of cd38 antibody and uses thereof |
AU2019316647A1 (en) | 2018-08-09 | 2021-02-25 | Juno Therapeutics, Inc. | Methods for assessing integrated nucleic acids |
AU2019338999A1 (en) | 2018-09-11 | 2021-03-18 | Jiangsu Hengrui Medicine Co., Ltd. | Anti-CD38 antibody, antigen-binding fragment thereof, and pharmaceutical use |
CN109053892B (zh) | 2018-09-19 | 2021-03-26 | 苏州思坦维生物技术股份有限公司 | 特异结合人及猴cd38抗原的单克隆抗体及其制备方法与应用 |
CN109265551B (zh) * | 2018-09-25 | 2020-09-15 | 华东师范大学 | Cd38抗体、嵌合抗原受体和药物 |
BR112021007227A2 (pt) | 2018-10-17 | 2021-08-10 | Janssen Biotech, Inc. | método para fornecer administração subcutânea de anticorpos anti-cd38 |
KR20210086651A (ko) | 2018-10-26 | 2021-07-08 | 테네오바이오, 인코포레이티드 | Cd38에 결합하는 중쇄 항체 |
CN111116743B (zh) * | 2018-10-30 | 2022-01-28 | 迈威(上海)生物科技股份有限公司 | Hsp90抗体及其在抗真菌感染中的应用 |
AU2019374103A1 (en) | 2018-11-01 | 2021-05-20 | Juno Therapeutics, Inc. | Chimeric antigen receptors specific for G Protein-Coupled Receptor Class C Group 5 Member D (GPRC5D) |
EP3873943A2 (en) | 2018-11-01 | 2021-09-08 | Juno Therapeutics, Inc. | Methods for treatment using chimeric antigen receptors specific for b-cell maturation antigen |
WO2020106886A1 (en) | 2018-11-20 | 2020-05-28 | Cornell University | Macrocyclic complexes of radionuclides and their use in radiotherapy of cancer |
SG11202104012QA (en) | 2018-12-14 | 2021-05-28 | Morphosys Ag | Antibody formulations |
AU2019410073A1 (en) | 2018-12-21 | 2021-06-10 | F. Hoffmann-La Roche Ag | Tumor-targeted agonistic CD28 antigen binding molecules |
GB201900530D0 (en) * | 2019-01-15 | 2019-03-06 | Bicyclerd Ltd | Bicyclic peptide ligands specific for CD38 |
AU2019429147A1 (en) | 2019-02-12 | 2021-09-09 | Prothena Biosciences Limited | Treatment of AL amyloidosis with the combination of monoclonal antibodies against immunoglobulin light chains and the CD38 cell membrane molecule on antibody-producing and other immune cells |
MX2021009851A (es) | 2019-02-18 | 2021-09-10 | Lilly Co Eli | Formulacion de anticuerpos terapeuticos. |
US20220098307A1 (en) * | 2019-02-22 | 2022-03-31 | Wuhan Yzy Biopharma Co., Ltd. | Modified fc fragment, antibody comprising same, and application thereof |
BR112021016923A2 (pt) | 2019-02-27 | 2021-11-03 | Genentech Inc | Métodos para tratar um paciente com câncer hematológico, métodos para tratar um paciente com mm recidivante ou refratário, métodos para tratar um paciente tendo um lnh recidivante ou refratário e kits |
MX2021010665A (es) | 2019-03-05 | 2021-12-10 | Prothena Biosciences Ltd | Metodos de tratamiento de amiloidosis al. |
WO2020187718A1 (en) | 2019-03-15 | 2020-09-24 | Morphosys Ag | Anti-cd38 antibodies and pharmaceutical compositions thereof for the treatment of autoantibody-mediated autoimmune disease |
CN114524877A (zh) * | 2019-03-29 | 2022-05-24 | 索伦托药业有限公司 | 结合cd38的经工程改造的变异抗体 |
WO2020212914A1 (en) * | 2019-04-19 | 2020-10-22 | Janssen Biotech, Inc. | Combination therapies comprising daratumumab, bortezomib, thalidomide and dexamethasone and their uses |
AU2020265741A1 (en) | 2019-05-01 | 2021-11-25 | Editas Medicine, Inc. | Cells expressing a recombinant receptor from a modified TGFBR2 Locus, related polynucleotides and methods |
KR20220016474A (ko) | 2019-05-01 | 2022-02-09 | 주노 쎄러퓨티크스 인코퍼레이티드 | 변형된 cd247 유전자 자리로부터 키메라 수용체를 발현하는 세포, 관련 폴리뉴클레오타이드 및 방법 |
US11655302B2 (en) | 2019-06-10 | 2023-05-23 | Sanofi | Anti-CD38 antibodies and formulations |
US20220241413A1 (en) | 2019-06-10 | 2022-08-04 | Takeda Pharmaceutical Company Limited | Combination therapies using cd-38 antibodies |
JP2022538836A (ja) | 2019-06-27 | 2022-09-06 | クリスパー セラピューティクス アクチェンゲゼルシャフト | がんを治療するためのキメラ抗原受容体t細胞及びnk細胞阻害剤の使用 |
WO2021009263A1 (en) | 2019-07-16 | 2021-01-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Antibodies having specificity for cd38 and uses thereof |
WO2021013950A1 (en) | 2019-07-23 | 2021-01-28 | Mnemo Therapeutics | Immune cells defective for suv39h1 |
KR20220092580A (ko) | 2019-11-06 | 2022-07-01 | 제넨테크, 인크. | 혈액암의 치료를 위한 진단과 치료 방법 |
WO2021113739A1 (en) | 2019-12-05 | 2021-06-10 | Thomas Ballet | Formulations of anti-cd38 antibodies for subcutaneous administration |
CN115023441A (zh) | 2019-12-18 | 2022-09-06 | 特诺福尔股份有限公司 | 与cd38结合的重链抗体 |
AU2020412805A1 (en) * | 2019-12-26 | 2022-07-14 | Hendrix College | Methods and compositions for inhibition of dihydroorotate dehydrogenase in combination with an anti-CD38 therapeutic agent |
KR20220124718A (ko) | 2020-01-07 | 2022-09-14 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 암 치료를 위한 개선된 인간 메틸 티오아데노신/아데노신 고갈 효소 변이체 |
JP6853392B2 (ja) * | 2020-01-15 | 2021-03-31 | テバ・ファーマシューティカルズ・オーストラリア・ピーティワイ・リミテッド | 抗cd38抗体及び弱毒化インターフェロンアルファ−2bとの融合物 |
JP2023510397A (ja) | 2020-01-16 | 2023-03-13 | ジェンマブ エー/エス | Cd38抗体の製剤およびその使用 |
AU2021251265A1 (en) | 2020-04-10 | 2022-11-03 | Juno Therapeutics, Inc. | Methods and uses related to cell therapy engineered with a chimeric antigen receptor targeting B-cell maturation antigen |
WO2021231657A1 (en) | 2020-05-13 | 2021-11-18 | Juno Therapeutics, Inc. | Methods of identifying features associated with clinical response and uses thereof |
JP2023106636A (ja) * | 2020-05-22 | 2023-08-02 | 国立研究開発法人医薬基盤・健康・栄養研究所 | ヒト抗破傷風毒素抗体 |
US20230312742A1 (en) | 2020-06-17 | 2023-10-05 | Y-Mabs Therapeutics, Inc. | CD38 antibodies for the treatment of human diseases |
CN116670285A (zh) * | 2020-06-23 | 2023-08-29 | 江苏康缘药业股份有限公司 | 抗cd38抗体及其用途 |
WO2021260657A1 (en) | 2020-06-26 | 2021-12-30 | Crispr Therapeutics Ag | Allogeneic cell therapy of b cell malignancies using genetically engineered t cells targeting cd19 |
EP4171616A1 (en) | 2020-06-26 | 2023-05-03 | Juno Therapeutics GmbH | Engineered t cells conditionally expressing a recombinant receptor, related polynucleotides and methods |
EP4188395A1 (en) | 2020-07-30 | 2023-06-07 | Institut Curie | Immune cells defective for socs1 |
CN114075283A (zh) * | 2020-08-12 | 2022-02-22 | 三生国健药业(上海)股份有限公司 | 结合人cd38的抗体、其制备方法和用途 |
IL301547A (en) | 2020-10-05 | 2023-05-01 | Genentech Inc | Dosage for treatment with bispecific anti-FCRH5/anti-CD3 antibodies |
WO2022097047A1 (en) * | 2020-11-04 | 2022-05-12 | Medimmune, Llc | Treatment methods using anti-bcma antibody-drug conjugates |
