HK1198159A1 - 合成 -二甲氧基苯基 丙- -烯腈的方法及其在合成伊伐布雷定及其可藥用酸加成鹽中的應用 - Google Patents

合成 -二甲氧基苯基 丙- -烯腈的方法及其在合成伊伐布雷定及其可藥用酸加成鹽中的應用

Info

Publication number
HK1198159A1
HK1198159A1 HK14111643.2A HK14111643A HK1198159A1 HK 1198159 A1 HK1198159 A1 HK 1198159A1 HK 14111643 A HK14111643 A HK 14111643A HK 1198159 A1 HK1198159 A1 HK 1198159A1
Authority
HK
Hong Kong
Prior art keywords
synthesis
enenitrile
ivabradine
dimethoxyphenyl
prop
Prior art date
Application number
HK14111643.2A
Other languages
English (en)
Inventor
Maria Del Pilar Carranza
Aranda Maria Isabel Garcia
Jos Lorenzo Gonzalez
Frdric Sanchez
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of HK1198159A1 publication Critical patent/HK1198159A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/32—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
    • B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
    • B01J23/44—Palladium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/34—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring with cyano groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by unsaturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Materials Engineering (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Saccharide Compounds (AREA)
  • Catalysts (AREA)
HK14111643.2A 2012-11-08 2014-11-18 合成 -二甲氧基苯基 丙- -烯腈的方法及其在合成伊伐布雷定及其可藥用酸加成鹽中的應用 HK1198159A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1260576A FR2997696B1 (fr) 2012-11-08 2012-11-08 Nouveau procede de synthese du (2e)-3-(3,4-dimethoxyphenyl)prop-2-enenitrile, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable

Publications (1)

Publication Number Publication Date
HK1198159A1 true HK1198159A1 (zh) 2015-03-13

Family

ID=47598957

Family Applications (2)

Application Number Title Priority Date Filing Date
HK14106802.9A HK1193408A1 (zh) 2012-11-08 2014-07-04 合成 -二甲氧基苯基 丙- -烯腈的新方法及其在合成伊伐布雷定及其可藥用酸加成鹽中的應用
HK14111643.2A HK1198159A1 (zh) 2012-11-08 2014-11-18 合成 -二甲氧基苯基 丙- -烯腈的方法及其在合成伊伐布雷定及其可藥用酸加成鹽中的應用

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HK14106802.9A HK1193408A1 (zh) 2012-11-08 2014-07-04 合成 -二甲氧基苯基 丙- -烯腈的新方法及其在合成伊伐布雷定及其可藥用酸加成鹽中的應用

Country Status (36)

Country Link
US (1) US8779122B2 (zh)
EP (1) EP2730562B1 (zh)
JP (2) JP6058519B2 (zh)
KR (1) KR20140059731A (zh)
CN (1) CN103804225B (zh)
AR (1) AR093373A1 (zh)
AU (1) AU2013245452C1 (zh)
BR (1) BR102013028259A2 (zh)
CA (1) CA2831289C (zh)
CY (1) CY1116253T1 (zh)
DK (1) DK2730562T3 (zh)
EA (1) EA027080B1 (zh)
ES (1) ES2539618T3 (zh)
FR (1) FR2997696B1 (zh)
GE (1) GEP20156308B (zh)
HK (2) HK1193408A1 (zh)
HR (1) HRP20150570T1 (zh)
HU (1) HUE026525T2 (zh)
JO (1) JO3189B1 (zh)
MA (1) MA35147B1 (zh)
MD (1) MD4392C1 (zh)
ME (1) ME02120B (zh)
MX (1) MX355590B (zh)
MY (1) MY159701A (zh)
NZ (1) NZ616768A (zh)
PL (1) PL2730562T3 (zh)
PT (1) PT2730562E (zh)
RS (1) RS53993B1 (zh)
SA (1) SA113350005B1 (zh)
SG (1) SG2013077235A (zh)
SI (1) SI2730562T1 (zh)
TW (1) TWI488833B (zh)
UA (1) UA118008C2 (zh)
UY (1) UY35108A (zh)
WO (1) WO2014072640A1 (zh)
ZA (1) ZA201308001B (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3101010A1 (en) 2015-06-03 2016-12-07 Urquima S.A. New method for the preparation of highly pure ivabradine base and salts thereof
CN105541605A (zh) * 2016-02-04 2016-05-04 扬州大学 一种轴手性联萘配体前体(s)-2,2’-二羧酸-1,1’-联萘的合成方法
KR102630307B1 (ko) 2017-08-31 2024-01-29 다이이찌 산쿄 가부시키가이샤 항체-약물 콘주게이트의 신규 제조 방법

