SG10201402428WA - Method of efficiently establishing induced pluripotent stem cells - Google Patents

Method of efficiently establishing induced pluripotent stem cells

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Publication number
SG10201402428WA
SG10201402428WA SG10201402428WA SG10201402428WA SG10201402428WA SG 10201402428W A SG10201402428W A SG 10201402428WA SG 10201402428W A SG10201402428W A SG 10201402428WA SG 10201402428W A SG10201402428W A SG 10201402428WA SG 10201402428W A SG10201402428W A SG 10201402428WA
Authority
SG
Singapore
Prior art keywords
stem cells
pluripotent stem
induced pluripotent
efficiently establishing
establishing induced
Prior art date
Application number
SG10201402428WA
Inventor
Shinya Yamanaka
Kazutoshi Takahashi
Keisuke Okita
Original Assignee
Univ Kyoto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Kyoto filed Critical Univ Kyoto
Publication of SG10201402428WA publication Critical patent/SG10201402428WA/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C12N2501/602—Sox-2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C12N2501/603—Oct-3/4
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C12N2501/604—Klf-4
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C12N2501/606—Transcription factors c-Myc
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/11—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
SG10201402428WA 2008-06-27 2009-06-26 Method of efficiently establishing induced pluripotent stem cells SG10201402428WA (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US7648708P 2008-06-27 2008-06-27
US9557308P 2008-09-09 2008-09-09
US19470008P 2008-09-30 2008-09-30
US20030708P 2008-11-25 2008-11-25
US20968609P 2009-03-10 2009-03-10

Publications (1)

Publication Number Publication Date
SG10201402428WA true SG10201402428WA (en) 2014-07-30

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SG10201402428WA SG10201402428WA (en) 2008-06-27 2009-06-26 Method of efficiently establishing induced pluripotent stem cells

Country Status (8)

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US (3) US8530238B2 (en)
EP (1) EP2288692B1 (en)
JP (1) JP5340265B2 (en)
KR (1) KR101606943B1 (en)
CN (1) CN101835890B (en)
CA (1) CA2695590C (en)
SG (1) SG10201402428WA (en)
WO (1) WO2009157593A1 (en)

