PT2772535T - Células estaminais mesenquimais abcb5 positivas como imunomoduladores - Google Patents
Células estaminais mesenquimais abcb5 positivas como imunomoduladoresInfo
- Publication number
- PT2772535T PT2772535T PT141681999T PT14168199T PT2772535T PT 2772535 T PT2772535 T PT 2772535T PT 141681999 T PT141681999 T PT 141681999T PT 14168199 T PT14168199 T PT 14168199T PT 2772535 T PT2772535 T PT 2772535T
- Authority
- PT
- Portugal
- Prior art keywords
- abc5
- immunomodulators
- stem cells
- mesenchymal stem
- positive mesenchymal
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0668—Mesenchymal stem cells from other natural sources
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80940706P | 2006-05-31 | 2006-05-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT2772535T true PT2772535T (pt) | 2022-07-04 |
Family
ID=38594403
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT141681999T PT2772535T (pt) | 2006-05-31 | 2007-05-31 | Células estaminais mesenquimais abcb5 positivas como imunomoduladores |
PT77956472T PT2035549E (pt) | 2006-05-31 | 2007-05-31 | Células estaminais mesenquimais abcb5 positivas como imunomoduladores |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT77956472T PT2035549E (pt) | 2006-05-31 | 2007-05-31 | Células estaminais mesenquimais abcb5 positivas como imunomoduladores |
Country Status (13)
Country | Link |
---|---|
US (4) | US8455245B2 (pt) |
EP (2) | EP2772535B1 (pt) |
AU (1) | AU2007254894B9 (pt) |
CA (1) | CA2685492C (pt) |
DK (2) | DK2772535T3 (pt) |
ES (2) | ES2511791T3 (pt) |
HK (2) | HK1129703A1 (pt) |
HU (1) | HUE059011T2 (pt) |
LT (1) | LT2772535T (pt) |
PL (2) | PL2772535T3 (pt) |
PT (2) | PT2772535T (pt) |
SI (2) | SI2772535T1 (pt) |
WO (1) | WO2007143139A1 (pt) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT1290028E (pt) | 2000-06-05 | 2010-03-12 | Brigham & Womens Hospital | Um gene que codifica um homólogo de glicoproteína p humana de resistência a múltiplos fármacos, situado no cromossoma 7p15-21 e suas utilizações |
LT2772535T (lt) | 2006-05-31 | 2022-08-25 | Children's Medical Center Corporation | Abc5 atžvilgiu teigiamos mezenchiminės kamieninės ląstelės kaip imunomoduliatoriai |
ES2687270T3 (es) | 2007-04-12 | 2018-10-24 | The Brigham And Women's Hospital, Inc. | Fijación como objetivo de ABCB5 para la terapia del cáncer |
US11542328B2 (en) | 2008-11-14 | 2023-01-03 | The Brigham And Women's Hospital, Inc. | Therapeutic and diagnostic methods relating to cancer stem cells |
CA2743464A1 (en) | 2008-11-14 | 2010-05-20 | The Brigham And Women's Hospital, Inc. | Therapeutic and diagnostic methods relating to cancer stem cells |
EP3865573A1 (en) * | 2013-02-19 | 2021-08-18 | Children's Medical Center Corporation | Abcb5(+) stem cells for treating ocular disease |
WO2014182994A1 (en) * | 2013-05-10 | 2014-11-13 | Children's Medical Center Corporation | Wound healing and tissue engineering |
US20150310380A1 (en) * | 2014-04-28 | 2015-10-29 | Patent Investment & Licensing Company | Dispatch system having control shared with dispatched service providers |