CN116802203A (zh) | 2020-11-04 | 2023-09-22 | 朱诺治疗学股份有限公司 | 从经修饰的恒定cd3免疫球蛋白超家族链基因座表达嵌合受体的细胞、相关多核苷酸和方法 |
EP4251282A1 (en) | 2020-11-27 | 2023-10-04 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods for diagnosis and monitoring of toxic epidermal necrolysis |
US20220202859A1 (en) | 2020-12-23 | 2022-06-30 | Crispr Therapeutics Ag | Cancer treatment using cd38 inhibitor and/or lenalidomide and t-cells expressing a chimeric antigen receptor |
AU2022208200A1 (en) | 2021-01-14 | 2023-07-20 | Morphosys Ag | Anti-cd38 antibodies and their uses |
US20220275090A1 (en) | 2021-02-22 | 2022-09-01 | Janssen Biotech, Inc. | Combination Therapies with Anti-CD38 Antibodies and PARP or Adenosine Receptor Inhibitors |
TW202302642A (zh) | 2021-03-01 | 2023-01-16 | 德商莫菲西斯公司 | 用於治療抗體介導移植物排斥用途之抗cd38抗體 |
JP2024509853A (ja) | 2021-03-03 | 2024-03-05 | ジュノー セラピューティクス インコーポレイテッド | T細胞療法およびdgk阻害剤の組合せ |
CN117916256A (zh) | 2021-05-06 | 2024-04-19 | 朱诺治疗学有限公司 | 用于刺激和转导t细胞的方法 |
WO2022238386A1 (en) | 2021-05-10 | 2022-11-17 | Institut Curie | Methods for the treatment of cancer, inflammatory diseases and autoimmune diseases |
TW202310870A (zh) | 2021-05-12 | 2023-03-16 | 瑞士商Crispr治療公司 | 用於治療造血惡性腫瘤之靶向cd70的基因工程化免疫細胞 |
AR125852A1 (es) | 2021-05-12 | 2023-08-16 | Crispr Therapeutics Ag | Células inmunes modificadas genéticamente que se focalizan en cd70 para su uso en tratamiento de tumores sólidos |
WO2022248602A1 (en) | 2021-05-25 | 2022-12-01 | Institut Curie | Myeloid cells overexpressing bcl2 |
WO2022271987A1 (en) | 2021-06-23 | 2022-12-29 | TeneoFour, Inc. | Anti-cd38 antibodies and epitopes of same |
TW202321303A (zh) | 2021-07-19 | 2023-06-01 | 德商莫菲西斯公司 | 抗pla2r自體抗體媒介膜性腎病變之治療 |
IL310372A (en) | 2021-07-28 | 2024-03-01 | Genentech Inc | IL15/IL15R alpha heterodimeric FC-fused proteins for the treatment of blood cancer |
TW202321308A (zh) | 2021-09-30 | 2023-06-01 | 美商建南德克公司 | 使用抗tigit抗體、抗cd38抗體及pd—1軸結合拮抗劑治療血液癌症的方法 |
WO2023079494A1 (en) | 2021-11-03 | 2023-05-11 | Janssen Biotech, Inc. | Corticosteriod reduction in treatment with anti-cd38 antibodies |
WO2023126458A1 (en) | 2021-12-28 | 2023-07-06 | Mnemo Therapeutics | Immune cells with inactivated suv39h1 and modified tcr |
WO2023147515A1 (en) | 2022-01-28 | 2023-08-03 | Juno Therapeutics, Inc. | Methods of manufacturing cellular compositions |
WO2023159182A1 (en) | 2022-02-18 | 2023-08-24 | Rakuten Medical, Inc. | Anti-programmed death-ligand 1 (pd-l1) antibody molecules, encoding polynucleotides, and methods of use |
WO2023178323A1 (en) * | 2022-03-18 | 2023-09-21 | Henry Ford Health System | Therapeutic inhibition of cd38 to treat hidradenitis suppurativa |
WO2023187024A1 (en) | 2022-03-31 | 2023-10-05 | Institut Curie | Modified rela protein for inducing interferon expression and engineered immune cells with improved interferon expression |
WO2023191816A1 (en) | 2022-04-01 | 2023-10-05 | Genentech, Inc. | Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies |
WO2023213969A1 (en) | 2022-05-05 | 2023-11-09 | Juno Therapeutics Gmbh | Viral-binding protein and related reagents, articles, and methods of use |
WO2023219613A1 (en) | 2022-05-11 | 2023-11-16 | Genentech, Inc. | Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies |
WO2023220655A1 (en) | 2022-05-11 | 2023-11-16 | Celgene Corporation | Methods to overcome drug resistance by re-sensitizing cancer cells to treatment with a prior therapy via treatment with a t cell therapy |
WO2023230548A1 (en) | 2022-05-25 | 2023-11-30 | Celgene Corporation | Method for predicting response to a t cell therapy |
WO2023230581A1 (en) | 2022-05-25 | 2023-11-30 | Celgene Corporation | Methods of manufacturing t cell therapies |
WO2023240135A2 (en) | 2022-06-07 | 2023-12-14 | Actinium Pharmaceuticals, Inc. | Bifunctional chelators and conjugates |
WO2024015897A1 (en) | 2022-07-13 | 2024-01-18 | Genentech, Inc. | Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies |
WO2024020432A1 (en) | 2022-07-19 | 2024-01-25 | Genentech, Inc. | Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies |
WO2024054944A1 (en) | 2022-09-08 | 2024-03-14 | Juno Therapeutics, Inc. | Combination of a t cell therapy and continuous or intermittent dgk inhibitor dosing |
WO2024079010A1 (en) | 2022-10-10 | 2024-04-18 | F. Hoffmann-La Roche Ag | Combination therapy of a gprc5d tcb and cd38 antibodies |
WO2024079711A1 (en) | 2022-10-14 | 2024-04-18 | Janssen Research & Development, Llc | Method for detection of antibody-dependent cellular phagocytosis |
WO2024091991A1 (en) | 2022-10-25 | 2024-05-02 | Genentech, Inc. | Therapeutic and diagnostic methods for multiple myeloma |
Family Cites Families (331)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5672A (en) | 1848-07-18 | Mark wilder | ||
US54A (en) | 1836-10-15 | Art of managing and supplying fie-e for generating steam in locomotive | ||
US835A (en) | 1838-07-12 | X i i i x | ||
US510A (en) | 1837-12-07 | soeel | ||
US5922A (en) | 1848-11-14 | Improvement in hillside-plows | ||
US941A (en) | 1838-09-22 | Machine for sawing shingles and staves | ||
US5719A (en) | 1848-08-22 | Ditching-machine | ||
US6077A (en) | 1849-01-30 | Improved hinged claw-wrench | ||
US576A (en) | 1838-01-20 | Ftjbnace of stoves fob bubning anthracite | ||
US6168A (en) | 1849-03-13 | Horizontal spark-arrester | ||
US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
US4634665A (en) | 1980-02-25 | 1987-01-06 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
US5179017A (en) | 1980-02-25 | 1993-01-12 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
US4475196A (en) | 1981-03-06 | 1984-10-02 | Zor Clair G | Instrument for locating faults in aircraft passenger reading light and attendant call control system |
US4447233A (en) | 1981-04-10 | 1984-05-08 | Parker-Hannifin Corporation | Medication infusion pump |
US4474893A (en) | 1981-07-01 | 1984-10-02 | The University of Texas System Cancer Center | Recombinant monoclonal antibodies |
JPS5896026A (ja) | 1981-10-30 | 1983-06-07 | Nippon Chemiphar Co Ltd | 新規ウロキナ−ゼ誘導体およびその製造法ならびにそれを含有する血栓溶解剤 |
US4439196A (en) | 1982-03-18 | 1984-03-27 | Merck & Co., Inc. | Osmotic drug delivery system |
