HRP20030475A2 - Drip liquid dispenser - Google Patents
Drip liquid dispenser Download PDFInfo
- Publication number
- HRP20030475A2 HRP20030475A2 HR20030475A HRP20030475A HRP20030475A2 HR P20030475 A2 HRP20030475 A2 HR P20030475A2 HR 20030475 A HR20030475 A HR 20030475A HR P20030475 A HRP20030475 A HR P20030475A HR P20030475 A2 HRP20030475 A2 HR P20030475A2
- Authority
- HR
- Croatia
- Prior art keywords
- container
- partition
- liquid
- bottle
- tip
- Prior art date
Links
- 239000007788 liquid Substances 0.000 title claims description 56
- 238000005192 partition Methods 0.000 claims description 62
- 239000012528 membrane Substances 0.000 claims description 37
- 239000002775 capsule Substances 0.000 claims description 12
- 230000002209 hydrophobic effect Effects 0.000 claims description 12
- 238000011049 filling Methods 0.000 claims description 11
- 238000009826 distribution Methods 0.000 claims description 9
- 239000007787 solid Substances 0.000 claims description 9
- 230000008859 change Effects 0.000 claims description 7
- 239000011148 porous material Substances 0.000 claims description 6
- 238000003825 pressing Methods 0.000 claims description 4
- 239000004695 Polyether sulfone Substances 0.000 claims description 3
- 229920006393 polyether sulfone Polymers 0.000 claims description 3
- 239000004952 Polyamide Substances 0.000 claims 1
- 229920001477 hydrophilic polymer Polymers 0.000 claims 1
- 239000012678 infectious agent Substances 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 230000035515 penetration Effects 0.000 claims 1
- 229920002647 polyamide Polymers 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 description 11
- 239000000047 product Substances 0.000 description 8
- 239000000243 solution Substances 0.000 description 6
- 238000003466 welding Methods 0.000 description 6
- 230000000845 anti-microbial effect Effects 0.000 description 5
- 230000008901 benefit Effects 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- 230000004888 barrier function Effects 0.000 description 4
- 238000011109 contamination Methods 0.000 description 4
- 238000003860 storage Methods 0.000 description 4
- 239000004599 antimicrobial Substances 0.000 description 3
- 238000005266 casting Methods 0.000 description 3
- 239000000470 constituent Substances 0.000 description 3
- 239000002537 cosmetic Substances 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 238000004026 adhesive bonding Methods 0.000 description 2
- -1 for coloring Substances 0.000 description 2
- 239000012263 liquid product Substances 0.000 description 2
- 239000006193 liquid solution Substances 0.000 description 2
- 239000002997 ophthalmic solution Substances 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 229920006122 polyamide resin Polymers 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 230000008719 thickening Effects 0.000 description 2
- 238000002604 ultrasonography Methods 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000003124 biologic agent Substances 0.000 description 1
- 230000003749 cleanliness Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000000203 droplet dispensing Methods 0.000 description 1
- 230000005489 elastic deformation Effects 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 229940012356 eye drops Drugs 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 239000003999 initiator Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000007348 radical reaction Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
- 238000004804 winding Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D51/00—Closures not otherwise provided for
- B65D51/18—Arrangements of closures with protective outer cap-like covers or of two or more co-operating closures
- B65D51/20—Caps, lids, or covers co-operating with an inner closure arranged to be opened by piercing, cutting, or tearing
- B65D51/22—Caps, lids, or covers co-operating with an inner closure arranged to be opened by piercing, cutting, or tearing having means for piercing, cutting, or tearing the inner closure
- B65D51/221—Caps, lids, or covers co-operating with an inner closure arranged to be opened by piercing, cutting, or tearing having means for piercing, cutting, or tearing the inner closure a major part of the inner closure being left inside the container after the opening
- B65D51/226—Caps, lids, or covers co-operating with an inner closure arranged to be opened by piercing, cutting, or tearing having means for piercing, cutting, or tearing the inner closure a major part of the inner closure being left inside the container after the opening the piercing or cutting means being non integral with, or not fixedly attached to, the outer closure
- B65D51/227—Caps, lids, or covers co-operating with an inner closure arranged to be opened by piercing, cutting, or tearing having means for piercing, cutting, or tearing the inner closure a major part of the inner closure being left inside the container after the opening the piercing or cutting means being non integral with, or not fixedly attached to, the outer closure and further comprising a device first inhibiting displacement of the piercing or cutting means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D47/00—Closures with filling and discharging, or with discharging, devices
- B65D47/04—Closures with discharging devices other than pumps
- B65D47/06—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages
- B65D47/18—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages for discharging drops; Droppers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1443—Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters
- A61J1/145—Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters using air filters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1443—Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters
- A61J1/1456—Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters using liquid filters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1468—Containers characterised by specific material properties
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D2251/00—Details relating to container closures
- B65D2251/0003—Two or more closures
- B65D2251/0006—Upper closure
- B65D2251/0015—Upper closure of the 41-type
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D2251/00—Details relating to container closures
- B65D2251/0003—Two or more closures
- B65D2251/0037—Intermediate closure(s)
- B65D2251/0056—Intermediate closure(s) of the 47-type
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D2251/00—Details relating to container closures
- B65D2251/0003—Two or more closures
- B65D2251/0068—Lower closure
- B65D2251/0093—Membrane
- B65D2251/0096—Membrane integral with the container
Landscapes
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Mechanical Engineering (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Veterinary Medicine (AREA)
- Closures For Containers (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
- Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
- Details Of Rigid Or Semi-Rigid Containers (AREA)
- Packages (AREA)
- Nozzles (AREA)
Description
UREĐAJ ZA RASPOREĐIVANJE TEKUĆINE KAP PO KAP DEVICE FOR DISTRIBUTION OF LIQUID DROP BY DROP
Opis izuma Description of the invention
Ovaj se izum odnosi na industriju kondicioniranja tekućih proizvoda, a posebice na koncepciju i proizvodnju boca koje na vrhu imaju distributer koji broji kapi onakav kakav služi za čuvanje tekućine koja se raspoređuje kap to kap. This invention relates to the industry of conditioning liquid products, and in particular to the conception and production of bottles that have a drop-counting distributor on top, such as is used to store liquid that is distributed drop by drop.
Ovakve boce koriste se u brojnim područjima primjene, posebice za čuvanje farmaceutskih ili kozmetičkih proizvoda u tekućem obliku, naime u obliku tekućih otopina, ali i za sredstva za podmazivanje, za bojenje, otopine aditiva koji se koriste u prehrambenoj industriji itd. Radi se o tekućim proizvodima koji se koriste u malim dozama, izbacujući svaki put samo nekoliko kapi iz boce koja sadržava tekućinu, a koja se treba dugo čuvati. Vrlo često proizvod koji se čuva u boci treba se, pored toga, čuvati zaštićen od svake mogućnosti zagađenja bakterijama ili drugim agensima koji dolaze izvana. To je slučaj naročito sa farmaceutskim kompozicijama, a među njima posebice oftamološkim otopinama koje će ovdje biti uzete kao primjer industrijske primjene koji je izuzetno karakterističan. Such bottles are used in numerous fields of application, especially for storing pharmaceutical or cosmetic products in liquid form, namely in the form of liquid solutions, but also for lubricants, for coloring, additive solutions used in the food industry, etc. These are liquid products that are used in small doses, throwing out only a few drops each time from the bottle that contains the liquid, which needs to be stored for a long time. Very often, a product stored in a bottle should, in addition, be stored protected from any possibility of contamination by bacteria or other agents coming from outside. This is especially the case with pharmaceutical compositions, and among them especially ophthalmological solutions, which will be taken here as an example of an extremely characteristic industrial application.
Zahtijevani uvjeti čistoće proizvoda ne dozvoljavaju da zrak iz okolice slobodno ulazi u bocu u zamjenu za volumen dijela tekućine koja izlazi prilikom svake operacije distribucije. Ako je uobičajeno da se zahtijeva od ove vrste boca da imaju sredstvo za zaštitu koje predstavlja garanciju da neće biti otvarane za vrijeme dok se čuvaju u skladištu prije nego što se prodaju finalnom korisniku, ovo osiguranje nepovredivosti važno je samo do prvog korištenja boce do te mjere da nema potrebe za tehnološkom otopinom za očuvanje čistoće tijekom korištenja boce sukcesivnim izbacivanjem doza proizvoda. The required product cleanliness conditions do not allow air from the surroundings to freely enter the bottle in exchange for the volume of part of the liquid that comes out during each distribution operation. If it is customary to require bottles of this type to have a means of protection which constitutes a guarantee that they will not be opened during the time they are kept in a warehouse before being sold to the end user, this assurance of inviolability is only important until the first use of the bottle to that extent that there is no need for a technological solution to preserve purity during the use of the bottle by successively ejecting doses of the product.
Da bi se riješili problemi s kojima se susreće industrijska praksa u području o kojem je riječ, izum bitno predlaže da se kombiniraju dva načina nepropusnog zatvaranja između jednog dijela boce koji formira posudu koja sadrži tekućinu koja se raspoređuje i vanjskog dijela boce, jedan mehaničke vrste i drugi fizičko-kemijske, u obliku kojim se osigurava ulazak zraka prilikom svake etape raspoređivanja proizvoda izbjegavajući pritom rizik zagađenja prisutnim agensima iz vanjskog zraka. Agensi zagađenja koje treba uzeti u obzir obično su bakterije, virusi i drugi biološki agensi, posebice u kontekstu farmaceutskih ili kozmetičkih proizvoda, ali moglo bi se isto tako raditi i o drugim oblicima štetnih agensa, posebice onih koji bi mogli uzrokovati destrukciju ili denaturiranje proizvoda koji se raspoređuje. In order to solve the problems faced by industrial practice in the field in question, the invention essentially proposes to combine two methods of sealing between one part of the bottle which forms the container containing the liquid to be dispensed and the outer part of the bottle, one of mechanical type and others physical-chemical, in a form that ensures the entry of air during each stage of product deployment, avoiding the risk of contamination by agents from the outside air. Contamination agents to be considered are usually bacteria, viruses and other biological agents, especially in the context of pharmaceutical or cosmetic products, but could also be other forms of harmful agents, especially those that could cause destruction or denaturation of the products being distributes.
