YU74201A - Nova sinteza prstena piperazina - Google Patents
Nova sinteza prstena piperazinaInfo
- Publication number
- YU74201A YU74201A YU74201A YUP74201A YU74201A YU 74201 A YU74201 A YU 74201A YU 74201 A YU74201 A YU 74201A YU P74201 A YUP74201 A YU P74201A YU 74201 A YU74201 A YU 74201A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- piperazine ring
- arylalkoxy
- aryloxy
- alkoxy
- aryl
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 125000004193 piperazinyl group Chemical group 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000002102 aryl alkyloxo group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000004104 aryloxy group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 230000001430 anti-depressive effect Effects 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- -1 formyl amine Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- RONZAEMNMFQXRA-UHFFFAOYSA-N mirtazapine Chemical compound C1C2=CC=CN=C2N2CCN(C)CC2C2=CC=CC=C21 RONZAEMNMFQXRA-UHFFFAOYSA-N 0.000 abstract 1
- 229960001785 mirtazapine Drugs 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Opisan je novi postupak za pripremanje jedinjenja formule (I) naznačenog time što R1 označava supstituisani ili nesupstituisani alkil, alkoksi, aril, ariloksi ili arilalkoksi, R2 označava supstituisani ili nesupstituisani alkil, alkoksi, aril, ariloksi, arilalkoksi, tozil, formil, acetil ili amin, a R3 označava supstituisani ili nesupstituisani alkil, alkoksi, aril, ariloksi ili arilalkoksi. Ova jedinjenja su korisna u sintezi antidepresiva mirtazapina i drugih tetracikličnih jedinjenja.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13004899P | 1999-04-19 | 1999-04-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
YU74201A true YU74201A (sh) | 2004-05-12 |
Family
ID=22442818
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU74201A YU74201A (sh) | 1999-04-19 | 2000-04-07 | Nova sinteza prstena piperazina |
Country Status (19)
Country | Link |
---|---|
US (2) | US6339156B1 (sh) |
EP (1) | EP1178972A4 (sh) |
JP (1) | JP2002542234A (sh) |
KR (1) | KR20020015313A (sh) |
CN (1) | CN1355793A (sh) |
AU (1) | AU777105B2 (sh) |
CA (1) | CA2370389A1 (sh) |
CZ (1) | CZ20013698A3 (sh) |
HK (1) | HK1042696A1 (sh) |
HR (1) | HRP20010759A2 (sh) |
HU (1) | HUP0200808A3 (sh) |
IL (1) | IL146024A0 (sh) |
PL (1) | PL351395A1 (sh) |
RU (1) | RU2001128228A (sh) |
SK (1) | SK14802001A3 (sh) |
TR (1) | TR200103035T2 (sh) |
WO (1) | WO2000063185A1 (sh) |
YU (1) | YU74201A (sh) |
ZA (1) | ZA200108480B (sh) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2001128228A (ru) * | 1999-04-19 | 2003-07-20 | Тева Фармасьютикал Индастриз Лтд. (Il) | Новый синтез пиперазинового кольца |
WO2001025185A1 (fr) | 1999-09-30 | 2001-04-12 | Sumika Fine Chemicals Co., Ltd. | Procede de production de derive de piperazine |
WO2001042239A1 (fr) * | 1999-12-13 | 2001-06-14 | Sumika Fine Chemicals Co., Ltd. | Procede de preparation d'un compose pyridinemethanol |
ATE392410T1 (de) * | 2001-09-14 | 2008-05-15 | Medichem Sa | Zwischenprodukte für die herstellung von mirtazapin und verfahren zu deren herstellung |
US7041826B2 (en) * | 2003-06-02 | 2006-05-09 | Aurobindo Pharma Ltd. | Process for preparing 1-methyl-3-phenylpiperazine using a novel intermediate |
CN102126978A (zh) * | 2005-09-26 | 2011-07-20 | 住友化学株式会社 | 光学活性的哌嗪化合物的制造方法 |
CN101440067B (zh) * | 2007-11-21 | 2010-08-25 | 上海津力化工有限公司 | 一种药物中间体1-甲基-3-苯基哌嗪的制备方法 |
CN102649779A (zh) * | 2012-04-20 | 2012-08-29 | 山东鲁药制药有限公司 | 一种药物中间体1-甲基-3-苯基哌嗪的合成方法 |
DK3261645T3 (da) | 2015-02-27 | 2021-06-07 | Dechra Ltd | Stimulering af appetit, håndtering af vægttab og behandling af anoreksi hos hunde og katte |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2891063A (en) * | 1959-06-16 | Piperazine derivatives and process of | ||
