HK1145319A1 - Icotinib hydrochloride, synthesis, crystallographic form, medical combination, and uses thereof - Google Patents

Icotinib hydrochloride, synthesis, crystallographic form, medical combination, and uses thereof

Info

Publication number: HK1145319A1
Authority: HK; Hong Kong
Prior art keywords: synthesis; crystallographic form; icotinib hydrochloride; medical combination; medical
Prior art date: 2008-07-08

Application number

HK10111360.7A

Other languages

English (en)

Inventor

Yinxiang Wang

Lieming Ding

Fenlai Tan

Yunyan Hu

Wei He

Bin Han

Wei Long

Yong Liu

Original Assignee

Zhejiang Beta Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-07-08

Filing date

2010-12-07

Publication date

2011-04-15

2010-12-07 Application filed by Zhejiang Beta Pharma Inc filed Critical Zhejiang Beta Pharma Inc

2011-04-15 Publication of HK1145319A1 publication Critical patent/HK1145319A1/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs

HK10111360.7A 2008-07-08 2010-12-07 Icotinib hydrochloride, synthesis, crystallographic form, medical combination, and uses thereof HK1145319A1 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
CN200810132631		2008-07-08
CN200810132458		2008-07-17
CN200810188272		2008-12-23
PCT/CN2009/000773 WO2010003313A1 (zh)	2008-07-08	2009-07-07	埃克替尼盐酸盐及其制备方法、晶型、药物组合物和用途

Publications (1)

Publication Number	Publication Date
HK1145319A1 true HK1145319A1 (en)	2011-04-15

Family

ID=41506667

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HK10111360.7A HK1145319A1 (en)	2008-07-08	2010-12-07	Icotinib hydrochloride, synthesis, crystallographic form, medical combination, and uses thereof

Country Status (11)

Country	Link
US (2)	US8822482B2 (ja)
EP (1)	EP2392576B1 (ja)
JP (2)	JP5719770B2 (ja)
KR (1)	KR20110031370A (ja)
CN (5)	CN102911179B (ja)
AU (1)	AU2009267683B2 (ja)
CA (1)	CA2730311A1 (ja)
HK (1)	HK1145319A1 (ja)
IL (1)	IL210447A0 (ja)
NZ (1)	NZ590334A (ja)
WO (1)	WO2010003313A1 (ja)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR20110031370A (ko) *	2008-07-08	2011-03-25	베타 파마, 인크.	염산 ｉｃｏｔｉｎｉｂ, 합성, 결정형, 약학적 조성물 및 이의 사용
DK3108750T3 (en) *	2010-03-19	2018-10-22	1Globe Biomedical Co Ltd	NEW RELATIONS AND COMPOSITIONS TARGETED FOR CANCER STAM CELLS
AU2011278832B2 (en) *	2010-07-14	2014-03-13	Betta Pharmaceuticals Co., Ltd	Novel fused heterocyclic derivatives useful as c-Met tyrosine kinase inhibitors
WO2012075210A2 (en) *	2010-12-01	2012-06-07	Niiki Pharma Inc.	Method for treating refractory cancer
TWI505828B (zh) *	2010-12-20	2015-11-01	葛蘭素史克智慧財產（第二）有限公司	新穎醫藥組成物
CA2854083C (en) *	2011-10-31	2016-12-13	Betta Pharmaceuticals Co., Ltd.	Methods of preparing icotinib and icotinib hydrochloride, and intermediates thereof
EP2752413B1 (en) *	2012-03-26	2016-03-23	Fujian Institute Of Research On The Structure Of Matter, Chinese Academy Of Sciences	Quinazoline derivative and application thereof
WO2014028914A1 (en) *	2012-08-17	2014-02-20	Beta Pharma, Inc.	Deuterated icotinib derivatives
US9994574B2 (en) *	2012-11-12	2018-06-12	Victoria Link Limited	Salt and polymorphic forms of (3R,4S)-L-((4-amino-5H-pyrrolo[3,2,-d]pyrimidin-7-yl)methyl)-4(methylthiomethyl)pyrodin-3-ol(MTDIA)
JP5955396B2 (ja) *	2012-12-28	2016-07-20	ベータファーマシューティカルズカンパニーリミテッド	イコチニブ、イコチニブ塩酸塩、及びそれらの中間体の製造方法
CA2914698C (en) *	2013-06-09	2017-08-22	Betta Pharmaceuticals Co., Ltd.	New polymorphic forms of icotinib phosphate and uses thereof
CN104470929B (zh) *	2013-06-09	2018-11-30	贝达药业股份有限公司	埃克替尼的晶型及其应用
CN104487443B (zh) *	2013-06-09	2016-03-23	贝达药业股份有限公司	埃克替尼马来酸盐的晶型及其用途
CN104470526B (zh) *	2013-06-09	2016-07-13	贝达药业股份有限公司	埃克替尼磷酸盐的晶型及其用途
SG11201509750VA (en) *	2013-06-09	2015-12-30	Betta Pharmaceuticals Co Ltd	Polymorph forms of icotinib maleate and uses thereof
KR101804449B1 (ko) *	2013-06-09	2017-12-04	베타 파머수티컬 컴퍼니 리미티드	아이코티닙의 다형체 형태 및 이의 용도
CN109512779A (zh) *	2013-10-11	2019-03-26	贝达药业股份有限公司	一种含埃克替尼的皮肤外用药物组合物及其应用
EP3056206A4 (en) *	2013-10-11	2017-07-05	Betta Pharmaceuticals Co., Ltd.	Icotinib-containing topical skin pharmaceutical composition and use thereof
CN103784412A (zh) *	2014-01-15	2014-05-14	青岛市肿瘤医院	一种盐酸埃克替尼分散片及其制备方法
CN103860521A (zh) *	2014-03-05	2014-06-18	王栾秋	盐酸埃克替尼胶囊组合物及其制备方法
CN106924739B (zh) *	2017-03-10	2022-07-29	上海交通大学医学院	Egfr抑制剂在制备治疗muc1阳性肿瘤药物中的应用
CN111909163B (zh) *	2020-04-21	2022-02-01	南开大学	具有ido1抑制功能的喹啉胺类化合物及其制备方法
CN111362957B (zh) *	2020-04-21	2022-02-18	上海百利佳生医药科技有限公司	一种埃克替尼关键中间体的制备方法
CN111763214B (zh) *	2020-08-10	2022-03-15	苏州富士莱医药股份有限公司	一种埃克替尼的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2002338577A (ja)	2001-05-15	2002-11-27	Orient Chem Ind Ltd	分子内架橋クラウンエーテル環を有するフタロシアニン誘導体及びその製造方法
US7078409B2 (en) *	2002-03-28	2006-07-18	Beta Pharma, Inc.	Fused quinazoline derivatives useful as tyrosine kinase inhibitors
KR20110031370A (ko) *	2008-07-08	2011-03-25	베타 파마, 인크.	염산 ｉｃｏｔｉｎｉｂ, 합성, 결정형, 약학적 조성물 및 이의 사용