KR101723265B1 (ko) * | 2013-08-16 | 2017-04-04 | 가톨릭대학교 산학협력단 | mTOR/STAT3 신호억제제 처리된 면역조절능을 갖는 간엽줄기세포 및 이를 포함하는 면역질환의 예방 또는 치료용 세포치료제 조성물 |
PT3091991T (pt) * | 2013-12-13 | 2020-02-04 | Swedish Stromabio Ab | Composições imunomodulatórias |
US10739338B2 (en) | 2014-03-24 | 2020-08-11 | Qt Holdings Corp | Shaped articles including hydrogels and methods of manufacture and use thereof |
US9790467B2 (en) * | 2015-09-22 | 2017-10-17 | Qt Holdings Corp | Methods and compositions for activation or expansion of T lymphocytes |
CN113301924A (zh) * | 2018-08-18 | 2021-08-24 | 哈佛学院校长同事会 | 原位基因编辑 |
US20200061365A1 (en) * | 2018-08-24 | 2020-02-27 | Instant Systems, Inc. | Cell storage container for use with sterile docking systems |
CN114245741A (zh) * | 2019-03-28 | 2022-03-25 | 儿童医学中心公司 | 高功能性的制造的abcb5+间充质干细胞 |
WO2020219895A1 (en) * | 2019-04-24 | 2020-10-29 | Children's Medical Center Corporation | Abcb5+ stem cell therapeutics for liver disease |
EP4125960A4 (en) * | 2020-03-30 | 2024-04-03 | Children's Medical Center Corporation | USE OF STEM CELLS FOR THE TREATMENT OF EXCESSIVE INFLAMMATION |
JP2024517954A (ja) * | 2021-05-13 | 2024-04-23 | プライムジェン ユーエス インコーポレイテッド | 肝疾患を治療するための方法および組成物 |
US20230256065A1 (en) * | 2022-02-16 | 2023-08-17 | Elena RUSYN | Autologous stem cell vaccine and methods |
CN115260098B (zh) * | 2022-06-09 | 2024-06-04 | 澳门科技大学 | Abcb5抑制剂在制备多耐药性类风湿性关节炎治疗药物中的应用 |
Family Cites Families (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4352883A (en) | 1979-03-28 | 1982-10-05 | Damon Corporation | Encapsulation of biological material |
EP0174810B1 (en) | 1984-09-10 | 1993-07-21 | HSC Research Development Corporation | Multidrug resistance in mammalian cell lines and isolation of determinant glycoprotein dna |
US4837306A (en) | 1985-02-25 | 1989-06-06 | The Ontario Cancer Institute | Method for selecting hybridomas producing antibodies specific to the P-glycoprotein cell suface antigen and a cDNA clone encoding the C-terminal portion of the antigen |
US5837258A (en) | 1991-08-30 | 1998-11-17 | University Of South Florida | Induction of tissue, bone or cartilage formation using connective tissue growth factor |
IT1257893B (it) | 1992-06-17 | 1996-02-16 | Ist Superiore Sanita | Anticorpi monoclonali che riconoscono un epitopo della p-glicoproteina umana. |
WO1994009363A1 (en) | 1992-10-14 | 1994-04-28 | Board Of Regents, The University Of Texas System | Cancer diagnosis and therapy |
US5906934A (en) | 1995-03-14 | 1999-05-25 | Morphogen Pharmaceuticals, Inc. | Mesenchymal stem cells for cartilage repair |
EP2311471A3 (en) | 1996-04-19 | 2013-05-15 | Osiris Therapeutics, Inc. | Regeneration and augmentation of bone using mesenchymal stem cells |
US6152142A (en) | 1997-02-28 | 2000-11-28 | Tseng; Scheffer C. G. | Grafts made from amniotic membrane; methods of separating, preserving, and using such grafts in surgeries |
WO1999046366A1 (en) | 1998-03-13 | 1999-09-16 | Osiris Therapeutics, Inc. | Uses for humane non-autologous mesenchymal stem cells |
