HK1254752A1 - 用於抗體碎片的改進的複性方法 - Google Patents

用於抗體碎片的改進的複性方法

Info

Publication number: HK1254752A1
Authority: HK; Hong Kong
Prior art keywords: fragments; antibody; refolding process; improved refolding; improved
Prior art date: 2015-08-17

Application number

HK18113795.0A

Other languages

English (en)

Inventor

Sandeep Somani

Ashish Pandey

Ashok Mishra

Rustom Sorab Mody

Original Assignee

Lupin Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2015-08-17

Filing date

2018-10-29

Publication date

2019-07-26

2018-10-29 Application filed by Lupin Ltd filed Critical Lupin Ltd

2019-07-26 Publication of HK1254752A1 publication Critical patent/HK1254752A1/zh

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/522—CH1 domain
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

HK18113795.0A 2015-08-17 2018-10-29 用於抗體碎片的改進的複性方法 HK1254752A1 (zh)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IN3118MU2015		2015-08-17
PCT/IB2016/054926 WO2017029620A1 (en)	2015-08-17	2016-08-17	An improved refolding process for antibody's fragments

Publications (1)

Publication Number	Publication Date
HK1254752A1 true HK1254752A1 (zh)	2019-07-26

Family

ID=56936450

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HK18113795.0A HK1254752A1 (zh)	2015-08-17	2018-10-29	用於抗體碎片的改進的複性方法

Country Status (19)

Country	Link
US (1)	US10781250B2 (zh)
EP (1)	EP3337820B1 (zh)
JP (1)	JP6755939B2 (zh)
CN (1)	CN108026165A (zh)
AU (1)	AU2016307976A1 (zh)
CA (1)	CA2993907A1 (zh)
DK (1)	DK3337820T3 (zh)
ES (1)	ES2843558T3 (zh)
HK (1)	HK1254752A1 (zh)
HR (1)	HRP20210067T1 (zh)
HU (1)	HUE052993T2 (zh)
LT (1)	LT3337820T (zh)
MX (1)	MX2018001994A (zh)
PH (1)	PH12018500362A1 (zh)
PL (1)	PL3337820T3 (zh)
PT (1)	PT3337820T (zh)
RU (1)	RU2018109102A (zh)
WO (1)	WO2017029620A1 (zh)
ZA (1)	ZA201801498B (zh)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB201506869D0 (en)	2015-04-22	2015-06-03	Ucb Biopharma Sprl	Method
CN110582510B (zh) *	2017-03-24	2023-09-15	科学与工业研究委员会	用于纯化重组抗体片段的方法
CN110636859B (zh) *	2017-05-19	2024-05-03	科学与工业研究委员会	用于产生重折叠的重组人源化兰尼单抗的方法
CN111128293B (zh) *	2019-11-25	2020-11-10	苏州纽博立科技有限公司	一种抗体药物生产工艺中碎片的修复方法
CN113073092A (zh) *	2021-04-15	2021-07-06	宁波瑞林生物科技有限公司	重组人组织型激肽释放酶及其制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5332671A (en)	1989-05-12	1994-07-26	Genetech, Inc.	Production of vascular endothelial cell growth factor and DNA encoding same
JP2008521420A (ja) *	2004-11-30	2008-06-26	ノボノルディスクアクティーゼルスカブ	抗体を産生する方法
CN100336824C (zh) *	2005-12-19	2007-09-12	百奥泰生物科技(广州)有限公司	一种重组蛋白的高效变复性的方法
NZ574308A (en) *	2006-07-10	2012-06-29	Esbatech Alcon Biomed Res Unit	Scfv antibodies which pass epithelial and/or endothelial layers
WO2008008975A2 (en) *	2006-07-14	2008-01-17	Genentech, Inc.	Refolding of recombinant proteins
JP5168604B2 (ja) *	2008-05-08	2013-03-21	味の素株式会社	タンパク質のリフォールディング方法
CN102206272B (zh) *	2009-12-11	2014-10-01	普罗特奥姆技术公司	生产重组α1-抗胰蛋白酶的方法
CA2815342A1 (en) *	2010-10-20	2012-04-26	Medimmune, Llc	Methods for processing inclusion bodies
US10065987B2 (en) *	2013-02-12	2018-09-04	Bristol-Myers Squibb Company	High pH protein refolding methods
WO2014178078A2 (en) *	2013-04-30	2014-11-06	Intas Boipharmaceuticals Limited	Novel cloning, expression & purification method for the preparation of ranibizumab
CN103804486B (zh) *	2014-01-20	2017-05-17	安徽安科生物工程（集团）股份有限公司	一种提高重组人干扰素α2b天然构象含率的制备工艺