Boca prema izumu predstavlja značajno tehnološko unapređenje u odnosu na dosada poznate uređaje za čuvanje tekućine koja se raspoređuje kap po kap, u kojima se predviđa ručno mijenjanje oblika posude u kojoj se nalazi tekućina za raspoređivanje, a koja je od plastike, zahvaljujući konfiguraciji cilindričnog mjehura, što omogućuje da se progresivno smanjuje unutarnji volumen u onoj mjeri u kojoj se tekućina izbacuje prilikom svakog raspoređivanja. Takova posuda u obliku mjehura mora biti zaštićena čvrstim omotačem na koji je pričvršćen vrh za raspoređivanje koji zatvara grlo posude i završava se van njega kanalom za izbacivanje kapi, a zaštita od zagađenja postiže se pomoću anti-bakterijskog filtera koji se stavlja na vrh raspoređivanja naviše od kanala za izbacivanje kapljica. The bottle according to the invention represents a significant technological improvement compared to previously known devices for storing liquid that is dispensed drop by drop, in which it is envisaged to manually change the shape of the container containing the liquid for dispensing, which is made of plastic, thanks to the configuration of the cylindrical bladder. which allows the internal volume to be progressively reduced to the extent that fluid is expelled with each deployment. Such a bladder-shaped container must be protected by a rigid jacket to which is attached a dispensing tip which closes the mouth of the container and terminates outside of it with a drop discharge channel, and protection against contamination is achieved by means of an anti-bacterial filter placed on the dispensing tip upwards of channels for dropping droplets.
Lako je shvatiti da bi bilo korisno kad bi se mogao izbjeći dodatni omotač posude kojeg predstavlja čvrsta obloga. U stvari, u ovom slučaju imamo kompleksnu i skupu proizvodnju, kako po pitanju realizacije svakog sastavnog dijela, tako i po pitanju montaže cjeline. Osim toga, ako se u okviru industrijske proizvodnje želi izmijeniti volumen boce, ne zna se kako bi se to moglo postići bez značajnih izmjena instalacije za proizvodnju, a samim tim i dodatni trošak koji nije zanemariv. It is easy to understand that it would be useful if one could avoid the additional shell of the container represented by a solid coating. In fact, in this case we have a complex and expensive production, both in terms of the realization of each component part, and in terms of the assembly of the whole. In addition, if it is desired to change the volume of the bottle within the framework of industrial production, it is not known how this could be achieved without significant changes to the production installation, and therefore an additional cost that is not negligible.
Pored ostalog, struktura poznatih boca ovog tipa zahtjeva da se boce pune u tvornici prije postavljanja vrha za raspoređivanje, što znači za vrijeme sklapanja boce. Proizvođač tekućine za raspoređivanje koja se čuva u ovim bocama treba, dakle, poslati na mjesto proizvodnje sve sastavne elemente boce da bi zatim dobio boce spremne za prodaju i nabaviti specijalni stroj za punjenje i finalnu montažu boce koja bi toliko koštala da bi mogla biti rentabilna samo u dugotrajnoj uporabi. Poželjno je da operacija punjenja boce može biti obavljena van tvornice gdje se proizvodi boca, od strane firme koja priprema tekućinu koja se raspoređuje, na primjer, pomoću stroja za punjenje običnih boca. Among other things, the structure of known bottles of this type requires that the bottles be filled in the factory before the placement of the top for deployment, which means during the assembly of the bottle. The manufacturer of the distribution fluid that is stored in these bottles should, therefore, send to the place of production all the constituent elements of the bottle in order to then receive the bottles ready for sale and acquire a special machine for filling and final assembly of the bottle, which would cost so much that it could be profitable only in long-term use. Preferably, the bottle filling operation can be performed outside the factory where the bottle is produced, by a company that prepares the liquid to be dispensed, for example, using a conventional bottle filling machine.
Izum ima za cilj zadovoljiti očekivanja industrije u području čuvanja tekućine koja se raspoređuje kap po kap, dakle, ona koja su upravo podvučena. On, dakle, osobito ima za cilj da predloži jednu novu bocu za tekućine koje se raspoređuju kap po kap, čija bi struktura bila pojednostavljena, spremna za punjenje na automatiziranom mjestu, koje je neovisno o proizvodnji boce i omogućuje da se dobiju različiti kapaciteti bez velikih izmjena u proizvodnji. The invention aims to meet the expectations of the industry in the field of liquid storage that is dispensed drop by drop, that is, those just underlined. He, therefore, particularly aims to propose a new bottle for liquids distributed drop by drop, the structure of which would be simplified, ready to be filled in an automated place, which is independent of the production of the bottle and allows to obtain different capacities without large change in production.
U tom smislu izum ima za cilj bocu za čuvanje tekućine koja se raspoređuje kap po kap, tipa koji sadrži posudu koja se završava čvrstim grlom u koji se montira vrh za raspoređivanje formirajući vanjski naglavak probijen kanalom za izbacivanje tekućine van posude, koji je karakterističan po tome što spomenuta posuda sadržava graničnu, elastičnu pregradu koja može mijenjati oblik kako bi se izbacio dio tekućine koji se nalazi u rezervoaru prilikom svake operacije raspoređivanja, po tome što spomenuti vrh raspoređivanja sadržava, montiranu popreko u odnosu na cirkulaciju tekućine koja se na taj način izbacuje iz posude, jednu membranu koja je djelomice hidrofilna kako bi se oslobodio prolaz tekućine pod utjecajem povećanog tlaka do kojeg dolazi u posudi mijenjanjem oblika pregrade i djelomice hidrofobne tako da membrana smočena izbačenom tekućinom omogućuje ulazak vanjskog zraka u posudu kad ovaj povrati elastično svoj prvobitni oblik poslije svake operacije raspoređivanja ručnim pritiskom, i po tome što, između ostalog sadržava pregradu posude koja se može prelomiti kako bi se, do prve uporabe, izolirala navedena membrana tekućine koja se nalazi u posudi, spomenuta pregrada se trga prolaskom vrha raspoređivača iz položaja osiguranja do položaja raspoloživosti. In this sense, the invention aims at a drop-dispensing liquid storage bottle, of the type containing a container ending in a solid neck in which a dispensing tip is mounted forming an external cap pierced with a channel for ejecting the liquid out of the container, which is characterized by that said container contains a boundary elastic partition capable of changing shape to eject a portion of the liquid contained in the reservoir during each dispensing operation, in that said dispensing tip comprises, mounted transversely to the circulation of the liquid thus ejected from container, one membrane that is partly hydrophilic to free the passage of liquid under the influence of the increased pressure that occurs in the container by changing the shape of the partition, and partly hydrophobic so that the membrane wetted by the ejected liquid allows the entry of outside air into the container when it elastically recovers its original shape after each deployment operations by manual push m, and because, among other things, it contains a partition of the container that can be broken in order to isolate, until the first use, the said membrane of the liquid that is in the container, the said partition breaks when the tip of the distributor moves from the position of security to the position of availability.
U oblicima realizacije boce kojima se daje prednost u izumu, a naročito onima koji su namijenjeni čuvanju vodenih otopina iz područja farmacije i kozmetike, a posebice za čuvanje oftalmoloških otopina, membrana koja je istodobno i hidrofilna i hidrofobna, između ostalog ima i tu karakteristiku da sprečava ulazak u bocu agensa koji zagađuju a koji se nalaze u vanjskoj atmosferi. Radi se, dakle, o membrani nazvanoj anti-mikrobna koja, prema svojim dimenzijama pora, može zaustaviti mikrobe koji su manje ili više pokretni. In the embodiments of the bottle that are preferred in the invention, and especially those intended for the storage of aqueous solutions from the field of pharmacy and cosmetics, and especially for the storage of ophthalmic solutions, the membrane, which is both hydrophilic and hydrophobic at the same time, has, among other things, the characteristic of preventing entry into the bottle of polluting agents that are in the external atmosphere. It is, therefore, a membrane called anti-microbial which, according to its pore dimensions, can stop microbes that are more or less mobile.
Prema drugim karakteristikama izuma, boca ima uglavnom cilindričan oblik, ili bar skoro takav (uglavnom je desni presjek okrugao ili duguljast) a lateralna cilindrična pregrada je elastična i može mijenjati oblik pritiskom ruke, po cijeloj ili djelomičnoj površini, kako bi se osigurao potreban dodatni tlak prilikom izbacivanja tekućine kod svakog raspoređivanja. U vezi s općom cilindričnom formom, predviđa se da dno koje zatvara posudu na donjoj strani, longitudinalno suprotstavljeno pregradi koja je lomljiva, bude izrađeno od čvrste kapsule koja je fiksirana nepropusna na cilindričnu pregradu poslije punjenja posude. According to other characteristics of the invention, the bottle has a mostly cylindrical shape, or at least almost so (mostly the right section is round or oblong) and the lateral cylindrical partition is elastic and can change shape by hand pressure, over the whole or part of the surface, in order to provide the necessary additional pressure when expelling liquid at each deployment. In connection with the general cylindrical form, it is envisaged that the bottom which closes the container on the lower side, longitudinally opposed to the partition which is fragile, will be made of a solid capsule which is fixed impermeable to the cylindrical partition after filling the container.
Ovdje ćemo se dalje baviti u okviru takovih načina realizacije izuma pogodnim za boce za oftalmološke kapljice, da bismo kompletirali opis karakteristika izuma i njegovih prednosti. Tim povodom podvući ćemo, promatrajući takovu bocu u normalnim uvjetima rada, da prisustvo tampon odjeljka između lomljive pregrade i hidrofilne/hidrofobne membrane igra veoma važnu ulogu u očuvanju čistoće proizvoda. Here we will continue to deal with such ways of realizing the invention suitable for bottles for ophthalmic drops, in order to complete the description of the characteristics of the invention and its advantages. On this occasion, we will underline, observing such a bottle under normal operating conditions, that the presence of a buffer section between the fragile partition and the hydrophilic/hydrophobic membrane plays a very important role in preserving the purity of the product.
Korištenje membrane sa hidrofilnim/hidrofobnim karakteristikama omogućuje uporabu elastične posude koja se vraća u prvobitni oblik poslije svake operacije raspoređivanja povlačenjem zraka koji zamjenjuje raspoređenu tekućinu, jer je ovaj zrak postao sterilan zahvaljujući anti-mikrobnim karakteristikama membrane i tekućina koja se nalazi u posudi na taj je način sačuvana od bilo kakvog zagađenja. Ovo omogućuje da se odstrani mjehur budući da je posuda iz jednog komada, koji je uglavnom cilindričan tako da mogu na njega stati svi korisni natpisi. The use of a membrane with hydrophilic/hydrophobic characteristics enables the use of an elastic vessel that returns to its original shape after each deployment operation by drawing air that replaces the deployed liquid, because this air has become sterile thanks to the anti-microbial characteristics of the membrane and the liquid contained in the vessel is way preserved from any pollution. This allows the bladder to be removed since the vessel is in one piece, which is generally cylindrical so that all useful inscriptions can fit on it.
