HK1179959A1 - 光學活性二苄胺衍生物及其製備方法 - Google Patents

光學活性二苄胺衍生物及其製備方法

Info

Publication number: HK1179959A1
Authority: HK; Hong Kong
Prior art keywords: manufacturing; same; optically active; derivative; dibenzylamine derivative
Prior art date: 2010-06-04

Application number

HK13107169.5A

Other languages

English (en)

Inventor

Tadaaki Ohgiya

Takeshi Murakami

Katsutoshi Miyosawa

Kimiyuki Shibuya

Koichi Yamazaki

Taichi Kusakabe

Original Assignee

Kowa Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-06-04

Filing date

2013-06-19

Publication date

2013-10-11

2013-06-19 Application filed by Kowa Co filed Critical Kowa Co

2013-10-11 Publication of HK1179959A1 publication Critical patent/HK1179959A1/zh

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Cardiology (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Diabetes (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Neurology (AREA)
Orthopedic Medicine & Surgery (AREA)
Obesity (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Epidemiology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Oncology (AREA)
Ophthalmology & Optometry (AREA)
Dermatology (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Tropical Medicine & Parasitology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

HK13107169.5A 2010-06-04 2013-06-19 光學活性二苄胺衍生物及其製備方法 HK1179959A1 (zh)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP2010128585		2010-06-04
JP2010218299		2010-09-29
PCT/JP2011/062751 WO2011152508A1 (ja)	2010-06-04	2011-06-03	光学活性ジベンジルアミン誘導体及びその製造方法

Publications (1)

Publication Number	Publication Date
HK1179959A1 true HK1179959A1 (zh)	2013-10-11

Family

ID=45066863

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HK13107169.5A HK1179959A1 (zh)	2010-06-04	2013-06-19	光學活性二苄胺衍生物及其製備方法

Country Status (18)

Country	Link
US (1)	US8906895B2 (zh)
EP (1)	EP2578574B1 (zh)
JP (1)	JP5555320B2 (zh)
KR (2)	KR20170078865A (zh)
CN (2)	CN102933559B (zh)
AU (1)	AU2011259929B2 (zh)
BR (1)	BR112012030787A2 (zh)
CA (1)	CA2801417C (zh)
EA (1)	EA024241B1 (zh)
ES (1)	ES2581557T3 (zh)
HK (1)	HK1179959A1 (zh)
IL (1)	IL223377A (zh)
IN (1)	IN2012CN10925A (zh)
MX (1)	MX338024B (zh)
PT (1)	PT2578574E (zh)
TW (1)	TWI492749B (zh)
WO (1)	WO2011152508A1 (zh)
ZA (1)	ZA201209372B (zh)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2012046681A1 (ja) *	2010-10-04	2012-04-12	興和株式会社	脂質代謝関連ｍＲＮＡの発現抑制剤
US9272966B2 (en)	2010-07-22	2016-03-01	Kowa Company, Ltd.	Method for preparing optically active 1-bromo-1[3,5-bis(trifluoromethyl)phenyl]ethane
JPWO2013080999A1 (ja) *	2011-11-29	2015-04-27	興和株式会社	ＮＰＣ１Ｌ１及び／又はＬＩＰＧｍＲＮＡの発現抑制剤並びに肥満症の予防及び／又は治療剤
JPWO2013081087A1 (ja) *	2011-12-02	2015-04-27	興和株式会社	光学活性化合物の製造方法
WO2013137371A1 (ja) *	2012-03-15	2013-09-19	興和株式会社	新規ピリミジン化合物及びそれらを含有する医薬
US9255154B2 (en)	2012-05-08	2016-02-09	Alderbio Holdings, Llc	Anti-PCSK9 antibodies and use thereof
AU2014255381A1 (en)	2013-04-17	2015-10-08	Pfizer Inc.	N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
CN105246877A (zh)	2013-05-31	2016-01-13	兴和株式会社	具有二苄胺结构的嘧啶化合物的新形态
WO2016029037A1 (en) *	2014-08-21	2016-02-25	Srx Cardio, Llc	Composition and methods of use of small molecules as binding ligands for the modulation of proprotein convertase subtilisin/kexin type 9(pcsk9) protein activity
TWI691331B (zh) *	2014-09-26	2020-04-21	日商興和股份有限公司	脂質異常症治療劑
WO2016084950A1 (ja) *	2014-11-28	2016-06-02	興和株式会社	医薬組成物
JPWO2016084949A1 (ja) *	2014-11-28	2017-09-07	興和株式会社	医薬
JP2019131472A (ja) *	2016-05-31	2019-08-08	興和株式会社	医薬組成物
CA3125767A1 (en)	2019-01-18	2020-07-23	Astrazeneca Ab	Pcsk9 inhibitors and methods of use thereof
MX2021008533A (es) *	2019-01-18	2021-08-19	Astrazeneca Ab	Inhibidores de la pcsk9 y metodos de uso de los mismos.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5189208A (en) *	1991-07-01	1993-02-23	Ethyl Corporation	Ibuprofen resolution
NZ580777A (en) *	2007-04-13	2011-05-27	Kowa Co	Novel pyrimidine compound having dibenzylamine structure, and medicine comprising the compound
US8673850B2 (en)	2008-05-30	2014-03-18	Institut De Recherches Cliniques De Montreal	PCSK9 inhibitors and methods of use thereof
WO2012046681A1 (ja)	2010-10-04	2012-04-12	興和株式会社	脂質代謝関連ｍＲＮＡの発現抑制剤

