HRP20041017B1 - A process for the preparation of clopidogrel - Google Patents

A process for the preparation of clopidogrel

Info

Publication number: HRP20041017B1
Authority: HR; Croatia
Prior art keywords: group; branched; straight; substituted; defined above
Prior art date: 2002-05-03

Application number

HR20041017A

Other languages

English (en)

Croatian (hr)

Inventor

Castaldi Graziano

Barreca Giuseppe

Bologna Alberto

Original Assignee

Dipharma S.P.A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-05-03

Filing date

2004-10-29

Publication date

2007-08-31

2004-10-29 Application filed by Dipharma S.P.A. filed Critical Dipharma S.P.A.

2004-12-31 Publication of HRP20041017A2 publication Critical patent/HRP20041017A2/xx

2007-08-31 Publication of HRP20041017B1 publication Critical patent/HRP20041017B1/xx

Links

239000005552 B01AC04 - Clopidogrel Substances 0.000 title 1
GKTWGGQPFAXNFI-HNNXBMFYSA-N clopidogrel Chemical compound C1([C@H](N2CC=3C=CSC=3CC2)C(=O)OC)=CC=CC=C1Cl GKTWGGQPFAXNFI-HNNXBMFYSA-N 0.000 title 1
229960003009 clopidogrel Drugs 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 abstract 1
ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
229910004679 ONO2 Inorganic materials 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
239000000460 chlorine Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004185 ester group Chemical group 0.000 abstract 1
229910052731 fluorine Inorganic materials 0.000 abstract 1
239000011737 fluorine Substances 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
229910052740 iodine Inorganic materials 0.000 abstract 1
239000011630 iodine Substances 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000005010 perfluoroalkyl group Chemical group 0.000 abstract 1
125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 abstract 1
OJMIONKXNSYLSR-UHFFFAOYSA-N phosphorous acid Chemical group OP(O)O OJMIONKXNSYLSR-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/06—Peri-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

HR20041017A 2002-05-03 2004-10-29 A process for the preparation of clopidogrel HRP20041017B1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT2002MI000933A ITMI20020933A1 (it)	2002-05-03	2002-05-03	Procedimento per la sintesi di clopidogrel
PCT/EP2003/004179 WO2003093276A1 (en)	2002-05-03	2003-04-22	A process for the preparation of clopidogrel

Publications (2)

Publication Number	Publication Date
HRP20041017A2 HRP20041017A2 (en)	2004-12-31
HRP20041017B1 true HRP20041017B1 (en)	2007-08-31

Family

ID=11449820

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20041017A HRP20041017B1 (en)	2002-05-03	2004-10-29	A process for the preparation of clopidogrel

Country Status (19)

Country	Link
US (1)	US7329751B2 (zh)
EP (1)	EP1501838B1 (zh)
JP (1)	JP2005530757A (zh)
KR (1)	KR20040106449A (zh)
CN (1)	CN1293080C (zh)
AT (1)	ATE359287T1 (zh)
AU (1)	AU2003224115A1 (zh)
CA (1)	CA2485070A1 (zh)
DE (1)	DE60313157T2 (zh)
DK (1)	DK1501838T3 (zh)
EA (1)	EA007907B1 (zh)
ES (1)	ES2285116T3 (zh)
HR (1)	HRP20041017B1 (zh)
IL (1)	IL164978A0 (zh)
IT (1)	ITMI20020933A1 (zh)
MX (1)	MXPA04010765A (zh)
PL (1)	PL375213A1 (zh)
PT (1)	PT1501838E (zh)
WO (1)	WO2003093276A1 (zh)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN100406568C (zh) *	2005-02-18	2008-07-30	淮北市辉克药业有限公司	氯吡格雷新生产工艺
KR100681512B1 (ko) *	2005-03-08	2007-02-09	주식회사 한서켐	클로피도그렐의 신규한 제조 중간체 및 이를 이용한 클로피도그렐의 제조방법
CN100390180C (zh) *	2005-12-15	2008-05-28	上海应用技术学院	氯吡格雷及其盐的制备方法
CN100396687C (zh) *	2006-05-26	2008-06-25	浙江海翔药业股份有限公司	(+)-(s-)-氯吡格雷硫酸氢盐(i型)的制备方法
CA2655844A1 (en) *	2006-08-03	2008-02-14	Teva Pharmaceutical Industries Ltd.	Process for preparing clopidogrel bisulphate
KR20160033792A (ko)	2007-04-27	2016-03-28	사이덱스 파마슈티칼스, 인크.	클로피도그렐 및 설포알킬 에테르 사이클로덱스트린을 함유하는 제형 및 사용 방법
KR100848936B1 (ko)	2007-05-17	2008-07-29	주식회사 대희화학	클로피도그렐 이성질체의 제조방법 및 이의 제조에사용되는 신규 중간체 화합물
EP2429291B1 (en)	2009-05-13	2016-07-06	Cydex Pharmaceuticals, Inc.	Pharmaceutical compositions comprising prasugrel and cyclodextrin derivatives and methods of making and using the same
CN110527722A (zh) *	2019-09-11	2019-12-03	上海交通大学	一种利用rs2644592和rs11264580检测氯吡格雷药效试剂盒

