BR112015022780A2 - reticuladores de produto químico - Google Patents
reticuladores de produto químicoInfo
- Publication number
- BR112015022780A2 BR112015022780A2 BR112015022780A BR112015022780A BR112015022780A2 BR 112015022780 A2 BR112015022780 A2 BR 112015022780A2 BR 112015022780 A BR112015022780 A BR 112015022780A BR 112015022780 A BR112015022780 A BR 112015022780A BR 112015022780 A2 BR112015022780 A2 BR 112015022780A2
- Authority
- BR
- Brazil
- Prior art keywords
- lysosomal
- target peptide
- contacting
- chemical crosslinkers
- introduce
- Prior art date
Links
- 239000000126 substance Substances 0.000 title abstract 3
- 239000004971 Cross linker Substances 0.000 title abstract 2
- 230000002132 lysosomal effect Effects 0.000 abstract 5
- 102000004190 Enzymes Human genes 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 2
- 125000003172 aldehyde group Chemical group 0.000 abstract 2
- 239000003431 cross linking reagent Substances 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 230000021615 conjugation Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000863 peptide conjugate Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
- C12N9/20—Triglyceride splitting, e.g. by means of lipase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
- C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
- C12N9/2434—Glucanases acting on beta-1,4-glucosidic bonds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2465—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1) acting on alpha-galactose-glycoside bonds, e.g. alpha-galactosidase (3.2.1.22)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2477—Hemicellulases not provided in a preceding group
- C12N9/2488—Mannanases
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/0102—Alpha-glucosidase (3.2.1.20)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicinal Preparation (AREA)
Abstract
resumo reticuladores de produto químico são revelados no presente documento métodos de conjugação de produto químico que compreendem colocar uma enzima lisossômica em contato com um primeiro agente de reticulação para introduzir grupos aldeído; colocar um peptídeo-alvo lisossômico em contato com um segundo agente de reticulação para introduzir um grupo hidrazida no resíduo n-terminal; colocar a enzima lisossômica com grupos aldeído da etapa a. em contato com o peptídeo-alvo lisossômico com um grupo hidrazida no resíduo n-terminal da etapa b; e formar um conjugado de enzima lisossômica - peptídeo-alvo lisossômico.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361794784P | 2013-03-15 | 2013-03-15 | |
PCT/US2014/027818 WO2014143734A2 (en) | 2013-03-15 | 2014-03-14 | Chemical crosslinkers |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112015022780A2 true BR112015022780A2 (pt) | 2018-02-06 |
Family
ID=51537517
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015022780A BR112015022780A2 (pt) | 2013-03-15 | 2014-03-14 | reticuladores de produto químico |
Country Status (15)
Country | Link |
---|---|
US (2) | US9889203B2 (pt) |
EP (2) | EP3714893A1 (pt) |
JP (2) | JP6506250B2 (pt) |
KR (1) | KR20150132126A (pt) |
CN (1) | CN105189742A (pt) |
AU (2) | AU2014228231B2 (pt) |
BR (1) | BR112015022780A2 (pt) |
CA (1) | CA2902210C (pt) |
ES (1) | ES2804594T3 (pt) |
HK (1) | HK1215049A1 (pt) |
IL (1) | IL240209A0 (pt) |
MX (1) | MX2015012873A (pt) |
SG (1) | SG11201505936QA (pt) |
WO (2) | WO2014143701A1 (pt) |
ZA (1) | ZA201506363B (pt) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014143701A1 (en) * | 2013-03-15 | 2014-09-18 | Amicus Therapeutics, Inc. | Chemical crosslinkers |
GB201508025D0 (en) | 2015-05-11 | 2015-06-24 | Ucl Business Plc | Fabry disease gene therapy |
WO2016195394A1 (ko) * | 2015-06-02 | 2016-12-08 | 한국생명공학연구원 | 효모 세포벽 만노단백질 유래의 당사슬을 이용한 만노스-6-인산 당사슬이 부가된 당단백질의 제조방법 |
EP3788064A1 (en) * | 2018-04-30 | 2021-03-10 | Amicus Therapeutics, Inc. | Gene therapy constructs and methods of use |
MX2021004188A (es) | 2018-10-10 | 2021-09-08 | Amicus Therapeutics Inc | Composiciones polipeptídicas estabilizadas con enlace disulfuro y métodos de uso. |
KR20220077921A (ko) * | 2019-10-10 | 2022-06-09 | 아미쿠스 세라퓨틱스, 인코포레이티드 | 변이체 igf2 작제물 |
CN116670152A (zh) | 2020-12-01 | 2023-08-29 | 宾夕法尼亚州大学信托人 | 具有组织特异性靶向基序的新型组合物和含有其的组合物 |