US4609546A (en) | 1982-06-24 | 1986-09-02 | Japan Chemical Research Co., Ltd. | Long-acting composition |
US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
US4447224A (en) | 1982-09-20 | 1984-05-08 | Infusaid Corporation | Variable flow implantable infusion apparatus |
US4487603A (en) | 1982-11-26 | 1984-12-11 | Cordis Corporation | Implantable microinfusion pump system |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4486194A (en) | 1983-06-08 | 1984-12-04 | James Ferrara | Therapeutic device for administering medicaments through the skin |
US4681581A (en) | 1983-12-05 | 1987-07-21 | Coates Fredrica V | Adjustable size diaper and folding method therefor |
CA1282721C (en) | 1984-06-04 | 1991-04-09 | Bernard Roizman | Herpes simplex virus as a vector |
JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
US4699880A (en) | 1984-09-25 | 1987-10-13 | Immunomedics, Inc. | Method of producing monoclonal anti-idiotype antibody |
JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
US4797368A (en) | 1985-03-15 | 1989-01-10 | The United States Of America As Represented By The Department Of Health And Human Services | Adeno-associated virus as eukaryotic expression vector |
US4596556A (en) | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
US5374548A (en) | 1986-05-02 | 1994-12-20 | Genentech, Inc. | Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor |
US4824659A (en) | 1985-06-07 | 1989-04-25 | Immunomedics, Inc. | Antibody conjugates |
US4766106A (en) | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
MX9203291A (es) | 1985-06-26 | 1992-08-01 | Liposome Co Inc | Metodo para acoplamiento de liposomas. |
US5776093A (en) | 1985-07-05 | 1998-07-07 | Immunomedics, Inc. | Method for imaging and treating organs and tissues |
US4735210A (en) | 1985-07-05 | 1988-04-05 | Immunomedics, Inc. | Lymphographic and organ imaging method and kit |
US5101827A (en) | 1985-07-05 | 1992-04-07 | Immunomedics, Inc. | Lymphographic and organ imaging method and kit |
US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
US5139941A (en) | 1985-10-31 | 1992-08-18 | University Of Florida Research Foundation, Inc. | AAV transduction vectors |
EP0247091B1 (en) | 1985-11-01 | 1993-09-29 | Xoma Corporation | Modular assembly of antibody genes, antibodies prepared thereby and use |
US5618920A (en) * | 1985-11-01 | 1997-04-08 | Xoma Corporation | Modular assembly of antibody genes, antibodies prepared thereby and use |
GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
US5057313A (en) | 1986-02-25 | 1991-10-15 | The Center For Molecular Medicine And Immunology | Diagnostic and therapeutic antibody conjugates |
US4954617A (en) | 1986-07-07 | 1990-09-04 | Trustees Of Dartmouth College | Monoclonal antibodies to FC receptors for immunoglobulin G on human mononuclear phagocytes |
US5260203A (en) | 1986-09-02 | 1993-11-09 | Enzon, Inc. | Single polypeptide chain binding molecules |
US4881175A (en) | 1986-09-02 | 1989-11-14 | Genex Corporation | Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides |
US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
US5834185A (en) | 1986-10-28 | 1998-11-10 | Johns Hopkins University | Formation of triple helix complexes of single stranded nucleic acids using nucleoside oligomers which comprise pyrimidine analogs, triple helix complexes formed thereby and oligomers used in their formation |
IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
WO1988007089A1 (en) | 1987-03-18 | 1988-09-22 | Medical Research Council | Altered antibodies |
US5013653A (en) | 1987-03-20 | 1991-05-07 | Creative Biomolecules, Inc. | Product and process for introduction of a hinge region into a fusion protein to facilitate cleavage |
US5091513A (en) | 1987-05-21 | 1992-02-25 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
US5132405A (en) | 1987-05-21 | 1992-07-21 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
JPH02500329A (ja) | 1987-05-21 | 1990-02-08 | クリエイテイブ・バイオマリキユールズ・インコーポレーテツド | ターゲット化多機能蛋白質 |
US5258498A (en) | 1987-05-21 | 1993-11-02 | Creative Biomolecules, Inc. | Polypeptide linkers for production of biosynthetic proteins |
US4941880A (en) | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
US4790824A (en) | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
US5750172A (en) | 1987-06-23 | 1998-05-12 | Pharming B.V. | Transgenic non human mammal milk |
GB8717430D0 (en) | 1987-07-23 | 1987-08-26 | Celltech Ltd | Recombinant dna product |
US5648471A (en) | 1987-12-03 | 1997-07-15 | Centocor, Inc. | One vial method for labeling antibodies with Technetium-99m |
WO1989008114A1 (en) | 1988-02-25 | 1989-09-08 | The General Hospital Corporation | Rapid immunoselection cloning method |
JPH03504196A (ja) | 1988-03-18 | 1991-09-19 | アメリカ合衆国 | 新規組換えワクチニアウイルス発現ベクター及びその選択方法 |
US5716826A (en) | 1988-03-21 | 1998-02-10 | Chiron Viagene, Inc. | Recombinant retroviruses |
GB8809129D0 (en) | 1988-04-18 | 1988-05-18 | Celltech Ltd | Recombinant dna methods vectors and host cells |
US5614404A (en) | 1988-06-10 | 1997-03-25 | Theriod Biologics, Incorporated | Self-assembled, defective, non-self-propagating lentivirus particles |
US5294533A (en) | 1988-07-05 | 1994-03-15 | Baylor College Of Medicine | Antisense oligonucleotide antibiotics complementary to the macromolecular synthesis operon, methods of treating bacterial infections and methods for identification of bacteria |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
US5866701A (en) | 1988-09-20 | 1999-02-02 | The Board Of Regents For Northern Illinois University Of Dekalb | HIV targeted hairpin ribozymes |
GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
US5176996A (en) | 1988-12-20 | 1993-01-05 | Baylor College Of Medicine | Method for making synthetic oligonucleotides which bind specifically to target sites on duplex DNA molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
US5168053A (en) | 1989-03-24 | 1992-12-01 | Yale University | Cleavage of targeted RNA by RNAase P |
US5624824A (en) | 1989-03-24 | 1997-04-29 | Yale University | Targeted cleavage of RNA using eukaryotic ribonuclease P and external guide sequence |