Izum omogućuje da se smanji broj sastavnih elemenata boce, a rezultat je znatno smanjenje troškova proizvodnje. Osim toga, ova struktura omogućuje da se mijenja sadržaj boce kako bi se prilagodila raznim primjenama uz jako malo povećanje investicije. The invention makes it possible to reduce the number of constituent elements of the bottle, and the result is a significant reduction in production costs. In addition, this structure allows the content of the bottle to be changed to adapt to various applications with very little increase in investment.
Činjenica da se predviđa lomljiva pregrada koja je vezana s posudom omogućuje da se upotrijebi vrh za raspoređivanje koji će, kod proizvodnje boce, biti postavljen u grlo na vrhu posude, neovisno o punjenju, koje će se, nasuprot tome, obaviti odozdol. Na taj način, isto tako, sama će proizvodnja posude biti lakša i obavljena lijevanjem samo jednog komada koji obuhvaća cilindričnu pregradu, grlo i lomljivu pregradu, tako što će ova transverzalna srednja pregrada biti dostupna sa obadvije strane. Iz toga, između ostalog, proizlazi smanjenje broja sastavnih elemenata boce jer je eliminiran dvostruki omotač posude kojega su sačinjavali mjehur sa volumenom koja je promjenljiva plastičnom deformacijom njegove pregrade i vanjski čvrsti vrh boca kakve su bile u poznatoj tehnici. The fact that a frangible partition is provided which is connected to the container makes it possible to use a deployment tip which, in the production of the bottle, will be placed in the throat at the top of the container, independently of the filling, which will, on the contrary, be done from below. In this way, also, the production of the container itself will be easier and done by casting only one piece that includes the cylindrical partition, the throat and the frangible partition, so that this transverse middle partition will be accessible from both sides. This results in, among other things, a reduction in the number of constituent elements of the bottle, as the double envelope of the container, which was made up of a bladder with a volume that can be changed by plastic deformation of its partition, and the outer solid top of the bottles, as they were in the known technique, were eliminated.
Još jedna prednost boce prema izumu je u činjenici da, s izuzetkom donje kapsule, elementi mogu biti potpuno sklopljeni u tvornici prije slanja proizvođaču koji može koristiti običan stroj za punjenje u radionici koja je automatizirana. Za punjenja, boce se, tada, postavljaju s vrhom na dolje, izolacija tekućine u odnosu na membranu je u potpunosti osigurana lomljivom pregradom. Dovoljno je, zatim, zatvoriti dno boce dok je ona još s vrhom na dolje. Ovo se zatvaranje obavlja fiksiranjem kapsule sa dna, o kojoj smo već govorili, nepropusno fiksiranje vrši se poznatom tehnikom, primjenjujući, na primjer, zavarivanje, lijepljenje i/ili zatvaranje zaporcem. Može se, isto tako, obaviti, u drugoj varijanti, ljepljenjem mekane pregrade posude rubom na rub po promjeru transverzalnog presjeka. Another advantage of the bottle according to the invention is the fact that, with the exception of the lower capsule, the elements can be completely assembled in the factory before being sent to the manufacturer who can use an ordinary filling machine in a workshop that is automated. For filling, the bottles are then placed upside down, the isolation of the liquid in relation to the membrane is completely ensured by a breakable partition. It is enough, then, to close the bottom of the bottle while it is still upside down. This closure is done by fixing the capsule from the bottom, which we have already talked about, the leakproof fixing is done by a known technique, applying, for example, welding, gluing and/or sealing with a seal. It can also be done, in another variant, by gluing the soft partition of the container edge to edge along the diameter of the cross section.
Prema drugoj karakteristici izuma spomenuti vrh za raspoređivanje montiran je pokretan s aksijalnim pomicanjem klizanjem u čvrstom grlu posude sa pregradom koja se elastično deformira između dva razna longitudinalna položaja u unutrašnjosti navedenog grla, podrazumijevajući navedeni položaj sigurnosti u kojem je veza između posude i spomenutog kanala preko spomenute membrane neprobojno zatvorena i spomenuti položaj raspoloživosti ili spomenuta veza postala slobodna uništenjem lomljive pregrade. U kombinaciji s ovakovim rasporedom, vrh raspoređivanja korisno je osiguran, na svom donjem dijelu, jednim šiljkom sposobnim da slomi ili potrga spomenutu pregradu prilikom prvog korištenja posude uz pritiskanje spomenutog vrha u spomenuto grlo posude, longitudinalnim pomicanjem. According to another characteristic of the invention, the said tip for deployment is mounted movable with axial movement by sliding in the solid neck of the container with a partition which elastically deforms between two different longitudinal positions inside the said neck, implying the said position of safety in which the connection between the container and the said channel is via the mentioned membrane impenetrably closed and said position of availability or said connection became free by destroying the frangible barrier. In combination with this arrangement, the deployment tip is usefully provided, on its lower part, with a single spike capable of breaking or tearing the said partition during the first use of the container by pressing the said tip into the said neck of the container, by longitudinal movement.
Prema sekundarnim karakteristikama izuma pomicanje ili utiskivanje vrha raspoređivanja može biti uspješno obavljeno, na način koji je poznat, pomoću zatvarača koji je zavrnut na čvrsto grlo posude. According to the secondary characteristics of the invention, the displacement or pressing of the top of the arrangement can be successfully carried out, in a known manner, by means of a closure which is screwed onto the solid neck of the container.
S druge strane, najbolje je da lomljiva pregrada bude tako konstruirana da pomaže kontrolu uvjeta raspoređivanja tekućine van posude, na primjer kad bude probušena da oslobađa jedan dio prolaska tekućine koji odgovara najmanje četvrtini aktivne površine hidrofilne/hidrofobne pregrade. On the other hand, it is best for the frangible barrier to be designed to help control the liquid distribution conditions outside the vessel, for example when it is perforated to release a portion of the liquid passage corresponding to at least a quarter of the active area of the hydrophilic/hydrophobic barrier.
Da bi bila lomljiva pregrada ima više oslabljenih crta, ili perforiranih crta, koje su usmjerene radijalno i raspoređene u obliku zvijezde, u pravilnom kružnom rasporedu, u jednakim kutnim intervalima. U kombinaciji sa ovim rasporedom, ali, eventualno, odvojeno, šiljak je konstruiran po mogućnosti uz poštovanje geometrije, sa simetrijom obrtaja. Na se taj način može ostvariti u obliku više radijalnih, trokutastih krilaca pravilno raspoređenih oko longitudinalne osi boce. Broj crta prethodno urezanih na pregradi onda je različit od broja krilaca šiljka. Ovim rasporedom izbjegava se da se krilca prethodno urezanih crta nađu u vezi jedna sa drugom, što garantira otvaranje posude uklanjanjem pokidanih obloga pregradnog zida. In order to be fragile, the partition has several weakened lines, or perforated lines, which are directed radially and arranged in the shape of a star, in a regular circular arrangement, at equal angular intervals. In combination with this arrangement, but possibly separately, the spike is constructed preferably with respect to geometry, with rotational symmetry. In this way, it can be realized in the form of several radial, triangular wings regularly distributed around the longitudinal axis of the bottle. The number of lines previously engraved on the partition is then different from the number of spike wings. This arrangement avoids that the wings of the previously incised lines are in relation to each other, which guarantees the opening of the container by removing the torn coverings of the partition wall.
Prema jednoj drugoj karakteristici izuma boca ima jedan prsten nepovredivosti koji se nalazi između unutarnjeg dijela vrha za raspoređivanje i gornjeg dijela grla posude kada je vrh raspoređivanja u sigurnom položaju. Činjenica da je stavljen taj prsten nepovredivosti između vrha raspoređivanja i grla posude omogućuje da se postigne dobar položaj vrha raspoređivanja u grlu u sigurnom položaju izbjegavajući svaki rizik bušenja lomljivog pregradnog zida prilikom montaže boce. Visina prstena određuje kretanje vrha raspoređivanja prilikom utiskivanja kod prve uporabe. Poslije uklanjanja ovog prstena, vrh se raspoređivanja pomiče vrlo precizno do položaja nazvanog raspoloživost gdje pregrada postaje otvorena za prolazak tekućine. According to another feature of the invention, the bottle has a tamper-evident ring located between the inner part of the dispensing tip and the upper part of the container neck when the dispensing tip is in the secure position. The fact that this safety ring is placed between the tip of the deployment and the neck of the container allows to achieve a good position of the tip of the deployment in the neck in a safe position avoiding any risk of puncturing the fragile partition wall when mounting the bottle. The height of the ring determines the movement of the placement tip when pressing in for the first time. After removing this ring, the top of the deployment moves very precisely to a position called availability where the partition becomes open for the passage of liquid.
Po jednoj varijanti realizacije prsten nepovredivosti montiran je pomoću lomljivih poklopaca zatvarača koji je zavrnut kao zaštita naglavka za raspoređivanje. Takav prsten može ostati fiksiran na tijelu boce poslije lomljenja spomenutih poklopaca kada, prilikom prve uporabe, korisnik pritisne zatvarač da ga odvije. According to one variant of the implementation, the inviolability ring is mounted by means of frangible shutter covers which are screwed as protection of the deployment head. Such a ring can remain fixed on the body of the bottle after breaking the mentioned caps when, during the first use, the user presses the cap to unscrew it.
Ovo je rješenje za prstenove nepovredivosti posebice povoljno u kombinaciji s drugim karakteristikama načina izvođenja uređaja izuma kojem se daje prednost, koji se posebno sastoji od načina koji upravljaju pomicanjem vrha raspoređivanja u aksijalnom kretanju u grlu boce rotacijom zaštitnog zatvarača prilikom odvijanja, a ovo pokretanje automatski provocira otvaranje lomljive pregrade kako bi se povezalo unutarnji volumen boce sa kanalom za izbacivanje vrha raspoređivanja pomoću jednog tampon odjeljka u unutrašnjosti kapsule koja čini unutarnje tijelo vrha raspoređivanja. This solution for the rings of inviolability is particularly advantageous in combination with other characteristics of the preferred embodiment of the device of the invention, which in particular consists of means that control the movement of the tip of the arrangement in an axial movement in the neck of the bottle by the rotation of the protective closure during unfolding, and this movement automatically provokes opening the frangible partition to connect the internal volume of the bottle to the ejection channel of the deployment tip by means of a buffer compartment in the interior of the capsule forming the inner body of the deployment tip.
