MX355590B - Nuevo procedimiento de síntesis del (2e)-3-(3,4-dimetoxifenil)prop -2-enonitrilo, y aplicación a la síntesis de la ivabradina y de sus sales de adición a un ácido farmacéuticamente aceptable. - Google Patents

Nuevo procedimiento de síntesis del (2e)-3-(3,4-dimetoxifenil)prop -2-enonitrilo, y aplicación a la síntesis de la ivabradina y de sus sales de adición a un ácido farmacéuticamente aceptable.

Info

Publication number
MX355590B
MX355590B MX2013012858A MX2013012858A MX355590B MX 355590 B MX355590 B MX 355590B MX 2013012858 A MX2013012858 A MX 2013012858A MX 2013012858 A MX2013012858 A MX 2013012858A MX 355590 B MX355590 B MX 355590B
Authority
MX
Mexico
Prior art keywords
acid
dimethoxyphenyl
synthesising
enenitrile
prop
Prior art date
Application number
MX2013012858A
Other languages
English (en)
Other versions
MX2013012858A (es
Inventor
Isabel Garcia Aranda Maria
Lorenzo Gonzalez José
Sanchez Frédéric
Del Pilar Carranza María
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of MX2013012858A publication Critical patent/MX2013012858A/es
Publication of MX355590B publication Critical patent/MX355590B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/32—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
    • B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
    • B01J23/44—Palladium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/34—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring with cyano groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by unsaturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Materials Engineering (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Saccharide Compounds (AREA)
  • Catalysts (AREA)

Abstract

Procedimiento de síntesis del compuesto de fórmula (1): (ver Fórmula) Aplicación en la síntesis de la ivabradina, de sus sales de adición a un ácido farmacéuticamente aceptable e hidratos de la misma.
MX2013012858A 2012-11-08 2013-11-04 Nuevo procedimiento de síntesis del (2e)-3-(3,4-dimetoxifenil)prop -2-enonitrilo, y aplicación a la síntesis de la ivabradina y de sus sales de adición a un ácido farmacéuticamente aceptable. MX355590B (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1260576A FR2997696B1 (fr) 2012-11-08 2012-11-08 Nouveau procede de synthese du (2e)-3-(3,4-dimethoxyphenyl)prop-2-enenitrile, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable

Publications (2)

Publication Number Publication Date
MX2013012858A MX2013012858A (es) 2014-08-07
MX355590B true MX355590B (es) 2018-04-24

Family

ID=47598957

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013012858A MX355590B (es) 2012-11-08 2013-11-04 Nuevo procedimiento de síntesis del (2e)-3-(3,4-dimetoxifenil)prop -2-enonitrilo, y aplicación a la síntesis de la ivabradina y de sus sales de adición a un ácido farmacéuticamente aceptable.

Country Status (36)

Country Link
US (1) US8779122B2 (es)
EP (1) EP2730562B1 (es)
JP (2) JP6058519B2 (es)
KR (1) KR20140059731A (es)
CN (1) CN103804225B (es)
AR (1) AR093373A1 (es)
AU (1) AU2013245452C1 (es)
BR (1) BR102013028259A2 (es)
CA (1) CA2831289C (es)
CY (1) CY1116253T1 (es)
DK (1) DK2730562T3 (es)
EA (1) EA027080B1 (es)
ES (1) ES2539618T3 (es)
FR (1) FR2997696B1 (es)
GE (1) GEP20156308B (es)
HK (2) HK1193408A1 (es)
HR (1) HRP20150570T1 (es)
HU (1) HUE026525T2 (es)
JO (1) JO3189B1 (es)
MA (1) MA35147B1 (es)
MD (1) MD4392C1 (es)
ME (1) ME02120B (es)
MX (1) MX355590B (es)
MY (1) MY159701A (es)
NZ (1) NZ616768A (es)
PL (1) PL2730562T3 (es)
PT (1) PT2730562E (es)
RS (1) RS53993B1 (es)
SA (1) SA113350005B1 (es)
SG (1) SG2013077235A (es)
SI (1) SI2730562T1 (es)
TW (1) TWI488833B (es)
UA (1) UA118008C2 (es)
UY (1) UY35108A (es)
WO (1) WO2014072640A1 (es)
ZA (1) ZA201308001B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3101010A1 (en) 2015-06-03 2016-12-07 Urquima S.A. New method for the preparation of highly pure ivabradine base and salts thereof
CN105541605A (zh) * 2016-02-04 2016-05-04 扬州大学 一种轴手性联萘配体前体(s)-2,2’-二羧酸-1,1’-联萘的合成方法
KR102630307B1 (ko) 2017-08-31 2024-01-29 다이이찌 산쿄 가부시키가이샤 항체-약물 콘주게이트의 신규 제조 방법

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5310598B2 (es) * 1972-01-28 1978-04-14
JPH0753692B2 (ja) * 1990-10-30 1995-06-07 工業技術院長 芳香族カルボン酸エステル類の製造方法
FR2681862B1 (fr) * 1991-09-27 1993-11-12 Adir Cie Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
DE4333711A1 (de) * 1993-10-02 1995-04-06 Hoechst Ag 2,4,5-Trihalogenzimtsäurenitrile und Verfahren zu ihrer Herstellung
DE10159270A1 (de) * 2001-12-03 2003-06-12 Bayer Ag Verfahren zur Arylierung von Olefinen
WO2005123662A1 (en) * 2004-06-18 2005-12-29 Janssen Pharmaceutica N.V. Modified heck reaction
CN101407474B (zh) * 2008-11-18 2011-12-14 东华大学 一种2-溴-4,5-二甲氧基苯丙腈的制备方法
WO2011138825A1 (ja) 2010-05-06 2011-11-10 株式会社島津製作所 材料試験機
HUP1000245A2 (en) * 2010-05-07 2011-11-28 Richter Gedeon Nyrt Industrial process for the production ivabradin salts
CN102464595B (zh) * 2010-11-17 2015-02-25 山东新时代药业有限公司 一种伊伐布雷定中间体的合成方法