US5108921A (en) | 1989-04-03 | 1992-04-28 | Purdue Research Foundation | Method for enhanced transmembrane transport of exogenous molecules |
US5102990A (en) | 1989-08-09 | 1992-04-07 | Rhomed Incorporated | Direct radiolabeling of antibodies and other proteins with technetium or rhenium |
EP0497922B1 (en) | 1989-10-24 | 2002-01-30 | Chiron Corporation | Infective protein delivery system |
US5312335A (en) | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
US5064413A (en) | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
US5633076A (en) | 1989-12-01 | 1997-05-27 | Pharming Bv | Method of producing a transgenic bovine or transgenic bovine embryo |
JP2507895B2 (ja) | 1989-12-19 | 1996-06-19 | 工業技術院長 | リボザイムの新規合成系 |
GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
JP3501286B2 (ja) | 1989-12-22 | 2004-03-02 | アプライド リサーチ システムズ,エーアールエス ホールディング ナームロゼ ベノートスハップ | 一定の細胞系又は微生物の内因性遺伝子の発現特徴の変性のための方法 |
US5672510A (en) | 1990-01-19 | 1997-09-30 | Genetic Therapy, Inc. | Retroviral vectors |
US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
US5476766A (en) | 1990-06-11 | 1995-12-19 | Nexstar Pharmaceuticals, Inc. | Ligands of thrombin |
US5795721A (en) | 1990-06-11 | 1998-08-18 | Nexstar Pharmaceuticals, Inc. | High affinity nucleic acid ligands of ICP4 |
US5503978A (en) | 1990-06-11 | 1996-04-02 | University Research Corporation | Method for identification of high affinity DNA ligands of HIV-1 reverse transcriptase |
US6030776A (en) | 1990-06-11 | 2000-02-29 | Nexstar Pharmaceuticals, Inc. | Parallel SELEX |
US5580737A (en) | 1990-06-11 | 1996-12-03 | Nexstar Pharmaceuticals, Inc. | High-affinity nucleic acid ligands that discriminate between theophylline and caffeine |
US5846713A (en) | 1990-06-11 | 1998-12-08 | Nexstar Pharmaceuticals, Inc. | High affinity HKGF nucleic acid ligands and inhibitors |
US5660985A (en) | 1990-06-11 | 1997-08-26 | Nexstar Pharmaceuticals, Inc. | High affinity nucleic acid ligands containing modified nucleotides |
US5731424A (en) | 1990-06-11 | 1998-03-24 | Nexstar Pharmaceuticals, Inc. | High affinity TGFβ nucleic acid ligands and inhibitors |
US6011020A (en) | 1990-06-11 | 2000-01-04 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligand complexes |
US5869641A (en) | 1990-06-11 | 1999-02-09 | Nexstar Pharmaceuticals, Inc. | High affinity nucleic acid ligands of CD4 |
US5861254A (en) | 1997-01-31 | 1999-01-19 | Nexstar Pharmaceuticals, Inc. | Flow cell SELEX |
US5543293A (en) | 1990-06-11 | 1996-08-06 | Nexstar Pharmaceuticals, Inc. | DNA ligands of thrombin |
US6001988A (en) | 1990-06-11 | 1999-12-14 | Nexstar Pharmaceuticals, Inc. | High affinity nucleic acid ligands to lectins |
US5723289A (en) | 1990-06-11 | 1998-03-03 | Nexstar Pharmaceuticals, Inc. | Parallel selex |
US5864026A (en) | 1990-06-11 | 1999-01-26 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands by exponential enrichment: tissue selex |
US5780228A (en) | 1990-06-11 | 1998-07-14 | Nexstar Pharmaceuticals, Inc. | High affinity nucleic acid ligands to lectins |
GB9014932D0 (en) | 1990-07-05 | 1990-08-22 | Celltech Ltd | Recombinant dna product and method |
WO1992020791A1 (en) | 1990-07-10 | 1992-11-26 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
US5135917A (en) | 1990-07-12 | 1992-08-04 | Nova Pharmaceutical Corporation | Interleukin receptor expression inhibiting antisense oligonucleotides |
WO1992001049A2 (en) | 1990-07-13 | 1992-01-23 | The General Hospital Corporation | Cd53 cell surface antigen and use thereof |
US5165424A (en) | 1990-08-09 | 1992-11-24 | Silverman Harvey N | Method and system for whitening teeth |
US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
US5814318A (en) | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
US5877397A (en) | 1990-08-29 | 1999-03-02 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
ES2108048T3 (es) | 1990-08-29 | 1997-12-16 | Genpharm Int | Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos. |
US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US6300129B1 (en) | 1990-08-29 | 2001-10-09 | Genpharm International | Transgenic non-human animals for producing heterologous antibodies |
US6255458B1 (en) | 1990-08-29 | 2001-07-03 | Genpharm International | High affinity human antibodies and human antibodies against digoxin |
US5789650A (en) | 1990-08-29 | 1998-08-04 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
US5874299A (en) | 1990-08-29 | 1999-02-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
US5194594A (en) | 1990-09-07 | 1993-03-16 | Techniclone, Inc. | Modified antibodies |
GB9023352D0 (en) | 1990-10-26 | 1990-12-05 | Lynxvale Ltd | Vaccinia vectors,vaccinia genes and expression products thereof |
US5173414A (en) | 1990-10-30 | 1992-12-22 | Applied Immune Sciences, Inc. | Production of recombinant adeno-associated virus vectors |
US5271941A (en) | 1990-11-02 | 1993-12-21 | Cho Chung Yoon S | Antisense oligonucleotides of human regulatory subunit RI.sub.α of cAMP-dependent protein kinases |
EP0564531B1 (en) | 1990-12-03 | 1998-03-25 | Genentech, Inc. | Enrichment method for variant proteins with altered binding properties |
SE9003978D0 (sv) | 1990-12-13 | 1990-12-13 | Henrik Garoff | Dna expressionssystem baserade paa ett virus replikon |
ES2330052T3 (es) | 1991-03-01 | 2009-12-03 | Dyax Corporation | Proteina quimerica que comprende micro-proteinas que tienen dos o mas puentes disulfuro y relaizaciones de las mismas. |
GB9105383D0 (en) | 1991-03-14 | 1991-05-01 | Immunology Ltd | An immunotherapeutic for cervical cancer |
US5683874A (en) | 1991-03-27 | 1997-11-04 | Research Corporation Technologies, Inc. | Single-stranded circular oligonucleotides capable of forming a triplex with a target sequence |
EP0580737B1 (en) | 1991-04-10 | 2004-06-16 | The Scripps Research Institute | Heterodimeric receptor libraries using phagemids |
US6028186A (en) | 1991-06-10 | 2000-02-22 | Nexstar Pharmaceuticals, Inc. | High affinity nucleic acid ligands of cytokines |
WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
AU2235992A (en) | 1991-06-14 | 1993-01-12 | Genpharm International, Inc. | Transgenic immunodeficient non-human animals |
