ME02576B - Derivati tetrahidropirolotiazina kao inhibitori bace - Google Patents

Derivati tetrahidropirolotiazina kao inhibitori bace

Info

Publication number
ME02576B
ME02576B MEP-2017-4A MEP20174A ME02576B ME 02576 B ME02576 B ME 02576B ME P20174 A MEP20174 A ME P20174A ME 02576 B ME02576 B ME 02576B
Authority
ME
Montenegro
Prior art keywords
tetrahydropyrrolothiazine
derivatives
bace inhibitors
bace
inhibitors
Prior art date
Application number
MEP-2017-4A
Other languages
German (de)
English (en)
French (fr)
Inventor
Eli Lilly And Company C/O
Eli Lillyand Company c/o
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of ME02576B publication Critical patent/ME02576B/me

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
MEP-2017-4A 2012-10-26 2017-02-10 Derivati tetrahidropirolotiazina kao inhibitori bace ME02576B (me)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261718728P 2012-10-26 2012-10-26
PCT/US2013/065418 WO2014066132A1 (en) 2012-10-26 2013-10-17 Bace inhibitors
EP13785730.6A EP2912041B1 (en) 2012-10-26 2013-10-17 Tetrahydropyrrolothiazine derivatives as bace inhibitors

Publications (1)

Publication Number Publication Date
ME02576B true ME02576B (me) 2017-06-20

Family

ID=49515508

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2017-4A ME02576B (me) 2012-10-26 2017-02-10 Derivati tetrahidropirolotiazina kao inhibitori bace

Country Status (17)

Country Link
US (1) US9328124B2 (me)
EP (1) EP2912041B1 (me)
JP (1) JP6243921B2 (me)
CN (1) CN104755484B (me)
CA (1) CA2886507C (me)
CY (1) CY1118623T1 (me)
DK (1) DK2912041T3 (me)
ES (1) ES2616835T3 (me)
HR (1) HRP20170025T1 (me)
HU (1) HUE031764T2 (me)
LT (1) LT2912041T (me)
ME (1) ME02576B (me)
PL (1) PL2912041T3 (me)
PT (1) PT2912041T (me)
RS (1) RS55561B1 (me)
SI (1) SI2912041T1 (me)
WO (1) WO2014066132A1 (me)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014134341A1 (en) 2013-03-01 2014-09-04 Amgen Inc. Perfluorinated 5,6-dihydro-4h-1,3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use
EP2964644B1 (en) 2013-03-08 2018-12-26 Amgen, Inc. Perfluorinated cyclopropyl fused 1,3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use
TWI684452B (zh) * 2014-03-14 2020-02-11 美國禮來大藥廠 胺基噻嗪化合物
WO2016022724A1 (en) 2014-08-08 2016-02-11 Amgen Inc. Cyclopropyl fused thiazin-2-amine compounds as beta-secretase inhibitors and methods of use
WO2017024180A1 (en) 2015-08-06 2017-02-09 Amgen Inc. Vinyl fluoride cyclopropyl fused thiazin-2-amine compounds as beta-secretase inhibitors and methods of use
JP7149272B2 (ja) 2016-12-15 2022-10-06 アムジエン・インコーポレーテツド β－セクレターゼ阻害剤としてのチアジン誘導体および使用方法
EP3555086B1 (en) 2016-12-15 2021-09-01 Amgen Inc. 1,4-thiazine dioxide and 1,2,4-thiadiazine dioxide derivatives as beta-secretase inhibitors and methods of use
CA3047287A1 (en) 2016-12-15 2018-06-21 Amgen Inc. Cyclopropyl fused thiazine derivatives as beta-secretase inhibitors and methods of use
ES2910367T3 (es) 2016-12-15 2022-05-12 Amgen Inc Derivados de tiazina y oxazina bicíclicos como inhibidores de beta-secretasa y métodos de uso
MX2019007101A (es) 2016-12-15 2019-12-16 Amgen Inc Derivados de oxazina como inhibidores de beta secretasa y metodos de uso.
CN106632001A (zh) * 2016-12-28 2017-05-10 山东诚汇双达药业有限公司 一种4‑（溴乙酰基）吡啶氢溴酸盐的制备方法
CN110452179A (zh) * 2019-06-25 2019-11-15 南京普锐达医药科技有限公司 一种2-氯-4-甲氧基-5-氰基嘧啶的合成方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI332005B (en) 2005-06-14 2010-10-21 Schering Corp Aspartyl protease inhibitors
JP5383483B2 (ja) 2007-04-24 2014-01-08 塩野義製薬株式会社 アルツハイマー症治療用医薬組成物
CA2711655C (en) 2008-01-18 2013-03-05 Eisai R&D Management Co., Ltd. Condensed aminodihydrothiazine derivative
AU2009239535A1 (en) 2008-04-22 2009-10-29 Schering Corporation Thiophenyl-substituted 2-imino-3-methyl pyrrolo pyrimidinone compounds as BACE-1 inhibitors, compositions, and their use
US8637504B2 (en) 2008-06-13 2014-01-28 Shionogi & Co., Ltd. Sulfur-containing heterocyclic derivative having beta secretase inhibitory activity
KR20110076965A (ko) 2008-09-30 2011-07-06 에자이 알앤드디 매니지먼트 가부시키가이샤 신규한 축합 아미노 디하이드로티아진 유도체
AR077277A1 (es) 2009-07-09 2011-08-17 Lilly Co Eli Compuestos de biciclo (1,3)tiazin-2-amina formulacion farmaceutica que lo comprende y su uso para la manufactura de un medicamento util para el tratamiento de la enfermedad de alzheimer
GB0912778D0 (en) * 2009-07-22 2009-08-26 Eisai London Res Lab Ltd Fused aminodihydro-oxazine derivatives
US20120245155A1 (en) 2009-12-11 2012-09-27 Shionogi & Co., Ltd. Fused heterocyclic compound having amino group
GB201100181D0 (en) 2011-01-06 2011-02-23 Eisai Ltd Fused aminodihydrothiazine derivatives
US8598161B2 (en) 2011-05-24 2013-12-03 Bristol-Myers Squibb Company Compounds for the reduction of beta-amyloid production
JO3143B1 (ar) 2012-04-03 2017-09-20 Lilly Co Eli مركبات تتراهيدرو بيرولو ثيازين
GB201212871D0 (en) 2012-07-20 2012-09-05 Eisai Ltd Novel compounds
TWI593692B (zh) 2013-03-12 2017-08-01 美國禮來大藥廠 四氫吡咯并噻嗪化合物

Also Published As

Publication number Publication date
CY1118623T1 (el) 2017-07-12
HUE031764T2 (en) 2017-07-28
HRP20170025T1 (hr) 2017-03-10
PT2912041T (pt) 2017-02-13
CA2886507A1 (en) 2014-05-01
DK2912041T3 (en) 2017-02-27
SI2912041T1 (sl) 2017-02-28
RS55561B1 (sr) 2017-05-31
EP2912041B1 (en) 2016-12-14
CN104755484A (zh) 2015-07-01
LT2912041T (lt) 2017-03-10
PL2912041T3 (pl) 2017-06-30
US9328124B2 (en) 2016-05-03
CN104755484B (zh) 2016-02-17
JP6243921B2 (ja) 2017-12-06
ES2616835T3 (es) 2017-06-14
CA2886507C (en) 2016-09-20
JP2015535247A (ja) 2015-12-10
EP2912041A1 (en) 2015-09-02
US20150232483A1 (en) 2015-08-20
WO2014066132A1 (en) 2014-05-01

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