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5310598B2 (zh) * 1972-01-28 1978-04-14
JPH0753692B2 (ja) * 1990-10-30 1995-06-07 工業技術院長 芳香族カルボン酸エステル類の製造方法
FR2681862B1 (fr) * 1991-09-27 1993-11-12 Adir Cie Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
DE4333711A1 (de) * 1993-10-02 1995-04-06 Hoechst Ag 2,4,5-Trihalogenzimtsäurenitrile und Verfahren zu ihrer Herstellung
DE10159270A1 (de) * 2001-12-03 2003-06-12 Bayer Ag Verfahren zur Arylierung von Olefinen
WO2005123662A1 (en) * 2004-06-18 2005-12-29 Janssen Pharmaceutica N.V. Modified heck reaction
CN101407474B (zh) * 2008-11-18 2011-12-14 东华大学 一种2-溴-4,5-二甲氧基苯丙腈的制备方法
WO2011138825A1 (ja) 2010-05-06 2011-11-10 株式会社島津製作所 材料試験機
HUP1000245A2 (en) * 2010-05-07 2011-11-28 Richter Gedeon Nyrt Industrial process for the production ivabradin salts
CN102464595B (zh) * 2010-11-17 2015-02-25 山东新时代药业有限公司 一种伊伐布雷定中间体的合成方法

Also Published As

Publication number Publication date
JP2014114275A (ja) 2014-06-26
US20140128598A1 (en) 2014-05-08
MD4392B1 (ro) 2016-01-31
EP2730562A1 (fr) 2014-05-14
CN103804225A (zh) 2014-05-21
CY1116253T1 (el) 2017-02-08
JO3189B1 (ar) 2018-03-08
ME02120B (me) 2015-10-20
JP6058519B2 (ja) 2017-01-11
HK1193408A1 (zh) 2014-09-19
AR093373A1 (es) 2015-06-03
CN103804225B (zh) 2016-02-17
SG2013077235A (en) 2014-06-27
HRP20150570T1 (en) 2015-07-03
PL2730562T3 (pl) 2015-08-31
FR2997696A1 (fr) 2014-05-09
SI2730562T1 (sl) 2015-07-31
NZ616768A (en) 2015-02-27
FR2997696B1 (fr) 2014-12-05
SA113350005B1 (ar) 2015-12-06
MY159701A (en) 2017-01-13
CA2831289C (en) 2016-02-09
KR20140059731A (ko) 2014-05-16
MX2013012858A (es) 2014-08-07
TWI488833B (zh) 2015-06-21
JP2016047837A (ja) 2016-04-07
ZA201308001B (en) 2014-07-30
EP2730562B1 (fr) 2015-03-25
UY35108A (es) 2014-05-30
AU2013245452B2 (en) 2017-02-16
DK2730562T3 (en) 2015-06-29
HUE026525T2 (en) 2016-06-28
US8779122B2 (en) 2014-07-15
AU2013245452A1 (en) 2014-05-22
PT2730562E (pt) 2015-05-20
GEP20156308B (en) 2015-06-25
TW201418197A (zh) 2014-05-16
MD4392C1 (ro) 2016-08-31
CA2831289A1 (en) 2014-05-08
MA35147B1 (fr) 2014-06-02
WO2014072640A1 (fr) 2014-05-15
BR102013028259A2 (pt) 2014-10-07
UA118008C2 (uk) 2018-11-12
MD20130082A2 (en) 2014-05-31
RS53993B1 (en) 2015-10-30
AU2013245452C1 (en) 2017-06-22
EA201301136A3 (ru) 2014-07-30
ES2539618T3 (es) 2015-07-02
MX355590B (es) 2018-04-24
EA027080B1 (ru) 2017-06-30
EA201301136A2 (ru) 2014-05-30

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20201109