Izum će sada biti kompletnije opisan u okviru preporučljivih karakteristika i njihovih prednosti, pozivajući se na slike 1 do 5 na kojima: The invention will now be more fully described within the framework of the recommended features and their advantages, with reference to Figures 1 to 5 in which:
slika 1 predstavlja aksijalni presjek boce prema izumu u kojoj je vrh raspoređivanja u sigurnosnom položaju; figure 1 represents an axial section of the bottle according to the invention in which the tip of the arrangement is in the safety position;
slika 2 je aksijalni presjek koji predstavlja posudu i unutrašnjost vrha raspoređivanja u položaju raspoloživosti; Fig. 2 is an axial section showing the container and interior of the deployment tip in the availability position;
slika 3 je presjek prema crti III-III slike 1; Fig. 3 is a section according to the line III-III of Fig. 1;
slika 4 je prikaz u perspektivi koji pokazuje gornji dio unutarnjeg tijela vrha raspoređivanja s vrškom; Fig. 4 is a perspective view showing the upper part of the inner body of the tip arrangement with the tip;
slika 5 je djelomičan prikaz aksijalnog presjeka koji predstavlja vrh raspoređivanja prije sklapanja, Figure 5 is a partial axial cross-sectional view showing the top of the deployment prior to assembly,
slika 6 ilustrira aksijalni presjek drugog preporučenog načina realizacije izuma Figure 6 illustrates an axial section of another recommended embodiment of the invention
Na slikama je prikazan primjer realizacije boce prema izumu, takve kakva je osmišljena, primjer izuma u radu koji se posebice preporučuje za čuvanje farmaceutskih tekućina koje se trebaju raspoređivati kap po kap, a naročito vodene oftalmološke otopine. The pictures show an example of the realization of the bottle according to the invention, as it was designed, an example of the invention in work, which is particularly recommended for storing pharmaceutical liquids that need to be dispensed drop by drop, especially aqueous ophthalmic solutions.
Da bi primila tekućinu boca ima jednu posudu 1 uglavnom cilindričnog oblika, s vertikalnom longitudinalnom osi na slikama 1 i 2, koja je zatvorena na donjoj strani kapsulom za dno 2 i koja se produžuje na gornjoj strani grlom 3 u koje je smješten vrh raspoređivanja 4, koji je montiran pokretan pomicanjem po longitudinalnoj osi. Sve zajedno je kompletirano jednim zatvaračem 5 koji je zavrnut na grlo 3 posude. To receive the liquid, the bottle has a container 1 of generally cylindrical shape, with a vertical longitudinal axis in figures 1 and 2, which is closed on the lower side by a capsule for the bottom 2 and which is extended on the upper side by a neck 3 in which the top of the arrangement 4 is placed, which is mounted moving along the longitudinal axis. Everything together is completed with one closure 5 which is screwed onto the neck 3 of the container.
U cijelom cilindričnom lateralnom dijelu susjedna pregrada 6 posuda 1 je savitljiva, s elastičnom deformacijom, tako da omogućuje privremeno smanjenje unutarnjeg volumena posude kad se pritisne na tu pregradu, a oslobađanje manuelnog pritiska ima tendenciju da vrati unutarnji volumen posude na vrijednost u stanju mirovanja elastičnim vraćanjem pregrade na prvobitnu cilindričnu formu. Nasuprot tome, kapsula 2 i grlo 3 su kruti. Throughout the cylindrical lateral part, the adjacent partition 6 of the vessel 1 is flexible, with elastic deformation, so that it allows a temporary reduction of the internal volume of the vessel when pressure is applied to that partition, and the release of manual pressure tends to return the internal volume of the vessel to its resting value by elastic recovery partitions to the original cylindrical form. In contrast, capsule 2 and throat 3 are rigid.
Posuda 1 ima, s druge strane, jednu poprečnu radijalnu pregradu 7, uspravno na svoju longitudinalnu os 8, koja se nalazi na donjoj strani grla 3. Ova središnja pregrada je zamišljena, kako će u daljem tekstu biti opisano, da se automatski potrga prilikom prve uporabe boce za raspoređivanje kapi i na taj način stvori otvor u posudi 1 poviše grla 3. The container 1 has, on the other hand, one transverse radial partition 7, perpendicular to its longitudinal axis 8, which is located on the lower side of the throat 3. This central partition is designed, as will be described below, to tear automatically at the first of using a bottle to distribute the drops and in this way create an opening in the container 1 above the neck 3.
Vrh raspoređivača 4 napravljen je iz dva dijela uzajamno povezana jedan s drugim, tj. Unutarnje tijelo ili čahura 9, šupljeg prstenastog oblika i pokretno se pomičući aksijalno u grlu 3 i jedan naglavak 11 koji je pričvršćen za gornju površinu čahure 9 i koji je probušen kanalom 12 za izbacivanje tekućine iz boce. Nepropusnost čahure 9 na unutarnjoj pregradi grla 3 osigurana je pomoću tri vanjska prstenasta zadebljanja 13, tako da uvijek ima dva koja su aktivna za promočivost veze između čahure i grla posude. Na gornjoj strani čahura 9 ima jednu potporu 14 koja je namijenjena kao podrška na vanjskoj površini 15 grla 3 kad je vrh raspoređivanja 4 u položaju raspoloživosti kako je to prikazano na slici 2. Na gornjoj površini potpore 14 je postavljen prstenasti otvor 16 u koji se postavlja donja prirubnica 17 naglavka 11 (slika 5). The top of the distributor 4 is made of two parts mutually connected to each other, i.e. the inner body or sleeve 9, hollow ring-shaped and movably moving axially in the throat 3 and a head 11 which is attached to the upper surface of the sleeve 9 and which is pierced with a channel 12 to eject the liquid from the bottle. The impermeability of the sleeve 9 on the inner partition of the neck 3 is ensured by means of three external annular thickenings 13, so that there are always two which are active for the permeability of the connection between the sleeve and the neck of the container. On the upper side, the sleeve 9 has one support 14, which is intended as a support on the outer surface 15 of the throat 3 when the top of the arrangement 4 is in the available position as shown in figure 2. On the upper surface of the support 14, an annular opening 16 is placed in which it is placed lower flange 17 of head 11 (picture 5).
Na svom donjem dijelu čahura 9 ima jedan šiljak 18 (vidjeti slike 4 i 5) čija je funkcija da osigura otvaranje pregrade 7 njenim definitivnim lomljenjem prilikom prve uporabe. Ovaj je šiljak napravljen u obliku četiri radijalna krilca 19, trokutastog oblika, postavljena pod pravim kutom jedan prema drugom, koji su povezani među sobom u osovini boce i svaki na donjem dijelu 21 čahure 9. U sigurnosnom položaju prikazanom na slici 1 jedna prstenasta karika 22 ubačena je između gornje površine 15 grla 3 i donje površine potpore 14 čahure 9. Ova karika igra klasičnu ulogu nepovredivosti. Ona je povezana s jednim od dva dijela, ovdje sa grlom 3 takvog oblika da ju je lako ukloniti trgajući je ili razbijajući prilikom prve uporabe boce. U praksi, ona je nastala lijevanjem sa posudom 1 i njezinim grlom 2. On its lower part, the sleeve 9 has one spike 18 (see pictures 4 and 5) whose function is to ensure the opening of the partition 7 by its definite breaking during the first use. This spike is made in the form of four radial wings 19, triangular in shape, placed at right angles to each other, which are connected to each other in the axis of the bottle and each on the lower part 21 of the sleeve 9. In the safety position shown in Figure 1, one ring link 22 it is inserted between the upper surface 15 of the throat 3 and the lower support surface 14 of the sleeve 9. This link plays a classic role of invulnerability. It is connected to one of the two parts, here with the neck 3 of such a shape that it is easy to remove by tearing or breaking it during the first use of the bottle. In practice, it was created by casting with the vessel 1 and its neck 2.
Zatvarač 5 ima jedan centralni pijun 23 koji lako ulazi u prošireni kraj kanala za izbacivanje 12, prstenastu krunu 24 koja ga vodi centriranjem na vanjsku površinu kupolastog produžetka 24 baze 26 naglavka 11 i drugu prstenastu krunu 27, većeg promjera koja se oslanja na vanjsku površinu baze 26. Zatvarač 5 ima unutarnji spiralni navoj 28 koji je u vezi sa spiralnim navojem 29 grla 3. The shutter 5 has one central pin 23 which easily enters the widened end of the ejection channel 12, an annular crown 24 which guides it by centering it on the outer surface of the domed extension 24 of the base 26 of the cap 11 and another annular crown 27, of a larger diameter, which rests on the outer surface of the base 26. The shutter 5 has an internal spiral thread 28 which is connected to the spiral thread 29 of the neck 3.
U skladu s izumom, i kako se može vidjeti posebice na slici 5, membrana 31 je umetnuta na put tekućini koja se izbacuje iz posude 1, preko vrha raspoređivanja kap po kap 4. Ona je postavljena i drži se na svojoj obodnici između čahure 9 i naglavka 11, točnije između gornje površine potpore 14 i donje površine baze 26 naglavka. In accordance with the invention, and as can be seen in particular in Figure 5, a membrane 31 is inserted in the path of the liquid ejected from the container 1, over the tip of the drop-by-drop distribution 4. It is placed and held on its circumference between the sleeve 9 and head 11, more precisely between the upper surface of the support 14 and the lower surface of the base 26 of the head.
Donja površina baze 26 naglavka 11 ima jednu kružnu centralnu posudu 32 čiji je promjer veći od unutarnjeg promjera čahure 9 i u koju ulazi donji dio kanala za izbacivanje 12. Na taj način membrana 31 je fiksirana samo na svojoj periferiji između čahure 9 i naglavka 11 i velikom većinom svoje površine slobodna je i dostupna za protok vode u prostoru koji odgovara unutrašnjosti čahure 9. The lower surface of the base 26 of the nozzle 11 has one circular central container 32 whose diameter is greater than the inner diameter of the sleeve 9 and into which the lower part of the ejection channel 12 enters. In this way, the membrane 31 is fixed only on its periphery between the sleeve 9 and the nozzle 11 and a large most of its surface is free and available for the flow of water in the space corresponding to the interior of the sleeve 9.
U skladu s izumom ova membrana 31 ima, prije svega, anti-mikrobne osobine koje omogućuju filtriranje bakterija i garantiraju da je tekućina koja se nalazi u posudi sterilna. Između ostalog, ova membrana je istovremeno hidrofilna i hidrofobna tako da ona omogućuje istodobno izlazak oftamološke tekućine van posude, povratak suvišne izbačene tekućine po raspoređivanju kapi i povratak zraka u posudu da bi se kompenzirao volumen tekućine koja je raspoređena u obliku kapi. According to the invention, this membrane 31 has, first of all, anti-microbial properties that allow bacteria to be filtered and guarantee that the liquid in the container is sterile. Among other things, this membrane is simultaneously hydrophilic and hydrophobic, so that it allows the simultaneous exit of the ophthalmic fluid out of the container, the return of the excess liquid expelled after the distribution of the drops, and the return of air into the container to compensate for the volume of the liquid that is distributed in the form of drops.