Families Citing this family (106)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004289539C1 (en) 2003-11-14 2012-06-07 Lorus Therapeutics Inc. Aryl imidazoles and their use as anti-cancer agents
EP1984487B1 (en) 2005-08-03 2022-10-12 Astellas Institute for Regenerative Medicine Improved methods of reprogramming animal somatic cells
EP2283118A4 (en) * 2008-05-06 2012-11-21 Agency Science Tech & Res Method of effecting de-differentiation of a cell
CA2695590C (en) 2008-06-27 2018-01-09 Kyoto University Method of efficiently establishing induced pluripotent stem cells
CN107012123A (en) * 2008-07-30 2017-08-04 国立大学法人京都大学 The method for effectively setting up the multipotential stem cell of induction
US9045737B2 (en) * 2008-12-13 2015-06-02 Dnamicroarray, Inc. Artificial three-dimensional microenvironment niche culture
US8470308B2 (en) * 2009-01-03 2013-06-25 Ray C. Wasielewski Enhanced medical implant comprising disrupted tooth pulp and tooth particles
US10328103B2 (en) 2009-01-03 2019-06-25 Ray C. Wasielewski Medical treatment composition comprising mammalian dental pulp stem cells
JP5637354B2 (en) * 2009-03-30 2014-12-10 独立行政法人産業技術総合研究所 Preparation of purified transcription factor and cell transfer technology
EP2548950B1 (en) * 2009-06-05 2017-10-25 Cellular Dynamics International, Inc. Reprogramming T cells and hematopoietic cells
AU2015200413B2 (en) * 2009-06-05 2017-08-24 FUJIFILM Cellular Dynamics, Inc. Reprogramming t cells and hematopoietic cells
ES2726766T3 (en) * 2009-08-07 2019-10-09 Univ Kyoto Method for the efficient development of induced pluripotent stem cells
WO2011031568A2 (en) 2009-08-27 2011-03-17 Synaptic Research, Llc A NOVEL PROTEIN DELIVERY SYSTEM TO GENERATE INDUCED PLURIPOTENT STEM (iPS) CELLS OR TISSUE-SPECIFIC CELLS
US9206394B2 (en) 2010-02-03 2015-12-08 The University Of Tokyo Method for reconstructing immune function using pluripotent stem cells
WO2011096482A1 (en) * 2010-02-03 2011-08-11 国立大学法人東京大学 Method for reconstructing immune system using pluripotent stem cells
CA2800498C (en) * 2010-03-31 2021-11-16 The Scripps Research Institute Reprogramming cells
CA2796599A1 (en) 2010-04-16 2011-10-20 Keio University Method for producing induced pluripotent stem cells
EP2616540A4 (en) * 2010-09-14 2014-02-19 Univ Kyoto Method of efficiently establishing induced pluripotent stem cells
WO2012044979A2 (en) * 2010-10-01 2012-04-05 The Goverment Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Manipulation of stem cell function by p53 isoforms
EP2635678A4 (en) * 2010-11-04 2014-04-23 Univ Kyoto Method of efficiently establishing induced pluripotent stem cells
EP2647698A4 (en) 2010-12-03 2015-10-07 Univ Kyoto Method for production of eosinophil from pluripotent stem cell
JP6029137B2 (en) * 2010-12-03 2016-11-24 国立大学法人京都大学 Efficient method for establishing induced pluripotent stem cells
CN102559587A (en) * 2010-12-16 2012-07-11 中国科学院上海药物研究所 Preparing method of iPS cell and medium for preparing iPS cell
JP2014501114A (en) * 2010-12-31 2014-01-20 ウニヴェルズィテート・フューア・ボーデンクルトゥーア・ウィーン Methods for generating induced pluripotent stem cells and differentiated cells
DK2705143T3 (en) 2011-05-02 2021-05-10 Univ Wayne State PROTEIN-INDUCED PLURIPOTENT CELL TECHNOLOGY AND ITS USE
US10865383B2 (en) 2011-07-12 2020-12-15 Lineage Cell Therapeutics, Inc. Methods and formulations for orthopedic cell therapy
CA2843234C (en) 2011-07-25 2019-08-13 Kyoto University Method for screening induced pluripotent stem cells
WO2013031826A1 (en) * 2011-08-29 2013-03-07 国立大学法人京都大学 Nuclear reprogramming substance
CN103917641B (en) 2011-10-21 2018-04-27 爱科来株式会社 The cultivation of the single cell dispersion of the maintenance versatility carried out by laminar flow
CN103131671B (en) * 2011-11-23 2017-06-06 北京大学 A kind of method of new inducing somatic reprogramming, kit and purposes
US20140329317A1 (en) 2011-11-25 2014-11-06 Kyoto University Method for culturing pluripotent stem cell
WO2013176233A1 (en) 2012-05-23 2013-11-28 国立大学法人京都大学 Highly efficient method for establishing artificial pluripotent stem cell
