HK1200189A1 - Targeted lysosomal enzyme compounds - Google Patents

Targeted lysosomal enzyme compounds

Info

Publication number
HK1200189A1
HK1200189A1 HK15100520.2A HK15100520A HK1200189A1 HK 1200189 A1 HK1200189 A1 HK 1200189A1 HK 15100520 A HK15100520 A HK 15100520A HK 1200189 A1 HK1200189 A1 HK 1200189A1
Authority
HK
Hong Kong
Prior art keywords
lysosomal enzyme
enzyme compounds
targeted
targeted lysosomal
compounds
Prior art date
Application number
HK15100520.2A
Other languages
English (en)
Chinese (zh)
Inventor
多米尼克．波依溫
讓-保羅．卡斯泰恩
米歇爾．德默勒
薩斯米塔．塔里帕西
讓-克里斯托夫．柯里
西蒙．洛德-杜富爾
Original Assignee
Angiochem Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Angiochem Inc filed Critical Angiochem Inc
Publication of HK1200189A1 publication Critical patent/HK1200189A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/06—Sulfuric ester hydrolases (3.1.6)
    • C12Y301/06013—Iduronate-2-sulfatase (3.1.6.13)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
HK15100520.2A 2011-12-01 2015-01-16 Targeted lysosomal enzyme compounds HK1200189A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161565764P 2011-12-01 2011-12-01
US201261596515P 2012-02-08 2012-02-08
US201261660564P 2012-06-15 2012-06-15
PCT/CA2012/050867 WO2013078564A2 (en) 2011-12-01 2012-11-30 Targeted lysosomal enzyme compounds

Publications (1)

Publication Number Publication Date
HK1200189A1 true HK1200189A1 (en) 2015-07-31

Family

ID=48536183

Family Applications (2)

Application Number Title Priority Date Filing Date
HK15100520.2A HK1200189A1 (en) 2011-12-01 2015-01-16 Targeted lysosomal enzyme compounds
HK15104430.3A HK1204002A1 (en) 2011-12-01 2015-05-11 Targeted lysosomal enzyme compounds

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK15104430.3A HK1204002A1 (en) 2011-12-01 2015-05-11 Targeted lysosomal enzyme compounds

Country Status (11)

Country Link
US (1) US20150037311A1 (xx)
EP (1) EP2785838A4 (xx)
JP (1) JP2015505824A (xx)
CN (1) CN104145015A (xx)
AU (1) AU2012344702A1 (xx)
BR (1) BR112014013161A2 (xx)
CA (1) CA2857567A1 (xx)
HK (2) HK1200189A1 (xx)
MX (1) MX2014006594A (xx)
RU (1) RU2014126484A (xx)
WO (1) WO2013078564A2 (xx)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1583562T3 (da) 2003-01-06 2011-09-19 Angiochem Inc Angiopep-1, beslægtede forbindelser og anvendelser deraf
ES2424242T3 (es) 2005-07-15 2013-09-30 Angiochem Inc. Uso de polipéptidos de aprotinina como portadores en conjugados farmacéuticos
US9365634B2 (en) 2007-05-29 2016-06-14 Angiochem Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
JP5860698B2 (ja) 2008-04-18 2016-02-16 アンジオケム，インコーポレーテッド パクリタキセル、パクリタキセル類似体またはパクリタキセルコンジュゲートの医薬組成物ならびに関連する調製方法および使用方法
BRPI0920209A2 (pt) 2008-10-15 2015-12-22 Angiochem Inc conjugados de agonistas de glp-1 e usos dos mesmos
RU2531591C2 (ru) 2008-10-15 2014-10-20 Ангиокем Инк. Конъюгаты этопозида и доксорубицина для доставки лекарственных средств
US9914754B2 (en) 2008-12-05 2018-03-13 Angiochem Inc. Conjugates of neurotensin or neurotensin analogs and uses thereof
MX2011006685A (es) 2008-12-17 2011-09-27 Angiochem Inc Inhibidores de metaloproteinas de matriz de membrana tipo-1 y sus usos.
ES2729261T3 (es) 2009-04-20 2019-10-31 Angiochem Inc Tratamiento del cáncer de ovario utilizando un agente anticancerígeno conjugado con un análogo de Angiopep-2
IN2012DN00248A (xx) 2009-07-02 2015-05-01 Angiochem Inc
WO2013185235A1 (en) * 2012-06-15 2013-12-19 Angiochem Inc. Targeted iduronidase compounds
EP2885318A4 (en) 2012-08-14 2016-03-30 Angiochem Inc PEPTIDE-DENDRIMER CONJUGATES AND USES THEREOF
BR112015022780A2 (pt) * 2013-03-15 2018-02-06 Amicus Therapeutics Inc reticuladores de produto químico
WO2014194428A1 (en) * 2013-06-06 2014-12-11 Angiochem Inc. Targeted heparan sulfatase compounds
EA201690205A1 (ru) 2013-07-11 2016-12-30 Новартис Аг Сайт-специфические химико-ферментативные модификации белков
EP3157942B1 (en) * 2014-06-23 2020-06-17 Novartis AG Site specific protein modifications
ES2826827T3 (es) 2015-06-15 2021-05-19 Angiochem Inc Métodos para el tratamiento de carcinomatosis leptomeníngea
JOP20190245A1 (ar) 2017-04-20 2019-10-15 Novartis Ag أنظمة توصيل إطلاق مستدام تتضمن روابط بلا أثر لنقطة الربط
CA3076369A1 (en) 2017-10-02 2019-04-11 Denali Therapeutics Inc. Fusion proteins comprising enzyme replacement therapy enzymes
AR116566A1 (es) 2018-10-03 2021-05-19 Novartis Ag Administración sostenida de polipéptidos similares a la angiopoyetina 3