Vrh raspoređivanja izrađuje se na slijedeći način. Najprije se napravi odvojeno naglavak 11 i čahura 9. Fiksira se membrana 31 u donjem dijelu naglavka 11 obavljajući periferno zavarivanje pomoću ultrazvuka ili visokih frekvencija. Membrana 31 potom je zaštićena prirubnicom 17 da bi se izbjeglo da bude oštećena prilikom rukovanja naglavkom 11. Komplet naglavka 11 i membrane 31 potom je fiksiran, prirubnica 17 naglavka 11 smješta se u otvor 16 čahure 9. Ova veza postaje nepropusna, na primjer zavarivanjem ultrazvukom ili termičkom fuzijom. Tada se dobiva kompletan vrh raspoređivanja 4 koji će, zatim, biti ubačen odozgor, u grlo 3 posude 1. The top of the deployment is made in the following way. First, the head 11 and the sleeve 9 are made separately. The membrane 31 is fixed in the lower part of the head 11 by peripheral welding using ultrasound or high frequencies. The membrane 31 is then protected by a flange 17 to avoid being damaged when handling the head 11. The assembly of the head 11 and the membrane 31 is then fixed, the flange 17 of the head 11 is placed in the opening 16 of the sleeve 9. This connection is made leak-proof, for example by ultrasonic welding or thermal fusion. Then a complete arrangement tip 4 is obtained, which will then be inserted from above, into the throat 3 of the container 1.
Kao što se može vidjeti na slici 3, gdje prepoznajemo gornji dio pregrade 6, grlo 3 i pregradni zid 7 ovo posljednje je oslabljeno u centralnom dijelu sa šest crta oslabljenja ili crta prethodno perforiranih 33, koje su raspoređene radijalno i pravilno raspoređene na razmaku pod kutom od 60 stupnjeva. Na taj način, kada se vrši pritisak na centar pregradnog zida 7, on se trga po linijama 33 i time se ostvaruje u centru prolaz za tekućinu koja se nalazi u posudi. As can be seen in Figure 3, where we recognize the upper part of the partition 6, the throat 3 and the partition wall 7, the latter is weakened in the central part by six lines of weakening or lines of pre-perforation 33, which are distributed radially and regularly spaced at an angle of 60 degrees. In this way, when pressure is exerted on the center of the partition wall 7, it tears along the lines 33 and thus a passage for the liquid in the container is realized in the center.
U tu svrhu čahura 9 ima, na svom gornjem dijelu, jedan šiljak koji se sastoji od četiri radijalna trokutasta krilca 19 čiji donji krajevi određuju vršak 34 koji udara centar pregradnog zida 7 kad se vrh raspoređivanja 4 pomiče prema dolje. Kao što se može vidjeti na slikama, šiljak 18 opisanog primjera ima četiri krilca dok pregradni zid 7 ima šest crta trganja. Ovaj različiti broj, odakle proizlazi različito periodično ponavljanje raspoređivanja u simetriji obrtanja, osigurava da se krilca ne mogu nikada sva podudariti sa crtama trganja i da, zbog toga, ne postoji rizik da krilca dođu u prostor koji ostave trganja i zatvore prolazak tekućini. For this purpose, the sleeve 9 has, on its upper part, a spike consisting of four radial triangular wings 19 whose lower ends define a tip 34 that strikes the center of the partition wall 7 when the tip of the arrangement 4 moves downwards. As can be seen in the figures, the spike 18 of the described example has four wings while the partition wall 7 has six tear lines. This different number, from which comes the different periodic repetition of the arrangement in rotational symmetry, ensures that the vanes can never all coincide with the tear lines and that, therefore, there is no risk of the vanes coming into the space that leaves the tears and closes the passage of the liquid.
Proizvodnja boce prema izumu jako je pojednostavljena jer cijela posuda, to znači lateralna pregrada 6, grlo 3 zajedno s prstenom nepovredivosti 22 i pregradnim zidom 7 napravljeni su u jednom komadu postupkom uštrcavanja ili ekstruzije sintetičkog materijala. Radi se, na primjer, o polietilenu pod visokim ili niskim tlakom, ali se može upotrijebiti i svaki drugi polimer ili sastav koji predstavlja dovoljnu prepreku za vodenu paru kao i dovoljnu savitljivost (u ovisnosti o prilagođenoj debljini) da bi se osigurala funkcija tlaka koji cilindrična pregrada treba obaviti. Ova proizvodnja lijevanjem iz jednog dijela olakšana je činjenicom da je lomljivi transverzalni pregradni zid na cilindričnoj pregradi dostupan sa obadvije strane kad nema dna. The production of the bottle according to the invention is greatly simplified because the entire container, that means the lateral partition 6, the neck 3 together with the inviolability ring 22 and the partition wall 7, are made in one piece by the process of injection or extrusion of synthetic material. This is, for example, polyethylene under high or low pressure, but any other polymer or composition can be used that presents a sufficient barrier to water vapor as well as sufficient flexibility (depending on the adapted thickness) to ensure the pressure function that cylindrical partition needs to be done. This one-piece casting production is facilitated by the fact that the frangible transverse bulkhead on the cylindrical bulkhead is accessible from both sides when there is no bottom.
Naglavak i čahura vrha raspoređivanja rade se posebno, zatim se membrana fiksira u unutrašnjosti koritašca 32 zavarivanjem pomoću ultrazvuka ili visokih frekvencija. Komplet naglavka i membrane zatim se stavlja na čahuru, prirubnica 17 stavlja se u udubljenje 16 čahure. Naglavak i čahura potom se spajaju da bi bili nepropusni, na primjer varenjem, tako da čine vrh raspoređivanja 4. The cap and sleeve of the deployment tip are made separately, then the membrane is fixed inside the trough 32 by welding using ultrasound or high frequencies. The head and membrane assembly is then placed on the sleeve, the flange 17 is placed in the recess 16 of the sleeve. The cap and sleeve are then joined together to make them leak-proof, for example by welding, to form the top of the arrangement 4.
Vrh raspoređivanja 4 se, zatim, uvlači u grlo 3 sve dok ne upre u prsten nepovredivosti u sigurnosnom položaju gdje se šiljak 18 nalazi malo iznad pregradnog zida 7, kako se to vidi na slici 1. Tada se može zavrnuti zatvarač 5 na grlu 3 sve dok ne upre na podlogu 26 naglavka 11. The tip of the deployment 4 is then inserted into the throat 3 until it points to the ring of inviolability in the safety position where the spike 18 is located slightly above the partition wall 7, as can be seen in Figure 1. Then the fastener 5 can be screwed on the throat 3 all until it points to the base 26 of heading 11.
Tako dobiveni komplet i kapsula sa dna 2 mogu biti poslani proizvođaču farmaceutskih proizvoda koji komercijalizira tekućinu koja se raspoređuje, a koji može postaviti boce u položaj sa vrhom na dolje u stroj za punjenje poznatog tipa gdje će se posuda napuniti, bez rizika od kontakta sa membranom 31, zahvaljujući prisustvu pregradnog zida 7. Kada se boca napuni, fiksira se kapsula za zatvaranje dna 2 na podlogu pregrade 6, tako da bude nepropusno, na primjer zavarivanjem i boca ispunjena tekućinom onda je spremna za komercijalizaciju. The kit and capsule from bottom 2 thus obtained can be sent to a pharmaceutical manufacturer commercializing the liquid to be dispensed, who can place the bottles in an upside-down position in a filling machine of a known type where the container will be filled, without risk of contact with the membrane 31, thanks to the presence of the partition wall 7. When the bottle is filled, the capsule for closing the bottom 2 is fixed on the base of the partition 6, so that it is impervious, for example by welding, and the bottle filled with liquid is then ready for commercialization.
Prilikom prve uporabe dovoljno je odviti zatvarač 5, skinuti prsten nepovrijedivosti 22 i ponovo zaviti zatvarač 5 na grlu 3. Ova radnja zavijanja omogućuje da se utisne vrh raspoređivanja 4 dok ne dođe u položaj raspoloživosti koji je prikazan na slici 2 poslije čega šiljak 18 provocira trganje pregrade 7 po crtama koje su prethodno narezane 33. Trokutasti otkinuti dijelovi pregrade 7 odstranjeni su krilcima šiljka 18 tako da se dobije prolaz za tekućinu koja se nalazi u posudi 1 odgovarajuće najmanje 3/4 slobodne površine membrane 31. Centralni dio 34 šiljka 18 omogućuje da se izbjegne direktan mlaz tekućine na membranu 31. At the first use, it is sufficient to unscrew the closure 5, remove the inviolability ring 22 and screw the closure 5 again on the neck 3. This act of twisting allows the deployment tip 4 to be pressed until it reaches the position of availability shown in figure 2, after which the spike 18 provokes a tear. partitions 7 according to the lines that were previously cut 33. The triangular torn-off parts of the partition 7 are removed by the wings of the spike 18 so that a passage for the liquid located in the vessel 1 corresponding to at least 3/4 of the free surface of the membrane 31 is obtained. The central part 34 of the spike 18 enables a direct jet of liquid onto the membrane 31 is avoided.
Prilikom svake uporabe, pritišće se na pregradu 6 posude 1, a boca je postavljena sa vrhom na dolje da bi se postiglo izbacivanje jedne ili više kapi iz kanala 12. Kad se oslobodi pritisak na pregradu 6, višak tekućine koji je izbačen van membrane 31 ponovo je usisan u bocu zahvaljujući porama s hidrofilnim osobinama membrane 31. Uostalom, samim tim što je tekućina ovlažila ovu membranu, njene pore s hidrofobnim osobinama propuštaju zrak koji zamjenjuje tekućinu koja je izbačena u obliku kapi. Budući da membrana 31 ima anti-mikrobne osobine, ovo ponovno unošenje tekućine i zraka u posudu 1 obavlja se na sterilan način tako da se tekućina koja se nalazi u posudi može koristiti duže vrijeme a da se pritom ne zagadi. At each use, pressure is applied to the partition 6 of the container 1, and the bottle is placed upside down to achieve the ejection of one or more drops from the channel 12. When the pressure on the partition 6 is released, the excess liquid that has been ejected outside the membrane 31 again is sucked into the bottle thanks to the pores with hydrophilic properties of the membrane 31. After all, by the very fact that the liquid moistened this membrane, its pores with hydrophobic properties allow air to pass through, which replaces the liquid that was ejected in the form of a drop. Since the membrane 31 has anti-microbial properties, this reintroduction of liquid and air into the container 1 is performed in a sterile manner so that the liquid contained in the container can be used for a long time without becoming contaminated.
