HK1186734A1 - 合成伊伐布雷定及其可藥用酸加成鹽的方法 - Google Patents

合成伊伐布雷定及其可藥用酸加成鹽的方法

Info

Publication number
HK1186734A1
HK1186734A1 HK13114206.6A HK13114206A HK1186734A1 HK 1186734 A1 HK1186734 A1 HK 1186734A1 HK 13114206 A HK13114206 A HK 13114206A HK 1186734 A1 HK1186734 A1 HK 1186734A1
Authority
HK
Hong Kong
Prior art keywords
ivabradine
synthesis
pharmaceutically acceptable
addition salts
acceptable acid
Prior art date
Application number
HK13114206.6A
Other languages
English (en)
Inventor
Jean-Luc Renaud
Nicolas Pannetier
Sylvain Gaillard
Jean-Pierre Lecouve
Lucile Vaysse-Ludot
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47355960&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1186734(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Servier Lab filed Critical Servier Lab
Publication of HK1186734A1 publication Critical patent/HK1186734A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK13114206.6A 2011-12-20 2013-12-23 合成伊伐布雷定及其可藥用酸加成鹽的方法 HK1186734A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1103934A FR2984320B1 (fr) 2011-12-20 2011-12-20 Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable

Publications (1)

Publication Number Publication Date
HK1186734A1 true HK1186734A1 (zh) 2014-03-21

Family

ID=47355960

Family Applications (1)

Application Number Title Priority Date Filing Date
HK13114206.6A HK1186734A1 (zh) 2011-12-20 2013-12-23 合成伊伐布雷定及其可藥用酸加成鹽的方法

Country Status (35)

Country Link
US (1) US8507668B2 (zh)
EP (1) EP2607354B1 (zh)
JP (1) JP5531084B2 (zh)
KR (1) KR101479986B1 (zh)
CN (1) CN103172567B (zh)
AR (1) AR089325A1 (zh)
AU (1) AU2012261583B2 (zh)
BR (1) BR102012032562A2 (zh)
CA (1) CA2798633C (zh)
CL (1) CL2012003579A1 (zh)
CY (1) CY1115620T1 (zh)
DK (1) DK2607354T3 (zh)
EA (1) EA021713B1 (zh)
ES (1) ES2516290T3 (zh)
FR (1) FR2984320B1 (zh)
GE (1) GEP20156245B (zh)
HK (1) HK1186734A1 (zh)
HR (1) HRP20140839T1 (zh)
JO (1) JO3083B1 (zh)
MA (1) MA34868B1 (zh)
MD (1) MD4275C1 (zh)
MX (1) MX2012014321A (zh)
MY (1) MY160928A (zh)
PE (1) PE20131325A1 (zh)
PL (1) PL2607354T3 (zh)
PT (1) PT2607354E (zh)
RS (1) RS53470B (zh)
SA (1) SA112340106B1 (zh)
SG (1) SG191498A1 (zh)
SI (1) SI2607354T1 (zh)
TW (1) TWI440628B (zh)
UA (1) UA111156C2 (zh)
UY (1) UY34508A (zh)
WO (1) WO2013093333A1 (zh)
ZA (1) ZA201209369B (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2988720B1 (fr) * 2012-03-27 2014-03-14 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2681862B1 (fr) * 1991-09-27 1993-11-12 Adir Cie Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
FR2868776B1 (fr) * 2004-04-13 2008-04-18 Servier Lab Nouveau procede de synthese de derives de la 1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2868777B1 (fr) * 2004-04-13 2006-05-26 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2868775B1 (fr) * 2004-04-13 2008-04-11 Servier Lab Nouveau procede de synthese de derives de la 1,3,4,5- tetrahydro-2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2870537A1 (fr) * 2004-05-19 2005-11-25 Servier Lab Nouveau procede de synthese du (1s)-4,5-dimethoxy-1-(methyl aminomethyl-)-benzocyclobutane et de ses sels d'addition, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
RU2473544C2 (ru) * 2007-05-30 2013-01-27 Инд-Свифт Лабораториз Лимитед Способ получения ивабрадина гидрохлорида и его полиморфных модификаций
FR2920773B1 (fr) * 2007-09-11 2009-10-23 Servier Lab Derives de 1,2,4,5-tetrahydro-3h-benzazepines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2932800B1 (fr) * 2008-06-20 2015-02-20 Servier Lab Nouveau procede de synthese de la 7,8-dimethoxy-1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2935381B1 (fr) * 2008-08-29 2010-12-17 Servier Lab Nouveau procede de resolution des enantiomerees du (3,4-dimethoxy-bicyclo°4.2.0!octa-1,3,5-trien-7-yl)nitrile et application a la synthese de l'ivabradine
FR2940287B1 (fr) * 2008-12-24 2010-12-24 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable.
FR2941695B1 (fr) * 2009-02-04 2011-02-18 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
AU2010216150B2 (en) * 2009-02-17 2015-05-14 Mallinckrodt Llc Process for the reductive alkylation of normorphinans
ME00986B (me) * 2009-03-31 2012-06-20 Servier Lab Novi postupak sinteze ivabradina i njegovih adicionih soli sa farmaceutski prihvatljivom kiselinom

Also Published As

Publication number Publication date
SG191498A1 (en) 2013-07-31
MX2012014321A (es) 2013-06-19
TW201331183A (zh) 2013-08-01
SA112340106B1 (ar) 2015-07-09
AR089325A1 (es) 2014-08-13
JP2013129656A (ja) 2013-07-04
EA201201571A1 (ru) 2013-07-30
PL2607354T3 (pl) 2014-10-31
RS53470B (en) 2014-12-31
CL2012003579A1 (es) 2014-09-05
HRP20140839T1 (hr) 2014-10-24
UA111156C2 (uk) 2016-04-11
PE20131325A1 (es) 2013-11-15
MD4275B1 (en) 2014-02-28
JP5531084B2 (ja) 2014-06-25
EA021713B1 (ru) 2015-08-31
KR101479986B1 (ko) 2015-01-08
UY34508A (es) 2013-06-28
TWI440628B (zh) 2014-06-11
EP2607354A1 (fr) 2013-06-26
JO3083B1 (ar) 2017-03-15
WO2013093333A1 (fr) 2013-06-27
CA2798633C (fr) 2014-08-19
CN103172567B (zh) 2015-08-12
EP2607354B1 (fr) 2014-07-16
PT2607354E (pt) 2014-08-27
CN103172567A (zh) 2013-06-26
NZ604890A (en) 2014-03-28
KR20130071389A (ko) 2013-06-28
CA2798633A1 (fr) 2013-06-20
GEP20156245B (en) 2015-02-10
CY1115620T1 (el) 2017-01-04
AU2012261583B2 (en) 2014-01-16
ES2516290T3 (es) 2014-10-30
US8507668B2 (en) 2013-08-13
MD4275C1 (ro) 2014-09-30
DK2607354T3 (da) 2014-10-13
BR102012032562A2 (pt) 2013-11-12
AU2012261583A1 (en) 2013-07-04
MA34868B1 (fr) 2014-02-01
US20130158257A1 (en) 2013-06-20
MY160928A (en) 2017-03-31
FR2984320B1 (fr) 2013-11-29
FR2984320A1 (fr) 2013-06-21
SI2607354T1 (sl) 2014-10-30
ZA201209369B (en) 2013-08-28

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20191218