DE4216134A1 (de) | 1991-06-20 | 1992-12-24 | Europ Lab Molekularbiolog | Synthetische katalytische oligonukleotidstrukturen |
EP0603194A4 (en) | 1991-07-05 | 1994-12-07 | Seragen Inc | TO THE RECEPTOR OF THE EPIDERMAL GROWTH FACTOR TARGETED MOLECULES FOR TREATING INFLAMMABLE ARTHRITIS. |
DE4122599C2 (de) | 1991-07-08 | 1993-11-11 | Deutsches Krebsforsch | Phagemid zum Screenen von Antikörpern |
DE69224906T2 (de) | 1991-07-08 | 1998-10-29 | Univ Massachusetts | Thermotropes flüssig-kristallines segment-blockcopolymer |
DK0605522T3 (da) | 1991-09-23 | 2000-01-17 | Medical Res Council | Fremgangsmåde til fremstilling af humaniserede antistoffer |
WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
US6063630A (en) | 1991-11-05 | 2000-05-16 | Transkaryotic Therapies, Inc. | Targeted introduction of DNA into primary or secondary cells and their use for gene therapy |
US5968502A (en) | 1991-11-05 | 1999-10-19 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
DE637965T1 (de) | 1991-11-26 | 1995-12-14 | Gilead Sciences Inc | Gesteigerte bildung von triple- und doppelhelices aus oligomeren mit modifizierten pyrimidinen. |
JPH05244982A (ja) | 1991-12-06 | 1993-09-24 | Sumitomo Chem Co Ltd | 擬人化b−b10 |
US5777085A (en) | 1991-12-20 | 1998-07-07 | Protein Design Labs, Inc. | Humanized antibodies reactive with GPIIB/IIIA |
US5652094A (en) | 1992-01-31 | 1997-07-29 | University Of Montreal | Nucleozymes |
CZ291039B6 (cs) | 1992-02-06 | 2002-12-11 | Schering Corporation | Monoklonální protilátka, hybridom, polypeptid a způsob jeho přípravy, izolovaná DNA, rekombinantní vektor, hostitelská buňka, humanizovaná protilátka a farmaceutický prostředek |
ATE208374T1 (de) | 1992-02-18 | 2001-11-15 | Otsuka Kagaku Kk | Beta-laktam und cepham verbindungen und ihre herstellung |
US5714350A (en) | 1992-03-09 | 1998-02-03 | Protein Design Labs, Inc. | Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region |
US5733743A (en) | 1992-03-24 | 1998-03-31 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
US5646020A (en) | 1992-05-14 | 1997-07-08 | Ribozyme Pharmaceuticals, Inc. | Hammerhead ribozymes for preferred targets |
US5693535A (en) | 1992-05-14 | 1997-12-02 | Ribozyme Pharmaceuticals, Inc. | HIV targeted ribozymes |
US5610054A (en) | 1992-05-14 | 1997-03-11 | Ribozyme Pharmaceuticals, Inc. | Enzymatic RNA molecule targeted against Hepatitis C virus |
US6017756A (en) | 1992-05-14 | 2000-01-25 | Ribozyme Pharmaceuticals, Inc. | Method and reagent for inhibiting hepatitis B virus replication |
US5972699A (en) | 1992-05-14 | 1999-10-26 | Ribozyme Pharmaceuticals, Inc. | Method and reagent for inhibiting herpes simplex virus replication |
US5989906A (en) | 1992-05-14 | 1999-11-23 | Ribozyme Pharmaceuticals, Inc. | Method and reagent for inhibiting P-glycoprotein (mdr-1-gene) |
EP0653488B1 (en) | 1992-07-02 | 2003-04-09 | Sankyo Company Limited | Looped, hairpin ribozyme |
US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
EP0656064B1 (en) | 1992-08-17 | 1997-03-05 | Genentech, Inc. | Bispecific immunoadhesins |
US5646042A (en) | 1992-08-26 | 1997-07-08 | Ribozyme Pharmaceuticals, Inc. | C-myb targeted ribozymes |
US5891684A (en) | 1992-10-15 | 1999-04-06 | Ribozyme Pharmaceuticals, Inc. | Base-modified enzymatic nucleic acid |
GB9223377D0 (en) | 1992-11-04 | 1992-12-23 | Medarex Inc | Humanized antibodies to fc receptors for immunoglobulin on human mononuclear phagocytes |
US5811300A (en) | 1992-12-07 | 1998-09-22 | Ribozyme Pharmaceuticals, Inc. | TNF-α ribozymes |
US5612215A (en) | 1992-12-07 | 1997-03-18 | Ribozyme Pharmaceuticals, Inc. | Stromelysin targeted ribozymes |
AU6088094A (en) | 1993-01-15 | 1994-08-15 | General Hospital Corporation, The | Rna assays using rna binary probes and ribozyme ligase |
US5593972A (en) | 1993-01-26 | 1997-01-14 | The Wistar Institute | Genetic immunization |
AU6123894A (en) | 1993-01-29 | 1994-08-15 | Board Of Trustees Of The Leland Stanford Junior University | Modulation of physiological responses of lymphocytes by cd38 or antibodies thereto |
US5786138A (en) | 1993-01-29 | 1998-07-28 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Hyperstabilizing antisense nucleic acid binding agents |
EP0804070B1 (en) | 1993-03-09 | 2000-05-24 | Genzyme Corporation | Process of isolation of proteins from milk |
JPH08508880A (ja) | 1993-04-21 | 1996-09-24 | アンスティテュ パストゥール | 生体内に治療用化合物を発現・分泌させるための生体適合移植片 |
CA2161351C (en) | 1993-04-26 | 2010-12-21 | Nils Lonberg | Transgenic non-human animals capable of producing heterologous antibodies |
AU693097B2 (en) | 1993-06-04 | 1998-06-25 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Method for treating kaposi's sarcoma with antisense oligonucleotides |
EP0714409A1 (en) | 1993-06-16 | 1996-06-05 | Celltech Therapeutics Limited | Antibodies |
US5962426A (en) | 1993-06-25 | 1999-10-05 | Yale University | Triple-helix forming oligonucleotides for targeted mutagenesis |
ATE227342T1 (de) | 1993-09-02 | 2002-11-15 | Ribozyme Pharm Inc | Enzymatische nukleiksaüre die nicht-nukleotide enthaltet |
DE69435233D1 (de) | 1993-09-15 | 2009-10-08 | Novartis Vaccines & Diagnostic | Rekombinante Alphavirus Vektoren |
US5861288A (en) | 1993-10-18 | 1999-01-19 | Ribozyme Pharmaceuticals, Inc. | Catalytic DNA |
US5616466A (en) | 1993-11-05 | 1997-04-01 | Cantor; Glenn H. | Ribozyme-mediated inhibition of bovine leukemia virus |
US5578716A (en) | 1993-12-01 | 1996-11-26 | Mcgill University | DNA methyltransferase antisense oligonucleotides |
US5827690A (en) | 1993-12-20 | 1998-10-27 | Genzyme Transgenics Corporatiion | Transgenic production of antibodies in milk |
US5712384A (en) | 1994-01-05 | 1998-01-27 | Gene Shears Pty Ltd. | Ribozymes targeting retroviral packaging sequence expression constructs and recombinant retroviruses containing such constructs |
US5641754A (en) | 1994-01-10 | 1997-06-24 | The Board Of Regents Of The University Of Nebraska | Antisense oligonucleotide compositions for selectively killing cancer cells |
US5580766A (en) | 1994-01-14 | 1996-12-03 | Alexion Pharmaceuticals, Inc. | Retroviral vector particles for transducing non-proliferating cells |
US5639647A (en) | 1994-03-29 | 1997-06-17 | Ribozyme Pharmaceuticals, Inc. | 2'-deoxy-2'alkylnucleotide containing nucleic acid |