US9175263B2 (en) * 2012-08-22 2015-11-03 Biotime, Inc. Methods and compositions for targeting progenitor cell lines
JP6183879B2 (en) * 2012-08-31 2017-08-23 国立大学法人弘前大学 Novel peptides and their pharmaceutical uses
WO2014065435A1 (en) 2012-10-23 2014-05-01 Kyoto University Method of efficiently establishing induced pluripotent stem cells
EP2955223B1 (en) 2013-02-08 2019-12-18 Kyoto University Production methods for megakaryocytes and platelets
WO2014136581A1 (en) 2013-03-06 2014-09-12 国立大学法人京都大学 Culture system for pluripotent stem cells and method for subculturing pluripotent stem cells
EP2977449B1 (en) 2013-03-21 2020-02-26 Kyoto University Pluripotent stem cell for neuronal differentiation induction
WO2014157257A1 (en) 2013-03-25 2014-10-02 公益財団法人先端医療振興財団 Cell sorting method
CA2909230C (en) 2013-04-12 2021-06-15 Kyoto University Method for inducing alveolar epithelial progenitor cells
US9822342B2 (en) 2013-05-14 2017-11-21 Kyoto University Method of efficiently inducing cardiomyocytes
JP5862915B2 (en) 2013-05-31 2016-02-16 ｉＨｅａｒｔ Ｊａｐａｎ株式会社 Laminated cell sheet incorporating hydrogel
US10961531B2 (en) 2013-06-05 2021-03-30 Agex Therapeutics, Inc. Compositions and methods for induced tissue regeneration in mammalian species
JP6450311B2 (en) 2013-06-11 2019-01-09 国立大学法人京都大学 Method for producing renal progenitor cells and medicament containing renal progenitor cells
CN103571794B (en) * 2013-07-19 2016-01-20 中国医学科学院血液病医院（血液学研究所） A kind of PUMA of suppression function improves the method that iPS cell sets up effect
WO2015013653A1 (en) 2013-07-26 2015-01-29 The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone Generating definitive endoderm and pancreatic progenitor cells
JP6378183B2 (en) 2013-08-07 2018-08-22 国立大学法人京都大学 Method for producing pancreatic hormone-producing cells
CA2923592A1 (en) 2013-09-05 2015-03-12 Kyoto University Method for inducing dopamine-producing neural precursor cells from pluripotent stem cells
CN104419683A (en) * 2013-09-10 2015-03-18 中国科学院生物物理研究所 Method for preparing autologous induced pluripotent stem cells of patient with Fanconi anemia and application of method
DK3052102T3 (en) 2013-10-04 2020-03-09 Aptose Biosciences Inc CANCER TREATMENT COMPOSITIONS
JP6635505B2 (en) 2013-11-01 2020-01-29 国立大学法人京都大学 New chondrocyte induction method
US11078462B2 (en) 2014-02-18 2021-08-03 ReCyte Therapeutics, Inc. Perivascular stromal cells from primate pluripotent stem cells
US10240127B2 (en) 2014-07-03 2019-03-26 ReCyte Therapeutics, Inc. Exosomes from clonal progenitor cells
EP3929302A1 (en) 2014-07-14 2021-12-29 Chugai Seiyaku Kabushiki Kaisha Method for identifying epitope on protein
WO2016057833A1 (en) * 2014-10-10 2016-04-14 Vygantas Garrett Methods of manufacturing keratin products and uses thereof
US10232050B1 (en) 2014-12-12 2019-03-19 Clemson University Multi-functional particles and methods of using the same
US11633355B2 (en) 2014-12-12 2023-04-25 Clemson University Research Foundation Multi-functional particles and methods of using the same
JP7253692B2 (en) 2014-12-26 2023-04-07 国立大学法人京都大学 Hepatocyte induction method
JP2018509890A (en) * 2015-01-30 2018-04-12 センター ナショナル ド ラ ルシェルシュ サイエンティフィーク Method for reprogramming the production of induced pluripotent stem cells (iPSC)
KR102648489B1 (en) 2015-04-06 2024-03-15 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 Chemically modified guide RNA for CRISPR/CAS-mediated gene regulation
JP2016202172A (en) 2015-04-16 2016-12-08 国立大学法人京都大学 Production method of pseudoislet
US10544396B2 (en) * 2015-07-10 2020-01-28 Heartseed Inc. Method for producing high-quality iPS cells
CN108601801A (en) 2015-10-05 2018-09-28 欧瑞3恩公司 Based on discriminating and improve hepatosis come diagnosing and treating Parkinson's disease
JPWO2017141900A1 (en) * 2016-02-16 2019-01-24 学校法人慶應義塾 Medium for differentiation of pluripotent stem cells into neural stem cells and use thereof
JP6948072B2 (en) 2016-04-15 2021-10-13 国立大学法人京都大学 How to induce CD8 positive T cells