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2530247B1 (fr) *	1982-07-13	1986-05-16	Sanofi Sa	Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique
FR2664596B1 (fr) *	1990-07-10	1994-06-10	Sanofi Sa	Procede de preparation d'un derive n-phenylacetique de tetrahydrothieno [3,2-c] pyridine et son intermediaire de synthese.
HU222283B1 (hu) *	1997-05-13	2003-05-28	Sanofi-Synthelabo	Eljárás tieno[3,2-c]piridin-származékok előállítására
FR2769313B1 (fr)	1997-10-06	2000-04-21	Sanofi Sa	Derives d'esters hydroxyacetiques, leur procede de preparation et leur utilisation comme intermediaires de synthese

2002
- 2002-05-03 IT IT2002MI000933A patent/ITMI20020933A1/it unknown
2003
- 2003-04-22 CA CA002485070A patent/CA2485070A1/en not_active Abandoned
- 2003-04-22 DK DK03720514T patent/DK1501838T3/da active
- 2003-04-22 DE DE60313157T patent/DE60313157T2/de not_active Expired - Fee Related
- 2003-04-22 AT AT03720514T patent/ATE359287T1/de not_active IP Right Cessation
- 2003-04-22 US US10/513,156 patent/US7329751B2/en not_active Expired - Fee Related
- 2003-04-22 EP EP03720514A patent/EP1501838B1/en not_active Expired - Lifetime
- 2003-04-22 JP JP2004501415A patent/JP2005530757A/ja not_active Ceased
- 2003-04-22 EA EA200401234A patent/EA007907B1/ru not_active IP Right Cessation
- 2003-04-22 CN CNB038099675A patent/CN1293080C/zh not_active Expired - Fee Related
- 2003-04-22 PL PL03375213A patent/PL375213A1/xx unknown
- 2003-04-22 MX MXPA04010765A patent/MXPA04010765A/es active IP Right Grant
- 2003-04-22 WO PCT/EP2003/004179 patent/WO2003093276A1/en active IP Right Grant
- 2003-04-22 ES ES03720514T patent/ES2285116T3/es not_active Expired - Lifetime
- 2003-04-22 IL IL16497803A patent/IL164978A0/xx unknown
- 2003-04-22 KR KR10-2004-7017632A patent/KR20040106449A/ko not_active Application Discontinuation
- 2003-04-22 PT PT03720514T patent/PT1501838E/pt unknown
- 2003-04-22 AU AU2003224115A patent/AU2003224115A1/en not_active Abandoned
2004
- 2004-10-29 HR HR20041017A patent/HRP20041017B1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
HRP20041017A2 (en)	2004-12-31
EP1501838A1 (en)	2005-02-02
ITMI20020933A0 (it)	2002-05-03
EP1501838B1 (en)	2007-04-11
PL375213A1 (en)	2005-11-28
DK1501838T3 (da)	2007-08-20
US7329751B2 (en)	2008-02-12
JP2005530757A (ja)	2005-10-13
WO2003093276A1 (en)	2003-11-13
ITMI20020933A1 (it)	2003-11-03
CN1293080C (zh)	2007-01-03
EA007907B1 (ru)	2007-02-27
ES2285116T3 (es)	2007-11-16
MXPA04010765A (es)	2005-07-05
KR20040106449A (ko)	2004-12-17
DE60313157D1 (de)	2007-05-24
DE60313157T2 (de)	2007-12-20
AU2003224115A1 (en)	2003-11-17
EA200401234A1 (ru)	2005-06-30
US20050143414A1 (en)	2005-06-30
PT1501838E (pt)	2007-06-28
IL164978A0 (en)	2005-12-18
ATE359287T1 (de)	2007-05-15
CA2485070A1 (en)	2003-11-13
CN1649877A (zh)	2005-08-03

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Legal Events

Date	Code	Title	Description
2004-12-31	A1OB	Publication of a patent application
2005-06-29	AIPI	Request for the grant of a patent on the basis of a substantive examination of a patent application
2007-08-31	B1PR	Patent granted
2008-04-17	ODRP	Renewal fee for the maintenance of a patent	Payment date: 20080417 Year of fee payment: 6
2009-10-23	PBON	Lapse due to non-payment of renewal fee	Effective date: 20090423