2009
- 2009-07-07 KR KR1020117002841A patent/KR20110031370A/ko not_active Application Discontinuation
- 2009-07-07 CN CN201210438377.6A patent/CN102911179B/zh active Active
- 2009-07-07 CN CN201410828693.3A patent/CN104530061B/zh active Active
- 2009-07-07 NZ NZ590334A patent/NZ590334A/xx not_active IP Right Cessation
- 2009-07-07 CN CN201410833295.0A patent/CN104592242B/zh active Active
- 2009-07-07 CN CN2009801006661A patent/CN101878218B/zh active Active
- 2009-07-07 CN CN201210437345.4A patent/CN103254204B/zh active Active
- 2009-07-07 WO PCT/CN2009/000773 patent/WO2010003313A1/zh active Application Filing
- 2009-07-07 AU AU2009267683A patent/AU2009267683B2/en not_active Ceased
- 2009-07-07 EP EP09793788.2A patent/EP2392576B1/en not_active Not-in-force
- 2009-07-07 US US13/003,216 patent/US8822482B2/en not_active Expired - Fee Related
- 2009-07-07 JP JP2011516948A patent/JP5719770B2/ja active Active
- 2009-07-07 CA CA2730311A patent/CA2730311A1/en not_active Abandoned
2010
- 2010-12-07 HK HK10111360.7A patent/HK1145319A1/xx unknown
2011
- 2011-01-03 IL IL210447A patent/IL210447A0/en unknown
2014
- 2014-07-31 US US14/448,070 patent/US9359370B2/en active Active
2015
- 2015-02-13 JP JP2015026902A patent/JP2015110649A/ja active Pending

Also Published As

Publication number	Publication date
CN103254204A (zh)	2013-08-21
US9359370B2 (en)	2016-06-07
KR20110031370A (ko)	2011-03-25
CN103254204B (zh)	2014-10-22
WO2010003313A1 (zh)	2010-01-14
US20140343082A1 (en)	2014-11-20
CA2730311A1 (en)	2010-01-14
US20110182882A1 (en)	2011-07-28
CN102911179A (zh)	2013-02-06
CN101878218B (zh)	2013-01-02
NZ590334A (en)	2012-12-21
US8822482B2 (en)	2014-09-02
EP2392576A1 (en)	2011-12-07
JP2015110649A (ja)	2015-06-18
WO2010003313A8 (zh)	2010-04-22
CN102911179B (zh)	2015-04-08
EP2392576A4 (en)	2012-04-11
CN104592242B (zh)	2017-01-25
CN104592242A (zh)	2015-05-06
JP5719770B2 (ja)	2015-05-20
JP2011527291A (ja)	2011-10-27
EP2392576B1 (en)	2016-02-17
CN104530061A (zh)	2015-04-22
CN101878218A (zh)	2010-11-03
AU2009267683B2 (en)	2014-04-03
AU2009267683A1 (en)	2010-01-14
CN104530061B (zh)	2017-05-10
IL210447A0 (en)	2011-03-31

Publication	Publication Date	Title
HK1145319A1 (en)	2011-04-15	Icotinib hydrochloride, synthesis, crystallographic form, medical combination, and uses thereof
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PL2192861T3 (pl)	2015-10-30	Retraktor chirurgiczny
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