US11898163B2 (en) 2016-04-22 2024-02-13 Kyoto University Method for producing dopaminergic neuron progenitor cell
WO2018048828A1 (en) 2016-09-06 2018-03-15 The Children's Medical Center Corporation Immune cells derived from induced pluripotent stem cell
WO2018049168A1 (en) 2016-09-09 2018-03-15 The Board Of Trustees Of The Leland Stanford Junior University High-throughput precision genome editing
CN110114470A (en) 2016-12-27 2019-08-09 住友化学株式会社 The preparation method of the multipotent stem cells of the evaluation method and selection method and induction of the multipotent stem cells of induction
EP3572502B1 (en) 2017-01-20 2023-01-11 Kyoto University Method for producing cd8alpha +beta + cytotoxic t cells
US20210130785A1 (en) 2017-01-26 2021-05-06 Osaka University Medium for inducing differentiation of stem cells into mesodermal cells and method for producing mesodermal cells
CN110546267A (en) * 2017-02-01 2019-12-06 哈佛学院董事及会员团体 Method for improving gene editing efficiency of cells
EP3597734A4 (en) 2017-03-14 2021-03-03 Kyoto University Method for producing helper t cells from pluripotent stem cells
CN107290543A (en) * 2017-05-02 2017-10-24 南方医科大学 It is a kind of to detect the intracellular method with p53 transcription activating domain interaction proteins
CN110662832B (en) 2017-05-25 2024-01-05 国立大学法人京都大学 Method for inducing kidney progenitor cells from differentiation of mesodermal cells and method for inducing kidney progenitor cells from differentiation of pluripotent stem cells
SG11201912436PA (en) 2017-06-19 2020-01-30 Foundation For Biomedical Res And Innovation At Kobe Method for predicting differentiation ability of pluripotent stem cell, and reagent for same
EP3699267A4 (en) 2017-10-17 2021-10-27 Kyoto University Method for obtaining artificial neuromuscular junction from pluripotent stem cells
KR20200096914A (en) 2017-10-30 2020-08-14 압토스 바이오사이언시스 인코포레이티드 Aryl imidazole for cancer treatment
WO2020000453A1 (en) * 2018-06-29 2020-01-02 深圳市博奥康生物科技有限公司 Novel human indo gene-targeted rnai interference fragment, rnai carrier and preparation method therefor and application thereof
US20210130777A1 (en) 2018-07-13 2021-05-06 Kyoto University Method for producing gamma delta t cells
WO2020017575A1 (en) 2018-07-19 2020-01-23 国立大学法人京都大学 Plate-shaped cartilage derived from pluripotent stem cells and method for producing plate-shaped cartilage
JP7357369B2 (en) 2018-07-23 2023-10-06 国立大学法人京都大学 Novel renal progenitor cell marker and method for enriching renal progenitor cells using it
CN113195710A (en) 2018-12-06 2021-07-30 麒麟控股株式会社 Method for producing T cell or NK cell, culture medium for T cell or NK cell, method for culturing T cell or NK cell, method for maintaining undifferentiated state of undifferentiated T cell, and agent for promoting proliferation of T cell or NK cell
JP7224001B2 (en) 2018-12-21 2023-02-17 国立大学法人京都大学 Lubricin-localized cartilage-like tissue, method for producing the same, and composition for treating articular cartilage injury containing the same
WO2020138371A1 (en) 2018-12-26 2020-07-02 キリンホールディングス株式会社 Modified tcr and production method therefor
JPWO2020213725A1 (en) 2019-04-17 2020-10-22
KR20220008894A (en) 2019-05-15 2022-01-21 아지노모토 가부시키가이샤 Method of Purification of Neuronal Cells or Corneal Epithelial Cells
CA3141455A1 (en) 2019-05-20 2020-11-26 Ajinomoto Co., Inc. Expansion culture method for cartilage or bone precursor cells
US20220257793A1 (en) * 2019-05-29 2022-08-18 Institute Of Zoology, Chinese Academy Of Sciences Compositions and use of engineered myogenic cells
CN115023233A (en) 2019-12-12 2022-09-06 国立大学法人千叶大学 Freeze-dried preparation comprising megakaryocytes and platelets
MX2022008648A (en) 2020-01-23 2022-12-15 The Children´S Medical Center Corp Stroma-free t cell differentiation from human pluripotent stem cells.
US20210292713A1 (en) 2020-02-28 2021-09-23 Millennium Pharmaceuticals, Inc. Method for producing natural killer cells from pluripotent stem cells