US5631359A (en) | 1994-10-11 | 1997-05-20 | Ribozyme Pharmaceuticals, Inc. | Hairpin ribozymes |
US5869248A (en) | 1994-03-07 | 1999-02-09 | Yale University | Targeted cleavage of RNA using ribonuclease P targeting and cleavage sequences |
US6077835A (en) | 1994-03-23 | 2000-06-20 | Case Western Reserve University | Delivery of compacted nucleic acid to cells |
US5879687A (en) | 1994-04-22 | 1999-03-09 | Corixa Corporation | Methods for enhancement of protective immune responses |
US5580967A (en) | 1994-05-13 | 1996-12-03 | The Scripps Research Institute | Optimized catalytic DNA-cleaving ribozymes |
US5683902A (en) | 1994-05-13 | 1997-11-04 | Northern Illinois University | Human papilloma virus inhibition by a hairpin ribozyme |
US5595873A (en) | 1994-05-13 | 1997-01-21 | The Scripps Research Institute | T. thermophila group I introns that cleave amide bonds |
US5650316A (en) | 1994-06-06 | 1997-07-22 | Research Development Foundation | Uses of triplex forming oligonucleotides for the treatment of human diseases |
US5658785A (en) | 1994-06-06 | 1997-08-19 | Children's Hospital, Inc. | Adeno-associated virus materials and methods |
US5998193A (en) | 1994-06-24 | 1999-12-07 | Gene Shears Pty., Ltd. | Ribozymes with optimized hybridizing arms, stems, and loops, tRNA embedded ribozymes and compositions thereof |
US5633133A (en) | 1994-07-14 | 1997-05-27 | Long; David M. | Ligation with hammerhead ribozymes |
EP0775204A1 (en) | 1994-08-09 | 1997-05-28 | Novartis AG | Antitumor antisense oligonucleotides |
US5688670A (en) | 1994-09-01 | 1997-11-18 | The General Hospital Corporation | Self-modifying RNA molecules and methods of making |
EP0772678A4 (en) | 1994-09-12 | 1999-10-20 | Hope City | MODULATION OF DRUGS AND RADIATION-RESISTANT GENES |
US5599706A (en) | 1994-09-23 | 1997-02-04 | Stinchcomb; Dan T. | Ribozymes targeted to apo(a) mRNA |
US5856103A (en) | 1994-10-07 | 1999-01-05 | Board Of Regents The University Of Texas | Method for selectively ranking sequences for antisense targeting |
JPH08113591A (ja) | 1994-10-14 | 1996-05-07 | Taiho Yakuhin Kogyo Kk | オリゴヌクレオチド及びこれを有効成分とする制癌剤 |
US5807718A (en) | 1994-12-02 | 1998-09-15 | The Scripps Research Institute | Enzymatic DNA molecules |
US20020164788A1 (en) | 1994-12-02 | 2002-11-07 | The Wellcome Foundation Limited | Humanized antibodies to CD38 |
GB9424449D0 (en) * | 1994-12-02 | 1995-01-18 | Wellcome Found | Antibodies |
US5683873A (en) | 1995-01-13 | 1997-11-04 | Innovir Laboratories, Inc. | EGS-mediated inactivation of target RNA |
US5631146A (en) | 1995-01-19 | 1997-05-20 | The General Hospital Corporation | DNA aptamers and catalysts that bind adenosine or adenosine-5'-phosphates and methods for isolation thereof |
US5994320A (en) | 1995-02-06 | 1999-11-30 | Regents Of The University Of Minnesota | Antisense oligonucleotides and methods for treating central nervous system tumors |
IT1275862B1 (it) | 1995-03-03 | 1997-10-24 | Consiglio Nazionale Ricerche | Trascritto antisenso associato ad alcuni tipi di cellule tumorali ed oligodeossinucleotidi sintetici utili nella diagnosi e nel trattamento |
US5770715A (en) | 1995-03-22 | 1998-06-23 | Toagosei Co., Ltd. | Hammerhead-like nucleic acid analogues and their synthesis |
US5703057A (en) | 1995-04-07 | 1997-12-30 | Board Of Regents The University Of Texas System | Expression library immunization |
US6121022A (en) | 1995-04-14 | 2000-09-19 | Genentech, Inc. | Altered polypeptides with increased half-life |
CA2218651A1 (en) | 1995-04-21 | 1996-10-24 | Abbott Laboratories | Repertoire cloning process, products derived therefrom and uses for said products |
US6013443A (en) | 1995-05-03 | 2000-01-11 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands by exponential enrichment: tissue SELEX |
US5646031A (en) | 1995-05-16 | 1997-07-08 | Northern Illinois University | SArMV and sCYMVI hairpin ribozymes |
JP4335975B2 (ja) | 1995-06-07 | 2009-09-30 | ギリード・サイエンシズ・インコーポレーテッド | Dnaポリメラーゼに対する結合・阻害核酸リガンド |
US5910408A (en) | 1995-06-07 | 1999-06-08 | The General Hospital Corporation | Catalytic DNA having ligase activity |
US5693773A (en) | 1995-06-07 | 1997-12-02 | Hybridon Incorporated | Triplex-forming antisense oligonucleotides having abasic linkers targeting nucleic acids comprising mixed sequences of purines and pyrimidines |
US6040296A (en) | 1995-06-07 | 2000-03-21 | East Carolina University | Specific antisense oligonucleotide composition & method for treatment of disorders associated with bronchoconstriction and lung inflammation |
US5877021A (en) | 1995-07-07 | 1999-03-02 | Ribozyme Pharmaceuticals, Inc. | B7-1 targeted ribozymes |
AU6691496A (en) | 1995-08-01 | 1997-02-26 | Advanced Therapies, Inc. | Enhanced artificial viral envelopes for cellular delivery of therapeutic substances |
NO953680D0 (no) | 1995-09-18 | 1995-09-18 | Hans Prydz | Cellesyklusenzymer |
AU7286696A (en) | 1995-10-13 | 1997-05-07 | F. Hoffmann-La Roche Ag | Antisense oligomers |
KR970029803A (ko) | 1995-11-03 | 1997-06-26 | 김광호 | 반도체 메모리장치의 프리차지 회로 |
ATE213019T1 (de) | 1995-11-14 | 2002-02-15 | Vimrx Holdings Ltd | Chimäre oligomere mit einer rns- spaltungsaktivität |
SK66098A3 (en) | 1995-11-21 | 1998-11-04 | Icn Pharmaceuticals | Inhibition of tumor growth by antisense oligonucleotides for il-8 and il-8 receptor |
US5998203A (en) | 1996-04-16 | 1999-12-07 | Ribozyme Pharmaceuticals, Inc. | Enzymatic nucleic acids containing 5'-and/or 3'-cap structures |
US5998602A (en) | 1996-02-15 | 1999-12-07 | The Cleveland Clinic Fouindation And Government | RNase L activators and antisense oligonucleotides effective to treat RSV infections |
US5877162A (en) | 1996-03-14 | 1999-03-02 | Innovir Laboratories, Inc. | Short external guide sequences |
WO1997041898A1 (en) | 1996-05-03 | 1997-11-13 | Immunomedics, Inc. | Targeted combination immunotherapy of cancer |
US6261552B1 (en) | 1997-05-22 | 2001-07-17 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Herpes simplex virus vectors |
US5792613A (en) | 1996-06-12 | 1998-08-11 | The Curators Of The University Of Missouri | Method for obtaining RNA aptamers based on shape selection |