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003032727A1 (en) * 2001-10-16 2003-04-24 Symbiontics Inc. Methods and compositions for targeting underglycosylated proteins across the blood brain barrier
CA2487815A1 (en) * 2002-05-29 2003-12-11 Symbiontics, Inc. Targeted therapeutic proteins
WO2004108071A2 (en) * 2003-06-05 2004-12-16 Salk Institute For Biological Studies Targeting polypeptides to the central nervous system
WO2006108052A2 (en) * 2005-04-06 2006-10-12 Genzyme Corporation Peg and polysialic lysosomal enzyme conjugates via acid labile linkers for therapeutic targeting
CN101946001A (zh) * 2007-12-20 2011-01-12 安吉奥开米公司 多肽-核酸结合物及其应用
US9914754B2 (en) * 2008-12-05 2018-03-13 Angiochem Inc. Conjugates of neurotensin or neurotensin analogs and uses thereof
CN102348723A (zh) * 2008-12-05 2012-02-08 安吉奥开米公司 肽治疗剂轭合物及其应用
JP2013506697A (ja) * 2009-10-06 2013-02-28 アンジオケム インコーポレーテッド 治療薬を輸送するための組成物と方法
EP2333074A1 (en) * 2009-12-14 2011-06-15 Robert Steinfeld Substances and methods for the treatment of lysosmal storage diseases
CA2857548A1 (en) * 2011-12-01 2013-06-06 Angiochem Inc. Targeted enzyme compounds and uses thereof

Also Published As

Publication number Publication date
HK1204002A1 (en) 2015-11-06
CN104145015A (zh) 2014-11-12
RU2014126484A (ru) 2016-02-10
WO2013078564A2 (en) 2013-06-06
MX2014006594A (es) 2015-09-16
AU2012344702A1 (en) 2014-06-19
EP2785838A4 (en) 2015-07-01
EP2785838A2 (en) 2014-10-08
BR112014013161A2 (pt) 2019-09-24
CA2857567A1 (en) 2013-06-06
US20150037311A1 (en) 2015-02-05
JP2015505824A (ja) 2015-02-26
WO2013078564A3 (en) 2013-09-06

Similar Documents

Publication Publication Date Title
HK1204002A1 (en) Targeted lysosomal enzyme compounds
HK1200190A1 (en) Targeted enzyme compounds and uses thereof
ZA201400678B (en) Alpha-amylase variants
EP2714970A4 (en) Enzyme QUANTIFICATION
EP2751265A4 (en) NEW CELLOBIOHYDROLASES
GB201007384D0 (en) Enzymes
GB201004179D0 (en) Enzyme inhibitors
GB201004178D0 (en) Enzyme inhibitors
HK1207880A1 (en) Improved enzyme variants
ZA201207687B (en) Enzyme granules
EP2748299A4 (en) TARGETED MICROBUMS
ZA201500911B (en) Enzymes
EP2730652A4 (en) ENZYME MADE FROM ARTHROBACTER GLOBIFORMS
PL2756076T3 (pl) Warianty enzymu o ulepszonych właściwościach
GB201115853D0 (en) New enzyme inhibitor compounds
GB201112231D0 (en) Micro-organism
PL2748311T3 (pl) Oksydaza glukozowa
GB201214938D0 (en) Alternative oxidase
EP2655646A4 (en) TARGETED PERHYDROLASES
EP2734620A4 (en) ENZYMES FOR REMOVING ORGANOPHOSPHATES
GB201207018D0 (en) Enzymes
ZA201400850B (en) Enzyme system
GB201105987D0 (en) Enzymes
EP2663657A4 (en) GENOMIC ASSEMBLY
GB201114017D0 (en) Inhibitors against endosomal/ysosomal enzymes