HN2001000244A - Inhibidores de espiropirimidin - 2, 4, 6 - triona metaloproteinasas. - Google Patents

Inhibidores de espiropirimidin - 2, 4, 6 - triona metaloproteinasas.

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Publication number
HN2001000244A
HN2001000244A HN2001000244A HN2001000244A HN2001000244A HN 2001000244 A HN2001000244 A HN 2001000244A HN 2001000244 A HN2001000244 A HN 2001000244A HN 2001000244 A HN2001000244 A HN 2001000244A HN 2001000244 A HN2001000244 A HN 2001000244A
Authority
HN
Honduras
Prior art keywords
metaloproteinasas
triona
inhibitors
spiropirimidin
spiropririmidin
Prior art date
Application number
HN2001000244A
Other languages
English (en)
Spanish (es)
Inventor
Brian Scott Bronk
Mark Carl Noe
Martin James Wythes
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of HN2001000244A publication Critical patent/HN2001000244A/es

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10Spiro-condensed systems
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    • C07D487/10Spiro-condensed systems

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  • Animal Behavior & Ethology (AREA)
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  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cardiology (AREA)
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HN2001000244A 2000-10-26 2001-10-24 Inhibidores de espiropirimidin - 2, 4, 6 - triona metaloproteinasas. HN2001000244A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US24338900P 2000-10-26 2000-10-26

Publications (1)

Publication Number Publication Date
HN2001000244A true HN2001000244A (es) 2003-11-07

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ID=22918584

Family Applications (1)

Application Number Title Priority Date Filing Date
HN2001000244A HN2001000244A (es) 2000-10-26 2001-10-24 Inhibidores de espiropirimidin - 2, 4, 6 - triona metaloproteinasas.

Country Status (32)