Membrana se može napraviti na poznat način od jednog polimernog materijala (na bazi, na primjer, poliamidnih smola, fluoriranog polivinila, polieter sulfona itd.) čiji mu sastav daje hidrofilnu osobinu i koji je postao hidrofoban izmjenom sastava samo na jednom slobodnom dijelu. Izmjena o kojoj je riječ vrši se na klasičan način kalemljenjem uz prisustvo inicijatora radikalskih reakcija. The membrane can be made in a known manner from one polymer material (based on, for example, polyamide resins, fluorinated polyvinyl, polyether sulfone, etc.) whose composition gives it a hydrophilic property and which has become hydrophobic by changing the composition only on one free part. The modification in question is carried out in the classic way by grafting with the presence of radical reaction initiators.
Prednost je postupka koji se obavlja da napravi membranu hidrofobnom po dijametralnoj traci koja pokriva 20 do 50% njene površine koju vlaži tekućina koja se izbacuje. Kao primjer tako je korištena membrana na bazi poliamidnih smola s promjerom pora od 0,2 mikrona. Prema jednom drugom primjeru, za istu propusnu moć promatrane tekuće otopine korištena je membrana polieterskih sulfon smola s promjerom pora smanjenim na 0,1 mikron, što omogućuje da se poboljša anti-mikrobno filtriranje zaustavljanjem najpokretljivijih bakterija koje se deformiraju. The advantage of the procedure is that it makes the membrane hydrophobic in a diametrical strip that covers 20 to 50% of its surface, which is wetted by the ejected liquid. As an example, a membrane based on polyamide resins with a pore diameter of 0.2 microns was used. According to another example, for the same permeability of the observed liquid solution, a membrane of polyether sulfone resins with a pore diameter reduced to 0.1 micron was used, which allows to improve the anti-microbial filtration by stopping the most mobile and deforming bacteria.
Sada ćemo se pozvati na sliku 6 koja prikazuje jednu varijantu realizacije uređaja prema izumu koja ima prednost u odnosu na prethodne, time što olakšava potrošaču uporabu boce. U stvari, dijelovi na vrhu boce tako su konstruirani da, što se tiče prve uporabe, korisnik odvija kapicu ili zatvarač 5, počinje time što izaziva trganje pločica 41 koje drže prsten nepovredivosti 42, a zatim izaziva bušenje srednje pregrade 43 šiljkom 44. Kad nastavi odvijati kapicu 5, potpuno je oslobađa izvan naglavka za raspoređivanje 11. We will now refer to figure 6, which shows one embodiment of the device according to the invention, which has an advantage over the previous ones, by making it easier for the consumer to use the bottle. In fact, the parts on the top of the bottle are so constructed that, as for the first use, the user unscrews the cap or the closure 5, first by causing the tearing of the plates 41 that hold the inviolability ring 42, and then causing the middle partition 43 to be pierced by the spike 44. When he continues unscrew the cap 5, it completely frees it from the deployment head 11.
Na slici se vidi rampa 45 koja je smještena u tu svrhu u unutrašnjost vrha za raspoređivanje i podržava čahuru koja predstavlja njeno unutarnje tijelo 46 sa internim elementima grla 47 boce. Ova rampa je s obrnutom mrežicom i većim padom u odnosu na mrežicu za zavijanje zatvarača 5. Ona stupa u akciju kad čahuru pokrene zatvarač prilikom njegovog odvijanja. The picture shows the ramp 45 which is placed for this purpose inside the top for deployment and supports the sleeve which represents its inner body 46 with the internal elements of the neck 47 of the bottle. This ramp has an inverted mesh and a higher drop compared to the shutter winding mesh 5. It comes into action when the sleeve is triggered by the shutter during its unfolding.
U položaju prikazanom na slici čahura 46 još je u visokom položaju. Ona formira oko šiljka 44 jednu krunu 48 koja predstavlja ispupčenja 51 koja se uklapaju na traku za oblaganje 52 predviđenu na ispustu tijela boce, na unutarnjoj pregradi lijevka 49 koji formira oko pregrade 43. In the position shown in the picture, the sleeve 46 is still in the high position. It forms around the spike 44 a crown 48 which represents protrusions 51 that fit on the lining strip 52 provided at the outlet of the bottle body, on the inner partition of the funnel 49 which forms around the partition 43.
U dijelu koji se povezuje s jedne strane s navojem zatvarača 5 sa vanjske strane, s druge strane s unutarnjom čahurom 46 preko rampe 45 s unutarnje strane, tijelo boce formira dvije prstenaste krune između kojih se smješta vanjska 'suknjica' (»jupe«) 54 čahure, dok se unutarnja 'suknjica' (»jupe«) koja se završava krunom 48 postavlja u unutrašnjost unutarnje krune 55. Unutarnja kruna se, dakle, nalazi ubačena između dvije koaksijalne 'suknjice'(»jupe«) čahure. Na tom je nivou predviđena rampa 45. Ova rampa se kreće po polukrugu boce, što omogućuje da se dio čahure koji sudjeluje spoji s njom bilo kakav da je prvobitni položaj u rotaciji. In the part that is connected on one side with the thread of the closure 5 on the outside, on the other side with the inner sleeve 46 via the ramp 45 on the inside, the body of the bottle forms two ring crowns between which the outer 'skirt' ('skirt') 54 is placed. bushing, while the inner 'skirt' ("jupe") that ends with the crown 48 is placed inside the inner crown 55. The inner crown is, therefore, inserted between two coaxial "skirts" ("jupe") of the bushing. At this level, a ramp 45 is provided. This ramp moves around the semicircle of the bottle, which allows the part of the participating sleeve to be connected to it whatever the initial position is in rotation.
Slika 6 prikazuje druge detalje konstrukcije, naročito što se tiče nastavka koji se formira na 'suknjici' (»jupe«) 54 u spoju odbojnika s rubom zatvarača 5 i činjenice da je rotacija čahure u odnosu na grlo boce ograničena u jednom malom dijelu prisustvom žljebova na zadebljanju na 'suknjice' (»jupe«) 54. Figure 6 shows other details of the construction, especially regarding the extension formed on the skirt 54 at the junction of the bumper with the edge of the closure 5 and the fact that the rotation of the sleeve in relation to the neck of the bottle is limited in one small part by the presence of grooves on the thickening of 'skirts' (jupes) 54.
Na slici se isto tako vidi odjeljak tampona 56 koji je, kao i kod primjera realizacije ilustriranog na slikama 1 i 2, napravljen u unutrašnjosti čahure između dijela ulaza koji se formira od široko otvorenih dijelova oko šiljka 44 i hidrofilne/hidrofobne membrane na ulazu u distribucijski kanal naglavka. Šiljak 44 malo je drugačije sastavljen od šiljka 18 na slici 1. On formira vrh trokutastog presjeka kojega dovodi u položaj izvan osovine unutarnje 'suknjice' (»jupe«) čahure 46. The figure also shows the buffer section 56, which, as in the example embodiment illustrated in figures 1 and 2, is made inside the sleeve between the part of the entrance formed by the wide open parts around the spike 44 and the hydrophilic/hydrophobic membrane at the entrance to the distribution head channel. Spike 44 is assembled a little differently from spike 18 in Figure 1. It forms the tip of a triangular cross-section which brings it into position outside the axis of the inner 'skirt' ('skirt') of bushing 46.
Slika 6 prikazuje uporabu istog vrha za raspoređivanje i istog tijela boce u osnovi kako bi se dobila globalna boca manjeg sadržaja zahvaljujući ispupčenom dnu 57. U ovom slučaju kao i u drugom ovo je dno fiksno na boci jer je zavareno odozgo prilikom punjenja. Fig. 6 shows the use of the same dispensing tip and basically the same bottle body to obtain an overall bottle of smaller content thanks to the raised bottom 57. In this case as in the other this bottom is fixed on the bottle because it is welded from above during filling.
Može se, isto tako, primijetiti da u slučaju sa slike 6, za razliku od onog na slici 1, prsten nepovredivosti ostaje na mjestu na prstenu fiksiranom na tijelu boce na kojoj je montiran, ali je bez lomljivih pločica koje su ga fiksirale na finalni rub zatvarača 5. It can also be noted that in the case of Figure 6, unlike that of Figure 1, the inviolability ring remains in place on the ring fixed to the body of the bottle on which it is mounted, but is without the frangible plates that fixed it to the final edge shutter 5.
Iz prethodno iznijetog proizlazi da izum nije ograničen na načine uporabe koji su specifično opisani u gornjim primjerima, već naprotiv, on se proteže na sve razne varijante odgovarajućih načina. Naročito se može koristiti kao šiljak, centralni naglavak fiksiran na donjem dijelu čahure 9. It follows from the above that the invention is not limited to the ways of use that are specifically described in the above examples, but on the contrary, it extends to all the various variants of the corresponding ways. In particular, it can be used as a spike, the central head fixed on the lower part of the sleeve 9.
Uostalom, kapsula sa dna može se fiksirati na svaki način koji osigurava dovoljnu nepropusnost; može se, na primjer predvidjeti fiksiranje sa zapornicom. Može se, isto tako, riješiti te kapsule zatvarajući dno stezanjem cilindrične pregrade posude. After all, the capsule from the bottom can be fixed in any way that ensures sufficient impermeability; it is possible, for example, to provide for fixing with a bolt. It is also possible to get rid of the capsule by closing the bottom by tightening the cylindrical partition of the container.
Izum onako kako je gore opisan i ilustriran nije više ograničen u primjenama. Naročito je očigledno da uređaj koji ima membranu koja je svojim hidrofilnim svojstvom namijenjena da propušta vodenu tekućinu, može biti isto tako uporabljen za raspoređivanje otopine kap po kap u polarnoj otopini prije nego u vodi. The invention as described and illustrated above is no longer limited in applications. In particular, it is obvious that a device having a membrane which, by its hydrophilic property, is intended to allow an aqueous liquid to pass through, can also be used to distribute the solution drop by drop in a polar solution rather than in water.