US2830056A (en) * | 1958-04-08 | Chj oh | ||
US2507408A (en) * | 1948-03-05 | 1950-05-09 | Rhone Poulenc Sa | 1-alkylsulfonyl-4-alkyl piperazines |
GB1181322A (en) * | 1967-06-29 | 1970-02-11 | Chugai Pharmaceutical Co Ltd | Piperazine Derivatives and processes for preparing the same |
US4217452A (en) * | 1974-02-09 | 1980-08-12 | Akzona Incorporated | Synthesis for the preparation of tetracyclic compounds |
NL179906C (nl) * | 1974-02-09 | 1986-12-01 | Akzo Nv | Werkwijze voor het bereiden van 1,2,3,4,10,14b-hexahydrodibenzo(c,f)pyrazino (1,2-a)azepine derivaten. |
NL189199C (nl) | 1975-04-05 | 1993-02-01 | Akzo Nv | Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten. |
FR2585702B1 (fr) * | 1985-07-31 | 1989-03-03 | Lafon Labor | Derives de phenyl-piperazine, procede de preparation et utilisation en therapeutique |
US4918190A (en) * | 1986-08-06 | 1990-04-17 | Ube Industries, Ltd. | Crystalline complex compounds of propargyl alcohols and tertiary diamines, and process of separation and purification of propargyl alcohols using the same |
US4935515A (en) * | 1988-02-23 | 1990-06-19 | American Home Products Corporation | 2,3,4,5-tetrahydro-1H-[1,2,5]triazocino(1,2-a)[1,2,4]benzotriazin-7(8H)-ones, thiones and derivatives |
RU2001128228A (ru) * | 1999-04-19 | 2003-07-20 | Тева Фармасьютикал Индастриз Лтд. (Il) | Новый синтез пиперазинового кольца |
-
2000
- 2000-04-07 RU RU2001128228/04A patent/RU2001128228A/ru not_active Application Discontinuation
- 2000-04-07 CA CA002370389A patent/CA2370389A1/en not_active Abandoned
- 2000-04-07 IL IL14602400A patent/IL146024A0/xx unknown
- 2000-04-07 US US09/545,011 patent/US6339156B1/en not_active Expired - Fee Related
- 2000-04-07 PL PL00351395A patent/PL351395A1/xx not_active Application Discontinuation
- 2000-04-07 AU AU42190/00A patent/AU777105B2/en not_active Ceased
- 2000-04-07 SK SK1480-2001A patent/SK14802001A3/sk unknown
- 2000-04-07 JP JP2000612277A patent/JP2002542234A/ja active Pending
- 2000-04-07 YU YU74201A patent/YU74201A/sh unknown
- 2000-04-07 CN CN00809049A patent/CN1355793A/zh active Pending
- 2000-04-07 TR TR2001/03035T patent/TR200103035T2/xx unknown
- 2000-04-07 KR KR1020017013280A patent/KR20020015313A/ko not_active Application Discontinuation
- 2000-04-07 HU HU0200808A patent/HUP0200808A3/hu unknown
- 2000-04-07 EP EP00921933A patent/EP1178972A4/en not_active Withdrawn
- 2000-04-07 CZ CZ20013698A patent/CZ20013698A3/cs unknown
- 2000-04-07 WO PCT/US2000/009418 patent/WO2000063185A1/en not_active Application Discontinuation
-
2001
- 2001-08-24 US US09/939,406 patent/US6852855B2/en not_active Expired - Fee Related
- 2001-10-16 ZA ZA200108480A patent/ZA200108480B/xx unknown
- 2001-10-18 HR HR20010759A patent/HRP20010759A2/hr not_active Application Discontinuation
-
2002
- 2002-05-13 HK HK02103576.4A patent/HK1042696A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
HRP20010759A2 (en) | 2003-02-28 |
WO2000063185A1 (en) | 2000-10-26 |
US20020035256A1 (en) | 2002-03-21 |
SK14802001A3 (sk) | 2002-07-02 |
EP1178972A4 (en) | 2002-06-12 |
US6339156B1 (en) | 2002-01-15 |
ZA200108480B (en) | 2003-01-29 |
PL351395A1 (en) | 2003-04-07 |
EP1178972A1 (en) | 2002-02-13 |
KR20020015313A (ko) | 2002-02-27 |
CN1355793A (zh) | 2002-06-26 |
AU777105B2 (en) | 2004-09-30 |
RU2001128228A (ru) | 2003-07-20 |
TR200103035T2 (tr) | 2002-01-21 |
HK1042696A1 (zh) | 2002-08-23 |
IL146024A0 (en) | 2002-07-25 |
AU4219000A (en) | 2000-11-02 |
US6852855B2 (en) | 2005-02-08 |
JP2002542234A (ja) | 2002-12-10 |
HUP0200808A2 (hu) | 2002-11-28 |
CZ20013698A3 (cs) | 2002-05-15 |
CA2370389A1 (en) | 2000-10-26 |
HUP0200808A3 (en) | 2002-12-28 |
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