HRP20080668T3 - Matrix metalloproteinase inhibitors - Google Patents

Matrix metalloproteinase inhibitors

Info

Publication number: HRP20080668T3
Authority: HR; Croatia
Prior art keywords: alkyl; alkylaryl; cor; optionally substituted; bond
Prior art date: 2003-09-13

Application number

HR20080668T

Other languages

English (en)

Croatian (hr)

Inventor

Gaines Simon

Peter Holmes Ian

Lewis Martin Stephen

Paul Watson Stephen

Original Assignee

Glaxo Group Limited

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-09-13

Filing date

2008-12-19

Publication date

2009-02-28

2008-12-19 Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited

2009-02-28 Publication of HRP20080668T3 publication Critical patent/HRP20080668T3/xx

Links

239000003771 matrix metalloproteinase inhibitor Substances 0.000 title 1
229940121386 matrix metalloproteinase inhibitor Drugs 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 11
125000002877 alkyl aryl group Chemical group 0.000 abstract 8
125000000623 heterocyclic group Chemical group 0.000 abstract 4
125000001475 halogen functional group Chemical group 0.000 abstract 3
125000001072 heteroaryl group Chemical group 0.000 abstract 3
229910052760 oxygen Inorganic materials 0.000 abstract 3
229910052717 sulfur Inorganic materials 0.000 abstract 3
125000005213 alkyl heteroaryl group Chemical group 0.000 abstract 2
125000004093 cyano group Chemical group *C#N 0.000 abstract 2
125000003107 substituted aryl group Chemical group 0.000 abstract 2
102000004190 Enzymes Human genes 0.000 abstract 1
108090000790 Enzymes Proteins 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
239000011159 matrix material Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000006168 tricyclic group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/4035—Isoindoles, e.g. phthalimide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Immunology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Transplantation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)
Macromonomer-Based Addition Polymer (AREA)
Anti-Oxidant Or Stabilizer Compositions (AREA)
Soft Magnetic Materials (AREA)
Lubricants (AREA)
Adhesives Or Adhesive Processes (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

HR20080668T 2003-09-13 2008-12-19 Matrix metalloproteinase inhibitors HRP20080668T3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0321538.1A GB0321538D0 (en)	2003-09-13	2003-09-13	Therapeutically useful compounds
PCT/EP2004/010319 WO2005026120A1 (en)	2003-09-13	2004-09-10	Matrix metalloproteinase inhibitors

Publications (1)

Publication Number	Publication Date
HRP20080668T3 true HRP20080668T3 (en)	2009-02-28

Family

ID=29227079

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20080668T HRP20080668T3 (en)	2003-09-13	2008-12-19	Matrix metalloproteinase inhibitors

Country Status (29)

Country	Link
US (3)	US7601729B2 (zh)
EP (3)	EP2042488B1 (zh)
JP (3)	JP2007505081A (zh)
KR (3)	KR20130079628A (zh)
CN (1)	CN1849306B (zh)
AT (2)	ATE413384T1 (zh)
AU (1)	AU2004272280C1 (zh)
BR (1)	BRPI0413791A (zh)
CA (1)	CA2538315C (zh)
CY (1)	CY1109400T1 (zh)
DE (2)	DE602004017622D1 (zh)
DK (1)	DK1663970T3 (zh)
ES (2)	ES2314436T3 (zh)
GB (1)	GB0321538D0 (zh)
HK (1)	HK1092141A1 (zh)
HR (1)	HRP20080668T3 (zh)
IL (1)	IL173305A (zh)
IS (2)	IS2622B (zh)
MA (1)	MA28039A1 (zh)
MX (1)	MXPA06002458A (zh)
NO (1)	NO20060540L (zh)
NZ (2)	NZ573479A (zh)
PL (1)	PL1663970T3 (zh)
PT (1)	PT1663970E (zh)
RU (2)	RU2370488C2 (zh)
SG (1)	SG145685A1 (zh)
SI (1)	SI1663970T1 (zh)
WO (1)	WO2005026120A1 (zh)
ZA (1)	ZA200602070B (zh)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0321538D0 (en) *	2003-09-13	2003-10-15	Glaxo Group Ltd	Therapeutically useful compounds
PL1856063T3 (pl) *	2005-02-22	2012-07-31	Sun Pharmaceutical Ind Ltd	Pochodne kwasu 5-fenylopentantowego jako inhibitory metaloproteinazy macierzy do leczenia astmy i innych chorób
EP2474531A3 (en)	2006-08-22	2013-12-04	Ranbaxy Laboratories Limited	Matrix metalloproteinase inhibitors
AU2013200728B2 (en) *	2006-08-22	2014-12-18	Sun Pharmaceutical Industries Limited	Matrix metalloproteinase inhibitors
CN103450077B (zh)	2007-06-08	2016-07-06	满康德股份有限公司	IRE-1α抑制剂
FR2949463B1 (fr) *	2009-08-26	2011-09-16	Commissariat Energie Atomique	Inhibiteurs de mmp
WO2012014114A1 (en)	2010-07-30	2012-02-02	Ranbaxy Laboratories Limited	Matrix metalloproteinase inhibitors
KR20130140688A (ko)	2010-09-24	2013-12-24	랜박시 래보러터리스 리미티드	기질 메탈로프로테나제 저해제
EP2926808A1 (en)	2012-11-28	2015-10-07	Administración General De La Communidad Autónoma De Euskadi	Use of metalloprotease inhibitors for the treatment of polycystic liver diseases
TWI773118B (zh)	2016-02-12	2022-08-01	美商細胞動力學股份有限公司	四氫異喹啉衍生物
CN110769866B (zh) *	2017-06-13	2022-07-29	爱惜康有限责任公司	具有可控愈合的外科缝合器