US20230257705A1 (en) 2020-06-17 2023-08-17 Kyoto University Chimeric antigen receptor-expressing immunocompetent cells
US20230256024A1 (en) 2020-07-13 2023-08-17 Kyoto University Skeletal muscle precursor cells and method for purifying same, composition for treating myogenic diseases, and method for producing cell group containing skeletal muscle precursor cells
US20230323289A1 (en) 2020-07-20 2023-10-12 Aichi Medical University Composition for Pluripotent Cell Undifferentiated State Maintenance Culture, Medium for Pluripotent Cell Undifferentiated State Maintenance Culture, Method for Pluripotent Cell Undifferentiated State Maintenance Culture, and Method for Producing Pluripotent Cells
WO2022039279A1 (en) 2020-08-18 2022-02-24 国立大学法人京都大学 Method for maintaining and amplifying human primordial germ cells / human primordial germ cell-like cells
JPWO2022196714A1 (en) 2021-03-17 2022-09-22
CA3218400A1 (en) 2021-04-30 2022-11-03 Riken Cord-like aggregates of retinal pigment epithelial cells, device and production method for producing same, and therapeutic agent comprising said cord-like aggregates
WO2022255489A1 (en) 2021-06-04 2022-12-08 キリンホールディングス株式会社 Cell composition, method for producing cell composition, and pharmaceutical composition containing cell composition
CA3222761A1 (en) 2021-06-10 2022-12-15 Ajinomoto Co., Inc. Method for producing mesenchymal stem cells
EP4355861A1 (en) 2021-06-15 2024-04-24 Takeda Pharmaceutical Company Limited Method for producing natural killer cells from pluripotent stem cells
WO2023286834A1 (en) 2021-07-15 2023-01-19 アステラス製薬株式会社 Pericyte-like cell expressing vascular endothelial growth factor (vegf) at high level
WO2023286832A1 (en) 2021-07-15 2023-01-19 アステラス製薬株式会社 Pericyte-like cells expressing vascular endothelial growth factor (vegf) at high level
WO2023017848A1 (en) 2021-08-11 2023-02-16 国立大学法人京都大学 Method for producing renal interstitial progenitor cells, erythropoietin-producing cells, and method for producing renin-producing cells
AU2022343300A1 (en) 2021-09-10 2024-04-18 Agilent Technologies, Inc. Guide rnas with chemical modification for prime editing
CN114540309A (en) * 2022-01-17 2022-05-27 安徽大学 Recombinant cell for efficiently amplifying RNA virus, and amplification method and application thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004085632A1 (en) * 2003-03-25 2004-10-07 Japan Science And Technology Agency Control of stem cell differentiation induction and differentiation potency
WO2005019440A1 (en) * 2003-08-20 2005-03-03 Northern Sydney And Central Coast Area Health Service Methods for enhancing embryo viability
EP1741776A4 (en) * 2004-03-30 2007-05-30 Univ Kyoto Process for producing multipotential stem cell originating in testoid cell
RU2007135164A (en) * 2005-02-23 2009-03-27 Эйдженси Фор Сайенс, Текнолоджи Энд Рисерч (Sg) IMMORTALIZED FEEDER CELLS
US20070006223A1 (en) * 2005-04-18 2007-01-04 Research In Motion Limited System and method for visual design of resource management references
EP4223769A3 (en) * 2005-12-13 2023-11-01 Kyoto University Nuclear reprogramming factor
US8278104B2 (en) * 2005-12-13 2012-10-02 Kyoto University Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2
ATE454632T1 (en) * 2006-04-20 2010-01-15 Northern Sydney And Central Co METHOD FOR ASSESSING THE VIABILITY OF EMBRYOS
EP2137296A2 (en) 2007-03-23 2009-12-30 Wisconsin Alumni Research Foundation Somatic cell reprogramming
CN101550406B (en) * 2008-04-03 2016-02-10 北京大学 Prepare the method for pluripotent stem cell, test kit and purposes
CA2695590C (en) 2008-06-27 2018-01-09 Kyoto University Method of efficiently establishing induced pluripotent stem cells

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EP2288692A4 (en) 2013-01-16
EP2288692B1 (en) 2017-08-02
CN101835890A (en) 2010-09-15
JP2011525793A (en) 2011-09-29
CA2695590C (en) 2018-01-09
US20140011279A1 (en) 2014-01-09
KR20110041430A (en) 2011-04-21
CN101835890B (en) 2013-07-24
CA2695590A1 (en) 2009-12-30
WO2009157593A1 (en) 2009-12-30
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