DK3337820T3 - Forbedret fremgangsmåde til genfoldning af fragmenter af antistoffer - Google Patents
Forbedret fremgangsmåde til genfoldning af fragmenter af antistoffer Download PDFInfo
- Publication number
- DK3337820T3 DK3337820T3 DK16766389.7T DK16766389T DK3337820T3 DK 3337820 T3 DK3337820 T3 DK 3337820T3 DK 16766389 T DK16766389 T DK 16766389T DK 3337820 T3 DK3337820 T3 DK 3337820T3
- Authority
- DK
- Denmark
- Prior art keywords
- refolding
- antibodies
- fragments
- improved method
- improved
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/522—CH1 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN3118MU2015 | 2015-08-17 | ||
| PCT/IB2016/054926 WO2017029620A1 (en) | 2015-08-17 | 2016-08-17 | An improved refolding process for antibody's fragments |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3337820T3 true DK3337820T3 (da) | 2021-01-18 |
Family
ID=56936450
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16766389.7T DK3337820T3 (da) | 2015-08-17 | 2016-08-17 | Forbedret fremgangsmåde til genfoldning af fragmenter af antistoffer |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US10781250B2 (da) |
| EP (1) | EP3337820B1 (da) |
| JP (1) | JP6755939B2 (da) |
| CN (1) | CN108026165A (da) |
| AU (1) | AU2016307976A1 (da) |
| CA (1) | CA2993907A1 (da) |
| DK (1) | DK3337820T3 (da) |
| ES (1) | ES2843558T3 (da) |
| HK (1) | HK1254752A1 (da) |
| HR (1) | HRP20210067T1 (da) |
| HU (1) | HUE052993T2 (da) |
| LT (1) | LT3337820T (da) |
| MX (1) | MX2018001994A (da) |
| PH (1) | PH12018500362A1 (da) |
| PL (1) | PL3337820T3 (da) |
| PT (1) | PT3337820T (da) |
| RU (1) | RU2018109102A (da) |
| WO (1) | WO2017029620A1 (da) |
| ZA (1) | ZA201801498B (da) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201506869D0 (en) | 2015-04-22 | 2015-06-03 | Ucb Biopharma Sprl | Method |
| CA3057286A1 (en) * | 2017-03-24 | 2018-09-27 | Council Of Scientific And Industrial Research | A process for the purification of recombinant antibody fragments |
| BR112019023795A2 (pt) * | 2017-05-19 | 2020-07-28 | Council Of Scientific & Industrial Research | método para produzir ranibizumabe humanizado recombinante redobrado |
| CN111128293B (zh) * | 2019-11-25 | 2020-11-10 | 苏州纽博立科技有限公司 | 一种抗体药物生产工艺中碎片的修复方法 |
| CN113073092A (zh) * | 2021-04-15 | 2021-07-06 | 宁波瑞林生物科技有限公司 | 重组人组织型激肽释放酶及其制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5332671A (en) | 1989-05-12 | 1994-07-26 | Genetech, Inc. | Production of vascular endothelial cell growth factor and DNA encoding same |
| EP1819730A2 (en) * | 2004-11-30 | 2007-08-22 | Novo Nordisk A/S | Method of producing antibodies |
| CN100336824C (zh) * | 2005-12-19 | 2007-09-12 | 百奥泰生物科技(广州)有限公司 | 一种重组蛋白的高效变复性的方法 |
| SI2046382T1 (sl) * | 2006-07-10 | 2016-12-30 | ESBATech an Alcon Biomedical Research Unit LLC | Protitelesa scFv, ki prehajajo epitelijske in/ali endotelijske plasti |