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DE4102024A1 (de) *	1991-01-24	1992-07-30	Thomae Gmbh Dr K	Biphenylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
WO1995029901A1 (en) *	1994-04-28	1995-11-09	Uniroyal Chemical Company, Inc.	Fungicidal azole derivatives
US5977105A (en) *	1995-12-06	1999-11-02	Astra Pharmaeuticals Ltd.	Compounds
EP0898566B1 (en)	1996-04-19	2002-11-06	Akzo Nobel N.V.	Substituted benzylamines and their use for the treatment of depression
ZA974032B (en) *	1996-05-15	1998-02-19	Bayer Ag	Substituted oxobutyric acids as matrix metalloproteinases inhibitors.
US6870058B2 (en) *	1996-12-03	2005-03-22	The Trustees Of The University Of Pennsylvania	Compounds which mimic the chemical and biological properties of discodermolide
US6242616B1 (en) *	1996-12-03	2001-06-05	The Trustees Of The University Of Pennsylvania	Synthetic techniques and intermediates for polyhydroxy, dienyl lactone derivatives
US5789605A (en) *	1996-12-03	1998-08-04	Trustees Of The University Of Pennsylvania	Synthetic techniques and intermediates for polyhydroxy, dienyl lactones and mimics thereof
US20050065353A1 (en) *	1996-12-03	2005-03-24	Smith Amos B.	Synthetic techniques and intermediates for polyhydroxy dienyl lactones and mimics thereof
US6096904A (en) *	1996-12-03	2000-08-01	The Trustees Of The University Of Pennsylvania	Synthetic techniques and intermediates for polyhydroxy, dienyl lactone derivatives
US5804581A (en) *	1997-05-15	1998-09-08	Bayer Corporation	Inhibition of matrix metalloproteases by substituted phenalkyl compounds
US6608052B2 (en) *	2000-02-16	2003-08-19	Boehringer Ingelheim Pharmaceuticals, Inc.	Compounds useful as anti-inflammatory agents
EP1381594A1 (en) *	2001-04-13	2004-01-21	Boehringer Ingelheim Pharmaceuticals Inc.	Urea compounds useful as anti-inflammatory agents
AU2003261319A1 (en) *	2002-08-01	2004-02-23	Bristol-Myers Squibb Company	Hydantoin derivatives as inhibitors of matrix metalloproteinases and/or tnf-alpha converting enzyme
AU2003290120A1 (en) *	2002-11-19	2004-06-15	Galderma Research & Development, S.N.C.	Biaromatic compounds which activate PPAR-Gama type receptors, and use thereof in cosmetic or pharmaceutical compositions
GB0312654D0 (en) *	2003-06-03	2003-07-09	Glaxo Group Ltd	Therapeutically useful compounds
GB0314488D0 (en) *	2003-06-20	2003-07-23	Glaxo Group Ltd	Therapeutically useful compounds
GB0319069D0 (en) *	2003-08-14	2003-09-17	Glaxo Group Ltd	Therapeutically useful compounds
GB0321538D0 (en)	2003-09-13	2003-10-15	Glaxo Group Ltd	Therapeutically useful compounds
PL1856063T3 (pl) *	2005-02-22	2012-07-31	Sun Pharmaceutical Ind Ltd	Pochodne kwasu 5-fenylopentantowego jako inhibitory metaloproteinazy macierzy do leczenia astmy i innych chorób
EP2474531A3 (en) *	2006-08-22	2013-12-04	Ranbaxy Laboratories Limited	Matrix metalloproteinase inhibitors