US6368636B1 (en) | 1998-03-18 | 2002-04-09 | Osiris Therapeutics, Inc. | Mesenchymal stem cells for prevention and treatment of immune responses in transplantation |
AU2999199A (en) | 1998-04-03 | 1999-10-25 | Osiris Therapeutics, Inc. | Mesenchymal stem cells as immunosuppressants |
GB9808836D0 (en) | 1998-04-27 | 1998-06-24 | Amersham Pharm Biotech Uk Ltd | Microfabricated apparatus for cell based assays |
AU4221399A (en) | 1998-05-29 | 1999-12-13 | Osiris Therapeutics, Inc. | Human cd45+ and/or fibroblast + mesenchymal stem cells |
PT1290028E (pt) | 2000-06-05 | 2010-03-12 | Brigham & Womens Hospital | Um gene que codifica um homólogo de glicoproteína p humana de resistência a múltiplos fármacos, situado no cromossoma 7p15-21 e suas utilizações |
JP2004500873A (ja) | 2000-06-22 | 2004-01-15 | ジェネンテック・インコーポレーテッド | アゴニスト抗−trk−cモノクローナル抗体 |
SE517275C2 (sv) * | 2000-09-20 | 2002-05-21 | Obducat Ab | Sätt vid våtetsning av ett substrat |
AU2002241569A1 (en) | 2000-10-27 | 2002-05-27 | Incyte Genomics, Inc. | Transporters and ion channels |
US6905678B2 (en) | 2001-07-07 | 2005-06-14 | Crucell Holland B.V. | Gene delivery vectors with cell type specificity for mesenchymal stem cells |
JP4409430B2 (ja) | 2002-07-03 | 2010-02-03 | 小野薬品工業株式会社 | 免疫賦活組成物 |
JP4511943B2 (ja) | 2002-12-23 | 2010-07-28 | ワイス エルエルシー | Pd−1に対する抗体およびその使用 |
GB0325130D0 (en) | 2003-10-28 | 2003-12-03 | Smith & Nephew | Apparatus with scaffold |
JP2007512017A (ja) | 2003-11-24 | 2007-05-17 | ザ ロックフェラー ユニバーシティー | 自己複製多能性遅延周期細胞を単離する方法 |
TR201815885T4 (tr) | 2004-01-07 | 2018-11-21 | Novartis Vaccines & Diagnostics Inc | M-csf spesifik monoklonal antikorlar ve bunların kullanımı. |
US20050186672A1 (en) | 2004-01-27 | 2005-08-25 | Reliance Life Sciences Pvt. Ltd. | Tissue system with undifferentiated stem cells derived from corneal limbus |
US10538742B2 (en) | 2004-11-12 | 2020-01-21 | Cambridge Enterprise Limited | Methods and means related to cancer stem cells |
WO2006103685A2 (en) | 2005-03-28 | 2006-10-05 | Vision Research Foundation | A method for cultivating cells derived from corneal limbal tissue and cells deived from corneal limbal tissue |
IN2014DN06624A (pt) * | 2005-10-18 | 2015-07-10 | Univ Colorado | |
LT2772535T (lt) | 2006-05-31 | 2022-08-25 | Children's Medical Center Corporation | Abc5 atžvilgiu teigiamos mezenchiminės kamieninės ląstelės kaip imunomoduliatoriai |
US20080118432A1 (en) | 2006-09-07 | 2008-05-22 | Ivan Bergstein | Monitoring cancer stem cells |
ES2687270T3 (es) | 2007-04-12 | 2018-10-24 | The Brigham And Women's Hospital, Inc. | Fijación como objetivo de ABCB5 para la terapia del cáncer |
US9011840B2 (en) | 2008-03-14 | 2015-04-21 | The Board Of Trustees Of The University Of Illinois | Activated mesenchymal stem cells for wound healing and impaired tissue regeneration |
CA2743464A1 (en) | 2008-11-14 | 2010-05-20 | The Brigham And Women's Hospital, Inc. | Therapeutic and diagnostic methods relating to cancer stem cells |
US11542328B2 (en) | 2008-11-14 | 2023-01-03 | The Brigham And Women's Hospital, Inc. | Therapeutic and diagnostic methods relating to cancer stem cells |
