MX2009005967A - Derivados de isoquinolina e isoquinolinona sustituidos con cicloalquilamina. - Google Patents

Derivados de isoquinolina e isoquinolinona sustituidos con cicloalquilamina.

Info

Publication number
MX2009005967A
MX2009005967A MX2009005967A MX2009005967A MX2009005967A MX 2009005967 A MX2009005967 A MX 2009005967A MX 2009005967 A MX2009005967 A MX 2009005967A MX 2009005967 A MX2009005967 A MX 2009005967A MX 2009005967 A MX2009005967 A MX 2009005967A
Authority
MX
Mexico
Prior art keywords
substituted isoquinoline
isoquinolinone derivatives
cycloalkylamine
cycloalkylamine substituted
rho
Prior art date
Application number
MX2009005967A
Other languages
English (en)
Inventor
Oliver Plettenburg
Jochen Goerlitzer
Matthias Loehn
Katrin Lorenz
Sandrine Biscarrat
Frederic Jeannot
Olivier Duclos
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of MX2009005967A publication Critical patent/MX2009005967A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P13/08—Drugs for disorders of the urinary system of the prostate
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P31/12—Antivirals
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    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
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    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)

Abstract

La invención se refiere a derivados de isoquinolina e isoquinolinona 6-sustituidos de la fórmula (I) (ver fórmula I) útiles para el tratamiento y/o prevención de enfermedades asociadas con la Rho-quinasa y/o la fosforilación mediada por la Rho-quinasa de la fosfatasa de la cadena ligera de miosina, y a composiciones que contienen tales compuestos.
MX2009005967A 2006-12-27 2007-12-19 Derivados de isoquinolina e isoquinolinona sustituidos con cicloalquilamina. MX2009005967A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06026897 2006-12-27
PCT/EP2007/011169 WO2008077556A1 (en) 2006-12-27 2007-12-19 Cycloalkylamine substituted isoquinoline and isoquinolinone derivatives

Publications (1)

Publication Number Publication Date
MX2009005967A true MX2009005967A (es) 2009-06-15

Family

ID=38050127

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009005967A MX2009005967A (es) 2006-12-27 2007-12-19 Derivados de isoquinolina e isoquinolinona sustituidos con cicloalquilamina.

Country Status (38)

Country Link
US (1) US8710077B2 (es)
EP (1) EP2102164B1 (es)
JP (1) JP5318779B2 (es)
KR (1) KR101494452B1 (es)
CN (1) CN101578266B (es)
AR (1) AR064531A1 (es)
AT (1) ATE490243T1 (es)
AU (1) AU2007338412B2 (es)
BR (1) BRPI0720859A2 (es)
CA (1) CA2673922C (es)
CL (1) CL2007003820A1 (es)
CO (1) CO6210815A2 (es)
CR (1) CR10811A (es)
CY (1) CY1111323T1 (es)
DE (1) DE602007010981D1 (es)
DK (1) DK2102164T3 (es)
EC (1) ECSP099468A (es)
ES (1) ES2355534T3 (es)
GT (1) GT200900183A (es)
HK (1) HK1138585A1 (es)
HR (1) HRP20100705T1 (es)
MA (1) MA31076B1 (es)
MX (1) MX2009005967A (es)
MY (1) MY154767A (es)
NI (1) NI200900111A (es)
NO (1) NO20092488L (es)
NZ (1) NZ577984A (es)
PL (1) PL2102164T3 (es)
PT (1) PT2102164E (es)
RS (1) RS51655B (es)
RU (1) RU2468011C2 (es)
SI (1) SI2102164T1 (es)
SV (1) SV2009003314A (es)
TN (1) TN2009000274A1 (es)
TW (1) TWI423803B (es)
UY (1) UY30845A1 (es)
WO (1) WO2008077556A1 (es)
ZA (1) ZA200903555B (es)

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