Also Published As

Publication number Publication date
JP2014114275A (ja) 2014-06-26
US20140128598A1 (en) 2014-05-08
MD4392B1 (ro) 2016-01-31
EP2730562A1 (fr) 2014-05-14
CN103804225A (zh) 2014-05-21
CY1116253T1 (el) 2017-02-08
JO3189B1 (ar) 2018-03-08
ME02120B (me) 2015-10-20
JP6058519B2 (ja) 2017-01-11
HK1193408A1 (en) 2014-09-19
AR093373A1 (es) 2015-06-03
CN103804225B (zh) 2016-02-17
SG2013077235A (en) 2014-06-27
HRP20150570T1 (en) 2015-07-03
PL2730562T3 (pl) 2015-08-31
FR2997696A1 (fr) 2014-05-09
SI2730562T1 (sl) 2015-07-31
NZ616768A (en) 2015-02-27
FR2997696B1 (fr) 2014-12-05
SA113350005B1 (ar) 2015-12-06
MY159701A (en) 2017-01-13
CA2831289C (en) 2016-02-09
KR20140059731A (ko) 2014-05-16
MX2013012858A (es) 2014-08-07
TWI488833B (zh) 2015-06-21
JP2016047837A (ja) 2016-04-07
ZA201308001B (en) 2014-07-30
HK1198159A1 (zh) 2015-03-13
EP2730562B1 (fr) 2015-03-25
UY35108A (es) 2014-05-30
AU2013245452B2 (en) 2017-02-16
DK2730562T3 (en) 2015-06-29
HUE026525T2 (en) 2016-06-28
US8779122B2 (en) 2014-07-15
AU2013245452A1 (en) 2014-05-22
PT2730562E (pt) 2015-05-20
GEP20156308B (en) 2015-06-25
TW201418197A (zh) 2014-05-16
MD4392C1 (ro) 2016-08-31
CA2831289A1 (en) 2014-05-08
MA35147B1 (fr) 2014-06-02
WO2014072640A1 (fr) 2014-05-15
BR102013028259A2 (pt) 2014-10-07
UA118008C2 (uk) 2018-11-12
MD20130082A2 (en) 2014-05-31
RS53993B1 (en) 2015-10-30
AU2013245452C1 (en) 2017-06-22
EA201301136A3 (ru) 2014-07-30
ES2539618T3 (es) 2015-07-02
EA027080B1 (ru) 2017-06-30
EA201301136A2 (ru) 2014-05-30

Similar Documents

Publication Publication Date Title
MA31071B1 (fr) Nouveau procede de synthese de la 7,8-dimethoxy-1,3-dihydro-2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et des sels d'addition a un acide pharmaceutiquement acceptable
CN101993405B (zh) 吲哚啉衍生物、及其制备方法和用途
MX2009012369A (es) Proceso para preparar un agonista del receptor de adenosina-a2a y sus polimorfos.
MX355590B (es) Nuevo procedimiento de síntesis del (2e)-3-(3,4-dimetoxifenil)prop -2-enonitrilo, y aplicación a la síntesis de la ivabradina y de sus sales de adición a un ácido farmacéuticamente aceptable.
NZ598354A (en) New process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
TN2011000590A1 (en) Preparation of nalmefene hydrochloride from naltrexone
EA201170181A1 (ru) Полиморфные формы разагилина гидрохлорида
ZA201004142B (en) Improved process for preparing hydrogen cyanide by catalytic dehydration of gaseous formamide
WO2010069280A3 (en) A method for the preparation of tizanidine hydrochloride
CN103420908A (zh) 孟鲁斯特手性中间体的制备方法
WO2014072998A9 (en) An improved process for preparation of agomelatine
NZ598138A (en) Synthesis of ivabradine via cyclisation of an acetal intermediate
RS52529B (en) A NEW PROCEDURE FOR THE SYNTHESIS OF IVABRADINE AND ITS ADDED SALTS
RU2013110311A (ru) Синтез соединений тиазолидиндиона
SA113350048B1 (ar) عملية جديدة لتصنيع 3-(2-برومو-4، 5- داي ميثوكسي فينيل) بروبان نيتريل، واستخدامها في تصنيع افابرادين وإضافة أملاح منه مع حمض مقبول صيدلانياً
MD20140048A2 (en) Process for the synthesis of 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
CN104725321A (zh) 一种嘧菌酯中间体的制备方法
RS54652B1 (en) NEW PROCEDURE FOR THE SYNTHESIS OF IVABRADINE AND ITS PHARMACEUTICALALLY ACCEPTABLE ACID ADDITIVE SALTS
HRP20160200T1 (hr) Novi postupak za sintezu 3-(2-brom-4,5-dimetoksifenil)propanonitrila i uporaba za sintezu ivabradina i dodanih soli s farmaceutski prihvatljivom kiselinom
CN103058965A (zh) 呋喃类香料制备方法
MX2011012946A (es) Procedimiento de transformacion de granulados de caucho para producir carbonizado semi-activo y plastificante.
TW201011037A (en) A novel mothod for preparation of Zyprexa
Beng et al. Asymmetric Synthesis of 2-Aryl and 2-Vinyl Piperidines by Dynamic Resolution
CN105367525A (zh) 一种取代苯并呋喃-2-甲酰胺的制备方法
CN103772271A (zh) 2-氨基-4-溴吡啶的新合成方法

Legal Events

Date Code Title Description
HH Correction or change in general
FG Grant or registration