Country Link
EP (1) EP1332146A2 (xx)
JP (1) JP2004518635A (xx)
KR (1) KR20040004412A (xx)
CN (1) CN1501937A (xx)
AP (1) AP2001002318A0 (xx)
AR (1) AR035069A1 (xx)
AU (1) AU2002210813A1 (xx)
BG (1) BG107653A (xx)
BR (1) BR0114913A (xx)
CA (1) CA2425283A1 (xx)
CZ (1) CZ20031083A3 (xx)
EA (1) EA005762B1 (xx)
EC (1) ECSP034567A (xx)
EE (1) EE200300196A (xx)
GT (1) GT200100213A (xx)
HN (1) HN2001000244A (xx)
HR (1) HRP20030332A2 (xx)
HU (1) HUP0301577A3 (xx)
IL (1) IL154948A0 (xx)
IS (1) IS6762A (xx)
MA (1) MA26957A1 (xx)
MX (1) MXPA03003735A (xx)
NO (1) NO20031853L (xx)
OA (1) OA12529A (xx)
PA (1) PA8531401A1 (xx)
PE (1) PE20020589A1 (xx)
PL (1) PL366201A1 (xx)
SK (1) SK4972003A3 (xx)
SV (1) SV2003000705A (xx)
TN (1) TNSN01149A1 (xx)
WO (1) WO2002034753A2 (xx)
ZA (1) ZA200302190B (xx)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PA8539501A1 (es) 2001-02-14 2002-09-30 Warner Lambert Co Compuestos triazolo como inhibidores de mmp
DOP2002000333A (es) 2001-02-14 2002-09-30 Warner Lambert Co Derivados de acido isoftalico como inhibidores de metaloproteinasas de la matriz
WO2002064578A1 (en) 2001-02-14 2002-08-22 Warner-Lambert Company Llc Benzo thiadiazine matrix metalloproteinase inhibitors
DOP2002000332A (es) 2001-02-14 2002-08-30 Warner Lambert Co Inhibidores de piridina de metaloproteinasas de la matriz
MXPA03004920A (es) 2001-02-14 2003-09-05 Warner Lambert Co Pirimidinas inhibidoras de metaloproteinasas de matriz.
US6924276B2 (en) 2001-09-10 2005-08-02 Warner-Lambert Company Diacid-substituted heteroaryl derivatives as matrix metalloproteinase inhibitors
MXPA04002537A (es) 2001-10-12 2004-05-31 Warner Lambert Co Alquinos como inhibidores de metaloproteinasa de matriz.
US6962922B2 (en) 2001-10-12 2005-11-08 Warner-Lambert Company Llc Alkynylated quinazoline compounds
US6894057B2 (en) 2002-03-08 2005-05-17 Warner-Lambert Company Oxo-azabicyclic compounds
WO2003091252A1 (en) * 2002-04-25 2003-11-06 Bristol-Myers Squibb Company Spirobarbituric acid derivatives useful as inhibitors of matrix metalloproteases
BR0308787A (pt) * 2002-04-26 2005-01-11 Pfizer Prod Inc Inibidores de metaloproteinase de n-substituìdos-heteroarilóxi-aril-espiro-pirimidina- 2,4,6-triona
JP2005527598A (ja) * 2002-04-26 2005-09-15 ファイザー・プロダクツ・インク トリアリール−オキシ−アリール−スピロ−ピリミジン−2,4,6−トリオンメタロプロテイナーゼ阻害剤
AU2003249540A1 (en) 2002-08-13 2004-02-25 Warner-Lambert Company Llc Fused bicyclic metalloproteinase inhibitors
MXPA05001783A (es) 2002-08-13 2005-04-25 Warner Lambert Co Derivados de pirimidina-2,4-diona como inhibidores de las metaloproteinasas de matriz.
AU2003249477A1 (en) 2002-08-13 2004-02-25 Warner-Lambert Company Llc Heterobicylcic metalloproteinase inhibitors
PA8578101A1 (es) 2002-08-13 2004-05-07 Warner Lambert Co Derivados de heterobiarilo como inhibidores de metaloproteinasa de la matriz
WO2004014923A1 (en) 2002-08-13 2004-02-19 Warner-Lambert Company Llc Pyrimidinone fused bicyclic metalloproteinase inhibitors
BR0313459A (pt) 2002-08-13 2005-06-21 Warner Lambert Co Derivados monocìclicos como inibidores de metaloproteinases de matriz
MXPA05001786A (es) 2002-08-13 2005-04-25 Warner Lambert Co Derivados de azaisoquinolina como inhibidores de la metaloproteinasa de matriz.
JP2005539020A (ja) 2002-08-13 2005-12-22 ワーナー−ランバート カンパニー リミティド ライアビリティー カンパニー マトリクスメタロプロテイナーゼ阻害物質としてのクロモン誘導体
AU2003250466A1 (en) 2002-08-13 2004-02-25 Warner-Lambert Company Llc 3-isoquinolinone derivatives as matrix metalloproteinase inhiitors
WO2004014909A1 (en) 2002-08-13 2004-02-19 Warner-Lambert Company Llc Fused tetrahydropyridine derivatives as matrix metalloproteinase inhibitors
US7208490B2 (en) 2002-10-07 2007-04-24 Pharmacia & Upjohn Company Llc Tricyclic tetrahydroquinoline antibacterial agents
GB0223249D0 (en) * 2002-10-08 2002-11-13 Amersham Plc Improved imaging agents
WO2004084903A1 (en) * 2003-03-27 2004-10-07 F. Hoffmann-La Roche Ag Use of a trioxopyrimidine for the treatment and prevention of ocular pathologic angiogenesis
WO2004084902A1 (en) * 2003-03-28 2004-10-07 F. Hoffmann-La Roche Ag Use of a trioxopyrimidine for the treatment of chronic wounds
FR2858232B1 (fr) * 2003-07-29 2006-03-03 Pierre Potier Utilisation d'un derive de biguanide pour proteger la peau des radiations uvb
AU2005230379B2 (en) * 2004-04-01 2010-07-22 Universite De Liege Use of a trioxopyrimidine for the treatment and prevention of bronchial inflammatory diseases
DOP2006000268A (es) 2005-12-22 2007-07-31 Pfizer Prod Inc Agentes antibacterianos
US8153166B2 (en) * 2006-06-08 2012-04-10 Chih-Hsiung Lin Composition for prophylaxis or treatment of urinary system infection and method thereof
CN102285934B (zh) * 2009-01-08 2013-08-14 四川大学 螺环二烯酮衍生物及其制备方法和用途
RS57190B1 (sr) * 2012-12-10 2018-07-31 Chugai Pharmaceutical Co Ltd Derivat hidantoina
KR101594506B1 (ko) * 2014-03-20 2016-02-17 한국화학연구원 골 관련 질환 치료용 조성물
KR102266021B1 (ko) 2014-06-09 2021-06-16 추가이 세이야쿠 가부시키가이샤 히단토인 유도체 함유 의약 조성물
US11292782B2 (en) 2018-11-30 2022-04-05 Nuvation Bio Inc. Diarylhydantoin compounds and methods of use thereof
CN110092790B (zh) * 2019-06-11 2020-07-24 东北农业大学 一种生物碱类化合物及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3714093A (en) * 1970-05-19 1973-01-30 American Home Prod Spiro [heterocycloalkyl-2'(1'h)-quinazoline]-4'(3'h)-ones
BR9810450A (pt) * 1997-06-21 2000-09-05 Roche Diagnostics Gmbh Derivados de ácido barbitúrico com atividade antimetastática e antitumor
US6265578B1 (en) * 1999-02-12 2001-07-24 Hoffmann-La Roche Inc. Pyrimidine-2,4,6-triones
HN2000000137A (es) * 1999-08-12 2001-02-02 Pfizer Prod Inc Pirimidina-2,4,6-trionas inhibidores de metaloproteinasas

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