2016
- 2016-08-17 AU AU2016307976A patent/AU2016307976A1/en not_active Abandoned
- 2016-08-17 LT LTEP16766389.7T patent/LT3337820T/lt unknown
- 2016-08-17 CA CA2993907A patent/CA2993907A1/en not_active Abandoned
- 2016-08-17 WO PCT/IB2016/054926 patent/WO2017029620A1/en active Application Filing
- 2016-08-17 PT PT167663897T patent/PT3337820T/pt unknown
- 2016-08-17 US US15/752,994 patent/US10781250B2/en active Active
- 2016-08-17 MX MX2018001994A patent/MX2018001994A/es unknown
- 2016-08-17 ES ES16766389T patent/ES2843558T3/es active Active
- 2016-08-17 JP JP2018508637A patent/JP6755939B2/ja active Active
- 2016-08-17 CN CN201680047993.5A patent/CN108026165A/zh active Pending
- 2016-08-17 HU HUE16766389A patent/HUE052993T2/hu unknown
- 2016-08-17 EP EP16766389.7A patent/EP3337820B1/en active Active
- 2016-08-17 RU RU2018109102A patent/RU2018109102A/ru not_active Application Discontinuation
- 2016-08-17 PL PL16766389T patent/PL3337820T3/pl unknown
- 2016-08-17 DK DK16766389.7T patent/DK3337820T3/da active
2018
- 2018-02-15 PH PH12018500362A patent/PH12018500362A1/en unknown
- 2018-03-05 ZA ZA2018/01498A patent/ZA201801498B/en unknown
- 2018-10-29 HK HK18113795.0A patent/HK1254752A1/zh unknown
2021
- 2021-01-13 HR HRP20210067TT patent/HRP20210067T1/hr unknown

Also Published As

Publication number	Publication date
HUE052993T2 (hu)	2021-06-28
WO2017029620A1 (en)	2017-02-23
PT3337820T (pt)	2021-01-19
US10781250B2 (en)	2020-09-22
PL3337820T3 (pl)	2021-11-22
ES2843558T3 (es)	2021-07-19
HRP20210067T1 (hr)	2021-03-05
US20180230206A1 (en)	2018-08-16
RU2018109102A (ru)	2019-09-19
ZA201801498B (en)	2018-12-19
CN108026165A (zh)	2018-05-11
AU2016307976A1 (en)	2018-03-08
EP3337820A1 (en)	2018-06-27
JP6755939B2 (ja)	2020-09-16
LT3337820T (lt)	2021-02-10
PH12018500362A1 (en)	2018-08-29
EP3337820B1 (en)	2020-10-14
MX2018001994A (es)	2018-11-09
DK3337820T3 (da)	2021-01-18
CA2993907A1 (en)	2017-02-23
JP2018529654A (ja)	2018-10-11
RU2018109102A3 (zh)	2020-01-30

Publication	Publication Date	Title
ZA202003742B (en)	2022-08-31	Anti-lag3 antibodies and antigen-binding fragments
HK1249023A1 (zh)	2018-10-26	Pd-l1("程序性死亡配體1")抗體
HK1254953A1 (zh)	2019-08-02	抗vista抗體和片段
IL247508A0 (en)	2016-11-30	A method for preparing human plasma proteins
SG11201605580RA (en)	2016-10-28	Antibodies directed against interleukin-33 (il-33)
GB201521391D0 (en)	2016-01-20	Antibodies
GB201521393D0 (en)	2016-01-20	Antibodies
HK1246804A1 (zh)	2018-09-14	Tau結合抗體
GB201521382D0 (en)	2016-01-20	Antibodies
HK1254752A1 (zh)	2019-07-26	用於抗體碎片的改進的複性方法
GB201508180D0 (en)	2015-06-24	Antibodies
GB201603279D0 (en)	2016-04-13	Recommending form fragments
EP3383497A4 (en)	2019-06-12	NEW ANTIBODIES FOR THE TREATMENT OF CANCERS
HUP1500363A2 (en)	2017-02-28	Method for increasing the galactose content of recombinant proteins
GB201608197D0 (en)	2016-06-22	Novel proteins
IL267271A (en)	2019-08-29	Antibodies against il-5
IL258981A (en)	2018-06-28	Methods for the production of proteins
HK1220727A1 (zh)	2017-05-12	使用綿羊細胞產生抗體的方法及其用途
GB201509907D0 (en)	2015-07-22	Antibodies
GB201522394D0 (en)	2016-02-03	Antibodies
GB201503438D0 (en)	2015-04-15	Antibodies
AU2015904525A0 (en)	2015-11-19	Anti-CCR6 antibodies (2)
GB201603763D0 (en)	2016-04-20	Method for protein expression
GB201518728D0 (en)	2015-12-09	Antibodies
GB201515570D0 (en)	2015-10-14	Anti-LAG-3 antibodies