Claims (11)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0015039A FR2816600B1 (en) | 2000-11-13 | 2000-11-13 | DISPENSING DEVICE FOR DROP FLUID LIQUIDS |
PCT/FR2001/003555 WO2002038464A1 (en) | 2000-11-13 | 2001-11-13 | Drip liquid dispenser |
Publications (2)
Publication Number | Publication Date |
---|---|
HRP20030475A2 true HRP20030475A2 (en) | 2005-04-30 |
HRP20030475B1 HRP20030475B1 (en) | 2011-03-31 |
Family
ID=8856732
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20030475A HRP20030475B1 (en) | 2000-11-13 | 2003-06-12 | Drip liquid dispenser |
Country Status (28)
Country | Link |
---|---|
US (1) | US20040074925A1 (en) |
EP (1) | EP1339616B1 (en) |
JP (1) | JP4159354B2 (en) |
KR (1) | KR100878215B1 (en) |
CN (1) | CN1251934C (en) |
AR (1) | AR031322A1 (en) |
AT (1) | ATE432890T1 (en) |
AU (1) | AU2002223064A1 (en) |
CA (1) | CA2428494C (en) |
CZ (1) | CZ296769B6 (en) |
DE (1) | DE60138910D1 (en) |
ES (1) | ES2328226T3 (en) |
FR (1) | FR2816600B1 (en) |
GT (1) | GT200100019U (en) |
HK (1) | HK1062429A1 (en) |
HR (1) | HRP20030475B1 (en) |
HU (1) | HU228559B1 (en) |
MY (1) | MY142758A (en) |
NO (1) | NO329819B1 (en) |
PA (1) | PA8532101A1 (en) |
PE (1) | PE20020488A1 (en) |
PL (1) | PL205278B1 (en) |
PT (1) | PT1339616E (en) |
RS (1) | RS50410B (en) |
RU (1) | RU2275316C2 (en) |
SK (1) | SK287352B6 (en) |
TN (1) | TNSN01159A1 (en) |
WO (1) | WO2002038464A1 (en) |
Families Citing this family (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10112332C1 (en) * | 2001-03-13 | 2002-08-29 | Stella Kunststofftechnik Gmbh | Drip cap for dosing liquid in drop form and container with drip cap |
JP3971329B2 (en) * | 2002-10-23 | 2007-09-05 | ロート製薬株式会社 | Nozzle structure of liquid container |
FR2862052B1 (en) * | 2003-11-10 | 2006-02-17 | Rexam Pharma | MICROFILTRANT MENBRANES LIQUID CONDITIONING AND DISPENSING ASSEMBLY |
EP1698317B1 (en) * | 2003-12-26 | 2013-05-22 | Santen Pharmaceutical Co., Ltd. | Liquid storage container with bottom filter |
KR101162076B1 (en) * | 2004-03-09 | 2012-07-03 | 산텐 세이야꾸 가부시키가이샤 | Liquid container |
US20050211734A1 (en) * | 2004-03-24 | 2005-09-29 | Spada Lon T | Skirted closure for small dropper bottles |
DE102004027734A1 (en) | 2004-06-07 | 2005-12-22 | Filtertek B.V., Newcastle West | Device for connecting a ventilator with the patient |
US7673653B2 (en) * | 2004-06-17 | 2010-03-09 | Filtertek Inc. | Check valve |
DE202004009721U1 (en) * | 2004-06-21 | 2004-08-26 | Filtertek B.V. | Device for dispensing liquids in the form of drops |
FR2872137B1 (en) * | 2004-06-24 | 2009-01-23 | Thea Sa Lab | CONTAINER FOR THE CONDITIONING OF A LIQUID WITH A DROPPER FLOW DISTRIBUTOR WITH REVERSIBLE DEFORMATION BY AIR INTAKE |
DE202005010459U1 (en) * | 2004-11-22 | 2005-10-13 | Filtertek B.V., Newcastle West | Device for introducing air into containers used in artificial nutrition |
ATE464242T1 (en) * | 2005-08-25 | 2010-04-15 | Hoffmann Neopac Ag | BREACH VALVE FOR A CONTAINER |
US20090008103A1 (en) * | 2006-03-02 | 2009-01-08 | Peter Cordani | Rapid deployment fire retardent gel pack |
US8702751B2 (en) * | 2006-06-30 | 2014-04-22 | Advanced Medical Solutions (Plymouth) Limited | Surgical adhesive applicator |
CA2672527A1 (en) * | 2006-12-07 | 2008-06-12 | Sun Pharma Advanced Research Company Ltd. | Metered drop bottle for dispensing microliter amounts of a liquid in the form of a drop |
US8518076B2 (en) * | 2007-01-08 | 2013-08-27 | Advanced Medical Solutions (Plymouth) Limited | Surgical adhesive applicator |
FR2918874B1 (en) * | 2007-07-20 | 2009-10-09 | Philippe Perovitch | DEVICE FOR CONDITIONING AND ADMINISTERING SUB-LINGUAL OF ACTIVE PRINCIPLES |
US20090101681A1 (en) * | 2007-10-19 | 2009-04-23 | Remedios Dato | Liquid Dispensing Tip With Reservoir |
FR2929249B1 (en) * | 2008-03-27 | 2012-02-17 | Rexam Pharma La Verpilliere | DEVICE FOR DISPENSING LIQUID CONTAINED IN A RESERVOIR |
JP5224915B2 (en) * | 2008-06-03 | 2013-07-03 | 大成化工株式会社 | Discharge container with filter |
US8342765B2 (en) * | 2008-06-12 | 2013-01-01 | Advanced Medical Solutions (Plymouth) Limited | Liquid applicator |
FR2934572A1 (en) | 2008-07-31 | 2010-02-05 | Thea Lab | BOTTLE FOR FLASK OF LIQUID CONDITIONING TO DISPENSE DROP GOUTTE. |
FR2939023B1 (en) * | 2008-12-03 | 2012-02-24 | Pharm Laboratoire G | DEVICE FOR ADMINISTERING A THERAPEUTIC, SANITARY OR OTHER TREATMENT PRODUCT |
FR2939321B1 (en) * | 2008-12-05 | 2011-08-26 | Philippe Perovitch | DEVICE FOR CONDITIONING AND ADMINISTERING ACTIVE INGREDIENTS IN HYDRO ALCOHOLIC SOLUTION |
FR2952040B1 (en) | 2009-10-29 | 2011-12-30 | Rexam Pharma La Verpilliere | DEVICE FOR DISPENSING LIQUID IN THE FORM OF DROPS |
FR2955842B1 (en) * | 2010-02-04 | 2012-03-16 | Thea Lab | FLUID FOR PACKAGING A LIQUID WITH A DROP-IN DISTRIBUTION HEAD |
FR2962044B1 (en) | 2010-04-21 | 2013-02-22 | Horus Pharma | LACRYMIMETIC EMULSION |
FR2963240B1 (en) | 2010-07-28 | 2013-03-15 | Horus Pharma | COMPOSITION FOR TOPICAL USE WITHOUT PRESERVATIVE COMPRISING HYALURONIC ACID |
FR2963329B1 (en) * | 2010-07-30 | 2013-06-28 | Thea Lab | HEAD FOR DISPENSING A DROP FLUID LIQUID |
CN102107747A (en) * | 2011-01-19 | 2011-06-29 | 广州科甫眼镜有限公司 | Container for preventing microbial contamination after contact lens care solution is unsealed and preparation method thereof |
FR2974742B1 (en) | 2011-05-04 | 2013-05-03 | Rexam Healthcare La Verpillier | LIQUID DISPENSING DEVICE WITH AIR CHANNEL CHANNEL |
EP2736476A4 (en) * | 2011-07-27 | 2015-03-18 | Nigel Kelly | Reservoir module for pump dispenser |
BRPI1105664A2 (en) * | 2011-12-19 | 2013-11-26 | Marcos Antonio Quimenton | PROCEDURE FOR OBTAINING DROP-WITH-MEMBRANE DROP CONTAINER AND DROP-ON WITH MOUNT MEMBRANE |
US9422100B2 (en) | 2012-05-09 | 2016-08-23 | Taisei Kako Co., Ltd. | Filtering discharge container |
EP2877138B1 (en) | 2012-07-26 | 2023-06-28 | Allergan, Inc. | Dual cap system for container-closures to maintain tip sterility during shelf storage |
BR112015011470B1 (en) | 2012-11-21 | 2021-01-19 | R.P. Scherer Technologies, Llc | disposable container designed to store and dispense a liquid substance |
US8944264B2 (en) * | 2013-02-04 | 2015-02-03 | World Bottling Cap, LLC | Medical vial cap |
FR3004431B1 (en) * | 2013-04-16 | 2016-01-22 | Thea Lab | FLUID OF PACKAGING OF LIQUID |
US20140350492A1 (en) * | 2013-05-26 | 2014-11-27 | Ever Rojas Escalante | Eyedrop dispenser |
GB201312986D0 (en) * | 2013-07-19 | 2013-09-04 | Grant William & Sons Ltd | Closure device, apparatus and method |
DE102013226253B4 (en) * | 2013-12-17 | 2016-03-24 | Aptar Radolfzell Gmbh | Protective cap for a dispenser and dispenser for dispensing pharmaceutical and / or cosmetic liquids |
NL2012570B1 (en) * | 2014-04-04 | 2016-03-08 | Sparkle Innovations B V | Device and method for applying a liquid drop by drop. |
WO2016025560A1 (en) * | 2014-08-13 | 2016-02-18 | University Of Florida Research Foundation, Inc. | Preservative removal from eye drops |
WO2016156897A1 (en) * | 2015-03-31 | 2016-10-06 | Laboratoires Thea | Device for dispensing liquid from a sterile packaging bottle with bifunctional membrane |
CN104909055A (en) * | 2015-06-19 | 2015-09-16 | 李红彪 | Flat-head sucker cap with automatic sealing function |
KR101666526B1 (en) * | 2015-09-15 | 2016-10-24 | 농업회사법인 한국오가닉 주식회사 | Preventing rancidity oil container |
FR3050184B1 (en) * | 2016-04-19 | 2018-10-12 | Albea Services | PERFORATOR CAP IN PARTICULAR FOR A FLEXIBLE TUBE |
IT201700056451A1 (en) * | 2017-05-24 | 2018-11-24 | Lumson Spa | Container of fluid substances with hermetic closure system and method of use |
IT201700056483A1 (en) | 2017-05-24 | 2018-11-24 | Lumson Spa | Container of fluid substances with mobile bottom, with hermetic closure system and method of use |
CN107815392A (en) * | 2017-11-10 | 2018-03-20 | 广州和实生物技术有限公司 | A kind of simple nucleic acid-extracting apparatus |
EP3743151A4 (en) | 2018-01-24 | 2021-04-07 | Nanodropper, Inc | Assembly and method for delivery of micro-volume droplets from a squeeze bottle |
US11203467B2 (en) | 2018-01-24 | 2021-12-21 | Nanodropper, Inc. | Assembly and method for delivery of micro-volume droplets from a squeeze bottle |
FR3077222B1 (en) * | 2018-01-26 | 2023-12-01 | Aptar France Sas | FLUID PRODUCT DISPENSER |
TW202005623A (en) | 2018-04-06 | 2020-02-01 | 美商蒂克利爾公司 | Systems and methods for delivery of a therapeutic agent |
US11872157B2 (en) | 2018-04-11 | 2024-01-16 | Nanodropper, Inc. | Micro drop adapter for dropper bottles |
US10932947B2 (en) | 2018-04-11 | 2021-03-02 | Paul Enemark | Micro drop adapter for dropper bottles |
FR3080844B1 (en) * | 2018-05-07 | 2020-06-05 | Horus Pharma | PACKAGING AND DISPENSING DEVICE OF A PRODUCT WITH BOTTLE AND METERING CAP WITH FILTER |
WO2020198655A1 (en) | 2019-03-28 | 2020-10-01 | TearClear Corp. | Devices and methods for flow control of ophthalmic formulations |
