HRP20070174A2 - Process for consstructing strain having compactin hydroxyation ability - Google Patents
Process for consstructing strain having compactin hydroxyation abilityInfo
- Publication number
- HRP20070174A2 HRP20070174A2 HR20070174A HRP20070174A HRP20070174A2 HR P20070174 A2 HRP20070174 A2 HR P20070174A2 HR 20070174 A HR20070174 A HR 20070174A HR P20070174 A HRP20070174 A HR P20070174A HR P20070174 A2 HRP20070174 A2 HR P20070174A2
- Authority
- HR
- Croatia
- Prior art keywords
- compactin
- consstructing
- hydroxyation
- strain
- ability
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- VGMFHMLQOYWYHN-UHFFFAOYSA-N Compactin Natural products OCC1OC(OC2C(O)C(O)C(CO)OC2Oc3cc(O)c4C(=O)C(=COc4c3)c5ccc(O)c(O)c5)C(O)C(O)C1O VGMFHMLQOYWYHN-UHFFFAOYSA-N 0.000 title abstract 2
- AJLFOPYRIVGYMJ-UHFFFAOYSA-N SJ000287055 Natural products C12C(OC(=O)C(C)CC)CCC=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 AJLFOPYRIVGYMJ-UHFFFAOYSA-N 0.000 title abstract 2
- AJLFOPYRIVGYMJ-INTXDZFKSA-N mevastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=CCC[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 AJLFOPYRIVGYMJ-INTXDZFKSA-N 0.000 title abstract 2
- BOZILQFLQYBIIY-UHFFFAOYSA-N mevastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CCC=C21 BOZILQFLQYBIIY-UHFFFAOYSA-N 0.000 title abstract 2
- TUZYXOIXSAXUGO-UHFFFAOYSA-N Pravastatin Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(O)C=C21 TUZYXOIXSAXUGO-UHFFFAOYSA-N 0.000 abstract 3
- 244000005700 microbiome Species 0.000 abstract 3
- TUZYXOIXSAXUGO-PZAWKZKUSA-N pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 abstract 3
- 229960002965 pravastatin Drugs 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 2
- 102000002004 Cytochrome P-450 Enzyme System Human genes 0.000 abstract 1
- 108010015742 Cytochrome P-450 Enzyme System Proteins 0.000 abstract 1
- 208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
- 208000031226 Hyperlipidaemia Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000640 hydroxylating effect Effects 0.000 abstract 1
- 230000002906 microbiologic effect Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63301104P | 2004-12-03 | 2004-12-03 | |
| PCT/US2005/044208 WO2006076094A2 (en) | 2004-12-03 | 2005-12-05 | Process for constructing strain having compactin hydroxylation ability |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20070174A2 true HRP20070174A2 (en) | 2007-07-31 |
Family
ID=36678066
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20070174A HRP20070174A2 (en) | 2004-12-03 | 2007-04-23 | Process for consstructing strain having compactin hydroxyation ability |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US7504244B2 (xx) |
| EP (1) | EP1817421A2 (xx) |
| JP (1) | JP4740256B2 (xx) |
| KR (1) | KR20070085385A (xx) |
| CN (1) | CN101076595A (xx) |
| CA (1) | CA2584812A1 (xx) |
| HR (1) | HRP20070174A2 (xx) |
| IL (1) | IL183238A0 (xx) |
| TW (1) | TWI307360B (xx) |
| WO (1) | WO2006076094A2 (xx) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2094841T3 (da) * | 2006-12-13 | 2012-05-29 | Dsm Sinochem Pharm Nl Bv | Fremgangsmåde til fremstilling af pravastatin |
| WO2008144073A1 (en) * | 2007-05-21 | 2008-11-27 | Teva Pharmaceutical Industries Ltd. | Enzymatic process for the preparation of paliperidone and its intermediate cmhtp |
| US8822381B2 (en) | 2008-12-31 | 2014-09-02 | Marrone Bio Innovations, Inc. | Uses of thaxtomin and thaxtomin compositions as herbicides |
| US9968085B2 (en) | 2008-12-31 | 2018-05-15 | Marrone Bio Innovations, Inc. | Uses of thaxtomin and thaxtomin compositions as herbicides |
| US8476195B2 (en) * | 2008-12-31 | 2013-07-02 | Marrone Bio Innovations | Uses of thaxtomin and thaxtomin compositions as herbicides |
| US9066516B2 (en) | 2008-12-31 | 2015-06-30 | Marrone Bio Innovations, Inc. | Uses of thaxtomin and thaxtomin compositions as herbicides |
| TW201038557A (en) * | 2009-04-16 | 2010-11-01 | Marrone Bio Innovations Inc | Use of thaxtomin for selective control of rice and aquatic based weeds |