2003
- 2003-09-13 GB GBGB0321538.1A patent/GB0321538D0/en not_active Ceased
2004
- 2004-09-10 RU RU2006106850/04A patent/RU2370488C2/ru not_active IP Right Cessation
- 2004-09-10 SG SG200805432-2A patent/SG145685A1/en unknown
- 2004-09-10 NZ NZ573479A patent/NZ573479A/en not_active IP Right Cessation
- 2004-09-10 PL PL04765231T patent/PL1663970T3/pl unknown
- 2004-09-10 AT AT04765231T patent/ATE413384T1/de active
- 2004-09-10 CN CN200480026229.7A patent/CN1849306B/zh not_active Expired - Fee Related
- 2004-09-10 ES ES04765231T patent/ES2314436T3/es active Active
- 2004-09-10 CA CA2538315A patent/CA2538315C/en not_active Expired - Fee Related
- 2004-09-10 EP EP08163972A patent/EP2042488B1/en active Active
- 2004-09-10 DE DE602004017622T patent/DE602004017622D1/de active Active
- 2004-09-10 PT PT04765231T patent/PT1663970E/pt unknown
- 2004-09-10 DE DE602004031991T patent/DE602004031991D1/de active Active
- 2004-09-10 WO PCT/EP2004/010319 patent/WO2005026120A1/en active Application Filing
- 2004-09-10 JP JP2006525794A patent/JP2007505081A/ja active Pending
- 2004-09-10 ES ES08163972T patent/ES2362954T3/es active Active
- 2004-09-10 AT AT08163972T patent/ATE502922T1/de not_active IP Right Cessation
- 2004-09-10 US US10/571,443 patent/US7601729B2/en not_active Expired - Fee Related
- 2004-09-10 SI SI200431008T patent/SI1663970T1/sl unknown
- 2004-09-10 KR KR1020137014317A patent/KR20130079628A/ko not_active Application Discontinuation
- 2004-09-10 KR KR1020067005114A patent/KR20060120648A/ko active Search and Examination
- 2004-09-10 EP EP10176905A patent/EP2295408A1/en not_active Withdrawn
- 2004-09-10 MX MXPA06002458A patent/MXPA06002458A/es active IP Right Grant
- 2004-09-10 EP EP04765231A patent/EP1663970B1/en active Active
- 2004-09-10 BR BRPI0413791-4A patent/BRPI0413791A/pt not_active IP Right Cessation
- 2004-09-10 NZ NZ545211A patent/NZ545211A/en not_active IP Right Cessation
- 2004-09-10 DK DK04765231T patent/DK1663970T3/da active
- 2004-09-10 AU AU2004272280A patent/AU2004272280C1/en not_active Ceased
- 2004-09-10 KR KR1020127000264A patent/KR20120007566A/ko not_active Application Discontinuation
2006
- 2006-01-23 IL IL173305A patent/IL173305A/en not_active IP Right Cessation
- 2006-01-26 IS IS8268A patent/IS2622B/is unknown
- 2006-02-02 NO NO20060540A patent/NO20060540L/no not_active Application Discontinuation
- 2006-03-10 ZA ZA200602070A patent/ZA200602070B/en unknown
- 2006-03-14 MA MA28873A patent/MA28039A1/fr unknown
- 2006-11-15 HK HK06112572.5A patent/HK1092141A1/xx not_active IP Right Cessation
2008
- 2008-11-07 US US12/266,767 patent/US8263602B2/en not_active Expired - Fee Related
- 2008-11-26 RU RU2008146479/04A patent/RU2008146479A/ru not_active Application Discontinuation
- 2008-12-19 HR HR20080668T patent/HRP20080668T3/xx unknown
2009
- 2009-01-27 CY CY20091100090T patent/CY1109400T1/el unknown
- 2009-08-19 IS IS8843A patent/IS8843A/is unknown
- 2009-09-01 US US12/551,892 patent/US8343986B2/en not_active Expired - Fee Related
2011
- 2011-06-14 JP JP2011132261A patent/JP2011231118A/ja not_active Withdrawn
2012
- 2012-01-25 JP JP2012012663A patent/JP2012107031A/ja active Pending