USD1017797S1 (en) | 2019-09-11 | 2024-03-12 | Nanodropper, Inc. | Microdrop dispensing adapter for eye dropper bottle |
USD1025353S1 (en) | 2019-09-11 | 2024-04-30 | Nanodropper, Inc. | Microdrop dispensing adapter for eye dropper bottle |
US11679026B2 (en) * | 2019-12-10 | 2023-06-20 | Obbjectives, Llc | Systems and devices, and methods for replacing an eye dropper tip on an eyedropper bottle with a replacement eyedropper tip |
US10945881B1 (en) * | 2019-12-19 | 2021-03-16 | Paolo Gobbi Frattini S.R.L. | Plural-use drop-by-drop dispenser for sterile liquid product, particularly for collyrium or other medicinal product or medical device |
CN112403705A (en) * | 2020-06-08 | 2021-02-26 | 璞真生活有限公司 | Essential oil atomizer |
CN112644845B (en) * | 2021-01-12 | 2023-10-17 | 赛克赛斯生物科技股份有限公司 | Bottleneck connecting piece and medicine bottle using same |
KR102593995B1 (en) * | 2021-03-22 | 2023-10-25 | 주식회사 중겸 | Reagent vessel and Reagent vessel assembly having the same |
FR3121131A1 (en) | 2021-03-27 | 2022-09-30 | Sivel | DEVICE FOR PACKAGING AND DISTRIBUTING A STERILE PRODUCT WITH DOSING TIP AND COVER |
FR3122651B1 (en) * | 2021-05-10 | 2023-12-08 | Aptar France Sas | Fluid product dispenser |
WO2023274529A1 (en) * | 2021-06-30 | 2023-01-05 | Hoffmann Neopac Ag | Sterile dropper tube |
FR3129666A1 (en) | 2021-11-29 | 2023-06-02 | Laboratoires Thea | Vial for dropwise dispensing of a sterile liquid product containing a surfactant |
FR3131735A1 (en) | 2022-01-10 | 2023-07-14 | Laboratoires Thea | Multi-dose vial containing a viscous ophthalmic product |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1355195A (en) * | 1920-03-15 | 1920-10-12 | Allen A Van Orsdale | Lubricator |
US3404811A (en) * | 1966-12-02 | 1968-10-08 | Cernei Jose | Container for maintaining in separate condition liquids which are to be mixed together and which may be manipulated to commingle such liquids |
FR2236748A1 (en) * | 1973-07-10 | 1975-02-07 | Goiffon Ets Leon | Closure for containers with distribution nozzle - has cutting edge inside screw down cap to pierce top of tube |
FR2622546B2 (en) * | 1987-05-25 | 1990-03-16 | Emballages Conseils Etudes | CLOSING DEVICE FOR CONTAINERS |
FR2638428B1 (en) * | 1988-10-28 | 1990-12-28 | Transphyto Sa | PACKAGING FOR PURIFYING LIQUIDS |
US4990016A (en) * | 1988-12-16 | 1991-02-05 | David Seidler | Liquid applicator sampler tube |
US5265770A (en) * | 1989-06-01 | 1993-11-30 | Pall Corporation | Contamination-resistant dispensing and metering device |
GB9011455D0 (en) * | 1989-06-01 | 1990-07-11 | Pall Corp | Contamination-resistant dispensing and metering device |
US5219101A (en) * | 1989-06-01 | 1993-06-15 | Pall Corporation | Contamination-resistant dispensing and metering drop forming device |
US5217433A (en) * | 1991-05-24 | 1993-06-08 | Merck & Co., Inc. | Medication container for mixing two components |
DE4120634A1 (en) * | 1991-06-22 | 1992-12-24 | Gurit Essex Ag | DEVICE FOR APPLYING A LIQUID MEDIUM |
DE69303434T2 (en) * | 1992-07-02 | 1997-02-06 | Cusi Lab | Containers for pharmaceutical products from two separate components, with means for mixing and dispensing them |
FR2696997B1 (en) * | 1992-10-21 | 1995-01-06 | Kerplas Snc | Drip tip for bottle, and bottle equipped with such a tip. |
EP0631770B1 (en) * | 1993-06-25 | 1998-07-22 | Alcon Cusi, S.A. | New use of polymeric membranes in the dispensing of pharmaceutical solutions that contain quaternary ammonium compounds as preservatives and corresponding dose dispensor |
EP0735975B1 (en) * | 1993-12-22 | 2001-08-16 | Merck & Co. Inc. | Ophthalmic package and delivery device |
FR2729920B1 (en) * | 1995-02-01 | 1997-06-06 | Kerplas Snc | BOTTLE BODY AND BOTTLE FOR DISPENSING A PRODUCT |
FR2729924B1 (en) * | 1995-02-01 | 1997-04-11 | Kerplas Snc | PRODUCT DISPENSING BOTTLE |
US5611464A (en) * | 1995-05-30 | 1997-03-18 | Ciba Geigy Corporation | Container for preserving media in the tip of a solution dispenser |
US5573047A (en) * | 1995-07-03 | 1996-11-12 | Akin; Richard M. | Seal-piercing insert for a bottled water dispenser |
JP3961608B2 (en) * | 1997-02-19 | 2007-08-22 | 大成化工株式会社 | Cap with punch |
FR2770495B1 (en) * | 1997-11-04 | 1999-12-24 | Transphyto Sa | PACKAGING DEVICE FOR DRIPPING LIQUID |
FR2813869B1 (en) * | 2000-09-08 | 2002-10-18 | Oreal | DEVICE FOR THE SEPARATE PACKAGING AND THE JOINT OUTPUT OF TWO EXTEMPORANEOUSLY MIXED PRODUCTS |
US6902076B2 (en) * | 2002-02-21 | 2005-06-07 | Eastman Kodak Company | Bottle and bottle closure assembly |
US6976494B2 (en) * | 2002-10-29 | 2005-12-20 | J.W. Industries, Inc. | Hair colorant dispenser |
-
2000
- 2000-11-13 FR FR0015039A patent/FR2816600B1/en not_active Expired - Lifetime
-
2001
- 2001-11-09 PE PE2001001120A patent/PE20020488A1/en active IP Right Grant
- 2001-11-12 MY MYPI20015202 patent/MY142758A/en unknown
- 2001-11-12 TN TNSN01159 patent/TNSN01159A1/en unknown
- 2001-11-12 AR ARP010105271 patent/AR031322A1/en active IP Right Grant
- 2001-11-12 PA PA8532101A patent/PA8532101A1/en unknown
- 2001-11-12 GT GT200100019U patent/GT200100019U/en unknown
- 2001-11-13 KR KR1020037006503A patent/KR100878215B1/en active IP Right Grant
- 2001-11-13 DE DE60138910T patent/DE60138910D1/en not_active Expired - Lifetime
- 2001-11-13 PT PT01993568T patent/PT1339616E/en unknown
- 2001-11-13 ES ES01993568T patent/ES2328226T3/en not_active Expired - Lifetime
- 2001-11-13 HU HU0400574A patent/HU228559B1/en unknown
- 2001-11-13 CN CNB018187188A patent/CN1251934C/en not_active Expired - Lifetime
- 2001-11-13 CA CA2428494A patent/CA2428494C/en not_active Expired - Lifetime
- 2001-11-13 CZ CZ20031317A patent/CZ296769B6/en not_active IP Right Cessation
- 2001-11-13 PL PL361301A patent/PL205278B1/en unknown
- 2001-11-13 RS YUP35803 patent/RS50410B/en unknown
- 2001-11-13 US US10/416,572 patent/US20040074925A1/en not_active Abandoned
- 2001-11-13 AU AU2002223064A patent/AU2002223064A1/en not_active Abandoned
- 2001-11-13 JP JP2002541012A patent/JP4159354B2/en not_active Expired - Lifetime
- 2001-11-13 WO PCT/FR2001/003555 patent/WO2002038464A1/en active IP Right Grant
- 2001-11-13 RU RU2003114418A patent/RU2275316C2/en active
- 2001-11-13 SK SK560-2003A patent/SK287352B6/en not_active IP Right Cessation
- 2001-11-13 AT AT01993568T patent/ATE432890T1/en active
- 2001-11-13 EP EP01993568A patent/EP1339616B1/en not_active Expired - Lifetime
-
2003
- 2003-05-12 NO NO20032127A patent/NO329819B1/en not_active IP Right Cessation
- 2003-06-12 HR HR20030475A patent/HRP20030475B1/en not_active IP Right Cessation
-
2004
- 2004-07-21 HK HK04105345A patent/HK1062429A1/en not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HRP20030475A2 (en) | Drip liquid dispenser | |
EP2723651B1 (en) | Container closure having means for introducing an additive into the contents of the container | |
EP1948528B1 (en) | One way valve assembly | |
DE69932163T2 (en) | DISPENSER WITH RIPPABLE MEMBRANE SEPARATING TWO PRODUCTS FROM EACH OTHER | |
US5240149A (en) | Closure cap | |
US4568004A (en) | Container allowing drop by drop dispensing of a dose of a fluid substance | |
CA2608966C (en) | Dispensing closure with a plug-through sleeve for fixing it to a container | |
US20190224044A1 (en) | Assembly and method for delivery of micro-volume droplets from a squeeze bottle | |
US20070194049A1 (en) | Clog resistant actuator and overcap | |
KR960008949Y1 (en) | Disposable spray dispensing assembly | |
US6000578A (en) | Bottle body and product dispensing bottle | |
ES2618961T3 (en) | Device for fluid-tight preservation of a substance to be mixed with another substance contained in a container | |
CN109415145A (en) | Container-closure with the mechanism introduced the additive into the liquid in container | |
US5992692A (en) | Bottle for dispensing a product | |
US7806258B2 (en) | Inserts for multiple component containers | |
US7156227B2 (en) | System and method for mixing at least two products | |
US6450216B1 (en) | Reservoir provided with a device for closing and/or filling and device for dispensing a fluid product comprising same | |
JP7368387B2 (en) | A device that temporarily connects two containers | |
CN109963794B (en) | Valve device for closing a pressurized tank in an apparatus | |
KR102124667B1 (en) | Dual cap system for container-closures to maintain tip sterility during shelf storage | |
JP2023536544A (en) | container closure system |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A1OB | Publication of a patent application | ||
AIPI | Request for the grant of a patent on the basis of a substantive examination of a patent application | ||
B1PR | Patent granted | ||
ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20191017 Year of fee payment: 19 |
|
ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20201016 Year of fee payment: 20 |
|
PB20 | Patent expired after termination of 20 years |
Effective date: 20211113 |