HK1154404A1 - Methods for purifying pancreatic endoderm cells derived from human embryonic stem cells - Google Patents
Methods for purifying pancreatic endoderm cells derived from human embryonic stem cellsInfo
- Publication number
- HK1154404A1 HK1154404A1 HK11108564.6A HK11108564A HK1154404A1 HK 1154404 A1 HK1154404 A1 HK 1154404A1 HK 11108564 A HK11108564 A HK 11108564A HK 1154404 A1 HK1154404 A1 HK 1154404A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- methods
- embryonic stem
- human embryonic
- pancreatic endoderm
- stem cells
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/117—Keratinocyte growth factors (KGF-1, i.e. FGF-7; KGF-2, i.e. FGF-12)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/119—Other fibroblast growth factors, e.g. FGF-4, FGF-8, FGF-10
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/41—Hedgehog proteins; Cyclopamine (inhibitor)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/415—Wnt; Frizzeled
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2008/061053 WO2009131568A1 (en) | 2008-04-21 | 2008-04-21 | Methods for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1154404A1 true HK1154404A1 (en) | 2012-04-20 |
Family
ID=41217089
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK11108564.6A HK1154404A1 (en) | 2008-04-21 | 2011-08-15 | Methods for purifying pancreatic endoderm cells derived from human embryonic stem cells |
Country Status (5)
| Country | Link |
|---|---|
| EP (2) | EP2283117B1 (da) |
| AU (1) | AU2008355123B2 (da) |
| DK (2) | DK2283117T3 (da) |
| HK (1) | HK1154404A1 (da) |
| WO (1) | WO2009131568A1 (da) |
Families Citing this family (50)
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| US8017395B2 (en) | 2004-12-17 | 2011-09-13 | Lifescan, Inc. | Seeding cells on porous supports |
| JP2009500297A (ja) | 2005-06-08 | 2009-01-08 | セントカー・インコーポレーテツド | 眼の変性についての細胞療法 |
| US8741643B2 (en) | 2006-04-28 | 2014-06-03 | Lifescan, Inc. | Differentiation of pluripotent stem cells to definitive endoderm lineage |
| US9080145B2 (en) | 2007-07-01 | 2015-07-14 | Lifescan Corporation | Single pluripotent stem cell culture |
| CN101952415B (zh) | 2007-07-31 | 2017-06-27 | 生命扫描有限公司 | 人胚胎干细胞的分化 |
| CA3123528A1 (en) | 2007-11-27 | 2009-06-04 | Lifescan, Inc. | Differentiation of human embryonic stem cells to pancreatic cells |
| CA2715878C (en) | 2008-02-21 | 2017-06-13 | Centocor Ortho Biotech Inc. | Methods, surface modified plates and compositions for cell attachment, cultivation and detachment |
| US8623648B2 (en) | 2008-04-24 | 2014-01-07 | Janssen Biotech, Inc. | Treatment of pluripotent cells |
| EP2942392B1 (en) | 2008-06-30 | 2018-10-03 | Janssen Biotech, Inc. | Differentiation of pluripotent stem cells |
| ES2727950T3 (es) | 2008-10-31 | 2019-10-21 | Janssen Biotech Inc | Diferenciación de células madre embrionarias humanas en linaje endocrino pancreático |
| AU2009308967C1 (en) | 2008-10-31 | 2017-04-20 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells to the pancreatic endocrine lineage |
| CN107267442A (zh) | 2008-11-20 | 2017-10-20 | 詹森生物科技公司 | 微载体上的多能干细胞培养 |
| KR101687344B1 (ko) | 2008-11-20 | 2016-12-16 | 얀센 바이오테크 인코포레이티드 | 평면 기재상의 세포 부착 및 배양을 위한 방법 및 조성물 |
| CN103952372B (zh) | 2009-07-20 | 2016-10-05 | 詹森生物科技公司 | 人胚胎干细胞的分化 |
| KR20170118969A (ko) | 2009-07-20 | 2017-10-25 | 얀센 바이오테크 인코포레이티드 | 인간 배아 줄기 세포의 분화 |
| CN102482640B (zh) | 2009-07-20 | 2015-03-11 | 詹森生物科技公司 | 人胚胎干细胞的分化 |
| ES2365343B1 (es) * | 2009-11-19 | 2012-07-10 | Fundación Centro Nacional De Investigaciones Cardiovasculares Carlos Iii | Uso de cd98 como marcador de receptividad endometrial. |