US5955590A (en) | 1996-07-15 | 1999-09-21 | Worcester Foundation For Biomedical Research | Conjugates of minor groove DNA binders with antisense oligonucleotides |
AU4556597A (en) | 1996-09-24 | 1998-04-17 | Bavarian Nordic Research Institute A/S | Recombinant mva virus expressing dengue virus antigens, and the use thereof in vaccines |
JP4233608B2 (ja) | 1996-10-15 | 2009-03-04 | 塩野義製薬株式会社 | 自己抗体測定方法 |
AU729515B2 (en) | 1996-10-17 | 2001-02-01 | Immunomedics Inc. | Non-antigenic toxin-conjugate and fusion protein of internalizing receptor system |
US5874566A (en) | 1996-10-25 | 1999-02-23 | Hisamitsu Pharmaceutical Co. Inc. | Il-15 triplex oligonucleotides |
US6051698A (en) | 1997-06-06 | 2000-04-18 | Janjic; Nebojsa | Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes |
EP0968284B1 (en) | 1996-11-20 | 2006-12-13 | Introgen Therapeutics, Inc. | An improved method for the production and purification of adenoviral vectors |
US7732129B1 (en) | 1998-12-01 | 2010-06-08 | Crucell Holland B.V. | Method for the production and purification of adenoviral vectors |
WO2000006194A2 (en) | 1997-02-05 | 2000-02-10 | Biotransplant, Inc. | Depletion of cells responsible for antibody-mediated graft rejection |
US6046004A (en) | 1997-02-27 | 2000-04-04 | Lorne Park Research, Inc. | Solution hybridization of nucleic acids with antisense probes having modified backbones |
US6277375B1 (en) | 1997-03-03 | 2001-08-21 | Board Of Regents, The University Of Texas System | Immunoglobulin-like domains with increased half-lives |
JP3835827B2 (ja) | 1997-05-02 | 2006-10-18 | ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ,アズ リプレゼンティッド バイ ザ セクレタリーオブ ザ デパートメント オブ ヘルス アンド ヒューマン サービシーズ | 悪性細胞に対する、oncタンパク質を含む、免疫毒素 |
EP1724282B1 (en) | 1997-05-21 | 2013-05-15 | Merck Patent GmbH | Method for the production of non-immunogenic proteins |
AU8067698A (en) | 1997-06-09 | 1998-12-30 | Genvec, Inc. | Chimeric vectors comprising a phage packaging site and a portion derived from a genome of a eukaryotic virus |
US6171586B1 (en) * | 1997-06-13 | 2001-01-09 | Genentech, Inc. | Antibody formulation |
JP2002510207A (ja) | 1997-06-19 | 2002-04-02 | リボザイム・ファーマシューティカルズ・インコーポレーテッド | 拡張された開裂ルールを有するハンマーヘッドリボザイム |
US6300483B1 (en) | 1997-06-19 | 2001-10-09 | Ribozyme Pharmaceuticals, Inc. | Compositions inducing cleavage of RNA motifs |
JPH1142091A (ja) | 1997-07-25 | 1999-02-16 | Toagosei Co Ltd | アンチセンス核酸化合物 |
DE69831417T2 (de) | 1997-09-23 | 2006-06-22 | Genvec, Inc. | Duale selektionkassette und sie enthaltende plasmide |
US6046319A (en) | 1997-10-22 | 2000-04-04 | University Technologies International, Inc. | Antisense oligodeoxynucleotides regulating expression of TNF-α |
WO1999021979A1 (en) | 1997-10-28 | 1999-05-06 | Maxygen, Inc. | Human papillomavirus vectors |
US5994136A (en) | 1997-12-12 | 1999-11-30 | Cell Genesys, Inc. | Method and means for producing high titer, safe, recombinant lentivirus vectors |
US6506559B1 (en) | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
US6719977B1 (en) | 1998-02-12 | 2004-04-13 | The General Hospital Corporation | Methods to potentiate cancer therapies |
US5922576A (en) | 1998-02-27 | 1999-07-13 | The John Hopkins University | Simplified system for generating recombinant adenoviruses |
JP2002509716A (ja) | 1998-03-31 | 2002-04-02 | ユニバーシティ テクノロジー コーポレイション | テロメラーゼ抗原に対する免疫応答を惹起するための方法および組成物 |
US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
PT1071700E (pt) | 1998-04-20 | 2010-04-23 | Glycart Biotechnology Ag | Modificação por glicosilação de anticorpos para melhorar a citotoxicidade celular dependente de anticorpos |
MXPA00010338A (es) | 1998-04-22 | 2005-06-17 | Genvec Inc | Purificacion eficiente de adenovirus. |
AU770718B2 (en) * | 1998-06-05 | 2004-02-26 | Mayo Foundation For Medical Education And Research | Use of genetically engineered antibodies to CD38 to treat multiple myeloma |
US6007995A (en) | 1998-06-26 | 1999-12-28 | Isis Pharmaceuticals Inc. | Antisense inhibition of TNFR1 expression |
MY136203A (en) * | 1998-08-11 | 2008-08-29 | Idec Pharma Corp | Combination therapies for b-cell lymphomas comprising administration of anti-cd20 antibody |
US5965358A (en) | 1998-08-26 | 1999-10-12 | Genvec, Inc. | Method for assessing the relative purity of viral gene transfer vector stocks |
US6875741B2 (en) | 1998-09-02 | 2005-04-05 | Renuka Pillutla | Insulin and IGF-1 receptor agonists and antagonists |
NZ510488A (en) | 1998-09-04 | 2003-07-25 | Aventis Pasteur | Immunotherapy for HPV DNA-positive cervical cancers with DNA constructs for the administration of HPV antigens to provide an immune response in a host |
US6387888B1 (en) | 1998-09-30 | 2002-05-14 | American Foundation For Biological Research, Inc. | Immunotherapy of cancer through expression of truncated tumor or tumor-associated antigen |
AU2220800A (en) | 1998-12-31 | 2000-07-31 | Chiron Corporation | Compositions and methods for packaging of alphavirus vectors |
US7223397B1 (en) * | 1999-01-07 | 2007-05-29 | Research Development Foundation | Potentiation of anti-CD38-Immunotoxin cytotoxicity |
ES2694002T3 (es) | 1999-01-15 | 2018-12-17 | Genentech, Inc. | Polipéptido que comprende una región Fc de IgG1 humana variante |
US6355271B1 (en) | 1999-02-03 | 2002-03-12 | Biosante Pharmaceuticals, Inc. | Therapeutic calcium phosphate particles and methods of manufacture and use |
US6013522A (en) | 1999-02-23 | 2000-01-11 | Isis Pharmaceuticals Inc. | Antisense inhibition of human Smad1 expression |
PT1914244E (pt) | 1999-04-09 | 2013-07-26 | Kyowa Hakko Kirin Co Ltd | Processo para regular a actividade de moléculas funcionais sob o ponto de vista imunológico |
US20050037969A1 (en) | 1999-05-14 | 2005-02-17 | Arbor Vita Corporation | Molecular interactions in hematopoietic cells |
US6281005B1 (en) | 1999-05-14 | 2001-08-28 | Copernicus Therapeutics, Inc. | Automated nucleic acid compaction device |
US6025198A (en) | 1999-06-25 | 2000-02-15 | Isis Pharmaceuticals Inc. | Antisense modulation of Ship-2 expression |
US6033910A (en) | 1999-07-19 | 2000-03-07 | Isis Pharmaceuticals Inc. | Antisense inhibition of MAP kinase kinase 6 expression |