2011
- 2011-06-03 EA EA201291447A patent/EA024241B1/ru not_active IP Right Cessation
- 2011-06-03 CN CN201180027596.9A patent/CN102933559B/zh not_active Expired - Fee Related
- 2011-06-03 PT PT117899096T patent/PT2578574E/pt unknown
- 2011-06-03 CN CN201510015412.7A patent/CN104529910B/zh not_active Expired - Fee Related
- 2011-06-03 TW TW100119614A patent/TWI492749B/zh not_active IP Right Cessation
- 2011-06-03 KR KR1020177017703A patent/KR20170078865A/ko not_active Application Discontinuation
- 2011-06-03 BR BR112012030787-8A patent/BR112012030787A2/pt not_active IP Right Cessation
- 2011-06-03 KR KR1020137000104A patent/KR20130111512A/ko active Search and Examination
- 2011-06-03 IN IN10925CHN2012 patent/IN2012CN10925A/en unknown
- 2011-06-03 MX MX2012014149A patent/MX338024B/es active IP Right Grant
- 2011-06-03 JP JP2012518458A patent/JP5555320B2/ja not_active Expired - Fee Related
- 2011-06-03 WO PCT/JP2011/062751 patent/WO2011152508A1/ja active Application Filing
- 2011-06-03 CA CA2801417A patent/CA2801417C/en not_active Expired - Fee Related
- 2011-06-03 AU AU2011259929A patent/AU2011259929B2/en not_active Ceased
- 2011-06-03 US US13/700,849 patent/US8906895B2/en not_active Expired - Fee Related
- 2011-06-03 EP EP11789909.6A patent/EP2578574B1/en not_active Not-in-force
- 2011-06-03 ES ES11789909.6T patent/ES2581557T3/es active Active
2012
- 2012-12-02 IL IL223377A patent/IL223377A/en active IP Right Grant
- 2012-12-11 ZA ZA2012/09372A patent/ZA201209372B/en unknown
2013
- 2013-06-19 HK HK13107169.5A patent/HK1179959A1/zh not_active IP Right Cessation

Also Published As

Publication number	Publication date
IL223377A (en)	2016-12-29
EP2578574A4 (en)	2013-12-04
IN2012CN10925A (zh)	2015-04-24
JPWO2011152508A1 (ja)	2013-08-01
IL223377A0 (en)	2013-03-05
ES2581557T3 (es)	2016-09-06
ZA201209372B (en)	2014-02-26
PT2578574E (pt)	2016-06-17
EP2578574B1 (en)	2016-04-27
KR20130111512A (ko)	2013-10-10
MX338024B (es)	2016-03-31
CN102933559B (zh)	2016-01-27
EA201291447A1 (ru)	2013-05-30
WO2011152508A1 (ja)	2011-12-08
AU2011259929B2 (en)	2014-07-31
TW201208688A (en)	2012-03-01
CA2801417C (en)	2017-07-11
MX2012014149A (es)	2013-02-27
CN102933559A (zh)	2013-02-13
JP5555320B2 (ja)	2014-07-23
CN104529910B (zh)	2017-05-10
EA024241B1 (ru)	2016-08-31
CN104529910A (zh)	2015-04-22
US8906895B2 (en)	2014-12-09
TWI492749B (zh)	2015-07-21
EP2578574A1 (en)	2013-04-10
KR20170078865A (ko)	2017-07-07
CA2801417A1 (en)	2011-12-08
US20130225814A1 (en)	2013-08-29
AU2011259929A1 (en)	2013-01-17
BR112012030787A2 (pt)	2020-09-01

Legal Events

Date	Code	Title	Description
2021-01-15	PC	Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)	Effective date: 20200530

Publication	Publication Date	Title
HK1179959A1 (zh)	2013-10-11	光學活性二苄胺衍生物及其製備方法
EP2610071A4 (en)	2014-03-26	TIRE AND MANUFACTURING METHOD THEREFOR
PL2552801T3 (pl)	2016-01-29	Pakowanie, sposób wytwarzania opakowania
EP2647616A4 (en)	2015-08-19	PROCESS FOR PRODUCING OPTICALLY ACTIVE MENTHOL
EP2610072A4 (en)	2014-03-26	TIRES AND TIRE MANUFACTURING METHOD
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EP2570400A4 (en)	2014-01-08	PROCESS FOR PREPARING -SIALON, -SIALON, AND PRODUCT USING THE SAME
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EP2608230A4 (en)	2018-03-28	Capacitor, and method and program for manufacturing same
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ZA201205650B (en)	2013-04-24	Manufacturing method for absorbent article
EP2587498A4 (en)	2017-11-01	Reactor and reactor manufacturing method
IL222607A0 (en)	2012-12-31	Method for disinfecting surfaces
EP2709127A4 (en)	2015-08-05	BELLOWS AND METHOD OF MANUFACTURING THE SAME
EP2474516A4 (en)	2013-08-14	PROCESS FOR THE PREPARATION OF 2,3,3,3-TETRAFLUORPROPES
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EP2613657A4 (en)	2014-10-22	SOCKS, AND SYSTEM AND METHOD FOR MANUFACTURING SOCKS
EP2586758A4 (en)	2014-02-19	PROCESS FOR THE PREPARATION OF 2,3,3,3-TETRAFLUORPROPES