ES2058182T3 - Analogos de mitomicina. un procedimiento para su preparacion y composiciones farmaceuticas. - Google Patents

Analogos de mitomicina. un procedimiento para su preparacion y composiciones farmaceuticas.

Info

Publication number
ES2058182T3
ES2058182T3 ES88109275T ES88109275T ES2058182T3 ES 2058182 T3 ES2058182 T3 ES 2058182T3 ES 88109275 T ES88109275 T ES 88109275T ES 88109275 T ES88109275 T ES 88109275T ES 2058182 T3 ES2058182 T3 ES 2058182T3
Authority
ES
Spain
Prior art keywords
analogs
mithomicine
procedure
preparation
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88109275T
Other languages
English (en)
Inventor
Takushi Kaneko
Henry S L Wong
Terrence W Doyle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of ES2058182T3 publication Critical patent/ES2058182T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A NUEVOS ANALOGOS DE MITOMICINA CONTENIENDO UN ACETAL O TIOACETAL CICLICO. ESTOS COMPUESTOS SON ANALOGOS DE MITOMICINA C EN LOS QUE EL GRUPO AMINO 7 LLEVA UN SUSTITUYENTE HETEROCICLICO DE 5 MIEMBROS. LA MITOMICINA C ES UN AGENTE ANTITUMORAL DE UTILIDAD ESTABLACIDA Y LOS ANALOGOS DE MITOSANO 7-N-SUSTIUIDOS TIENEN UTILIDAD SIMILAR.
ES88109275T 1987-06-12 1988-06-10 Analogos de mitomicina. un procedimiento para su preparacion y composiciones farmaceuticas. Expired - Lifetime ES2058182T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6183987A 1987-06-12 1987-06-12

Publications (1)

Publication Number Publication Date
ES2058182T3 true ES2058182T3 (es) 1994-11-01

Family

ID=22038465

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88109275T Expired - Lifetime ES2058182T3 (es) 1987-06-12 1988-06-10 Analogos de mitomicina. un procedimiento para su preparacion y composiciones farmaceuticas.

Country Status (10)

Country Link
US (1) US5374739A (es)
EP (1) EP0294828B1 (es)
JP (1) JPS63316781A (es)
AT (1) ATE93524T1 (es)
CA (1) CA1326487C (es)
CY (1) CY1742A (es)
DE (1) DE3883434T2 (es)
ES (1) ES2058182T3 (es)
HK (1) HK127993A (es)
IL (1) IL86665A0 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6495348B1 (en) * 1993-10-07 2002-12-17 Regents Of The University Of Minnesota Mitomycin biosynthetic gene cluster
US6524812B1 (en) 1993-10-07 2003-02-25 Regents Of The University Of Minnesota Genes encoding resistance to DNA alkylating agents
MXPA05003238A (es) 2002-09-26 2005-09-12 Endovascular Devices Inc Aparato y metodo para administrar mitomicina a traves de un dispositivo medico implantable biocompatible de elucion.

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL129868C (es) * 1963-06-07
DE1570029A1 (de) * 1964-07-09 1970-04-09 Kyowa Hakko Kogyo Kk Verfahren zur Herstellung von Mitosanverbindungen
US3420846A (en) * 1964-08-25 1969-01-07 Kyowa Hakko Kogyo Kk 7-substituted mitomycin a
US3332944A (en) * 1964-11-02 1967-07-25 American Cyanamid Co Antibiotic derivatives of mitomycins a, b, c and porfiromycin
JPS5439098A (en) * 1977-08-31 1979-03-24 Kyowa Hakko Kogyo Co Ltd Mitomycin c derivatives
US4460599A (en) * 1979-12-05 1984-07-17 University Patents, Inc. Mitomycin analogs
US4268676A (en) * 1979-12-05 1981-05-19 University Patents, Inc. Mitomycin analogs
US4487769A (en) * 1982-06-04 1984-12-11 Bristol-Myers Company Amidines
US4567256A (en) * 1983-05-09 1986-01-28 Bristol-Myers Company Amidine process
US4579737A (en) * 1983-05-09 1986-04-01 Bristol-Myers Company Bis-amidines
AU581673B2 (en) * 1984-09-04 1989-03-02 Bristol-Myers Company Substituted 7-oxomitosanes
FR2571373A1 (fr) * 1984-10-09 1986-04-11 Bristol Myers Co Procede de preparation de derives n7-substitues de la mitomycine c

Also Published As

Publication number Publication date
EP0294828A2 (en) 1988-12-14
DE3883434D1 (de) 1993-09-30
US5374739A (en) 1994-12-20
EP0294828A3 (en) 1990-05-09
IL86665A0 (en) 1988-11-30
DE3883434T2 (de) 1993-12-09
EP0294828B1 (en) 1993-08-25
JPS63316781A (ja) 1988-12-26
CY1742A (en) 1995-10-20
HK127993A (en) 1993-11-26
ATE93524T1 (de) 1993-09-15
CA1326487C (en) 1994-01-25
JPH0563476B2 (es) 1993-09-10

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