SG10202106529XA - Methods of preparing cytotoxic benzodiazepine derivatives - Google Patents

Methods of preparing cytotoxic benzodiazepine derivatives

Info

Publication number: SG10202106529XA
Authority: SG; Singapore
Prior art keywords: methods; benzodiazepine derivatives; cytotoxic benzodiazepine; preparing cytotoxic; preparing
Prior art date: 2015-07-21

Application number

SG10202106529XA

Inventor

Baudouin Gérard

Manami Shizuka

Michael Louis Miller

Richard A Silva

Original Assignee

Immunogen Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2015-07-21

Filing date

2016-07-21

Publication date

2021-07-29

2016-07-21 Application filed by Immunogen Inc filed Critical Immunogen Inc

2021-07-29 Publication of SG10202106529XA publication Critical patent/SG10202106529XA/en

Links

229940053197 benzodiazepine derivative antiepileptics Drugs 0.000 title 1
125000003310 benzodiazepinyl group Chemical class N1N=C(C=CC2=C1C=CC=C2)* 0.000 title 1
231100000433 cytotoxic Toxicity 0.000 title 1
230000001472 cytotoxic effect Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
- C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

SG10202106529XA 2015-07-21 2016-07-21 Methods of preparing cytotoxic benzodiazepine derivatives SG10202106529XA (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201562195023P	2015-07-21	2015-07-21
US201662327973P	2016-04-26	2016-04-26

Publications (1)

Publication Number	Publication Date
SG10202106529XA true SG10202106529XA (en)	2021-07-29

Family

ID=56557925

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
SG10202106529XA SG10202106529XA (en)	2015-07-21	2016-07-21	Methods of preparing cytotoxic benzodiazepine derivatives
SG10202009354SA SG10202009354SA (en)	2015-07-21	2016-07-21	Methods of preparing cytotoxic benzodiazepine derivatives

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
SG10202009354SA SG10202009354SA (en)	2015-07-21	2016-07-21	Methods of preparing cytotoxic benzodiazepine derivatives

Country Status (22)

Country	Link
US (11)	US9873708B2 (en)
EP (7)	EP3653628B1 (en)
JP (8)	JP6787995B2 (en)
KR (1)	KR20180038460A (en)
CN (5)	CN108026103B (en)
AU (7)	AU2016297607A1 (en)
CA (4)	CA2991305C (en)
CY (2)	CY1122553T1 (en)
DK (2)	DK3325483T3 (en)
ES (4)	ES2933376T3 (en)
HK (3)	HK1252323A1 (en)
HR (1)	HRP20201479T1 (en)
HU (1)	HUE051541T2 (en)
IL (10)	IL283355B (en)
LT (2)	LT3325482T (en)
PL (2)	PL3325482T3 (en)
PT (2)	PT3325482T (en)
RS (2)	RS59806B1 (en)
RU (3)	RU2018105752A (en)
SG (2)	SG10202106529XA (en)
SI (2)	SI3325483T1 (en)
WO (3)	WO2017015495A1 (en)

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2016
- 2016-07-21 WO PCT/US2016/043402 patent/WO2017015495A1/en active Application Filing
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2017
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2018
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2019
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2020
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