HK1140189A1 - Cycloalkylamine substituted isoquinoline derivatives - Google Patents
Cycloalkylamine substituted isoquinoline derivativesInfo
- Publication number
- HK1140189A1 HK1140189A1 HK10106146.8A HK10106146A HK1140189A1 HK 1140189 A1 HK1140189 A1 HK 1140189A1 HK 10106146 A HK10106146 A HK 10106146A HK 1140189 A1 HK1140189 A1 HK 1140189A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- isoquinoline derivatives
- substituted isoquinoline
- rho
- cycloalkylamine
- cycloalkylamine substituted
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Reproductive Health (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Gynecology & Obstetrics (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Physical Education & Sports Medicine (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Hospice & Palliative Care (AREA)
- Pregnancy & Childbirth (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Virology (AREA)
- Psychiatry (AREA)
- Molecular Biology (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06026894 | 2006-12-27 | ||
PCT/EP2007/011167 WO2008077554A1 (en) | 2006-12-27 | 2007-12-19 | Cycloalkylamine substituted isoquinoline derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1140189A1 true HK1140189A1 (en) | 2010-10-08 |
Family
ID=38055425
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK10106146.8A HK1140189A1 (en) | 2006-12-27 | 2010-06-22 | Cycloalkylamine substituted isoquinoline derivatives |
Country Status (16)
Country | Link |
---|---|
US (1) | US8710228B2 (xx) |
EP (1) | EP2125746B1 (xx) |
JP (1) | JP5405316B2 (xx) |
KR (1) | KR20090092303A (xx) |
CN (1) | CN101611012B (xx) |
AT (1) | ATE554072T1 (xx) |
AU (1) | AU2007338410B2 (xx) |
BR (1) | BRPI0721180A2 (xx) |
CA (1) | CA2673920C (xx) |
HK (1) | HK1140189A1 (xx) |
IL (1) | IL199539A (xx) |
MX (1) | MX2009005964A (xx) |
MY (1) | MY151953A (xx) |
NO (1) | NO20092432L (xx) |
SV (1) | SV2009003317A (xx) |
WO (1) | WO2008077554A1 (xx) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
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ES2580108T3 (es) | 2005-07-11 | 2016-08-19 | Aerie Pharmaceuticals, Inc | Compuestos de isoquinolina |
EP2068878B1 (en) | 2006-09-20 | 2019-04-10 | Aerie Pharmaceuticals, Inc. | Rho kinase inhibitors |
US8455513B2 (en) | 2007-01-10 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-aminoisoquinoline compounds |
GB0719644D0 (en) | 2007-10-05 | 2007-11-14 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
US8455514B2 (en) | 2008-01-17 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-and 7-amino isoquinoline compounds and methods for making and using the same |
GB0803018D0 (en) | 2008-02-19 | 2008-03-26 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
DK2303845T3 (da) * | 2008-06-24 | 2013-12-16 | Sanofi Sa | Bi- og polycyklisk substitueret isoquinolin og bi- og polycykliske substituerede isoquinolinderivater som rho-kinasehæmmere |
MX2010013974A (es) * | 2008-06-24 | 2011-01-14 | Sanofi Aventis | Isoquinolinas e isoquinolinonas 6-sustituidas. |
RU2538588C2 (ru) * | 2008-06-24 | 2015-01-10 | Санофи-Авентис | ЗАМЕЩЕННЫЕ ИЗИХИНОЛИНЫ И ИЗОХИНОЛИНОНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ Rho-КИНАЗЫ |
US8450344B2 (en) | 2008-07-25 | 2013-05-28 | Aerie Pharmaceuticals, Inc. | Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds |
ES2834451T3 (es) | 2009-05-01 | 2021-06-17 | Aerie Pharmaceuticals Inc | Inhibidores de mecanismo doble para el tratamiento de enfermedades |
EA019523B1 (ru) | 2009-06-19 | 2014-04-30 | Д. Вестерн Терапьютикс Инститьют, Инк. | Производное замещенного изохинолина, содержащая его фармацевтическая композиция и применение для лечения заболеваний |
WO2013068755A1 (en) | 2011-11-09 | 2013-05-16 | Cancer Research Technology Limited | 5-(pyridin-2-yl-amino)-pyrazine-2-carbonitrile compounds and their therapeutic use |
JP6027230B2 (ja) | 2012-05-15 | 2016-11-16 | キャンサー・リサーチ・テクノロジー・リミテッド | 5−[[4−[[モルホリン−2−イル]メチルアミノ]−5−(トリフルオロメチル)−2−ピリジル]アミノ]ピラジン−2−カルボニトリルおよびその治療上の使用 |
