MX2010013974A - Isoquinolinas e isoquinolinonas 6-sustituidas. - Google Patents
Isoquinolinas e isoquinolinonas 6-sustituidas.Info
- Publication number
- MX2010013974A MX2010013974A MX2010013974A MX2010013974A MX2010013974A MX 2010013974 A MX2010013974 A MX 2010013974A MX 2010013974 A MX2010013974 A MX 2010013974A MX 2010013974 A MX2010013974 A MX 2010013974A MX 2010013974 A MX2010013974 A MX 2010013974A
- Authority
- MX
- Mexico
- Prior art keywords
- isoquinolinones
- rho
- substituted isoquinolines
- kinase
- substituted
- Prior art date
Links
- -1 6-substituted isoquinolines Chemical class 0.000 title abstract 2
- VDBNYAPERZTOOF-UHFFFAOYSA-N isoquinolin-1(2H)-one Chemical class C1=CC=C2C(=O)NC=CC2=C1 VDBNYAPERZTOOF-UHFFFAOYSA-N 0.000 title abstract 2
- 102000000568 rho-Associated Kinases Human genes 0.000 abstract 2
- 108010041788 rho-Associated Kinases Proteins 0.000 abstract 2
- 102000011131 Myosin-Light-Chain Phosphatase Human genes 0.000 abstract 1
- 108010037801 Myosin-Light-Chain Phosphatase Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000026731 phosphorylation Effects 0.000 abstract 1
- 238000006366 phosphorylation reaction Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
La invención se refiere a derivados de isoquinolina e isoquinolinona 6-sustituidos de la fórmula (I) (ver fórmula I) útiles para el tratamiento y/o la prevención de enfermedades asociadas con la cinasa Rho y/o la fosforilación mediada por la cinasa Rho de la fosfatasa de miosina de cadena ligera y a composiciones que contienen dichos compuestos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08290605 | 2008-06-24 | ||
PCT/EP2009/004420 WO2009156099A1 (en) | 2008-06-24 | 2009-06-19 | 6-substituted isoquinolines and isoquinolinones |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2010013974A true MX2010013974A (es) | 2011-01-14 |
Family
ID=40044043
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2010013974A MX2010013974A (es) | 2008-06-24 | 2009-06-19 | Isoquinolinas e isoquinolinonas 6-sustituidas. |
Country Status (29)
Country | Link |
---|---|
US (2) | US8399482B2 (es) |
EP (1) | EP2313374B1 (es) |
JP (1) | JP5714485B2 (es) |
KR (1) | KR101607090B1 (es) |
CN (1) | CN102131785B (es) |
AR (1) | AR072280A1 (es) |
AU (1) | AU2009262516B8 (es) |
BR (1) | BRPI0914735A2 (es) |
CA (1) | CA2728128C (es) |
CO (1) | CO6321249A2 (es) |
CR (1) | CR11830A (es) |
DK (1) | DK2313374T3 (es) |
DO (1) | DOP2010000392A (es) |
ES (1) | ES2436531T3 (es) |
HK (1) | HK1158643A1 (es) |
HR (1) | HRP20131041T1 (es) |
IL (1) | IL210115A (es) |
MA (1) | MA32399B1 (es) |
MX (1) | MX2010013974A (es) |
MY (1) | MY153615A (es) |
PE (1) | PE20110054A1 (es) |
PL (1) | PL2313374T3 (es) |
PT (1) | PT2313374E (es) |
RU (1) | RU2528229C2 (es) |
SI (1) | SI2313374T1 (es) |
SV (1) | SV2010003771A (es) |
TW (1) | TWI480265B (es) |
UY (1) | UY31926A (es) |
WO (1) | WO2009156099A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR3017868A1 (fr) | 2014-02-21 | 2015-08-28 | Servier Lab | Derives d'isoquinoleine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
CN106467477A (zh) * | 2016-08-26 | 2017-03-01 | 天津雅奥科技发展有限公司 | 一种合成化合物(1‑环丙基‑1‑氰基‑4‑环己酮)的新方法 |
US11738030B2 (en) | 2021-10-30 | 2023-08-29 | Aneuryst, Inc. | Treatments for disturbed cerebral homeostasis |
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PT2102164E (pt) | 2006-12-27 | 2011-01-21 | Sanofi Aventis | Derivados de isoquinolina e de isoquinolinona substituída com cicloalquilamina |
PT2125744E (pt) * | 2006-12-27 | 2011-07-01 | Sanofi Aventis | Derivados de isoquinolona e isoquinolinona substituídos com cicloalquilamina |
AU2007338408B2 (en) * | 2006-12-27 | 2012-07-26 | Sanofi-Aventis | Substituted isoquinoline and isoquinolinone derivatives |
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- 2009-06-19 MX MX2010013974A patent/MX2010013974A/es active IP Right Grant
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