HRP20020647A2 - A method for maintaining or improving the synthesis of mucins - Google Patents

A method for maintaining or improving the synthesis of mucins Download PDF

Info

Publication number: HRP20020647A2
Authority: HR; Croatia
Prior art keywords: threonine; protein; preparation; amino acids; use according
Prior art date: 2000-02-04

Application number

Other languages

English (en)

Croatian (hr)

Inventor

Olivier Ballevre

Paul-Andre Finot

Denis Breuille

Original Assignee

Sociutu Des Produits Nestlu S

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-02-04

Filing date

2002-07-31

Publication date

2004-12-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27052980&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20020647(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2001-01-30 Priority claimed from US09/774,814 external-priority patent/US6833350B2/en

2002-07-31 Application filed by Sociutu Des Produits Nestlu S filed Critical Sociutu Des Produits Nestlu S

2004-12-31 Publication of HRP20020647A2 publication Critical patent/HRP20020647A2/hr

Links

238000000034 method Methods 0.000 title claims abstract description 61
102000015728 Mucins Human genes 0.000 title abstract description 39
108010063954 Mucins Proteins 0.000 title abstract description 39
230000015572 biosynthetic process Effects 0.000 title abstract description 20
229940051875 mucins Drugs 0.000 title abstract description 5
238000003786 synthesis reaction Methods 0.000 title abstract description 3
239000004473 Threonine Substances 0.000 claims abstract description 126
AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims abstract description 125
235000016709 nutrition Nutrition 0.000 claims abstract description 55
239000000203 mixture Substances 0.000 claims abstract description 34
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 25
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238000002360 preparation method Methods 0.000 claims description 56
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LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 2
MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 1
PZNPLUBHRSSFHT-RRHRGVEJSA-N 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[C@@H](COP([O-])(=O)OCC[N+](C)(C)C)COC(=O)CCCCCCCCCCCCCCC PZNPLUBHRSSFHT-RRHRGVEJSA-N 0.000 description 1
QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 description 1
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CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
102000003886 Glycoproteins Human genes 0.000 description 1
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GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
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102000014171 Milk Proteins Human genes 0.000 description 1
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241000244206 Nematoda Species 0.000 description 1
101150010952 OAT gene Proteins 0.000 description 1
240000007594 Oryza sativa Species 0.000 description 1
235000007164 Oryza sativa Nutrition 0.000 description 1
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108090000284 Pepsin A Proteins 0.000 description 1
208000008469 Peptic Ulcer Diseases 0.000 description 1
241000700157 Rattus norvegicus Species 0.000 description 1
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
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DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 description 1
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210000000941 bile Anatomy 0.000 description 1
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239000000828 canola oil Substances 0.000 description 1
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239000005018 casein Substances 0.000 description 1
BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
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239000011521 glass Substances 0.000 description 1
239000008103 glucose Substances 0.000 description 1
ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
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239000008101 lactose Substances 0.000 description 1
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235000014666 liquid concentrate Nutrition 0.000 description 1
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235000019426 modified starch Nutrition 0.000 description 1
210000004400 mucous membrane Anatomy 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 1
235000008935 nutritious Nutrition 0.000 description 1
235000020660 omega-3 fatty acid Nutrition 0.000 description 1
244000045947 parasite Species 0.000 description 1
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235000020777 polyunsaturated fatty acids Nutrition 0.000 description 1
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239000008347 soybean phospholipid Substances 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Nutrition Science (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Mycology (AREA)
Oil, Petroleum & Natural Gas (AREA)
Obesity (AREA)
Food Science & Technology (AREA)
Polymers & Plastics (AREA)
Hematology (AREA)
Diabetes (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

HRP20020647 2000-02-04 2002-07-31 A method for maintaining or improving the synthesis of mucins HRP20020647A2 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US49890500A	2000-02-04	2000-02-04
US09/774,814 US6833350B2 (en)	2000-02-04	2001-01-30	Method for maintaining or improving the synthesis of mucins
PCT/EP2001/001013 WO2001056405A2 (en)	2000-02-04	2001-01-31	A method for maintaining or improving the synthesis of mucins

Publications (1)

Publication Number	Publication Date
HRP20020647A2 true HRP20020647A2 (en)	2004-12-31

Family

ID=27052980

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HRP20020647 HRP20020647A2 (en)	2000-02-04	2002-07-31	A method for maintaining or improving the synthesis of mucins

Country Status (22)

Country	Link
EP (1)	EP1255452B2 (de)
JP (1)	JP2003533436A (de)
CN (1)	CN1434681B (de)
AT (1)	ATE323422T1 (de)
AU (1)	AU784137B2 (de)
BG (1)	BG106967A (de)
BR (1)	BRPI0108096B1 (de)
CA (1)	CA2399063C (de)
CZ (1)	CZ20022978A3 (de)
DE (1)	DE60118888T3 (de)
DZ (1)	DZ3298A1 (de)
ES (1)	ES2261383T5 (de)
HR (1)	HRP20020647A2 (de)
HU (1)	HUP0204439A3 (de)
IL (1)	IL150977A (de)
MA (1)	MA25656A1 (de)
MX (1)	MXPA02007491A (de)
NO (1)	NO20023640L (de)
NZ (1)	NZ520605A (de)
PL (1)	PL357078A1 (de)
SK (1)	SK11212002A3 (de)
WO (1)	WO2001056405A2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK1638418T3 (da)	2003-06-23	2012-09-17	Nestec Sa	Aminosyretilsætning til et sundt mikrobiota-økosystem
JPWO2007004613A1 (ja)	2005-07-01	2009-01-29	味の素株式会社	炎症性腸疾患治療薬及びＴＮＦ−α産生抑制剤
US20090011077A1 (en) *	2006-01-09	2009-01-08	Nestec S.A.	Treatment of Stressed Patients
WO2012133198A1 (ja) *	2011-03-25	2012-10-04	イーエヌ大塚製薬株式会社	炎症性疾患用栄養組成物
CA2842672A1 (en)	2011-07-22	2013-01-31	Abbott Laboratories	Galactooligosaccharides for preventing injury and/or promoting healing of the gastrointestinal tract
EP3167895A1 (de) *	2015-11-10	2017-05-17	University College Dublin	Nahrungsergänzung enhaltend beta-glukan und caseinhydrolysat zur verbesserung des gesundheits- und wachstumsleistung in einem säugetier