Also Published As

Publication number	Publication date
GB0321538D0 (en)	2003-10-15
WO2005026120A1 (en)	2005-03-24
ZA200602070B (en)	2007-05-30
AU2004272280A1 (en)	2005-03-24
EP2042488A1 (en)	2009-04-01
MXPA06002458A (es)	2006-06-20
NO20060540L (no)	2006-04-04
JP2011231118A (ja)	2011-11-17
ATE413384T1 (de)	2008-11-15
SI1663970T1 (sl)	2009-04-30
RU2008146479A (ru)	2010-06-20
EP1663970B1 (en)	2008-11-05
ES2314436T3 (es)	2009-03-16
EP1663970A1 (en)	2006-06-07
HK1092141A1 (en)	2007-02-02
KR20130079628A (ko)	2013-07-10
RU2370488C2 (ru)	2009-10-20
EP2295408A1 (en)	2011-03-16
JP2007505081A (ja)	2007-03-08
IL173305A (en)	2011-01-31
PT1663970E (pt)	2009-01-09
IS8843A (is)	2009-08-19
DE602004017622D1 (de)	2008-12-18
ATE502922T1 (de)	2011-04-15
CY1109400T1 (el)	2014-07-02
EP2042488B1 (en)	2011-03-23
ES2362954T3 (es)	2011-07-15
JP2012107031A (ja)	2012-06-07
SG145685A1 (en)	2008-09-29
AU2004272280C1 (en)	2011-10-27
US8263602B2 (en)	2012-09-11
RU2006106850A (ru)	2007-10-20
NZ573479A (en)	2010-09-30
DE602004031991D1 (de)	2011-05-05
PL1663970T3 (pl)	2009-04-30
AU2004272280B2 (en)	2011-04-21
IS8268A (is)	2006-01-26
US20100029699A1 (en)	2010-02-04
US20090082377A1 (en)	2009-03-26
US8343986B2 (en)	2013-01-01
BRPI0413791A (pt)	2006-11-07
MA28039A1 (fr)	2006-07-03
DK1663970T3 (da)	2009-01-12
US20060293353A1 (en)	2006-12-28
CN1849306B (zh)	2014-01-29
US7601729B2 (en)	2009-10-13
NZ545211A (en)	2009-01-31
KR20060120648A (ko)	2006-11-27
CA2538315C (en)	2014-04-08
IS2622B (is)	2010-05-15
IL173305A0 (en)	2006-06-11
CN1849306A (zh)	2006-10-18
KR20120007566A (ko)	2012-01-20
CA2538315A1 (en)	2005-03-24

Publication	Publication Date	Title
HRP20080668T3 (en)	2009-02-28	Matrix metalloproteinase inhibitors
ATE362910T1 (de)	2007-06-15	Matrix metalloprotease inhibitoren
IL154893A0 (en)	2003-10-31	Aliphatic nitrogen-containing cyclic compounds, methods for the preparation thereof and pharmaceutical compositions containing the same
HUP0201475A2 (hu)	2003-10-28	Heteroarilamidin-, metilamidin- és guanidinszármazékok, előállításuk és alkalmazásuk, valamint e vegyületeket tartalmazó gyógyászati készítmények
EA200300044A1 (ru)	2003-06-26	Новые замещенные фталиды, способ их получения и содержащие их фармацевтические композиции
DE3883140D1 (de)	1993-09-16	Imidazo(2,1-b)benzothiazole und ihre saeureadditionssalze, verfahren und zwischenprodukte zu ihrer herstellung, ihre verwendung als arzneimittel und diese enthaltende pharmazeutische zubereitungen.
YU74201A (sh)	2004-05-12	Nova sinteza prstena piperazina
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