EP3865573A1 (en) | 2013-02-19 | 2021-08-18 | Children's Medical Center Corporation | Abcb5(+) stem cells for treating ocular disease |
WO2014182994A1 (en) | 2013-05-10 | 2014-11-13 | Children's Medical Center Corporation | Wound healing and tissue engineering |
JP2021522266A (ja) | 2018-04-25 | 2021-08-30 | チルドレンズ メディカル センター コーポレーションChildren’S Medical Center Corporation | Abcb5のリガンドおよび基質 |
CN114245741A (zh) | 2019-03-28 | 2022-03-25 | 儿童医学中心公司 | 高功能性的制造的abcb5+间充质干细胞 |
-
2007
- 2007-05-31 LT LTEP14168199.9T patent/LT2772535T/lt unknown
- 2007-05-31 ES ES07795647.2T patent/ES2511791T3/es active Active
- 2007-05-31 SI SI200732189T patent/SI2772535T1/sl unknown
- 2007-05-31 DK DK14168199.9T patent/DK2772535T3/da active
- 2007-05-31 PT PT141681999T patent/PT2772535T/pt unknown
- 2007-05-31 EP EP14168199.9A patent/EP2772535B1/en active Active
- 2007-05-31 DK DK07795647.2T patent/DK2035549T3/da active
- 2007-05-31 WO PCT/US2007/013022 patent/WO2007143139A1/en active Application Filing
- 2007-05-31 HU HUE14168199A patent/HUE059011T2/hu unknown
- 2007-05-31 EP EP07795647.2A patent/EP2035549B1/en active Active
- 2007-05-31 PT PT77956472T patent/PT2035549E/pt unknown
- 2007-05-31 PL PL14168199.9T patent/PL2772535T3/pl unknown
- 2007-05-31 PL PL07795647T patent/PL2035549T3/pl unknown
- 2007-05-31 SI SI200731523T patent/SI2035549T1/sl unknown
- 2007-05-31 AU AU2007254894A patent/AU2007254894B9/en active Active
- 2007-05-31 ES ES14168199T patent/ES2918323T3/es active Active
- 2007-05-31 CA CA2685492A patent/CA2685492C/en active Active
- 2007-05-31 US US11/809,790 patent/US8455245B2/en active Active
-
2009
- 2009-09-17 HK HK09108538.3A patent/HK1129703A1/xx unknown
- 2009-09-17 HK HK15101859.1A patent/HK1201295A1/xx unknown
-
2013
- 2013-03-15 US US13/832,419 patent/US10017738B2/en active Active
-
2018
- 2018-07-09 US US16/029,777 patent/US11624054B2/en active Active
-
2023
- 2023-03-10 US US18/120,301 patent/US20230313136A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2007143139A1 (en) | 2007-12-13 |
CA2685492A1 (en) | 2007-12-13 |
HK1129703A1 (en) | 2009-12-04 |
HK1201295A1 (en) | 2015-08-28 |
US20080003206A1 (en) | 2008-01-03 |
PL2035549T3 (pl) | 2014-12-31 |
LT2772535T (lt) | 2022-08-25 |
EP2035549B1 (en) | 2014-07-09 |
EP2772535B1 (en) | 2022-04-06 |
CA2685492C (en) | 2018-01-16 |
AU2007254894A1 (en) | 2007-12-13 |
US8455245B2 (en) | 2013-06-04 |
US20230313136A1 (en) | 2023-10-05 |
ES2511791T3 (es) | 2014-10-23 |
PL2772535T3 (pl) | 2022-09-05 |
AU2007254894B2 (en) | 2014-10-23 |
PT2035549E (pt) | 2014-10-06 |
US10017738B2 (en) | 2018-07-10 |
DK2772535T3 (da) | 2022-07-04 |
DK2035549T3 (da) | 2014-10-13 |
AU2007254894B9 (en) | 2014-11-13 |
ES2918323T3 (es) | 2022-07-15 |
HUE059011T2 (hu) | 2022-09-28 |
US11624054B2 (en) | 2023-04-11 |
SI2035549T1 (sl) | 2015-03-31 |
US20130315880A1 (en) | 2013-11-28 |
US20180320131A1 (en) | 2018-11-08 |
EP2035549A1 (en) | 2009-03-18 |
EP2772535A1 (en) | 2014-09-03 |
SI2772535T1 (sl) | 2022-08-31 |
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