NZ517372A (en) | 1999-07-29 | 2004-04-30 | Medarex Inc | Human monoclonal antibodies to HER2/neu |
EP1212422B1 (en) | 1999-08-24 | 2007-02-21 | Medarex, Inc. | Human ctla-4 antibodies and their uses |
AU2001245793A1 (en) | 2000-03-16 | 2001-09-24 | Cold Spring Harbor Laboratory | Methods and compositions for rna interference |
WO2001081609A2 (en) | 2000-03-22 | 2001-11-01 | Chiron Corporation | Compositions and methods for generating an immune response utilizing alphavirus-based vector systems |
IL151928A0 (en) | 2000-03-30 | 2003-04-10 | Whitehead Biomedical Inst | Rna sequence-specific mediators of rna interference |
US6168941B1 (en) | 2000-04-07 | 2001-01-02 | Genvec, Inc. | Method of producing adenoviral vector stocks |
CA2407050A1 (en) | 2000-04-25 | 2001-11-01 | Chiron Corporation | Alphavirus-based vectors for persistent infection |
EP1174440A1 (en) | 2000-07-19 | 2002-01-23 | U-BISys B.V. | A selectively-expressed epitope on the human CD38 molecule detected by a phage display library-derived human scFv antibody fragment |
JP4139214B2 (ja) | 2000-10-17 | 2008-08-27 | トリュデュ インスティチュート,インク. | Cd38により調節される走化性 |
US20070042436A1 (en) | 2000-10-17 | 2007-02-22 | Lund Frances E | CD38 modulated chemotaxis |
CN1205479C (zh) * | 2000-10-31 | 2005-06-08 | 杨梦甦 | 免疫学诊断蛋白芯片制备方法 |
US20020132788A1 (en) | 2000-11-06 | 2002-09-19 | David Lewis | Inhibition of gene expression by delivery of small interfering RNA to post-embryonic animal cells in vivo |
WO2002042468A2 (en) | 2000-11-27 | 2002-05-30 | Geron Corporation | Glycosyltransferase vectors for treating cancer |
ATE378403T1 (de) | 2000-11-30 | 2007-11-15 | Medarex Inc | Transchromosomale transgen-nagetiere zur herstellung von humänen antikörpern |
US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
CN100497389C (zh) | 2001-06-13 | 2009-06-10 | 根马布股份公司 | 表皮生长因子受体(egfr)的人单克隆抗体 |
US20040166490A1 (en) * | 2002-12-17 | 2004-08-26 | Morris David W. | Novel therapeutic targets in cancer |
EP1575976A4 (en) | 2001-11-02 | 2006-08-23 | Insert Therapeutics Inc | METHODS AND COMPOSITIONS FOR THE THERAPEUTIC USE OF RNA INTERFERENCE |
US20040063654A1 (en) | 2001-11-02 | 2004-04-01 | Davis Mark E. | Methods and compositions for therapeutic use of RNA interference |
AR039067A1 (es) * | 2001-11-09 | 2005-02-09 | Pfizer Prod Inc | Anticuerpos para cd40 |
WO2003044168A2 (en) | 2001-11-16 | 2003-05-30 | University Of Massachusetts | Facilitation of rna interference |
US20030167490A1 (en) | 2001-11-26 | 2003-09-04 | Hunter Craig P. | Gene silencing by systemic RNA interference |
AU2002359464A1 (en) | 2001-11-30 | 2003-06-17 | Genvec, Inc. | Angiopioetin related factors |
US20040009498A1 (en) | 2002-01-14 | 2004-01-15 | Diversa Corporation | Chimeric antigen binding molecules and methods for making and using them |
WO2003080672A1 (en) | 2002-03-22 | 2003-10-02 | Aprogen, Inc. | Humanized antibody and process for preparing same |
US20040019915A1 (en) * | 2002-04-01 | 2004-01-29 | Challita-Eid Pia M. | Nucleic acid and corresponding protein entitled 213P1F11 useful in treatment and detection of cancer |
US20040009946A1 (en) | 2002-05-23 | 2004-01-15 | Ceptyr, Inc. | Modulation of PTP1B expression and signal transduction by RNA interference |
EP1537227B1 (en) | 2002-05-31 | 2010-02-17 | The Regents Of The University Of California | Method for efficient rna interference in mammalian cells |
AU2003276666A1 (en) | 2002-06-12 | 2003-12-31 | Ambion, Inc. | Methods and compositions relating to polypeptides with rnase iii domains that mediate rna interference |
EP1393720A1 (en) | 2002-08-27 | 2004-03-03 | Universiteit Utrecht | Vesicle-encapsulated corticosteroids for treatment of cancer |
EP2330130B1 (en) * | 2002-10-17 | 2014-08-27 | Genmab A/S | Human monoclonal antibodies against CD20 |
MXPA05005160A (es) * | 2002-11-15 | 2005-07-22 | Genmab As | Anticuerpos monoclonales humanos contra la cd25. |
DK1613350T3 (da) * | 2003-04-09 | 2009-06-22 | Genentech Inc | Behandling af autoimmun sygdom hos en patient med et utilstrækkeligt respons på en TNF-alfa-inhibitor |
EP1648512A4 (en) * | 2003-07-31 | 2009-01-21 | Immunomedics Inc | ANTI-CD19 ANTIBODIES |
WO2005042019A1 (en) | 2003-10-22 | 2005-05-12 | University Of Rochester | Anti-thymocyte antiserum and use thereof to trigger b cell apoptosis |
ES2346978T3 (es) * | 2003-11-04 | 2010-10-22 | Novartis Vaccines And Diagnostics, Inc. | Uso de anticuerpos monoclonantes anti-cd40 antagonistas para el tratamiento del mieloma multiple. |
AU2005235811B2 (en) * | 2004-02-06 | 2011-11-03 | Morphosys Ag | Anti-CD38 human antibodies and uses therefor |
EP1720907B1 (en) | 2004-02-06 | 2015-04-08 | MorphoSys AG | Anti-cd38 human antibodies and uses therefor |
US20050266008A1 (en) | 2004-03-29 | 2005-12-01 | Medarex, Inc. | Human anti-IRTA-5 antibodies |
US20060019303A1 (en) | 2004-07-23 | 2006-01-26 | Boehringer Ingelheim Pharmaceuticals, Inc. | Method to identify and analyze genes having modified expression in stimulated T cells |
SG10201912554TA (en) * | 2005-03-23 | 2020-02-27 | Genmab As | Antibodies against cd38 for treatment of multiple myeloma |
EP1888647A2 (en) | 2005-05-24 | 2008-02-20 | MorphoSys AG | Generation and profiling of fully human hucal gold®-derived therapeutic antibodies specific for human cd38 |
SI2081595T1 (sl) * | 2006-09-26 | 2019-10-30 | Genmab As | Anti-cd38 plus kortikosteroidi plus ne-kortikosteroidni kemoterapevtik za zdravljenje tumorjev |
US20090076249A1 (en) * | 2007-09-19 | 2009-03-19 | Michel De Weers | Antibodies against CD38 for treatment of multiple myeloma |
WO2016040294A2 (en) * | 2014-09-09 | 2016-03-17 | Janssen Biotech, Inc. | Combination therapies with anti-cd38 antibodies |
SG11201704390PA (en) * | 2014-12-04 | 2017-06-29 | Janssen Biotech Inc | Anti-cd38 antibodies for treatment of acute myeloid leukemia |
CA2990406A1 (en) * | 2015-06-22 | 2016-12-29 | Janssen Biotech, Inc. | Combination therapies for heme malignancies with anti-cd38 antibodies and survivin inhibitors |
US20160376373A1 (en) * | 2015-06-24 | 2016-12-29 | Janssen Biotech, Inc. | Immune Modulation and Treatment of Solid Tumors with Antibodies that Specifically Bind CD38 |
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