CN110396085A (zh) | 2013-03-15 | 2019-11-01 | 爱瑞制药公司 | 联合治疗 |
FR3017868A1 (fr) | 2014-02-21 | 2015-08-28 | Servier Lab | Derives d'isoquinoleine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
UY36391A (es) | 2014-11-05 | 2016-06-01 | Flexus Biosciences Inc | Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido1), sus métodos de síntesis y composiciones farmacèuticas que las contienen |
AU2015414743B2 (en) | 2015-11-17 | 2019-07-18 | Aerie Pharmaceuticals, Inc. | Process for the preparation of kinase inhibitors and intermediates thereof |
US9643927B1 (en) | 2015-11-17 | 2017-05-09 | Aerie Pharmaceuticals, Inc. | Process for the preparation of kinase inhibitors and intermediates thereof |
MX2019002396A (es) | 2016-08-31 | 2019-07-08 | Aerie Pharmaceuticals Inc | Composiciones oftalmicas. |
AU2018243770A1 (en) | 2017-03-30 | 2019-09-19 | F. Hoffmann-La Roche Ag | Isoquinolines as inhibitors of HPK1 |
KR20190135027A (ko) | 2017-03-31 | 2019-12-05 | 에어리 파마슈티컬즈, 인코포레이티드 | 아릴 시클로프로필-아미노-이소퀴놀리닐 아미드 화합물 |
CN108997222A (zh) * | 2018-07-23 | 2018-12-14 | 山东省农药科学研究院 | 一种氟嘧菌酯中间体4,6-二氯-5-氟嘧啶的合成方法 |
JP7386841B2 (ja) * | 2018-07-24 | 2023-11-27 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | イソキノリン化合物及びその使用 |
EP3849555A4 (en) | 2018-09-14 | 2022-05-04 | Aerie Pharmaceuticals, Inc. | ARYL CYCLOPROPYL AMINO ISOCHINOLINYL AMIDE COMPOUNDS |
US11612606B2 (en) | 2018-10-03 | 2023-03-28 | Genentech, Inc. | 8-aminoisoquinoline compounds and uses thereof |
CN111574413B (zh) * | 2020-06-08 | 2022-04-05 | 杭州尚合生物医药科技有限公司 | 一种2-氨甲基吡啶与dmf-dma作为胺源的磺酰脒的制备方法 |
US11351149B2 (en) | 2020-09-03 | 2022-06-07 | Pfizer Inc. | Nitrile-containing antiviral compounds |
CN115572262A (zh) * | 2022-10-27 | 2023-01-06 | 厦门沃克沃德医药科技有限公司 | 一种异喹啉衍生物及其制备方法 |
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2007
- 2007-12-19 CA CA2673920A patent/CA2673920C/en not_active Expired - Fee Related
- 2007-12-19 AT AT07856890T patent/ATE554072T1/de active
- 2007-12-19 WO PCT/EP2007/011167 patent/WO2008077554A1/en active Application Filing
- 2007-12-19 EP EP07856890A patent/EP2125746B1/en not_active Not-in-force
- 2007-12-19 KR KR1020097013325A patent/KR20090092303A/ko active IP Right Grant
- 2007-12-19 BR BRPI0721180-5A patent/BRPI0721180A2/pt not_active IP Right Cessation
- 2007-12-19 AU AU2007338410A patent/AU2007338410B2/en not_active Ceased
- 2007-12-19 MX MX2009005964A patent/MX2009005964A/es active IP Right Grant
- 2007-12-19 MY MYPI20092541 patent/MY151953A/en unknown
- 2007-12-19 CN CN200780048527XA patent/CN101611012B/zh not_active Expired - Fee Related
- 2007-12-19 JP JP2009543375A patent/JP5405316B2/ja not_active Expired - Fee Related
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- 2009-06-24 IL IL199539A patent/IL199539A/en not_active IP Right Cessation
- 2009-06-24 SV SV2009003317A patent/SV2009003317A/es unknown
- 2009-06-26 NO NO20092432A patent/NO20092432L/no not_active Application Discontinuation
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Also Published As
Publication number | Publication date |
---|---|
JP5405316B2 (ja) | 2014-02-05 |
EP2125746A1 (en) | 2009-12-02 |
AU2007338410A1 (en) | 2008-07-03 |
CN101611012B (zh) | 2012-11-14 |
CN101611012A (zh) | 2009-12-23 |
ATE554072T1 (de) | 2012-05-15 |
WO2008077554A1 (en) | 2008-07-03 |
JP2010514719A (ja) | 2010-05-06 |
IL199539A (en) | 2014-07-31 |
EP2125746B1 (en) | 2012-04-18 |
MX2009005964A (es) | 2009-06-15 |
CA2673920C (en) | 2015-03-24 |
MY151953A (en) | 2014-07-31 |
CA2673920A1 (en) | 2008-07-03 |
BRPI0721180A2 (pt) | 2014-03-18 |
SV2009003317A (es) | 2010-02-05 |
AU2007338410B2 (en) | 2012-08-16 |
KR20090092303A (ko) | 2009-08-31 |
US8710228B2 (en) | 2014-04-29 |
NO20092432L (no) | 2009-09-17 |
US20100081671A1 (en) | 2010-04-01 |
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PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20161219 |