WO2022226263A1 (en) | 2021-04-23 | 2022-10-27 | The Trustees Of The University Of Pennsylvania | Novel compositions with brain-specific targeting motifs and compositions containing same |
WO2024130070A2 (en) | 2022-12-17 | 2024-06-20 | The Trustees Of The University Of Pennsylvania | Recombinant aav capsids with cardiac- and skeletal muscle- specific targeting motifs and uses thereof |
WO2024130067A2 (en) | 2022-12-17 | 2024-06-20 | The Trustees Of The University Of Pennsylvania | Recombinant aav mutant vectors with cardiac and skeletal muscle-specific targeting motifs and compositions containing same |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5401650A (en) * | 1990-10-24 | 1995-03-28 | The Mount Sinai School Of Medicine Of The City University Of New York | Cloning and expression of biologically active α-galactosidase A |
EP2298736B1 (en) * | 2000-03-22 | 2015-07-15 | Solulink, Inc. | Hydrazine-based and carbonyl-based bifunctional crosslinking reagents |
EP1877099B1 (en) * | 2005-04-06 | 2012-09-19 | Genzyme Corporation | Therapeutic conjugates comprising a lysosomal enzyme, polysialic acid and a targeting moiety |
EP1877101B1 (en) * | 2005-04-28 | 2016-11-16 | Ventana Medical Systems, Inc. | Enzymes conjugated to antibodies via a peg heterobifuctional linker |
US8993295B2 (en) * | 2006-07-20 | 2015-03-31 | The General Hospital Corporation | Methods, compositions, and kits for the selective activation of protoxins through combinatorial targeting |
JP2013506697A (ja) * | 2009-10-06 | 2013-02-28 | アンジオケム インコーポレーテッド | 治療薬を輸送するための組成物と方法 |
JP6300720B2 (ja) * | 2011-05-27 | 2018-03-28 | アミカス セラピューティックス インコーポレイテッド | リソソーム蓄積症の改善された治療のための組換えリソソーム酵素にターゲティングペプチドをカップリングするための方法 |
CA2857567A1 (en) * | 2011-12-01 | 2013-06-06 | Angiochem Inc. | Targeted lysosomal enzyme compounds |
WO2014143701A1 (en) * | 2013-03-15 | 2014-09-18 | Amicus Therapeutics, Inc. | Chemical crosslinkers |
-
2014
- 2014-03-14 WO PCT/US2014/027771 patent/WO2014143701A1/en active Application Filing
- 2014-03-14 US US14/762,647 patent/US9889203B2/en active Active
- 2014-03-14 EP EP20170446.7A patent/EP3714893A1/en not_active Withdrawn
- 2014-03-14 AU AU2014228231A patent/AU2014228231B2/en active Active
- 2014-03-14 MX MX2015012873A patent/MX2015012873A/es unknown
- 2014-03-14 BR BR112015022780A patent/BR112015022780A2/pt not_active Application Discontinuation
- 2014-03-14 ES ES14764160T patent/ES2804594T3/es active Active
- 2014-03-14 CA CA2902210A patent/CA2902210C/en active Active
- 2014-03-14 JP JP2016502634A patent/JP6506250B2/ja active Active
- 2014-03-14 SG SG11201505936QA patent/SG11201505936QA/en unknown
- 2014-03-14 CN CN201480008669.3A patent/CN105189742A/zh active Pending
- 2014-03-14 WO PCT/US2014/027818 patent/WO2014143734A2/en active Application Filing
- 2014-03-14 KR KR1020157023763A patent/KR20150132126A/ko not_active Application Discontinuation
- 2014-03-14 EP EP14764160.9A patent/EP2976092B1/en active Active
-
2015
- 2015-07-29 IL IL240209A patent/IL240209A0/en unknown
- 2015-08-31 ZA ZA2015/06363A patent/ZA201506363B/en unknown
-
2016
- 2016-03-15 HK HK16102953.3A patent/HK1215049A1/zh unknown
-
2018
- 2018-02-08 US US15/891,397 patent/US10814008B2/en active Active
-
2019
- 2019-03-28 JP JP2019063679A patent/JP2019142889A/ja active Pending
- 2019-05-16 AU AU2019203437A patent/AU2019203437A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
SG11201505936QA (en) | 2015-09-29 |
EP2976092A2 (en) | 2016-01-27 |
CA2902210A1 (en) | 2014-09-18 |
HK1215049A1 (zh) | 2016-08-12 |
AU2014228231B2 (en) | 2019-02-21 |
JP2016515510A (ja) | 2016-05-30 |
ZA201506363B (en) | 2017-11-29 |
WO2014143701A1 (en) | 2014-09-18 |
AU2019203437A1 (en) | 2019-06-13 |
AU2014228231A1 (en) | 2015-08-13 |
CA2902210C (en) | 2021-07-20 |
JP6506250B2 (ja) | 2019-04-24 |
ES2804594T3 (es) | 2021-02-08 |
IL240209A0 (en) | 2015-09-24 |
MX2015012873A (es) | 2016-02-03 |
EP2976092B1 (en) | 2020-04-22 |
KR20150132126A (ko) | 2015-11-25 |
JP2019142889A (ja) | 2019-08-29 |
US20180185503A1 (en) | 2018-07-05 |
WO2014143734A2 (en) | 2014-09-18 |
US20160129126A1 (en) | 2016-05-12 |
US9889203B2 (en) | 2018-02-13 |
WO2014143734A3 (en) | 2014-12-04 |
EP2976092A4 (en) | 2016-11-23 |
EP3714893A1 (en) | 2020-09-30 |
CN105189742A (zh) | 2015-12-23 |
US10814008B2 (en) | 2020-10-27 |
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