| RU2439076C2 (ru) * | 2006-07-14 | 2012-01-10 | Дженентек, Инк. | Способ выделения повторно свернутого рекомбинантного белка из культуры прокариотических клеток (варианты) |
| CN102089319B (zh) * | 2008-05-08 | 2013-11-13 | 味之素株式会社 | 蛋白质的重折叠方法 |
| CN102206272B (zh) * | 2009-12-11 | 2014-10-01 | 普罗特奥姆技术公司 | 生产重组α1-抗胰蛋白酶的方法 |
| CA2815342A1 (en) * | 2010-10-20 | 2012-04-26 | Medimmune, Llc | Methods for processing inclusion bodies |
| ES2645634T3 (es) * | 2013-02-12 | 2017-12-07 | Bristol-Myers Squibb Company | Métodos de replegado de proteínas a elevado pH |
| RU2646098C2 (ru) * | 2013-04-30 | 2018-03-01 | Интас Фармасьютикалс Лтд | Новый способ клонирования, экспрессии и очистки для получения ранибизумаба |
| CN103804486B (zh) * | 2014-01-20 | 2017-05-17 | 安徽安科生物工程（集团）股份有限公司 | 一种提高重组人干扰素α2b天然构象含率的制备工艺 |
-
2016
- 2016-08-17 WO PCT/IB2016/054926 patent/WO2017029620A1/en active Application Filing
- 2016-08-17 PT PT167663897T patent/PT3337820T/pt unknown
- 2016-08-17 AU AU2016307976A patent/AU2016307976A1/en not_active Abandoned
- 2016-08-17 ES ES16766389T patent/ES2843558T3/es active Active
- 2016-08-17 CN CN201680047993.5A patent/CN108026165A/zh active Pending
- 2016-08-17 JP JP2018508637A patent/JP6755939B2/ja active Active
- 2016-08-17 PL PL16766389T patent/PL3337820T3/pl unknown
- 2016-08-17 CA CA2993907A patent/CA2993907A1/en not_active Abandoned
- 2016-08-17 MX MX2018001994A patent/MX2018001994A/es unknown
- 2016-08-17 RU RU2018109102A patent/RU2018109102A/ru not_active Application Discontinuation
- 2016-08-17 EP EP16766389.7A patent/EP3337820B1/en active Active
- 2016-08-17 DK DK16766389.7T patent/DK3337820T3/da active
- 2016-08-17 US US15/752,994 patent/US10781250B2/en active Active
- 2016-08-17 HU HUE16766389A patent/HUE052993T2/hu unknown
- 2016-08-17 LT LTEP16766389.7T patent/LT3337820T/lt unknown
-
2018
- 2018-02-15 PH PH12018500362A patent/PH12018500362A1/en unknown
- 2018-03-05 ZA ZA2018/01498A patent/ZA201801498B/en unknown
- 2018-10-29 HK HK18113795.0A patent/HK1254752A1/zh unknown
-
2021
- 2021-01-13 HR HRP20210067TT patent/HRP20210067T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PH12018500362A1 (en) | 2018-08-29 |
| HK1254752A1 (zh) | 2019-07-26 |
| WO2017029620A1 (en) | 2017-02-23 |
| US20180230206A1 (en) | 2018-08-16 |
| CA2993907A1 (en) | 2017-02-23 |
| CN108026165A (zh) | 2018-05-11 |
| PL3337820T3 (pl) | 2021-11-22 |
| RU2018109102A3 (da) | 2020-01-30 |
| ES2843558T3 (es) | 2021-07-19 |
| LT3337820T (lt) | 2021-02-10 |
| PT3337820T (pt) | 2021-01-19 |
| RU2018109102A (ru) | 2019-09-19 |
| HUE052993T2 (hu) | 2021-06-28 |
| EP3337820A1 (en) | 2018-06-27 |
| HRP20210067T1 (hr) | 2021-03-05 |
| US10781250B2 (en) | 2020-09-22 |
| AU2016307976A1 (en) | 2018-03-08 |
| JP6755939B2 (ja) | 2020-09-16 |
| EP3337820B1 (en) | 2020-10-14 |
| JP2018529654A (ja) | 2018-10-11 |
| ZA201801498B (en) | 2018-12-19 |
| MX2018001994A (es) | 2018-11-09 |
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