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2459620B1 (fr) *	1979-06-26	1983-08-05	Agronomique Inst Nat Rech	Hydrolisat enzymatique total de proteines de lactoserum, obtention et application
US5162373A (en) *	1986-01-17	1992-11-10	Board Of Regents, The University Of Texas System	Methods and improved formulations for the determination and treatment of malignant disease in patients
JP2631470B2 (ja) *	1987-05-15	1997-07-16	雪印乳業株式会社	感染防御剤
CA1338682C (en) *	1988-12-23	1996-10-29	Gustavo Bounous	Biologically active undenatured whey protein concentrate as food supplement
JP2805490B2 (ja) *	1989-02-07	1998-09-30	雪印乳業株式会社	細菌毒素中和剤
JP3007694B2 (ja) *	1990-12-14	2000-02-07	雪印乳業株式会社	胃潰瘍予防または治療のための医薬及び飲食品
CA2143420C (en) *	1992-12-23	1999-01-19	Phyllis J. B. Acosta	Medical foods for the nutritional support of infant/toddler metabolic diseases
NZ248605A (en) *	1993-05-28	1994-12-22	Abbott Lab	Enteral nutritional product comprising protein and fat
FR2711529B1 (fr) *	1993-10-28	1996-07-05	Clintec Nutrition Cy	Composition à base d'acides aminés destinée au traitement d'une infection ou d'une agression engendrant une réaction inflammatoire, chez les animaux et chez l'homme.
JPH07267855A (ja) *	1994-03-30	1995-10-17	Taiho Yakuhin Kogyo Kk	グルタミン産生剤
US5952314A (en) *	1994-04-01	1999-09-14	Demichele; Stephen Joseph	Nutritional product for a person having ulcerative colitis
US5728678A (en) *	1995-06-06	1998-03-17	Nestec Ltd.	Method and composition for providing nutrition to a renal failure patient
US5670157A (en) *	1995-12-11	1997-09-23	Nestec Ltd.	Method for reducing and controlling immunoglobulin concentrations
US5922766A (en) *	1997-07-02	1999-07-13	Acosta; Phyllis J. B.	Palatable elemental medical food
ES2265669T3 (es) *	1997-09-16	2007-02-16	Societe Des Produits Nestle S.A.	Uso de una composicion nutritiva especifica para un organo.
AU4710899A (en) *	1998-06-24	2000-01-10	Boyce Thompson Institute For Plant Research Inc.	A novel invertebrate intestinal mucin cdna and related products and methods
EP1034704A1 (de) *	1999-03-12	2000-09-13	Societe Des Produits Nestle S.A.	Nahrungszusammensetzung insbesondere für die spezifische gastrointestinale Reifung in frühgeborenen Säugetieren
CA2387907A1 (en) *	1999-10-22	2001-05-03	The Board Of Regents Of The University Of Nebraska	Serum amyloid a isoform from colostrum

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Also Published As

Publication number	Publication date
EP1255452B1 (de)	2006-04-19
CA2399063A1 (en)	2001-08-09
EP1255452B2 (de)	2010-03-03
IL150977A0 (en)	2003-02-12
DE60118888T3 (de)	2010-09-23
HUP0204439A2 (hu)	2003-04-28
MA25656A1 (fr)	2002-12-31
PL357078A1 (en)	2004-07-12
BR0108096A (pt)	2002-10-29
DE60118888D1 (de)	2006-05-24
JP2003533436A (ja)	2003-11-11
NO20023640D0 (no)	2002-07-31
ATE323422T1 (de)	2006-05-15
IL150977A (en)	2005-09-25
MXPA02007491A (es)	2002-12-13
BRPI0108096B1 (pt)	2017-05-09
CN1434681B (zh)	2010-12-08
CA2399063C (en)	2014-01-28
WO2001056405A3 (en)	2002-01-24
ES2261383T5 (es)	2010-06-18
AU784137B2 (en)	2006-02-09
SK11212002A3 (sk)	2003-01-09
CZ20022978A3 (cs)	2003-02-12
HUP0204439A3 (en)	2004-12-28
NO20023640L (no)	2002-09-19
DE60118888T2 (de)	2007-01-18
CN1434681A (zh)	2003-08-06
BG106967A (bg)	2003-04-30
AU4056401A (en)	2001-08-14
DZ3298A1 (fr)	2001-08-09
EP1255452A2 (de)	2002-11-13
NZ520605A (en)	2004-06-25
ES2261383T3 (es)	2010-06-14
WO2001056405A2 (en)	2001-08-09

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