| KR101923537B1 (ko) | 2009-12-23 | 2018-11-29 | 얀센 바이오테크 인코포레이티드 | 인간 배아 줄기 세포의 분화 |
| MX343786B (es) | 2009-12-23 | 2016-11-22 | Janssen Biotech Inc | Diferenciacion de celulas madre embrionarias humanas. |
| CN107189979B (zh) | 2010-03-01 | 2021-05-04 | 詹森生物科技公司 | 纯化衍生自多能干细胞的细胞的方法 |
| SG10201503652WA (en) | 2010-05-12 | 2015-08-28 | Janssen Biotech Inc | Differentiation of human embryonic stem cells |
| US9181528B2 (en) | 2010-08-31 | 2015-11-10 | Janssen Biotech, Inc. | Differentiation of pluripotent stem cells |
| AU2011296381B2 (en) | 2010-08-31 | 2016-03-31 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells |
| PL2853589T3 (pl) | 2010-08-31 | 2018-05-30 | Janssen Biotech, Inc | Różnicowanie ludzkich zarodkowych komórek macierzystych |
| EP2616554A1 (en) * | 2010-09-17 | 2013-07-24 | President and Fellows of Harvard College | Functional genomics assay for characterizing pluripotent stem cell utility and safety |
| RU2668798C2 (ru) | 2011-12-22 | 2018-10-02 | Янссен Байотек, Инк. | Способы in vitro пошаговой дифференцировки полюрипотентных клеток |
| CA2866590A1 (en) | 2012-03-07 | 2013-09-12 | Janssen Biotech, Inc. | Defined media for expansion and maintenance of pluripotent stem cells |
| DK3450542T3 (da) | 2012-06-08 | 2021-11-01 | Janssen Biotech Inc | Differentiering af humane embryonale stamceller til endokrine pancreatiske celler |
| CN104903440B (zh) | 2012-09-03 | 2018-04-06 | 诺和诺德股份有限公司 | 使用小分子从多能干细胞产生胰内胚层 |
| RU2018108090A (ru) | 2012-12-31 | 2019-02-25 | Янссен Байотек, Инк. | Суспендирование и кластеризация плюрипотентных клеток человека с целью их дифференцировки в панкреатические эндокринные клетки |
| US10370644B2 (en) | 2012-12-31 | 2019-08-06 | Janssen Biotech, Inc. | Method for making human pluripotent suspension cultures and cells derived therefrom |
| US10138465B2 (en) | 2012-12-31 | 2018-11-27 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells into pancreatic endocrine cells using HB9 regulators |
| RU2658488C2 (ru) | 2012-12-31 | 2018-06-21 | Янссен Байотек, Инк. | Способ получения клеток, экспрессирующих маркеры, характерные для панкреатических эндокринных клеток |
| EP3008229B1 (en) | 2013-06-10 | 2020-05-27 | President and Fellows of Harvard College | Early developmental genomic assay for characterizing pluripotent stem cell utility and safety |
| JP6514689B2 (ja) | 2013-06-11 | 2019-05-15 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ＳＣ−β細胞及び組成物並びにその生成方法 |
| RU2694311C2 (ru) | 2014-05-16 | 2019-07-11 | Янссен Байотек, Инк. | Применение малых молекул для увеличения экспрессии mafa в панкреатических эндокринных клетках |
| CN113234661A (zh) | 2014-12-18 | 2021-08-10 | 哈佛学院校长同事会 | 干细胞来源的β细胞的产生方法及其使用方法 |
| US10190096B2 (en) | 2014-12-18 | 2019-01-29 | President And Fellows Of Harvard College | Methods for generating stem cell-derived β cells and uses thereof |
| WO2016100898A1 (en) | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | Serum-free in vitro directed differentiation protocol for generating stem cell-derived b cells and uses thereof |
| JP6954711B2 (ja) | 2015-04-24 | 2021-10-27 | ユニバーシティ オブ コペンハーゲン | 真正膵臓前駆細胞の単離 |
| EP3384286B1 (en) * | 2015-11-30 | 2023-04-19 | Kadimastem Ltd. | Methods for differentiating and purifying pancreatic endocrine cells |
| MA45479A (fr) | 2016-04-14 | 2019-02-20 | Janssen Biotech Inc | Différenciation de cellules souches pluripotentes en cellules de l'endoderme de l'intestin moyen |
| US20210147807A1 (en) * | 2017-06-14 | 2021-05-20 | Helmholtz Zentrum Munchen - Deutsches Forschungszentrum Fur Gesundheit Und Umwelt (Gmbh) | Methods for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells |
| CA2983845C (en) | 2017-10-26 | 2024-01-30 | University Of Copenhagen | Generation of glucose-responsive beta cells |
| JP7428653B2 (ja) | 2017-11-15 | 2024-02-06 | バーテックス ファーマシューティカルズ インコーポレイテッド | 島細胞製造組成物および使用方法 |
| CA3108275A1 (en) | 2018-08-10 | 2020-02-13 | Vertex Pharmaceuticals Incorporated | Stem cell derived islet differentiation |
| WO2020243665A1 (en) | 2019-05-31 | 2020-12-03 | W. L. Gore & Associates, Inc. | A biocompatible membrane composite |
| EP3976237A1 (en) | 2019-05-31 | 2022-04-06 | W.L. Gore & Associates Inc. | Cell encapsulation devices with controlled oxygen diffusion distances |
| AU2020284245B2 (en) | 2019-05-31 | 2023-10-05 | Viacyte, Inc. | A biocompatible membrane composite |
| US20220234006A1 (en) | 2019-05-31 | 2022-07-28 | W. L. Gore & Associates, Inc. | A biocompatible membrane composite |
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| CA1335181C (en) | 1988-10-11 | 1995-04-11 | R. Alan Hardwick | System for selective cell separation from cell concentrate |
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| US5272257A (en) | 1990-05-21 | 1993-12-21 | Coulter Corporation | Method of preferential labelling of a phycobiliprotein with an amine-reactive dye for use in a multiple color assay and product for such use |
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| US5248772A (en) | 1992-01-29 | 1993-09-28 | Coulter Corporation | Formation of colloidal metal dispersions using aminodextrans as reductants and protective agents |
| US5690926A (en) | 1992-10-08 | 1997-11-25 | Vanderbilt University | Pluripotential embryonic cells and methods of making same |
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| AU6920194A (en) | 1993-06-11 | 1995-01-03 | Coulter Corporation | Anti-cd3 antibody-aminodextran conjugates for induction of t-cell activation and proliferation |
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| EP1670900A4 (en) * | 2003-08-27 | 2008-06-11 | Stemcells California Inc | ENHANCED PANCREATIC STEM CELL AND PRECURSOR CELL POPULATIONS AND METHOD OF IDENTIFYING, INSULATING AND ENRICHING SUCH POPULATIONS |
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| PL2471904T3 (pl) * | 2005-12-29 | 2019-08-30 | Celularity, Inc. | Populacje komórek macierzystych łożyska |
| US8741643B2 (en) * | 2006-04-28 | 2014-06-03 | Lifescan, Inc. | Differentiation of pluripotent stem cells to definitive endoderm lineage |
| GB2506936A (en) | 2012-10-15 | 2014-04-16 | Innovia Films Ltd | Birefringence authentication apparatus and method |
-
2008
- 2008-04-21 DK DK08816858.8T patent/DK2283117T3/da active
- 2008-04-21 DK DK13188913.1T patent/DK2727998T3/da active
- 2008-04-21 EP EP08816858.8A patent/EP2283117B1/en active Active
- 2008-04-21 AU AU2008355123A patent/AU2008355123B2/en active Active
- 2008-04-21 EP EP13188913.1A patent/EP2727998B1/en active Active
- 2008-04-21 WO PCT/US2008/061053 patent/WO2009131568A1/en active Application Filing
-
2011
- 2011-08-15 HK HK11108564.6A patent/HK1154404A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009131568A1 (en) | 2009-10-29 |
| EP2727998B1 (en) | 2019-06-12 |
| AU2008355123A2 (en) | 2010-12-16 |
| EP2283117A1 (en) | 2011-02-16 |
| DK2283117T3 (da) | 2014-01-20 |
| EP2283117A4 (en) | 2011-09-07 |
| AU2008355123A1 (en) | 2009-10-29 |
| DK2727998T3 (da) | 2019-08-26 |
| EP2727998A2 (en) | 2014-05-07 |
| AU2008355123B2 (en) | 2014-12-04 |
| EP2727998A3 (en) | 2014-08-13 |
| EP2283117B1 (en) | 2013-10-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20200419 |