HK1252322A1 - 製備細胞毒性苯並二氮雜䓬衍生物的方法 - Google Patents
製備細胞毒性苯並二氮雜䓬衍生物的方法Info
- Publication number
- HK1252322A1 HK1252322A1 HK18111602.7A HK18111602A HK1252322A1 HK 1252322 A1 HK1252322 A1 HK 1252322A1 HK 18111602 A HK18111602 A HK 18111602A HK 1252322 A1 HK1252322 A1 HK 1252322A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- methods
- benzodiazepine derivatives
- cytotoxic benzodiazepine
- preparing cytotoxic
- preparing
- Prior art date
Links
- 229940053197 benzodiazepine derivative antiepileptics Drugs 0.000 title 1
- 125000003310 benzodiazepinyl group Chemical class N1N=C(C=CC2=C1C=CC=C2)* 0.000 title 1
- 231100000433 cytotoxic Toxicity 0.000 title 1
- 230000001472 cytotoxic effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
- C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562195023P | 2015-07-21 | 2015-07-21 | |
US201662327973P | 2016-04-26 | 2016-04-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1252322A1 true HK1252322A1 (zh) | 2019-05-24 |
Family
ID=56557925
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK18111603.6A HK1252323A1 (zh) | 2015-07-21 | 2018-09-10 | 製備細胞毒性苯並二氮雜䓬衍生物的方法 |
HK18111601.8A HK1252321A1 (zh) | 2015-07-21 | 2018-09-10 | 製備細胞毒性苯並二氮雜䓬衍生物的方法 |
HK18111602.7A HK1252322A1 (zh) | 2015-07-21 | 2018-09-10 | 製備細胞毒性苯並二氮雜䓬衍生物的方法 |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK18111603.6A HK1252323A1 (zh) | 2015-07-21 | 2018-09-10 | 製備細胞毒性苯並二氮雜䓬衍生物的方法 |
HK18111601.8A HK1252321A1 (zh) | 2015-07-21 | 2018-09-10 | 製備細胞毒性苯並二氮雜䓬衍生物的方法 |
Country Status (22)
Country | Link |
---|---|
US (11) | US9890179B2 (zh) |
EP (7) | EP4286387A3 (zh) |
JP (8) | JP6787995B2 (zh) |
KR (5) | KR20240055903A (zh) |
CN (5) | CN108055844A (zh) |
AU (7) | AU2016297607A1 (zh) |
CA (4) | CA2992082A1 (zh) |
CY (2) | CY1122553T1 (zh) |
DK (2) | DK3325482T3 (zh) |
ES (4) | ES2764548T3 (zh) |
HK (3) | HK1252323A1 (zh) |
HR (1) | HRP20201479T1 (zh) |
HU (1) | HUE051541T2 (zh) |
IL (10) | IL305279A (zh) |
LT (2) | LT3325482T (zh) |
PL (2) | PL3325483T3 (zh) |
PT (2) | PT3325482T (zh) |
RS (2) | RS59806B1 (zh) |
RU (3) | RU2018105752A (zh) |
SG (2) | SG10202009354SA (zh) |
SI (2) | SI3325482T1 (zh) |
WO (3) | WO2017015496A1 (zh) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
LT3325482T (lt) | 2015-07-21 | 2020-11-25 | Immunogen, Inc. | Citotoksinių benzodiazepino darinių paruošimo būdai |
EP3433875B1 (de) | 2016-03-22 | 2022-05-04 | EV Group E. Thallner GmbH | Verfahren zum bonden von substraten |
KR102617264B1 (ko) | 2016-10-19 | 2023-12-29 | 인벤라 인코포레이티드 | 항체 구조물 |
EA201991204A1 (ru) | 2016-12-22 | 2019-12-30 | Университа Дельи Студи Манья Греча Катандзаро | Моноклональное антитело против уникального сиалогликозилированного опухолеассоциированного эпитопа cd43 |
CN116102615A (zh) * | 2017-01-25 | 2023-05-12 | 伊缪诺金公司 | 制备细胞毒性苯二氮䓬衍生物的方法 |
JP2021527047A (ja) | 2018-06-05 | 2021-10-11 | キングス・カレッジ・ロンドン | 消化管系へのペイロード送達のための、btnl3/8を標的とする構築物 |
US10851117B2 (en) | 2018-11-12 | 2020-12-01 | Immunogen, Inc. | Methods of preparing cytotoxic benzodiazepine derivatives |
IL308670A (en) * | 2018-11-12 | 2024-01-01 | Immunogen Inc | Methods for preparing cytotoxic benzodiazepine derivatives |
TW202102506A (zh) * | 2019-03-29 | 2021-01-16 | 美商伊繆諾金公司 | 苯二氮平衍生物 |
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2016
- 2016-07-21 LT LTEP16745598.9T patent/LT3325482T/lt unknown
- 2016-07-21 EP EP23183947.3A patent/EP4286387A3/en active Pending
- 2016-07-21 AU AU2016297607A patent/AU2016297607A1/en not_active Abandoned
- 2016-07-21 CN CN201680053120.5A patent/CN108055844A/zh active Pending
- 2016-07-21 SG SG10202009354SA patent/SG10202009354SA/en unknown
- 2016-07-21 KR KR1020247012991A patent/KR20240055903A/ko active Search and Examination
- 2016-07-21 PT PT167455989T patent/PT3325482T/pt unknown
- 2016-07-21 ES ES16745961T patent/ES2764548T3/es active Active
- 2016-07-21 HU HUE16745598A patent/HUE051541T2/hu unknown
- 2016-07-21 RU RU2018105752A patent/RU2018105752A/ru not_active Application Discontinuation
- 2016-07-21 IL IL305279A patent/IL305279A/en unknown
- 2016-07-21 EP EP22195446.4A patent/EP4163284A1/en active Pending
- 2016-07-21 IL IL305989A patent/IL305989A/en unknown
- 2016-07-21 US US15/216,517 patent/US9890179B2/en not_active Expired - Fee Related
- 2016-07-21 IL IL286788A patent/IL286788B2/en unknown
- 2016-07-21 CN CN201680053093.1A patent/CN108026103B/zh active Active
- 2016-07-21 EP EP16745961.9A patent/EP3325483B1/en active Active
- 2016-07-21 CA CA2992082A patent/CA2992082A1/en active Pending
- 2016-07-21 WO PCT/US2016/043406 patent/WO2017015496A1/en active Application Filing
- 2016-07-21 IL IL294651A patent/IL294651B2/en unknown
- 2016-07-21 KR KR1020187005040A patent/KR20180038460A/ko unknown
- 2016-07-21 DK DK16745598.9T patent/DK3325482T3/da active
- 2016-07-21 SG SG10202106529XA patent/SG10202106529XA/en unknown
- 2016-07-21 JP JP2018502791A patent/JP6787995B2/ja active Active
- 2016-07-21 AU AU2016297087A patent/AU2016297087B2/en active Active
- 2016-07-21 RS RS20191647A patent/RS59806B1/sr unknown
- 2016-07-21 RS RS20201132A patent/RS60840B1/sr unknown
- 2016-07-21 SI SI201630923T patent/SI3325482T1/sl unknown
- 2016-07-21 PL PL16745961T patent/PL3325483T3/pl unknown
- 2016-07-21 JP JP2018502800A patent/JP2018522018A/ja not_active Withdrawn
- 2016-07-21 RU RU2018105609A patent/RU2746322C2/ru active
- 2016-07-21 AU AU2016297608A patent/AU2016297608B2/en active Active
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