| CN103898071B (zh) * | 2012-12-24 | 2017-04-12 | 清华大学 | P450sca‑2酶突变体、其制备方法和应用 |
| US8993762B2 (en) | 2013-03-15 | 2015-03-31 | Marrone Bio Innovations, Inc. | Total synthesis of thaxtomin A analogues and their intermediates |
| US11554087B2 (en) | 2020-11-05 | 2023-01-17 | The Gillette Company Llc | Shaving aid comprising an antioxidant |
| CN115161355B (zh) * | 2022-09-08 | 2022-11-25 | 上海现代制药股份有限公司 | 一种利用发酵工艺制备高稳定性普伐他汀的方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK149080C (da) | 1980-06-06 | 1986-07-28 | Sankyo Co | Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre |
| JPS5810572A (ja) | 1981-07-07 | 1983-01-21 | Sankyo Co Ltd | Ｍｌ−２３６ｂ誘導体およびその製造法 |
| JPS5889191A (ja) | 1981-11-20 | 1983-05-27 | Sankyo Co Ltd | ３−ヒドロキシ−ｍｌ−２３６ｂ誘導体の製造法 |
| US5179013A (en) | 1987-02-02 | 1993-01-12 | Sankyo Company, Limited | Cytochrome P-450 enzymes |
| JPH0670780A (ja) * | 1992-08-28 | 1994-03-15 | Sankyo Co Ltd | 放線菌のシトクロムＰ−４５０ｓｃａ遺伝子 |
| NZ250609A (en) | 1992-12-28 | 1995-07-26 | Sankyo Co | Hexahydronaphthalene esters and ring closed lactones; preparation and medicaments |
| SI9300303A (en) | 1993-06-08 | 1994-12-31 | Krka Tovarna Zdravil | Process for isolation of hypolipemic effective substance |
| US5942423A (en) | 1995-06-07 | 1999-08-24 | Massachusetts Institute Of Technology | Conversion of compactin to pravastatin by actinomadura |
| ATE189804T1 (de) | 1995-08-03 | 2000-03-15 | Dsm Nv | Selektives verfahren zur deacylierung von acylverbindungen |
| NZ299835A (en) | 1995-11-29 | 1997-08-22 | Sankyo Co | Actinomycete promoter for the expression of p-450 cytochromes |
| JP2931971B1 (ja) | 1998-02-23 | 1999-08-09 | 利夫 佐藤 | プラバスタチンの製造法 |
| US6682913B1 (en) | 1999-02-03 | 2004-01-27 | Institute For Drug Research Ltd. | Microbial process for preparing pravastatin |
| WO2000046175A1 (en) | 1999-02-03 | 2000-08-10 | Institute For Drug Research Ltd. | Microbial process for preparing pravastatin |
| JPWO2002099109A1 (ja) * | 2001-06-01 | 2004-09-16 | メルシャン株式会社 | 新規なポリペプチド、そのポリペプチドをコードするｄｎａおよびそれらの用途 |
| EP1500704B1 (en) | 2002-04-12 | 2009-03-25 | Mercian Corporation | Expression system of actinomycete-origin cytochrome p-450 in escherichia coli |
-
2005
- 2005-12-02 TW TW094142662A patent/TWI307360B/zh not_active IP Right Cessation
- 2005-12-05 JP JP2007544624A patent/JP4740256B2/ja not_active Expired - Fee Related
- 2005-12-05 EP EP05853197A patent/EP1817421A2/en not_active Ceased
- 2005-12-05 WO PCT/US2005/044208 patent/WO2006076094A2/en active Application Filing
- 2005-12-05 CN CNA2005800410414A patent/CN101076595A/zh active Pending
- 2005-12-05 KR KR1020077011160A patent/KR20070085385A/ko active Search and Examination
- 2005-12-05 CA CA002584812A patent/CA2584812A1/en not_active Abandoned
- 2005-12-05 US US11/295,142 patent/US7504244B2/en not_active Expired - Fee Related
-
2007
- 2007-04-23 HR HR20070174A patent/HRP20070174A2/xx not_active Application Discontinuation
- 2007-05-15 IL IL183238A patent/IL183238A0/en unknown
- 2007-07-10 US US11/827,200 patent/US7700337B2/en not_active Expired - Fee Related
- 2007-07-10 US US11/827,162 patent/US7700752B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008521448A (ja) | 2008-06-26 |
| KR20070085385A (ko) | 2007-08-27 |
| WO2006076094A3 (en) | 2006-12-14 |
| WO2006076094A2 (en) | 2006-07-20 |
| US7700752B2 (en) | 2010-04-20 |
| US20090005537A1 (en) | 2009-01-01 |
| US7504244B2 (en) | 2009-03-17 |
| CN101076595A (zh) | 2007-11-21 |
| JP4740256B2 (ja) | 2011-08-03 |
| TW200634157A (en) | 2006-10-01 |
| EP1817421A2 (en) | 2007-08-15 |
| IL183238A0 (en) | 2007-08-19 |
| US20060172383A1 (en) | 2006-08-03 |
| US7700337B2 (en) | 2010-04-20 |
| CA2584812A1 (en) | 2006-07-20 |
| US20090004695A1 (en) | 2009-01-01 |
| TWI307360B (en) | 2009-03-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A1OB | Publication of a patent application | ||
| AIPI | Request for the grant of a patent on the basis of a substantive examination of a patent application | ||
| ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20091203 Year of fee payment: 5 |
|
| OBST | Application withdrawn |