HK1124341A1 - Cleavage of precursors of insulins by a variant of trypsin - Google Patents

Cleavage of precursors of insulins by a variant of trypsin

Info

Publication number
HK1124341A1
HK1124341A1 HK09101249.8A HK09101249A HK1124341A1 HK 1124341 A1 HK1124341 A1 HK 1124341A1 HK 09101249 A HK09101249 A HK 09101249A HK 1124341 A1 HK1124341 A1 HK 1124341A1
Authority
HK
Hong Kong
Prior art keywords
insulins
trypsin
precursors
cleavage
variant
Prior art date
Application number
HK09101249.8A
Other languages
English (en)
Inventor
Frank Geipel
Stephan Glaser
Christoph Hoh
Erhard Kopetzki
Rainer Mueller
Frank Zocher
Original Assignee
Sanofi Aventis Deutschland
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland, Hoffmann La Roche filed Critical Sanofi Aventis Deutschland
Publication of HK1124341A1 publication Critical patent/HK1124341A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6427—Chymotrypsins (3.4.21.1; 3.4.21.2); Trypsin (3.4.21.4)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
HK09101249.8A 2005-09-14 2009-02-11 Cleavage of precursors of insulins by a variant of trypsin HK1124341A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05077086 2005-09-14
PCT/EP2006/008380 WO2007031187A1 (en) 2005-09-14 2006-08-26 Cleavage of precursors of insulins by a variant of trypsin

Publications (1)

Publication Number Publication Date
HK1124341A1 true HK1124341A1 (en) 2009-07-10

Family

ID=36190640

Family Applications (1)

Application Number Title Priority Date Filing Date
HK09101249.8A HK1124341A1 (en) 2005-09-14 2009-02-11 Cleavage of precursors of insulins by a variant of trypsin

Country Status (20)

Country Link
US (1) US7981635B2 (xx)
EP (1) EP1926749B1 (xx)
JP (1) JP5027812B2 (xx)
KR (1) KR101304958B1 (xx)
CN (1) CN101253196B (xx)
AR (1) AR055428A1 (xx)
AT (1) ATE517919T1 (xx)
AU (1) AU2006291780B2 (xx)
BR (1) BRPI0616054B8 (xx)
CA (1) CA2621344C (xx)
CY (1) CY1112667T1 (xx)
ES (1) ES2370657T3 (xx)
HK (1) HK1124341A1 (xx)
IL (1) IL189887A (xx)
MX (1) MX2008003362A (xx)
MY (1) MY146082A (xx)
PL (1) PL1926749T3 (xx)
PT (1) PT1926749E (xx)
SI (1) SI1926749T1 (xx)
WO (1) WO2007031187A1 (xx)

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CA2711749A1 (en) 2008-01-09 2009-07-16 Sanofi-Aventis Deutschland Gmbh Novel insulin derivatives having an extremely delayed time-action profile
DE102008003568A1 (de) 2008-01-09 2009-07-16 Sanofi-Aventis Deutschland Gmbh Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
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CN102816785B (zh) * 2012-05-24 2016-03-09 上海仁会生物制药股份有限公司 一种甘精胰岛素及其类似物的制备方法
CN102994600A (zh) * 2012-12-11 2013-03-27 鲁南新时代生物技术有限公司 甘精胰岛素前体的酶切转化方法
MX2017007699A (es) 2014-12-12 2017-09-18 Sanofi Aventis Deutschland Formulacion de proporcion fija de insulina glargina/lixisenatida.
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
CN108018277A (zh) * 2016-11-04 2018-05-11 江苏万邦生化医药股份有限公司 重组牛胰蛋白酶突变体及其制备方法
KR20190036956A (ko) 2017-09-28 2019-04-05 한미약품 주식회사 지속형 단쇄 인슐린 아날로그 및 이의 결합체
CA3091943A1 (en) * 2018-02-22 2019-08-29 Sanofi-Aventis Deutschland Gmbh Variants of porcine trypsin
EP3650541A1 (en) * 2018-11-08 2020-05-13 BioPharma Translationsinstitut Dessau Forschungs GmbH Trypsin mutant for c- and n-terminal modification of polypeptides
KR20200080747A (ko) * 2018-12-27 2020-07-07 주식회사 폴루스 인슐린 전구체의 인슐린 효소 전환용 조성물 및 이를 이용하여 인슐린 전구체를 인슐린으로 전환하는 방법
AU2020399194A1 (en) 2019-12-10 2022-07-28 Sanofi A method of forming a conjugate of a sulfonamide and a polypeptide
CN113773391B (zh) * 2020-06-09 2023-10-20 宁波鲲鹏生物科技有限公司 一种门冬胰岛素的制备方法

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Also Published As

Publication number Publication date
ES2370657T3 (es) 2011-12-21
KR20080055843A (ko) 2008-06-19
KR101304958B1 (ko) 2013-09-17
EP1926749A1 (en) 2008-06-04
JP2009507500A (ja) 2009-02-26
AU2006291780A1 (en) 2007-03-22
BRPI0616054B1 (pt) 2019-08-06
CA2621344A1 (en) 2007-03-22
MX2008003362A (es) 2008-03-25
US20100196953A1 (en) 2010-08-05
ATE517919T1 (de) 2011-08-15
WO2007031187A8 (en) 2007-08-16
CA2621344C (en) 2014-12-16
CN101253196A (zh) 2008-08-27
EP1926749B1 (en) 2011-07-27
PT1926749E (pt) 2011-09-29
US7981635B2 (en) 2011-07-19
AU2006291780B2 (en) 2011-12-08
MY146082A (en) 2012-06-29
IL189887A (en) 2012-02-29
SI1926749T1 (sl) 2011-11-30
JP5027812B2 (ja) 2012-09-19
AR055428A1 (es) 2007-08-22
CN101253196B (zh) 2012-09-05
PL1926749T3 (pl) 2011-12-30
IL189887A0 (en) 2008-11-03
CY1112667T1 (el) 2016-02-10
BRPI0616054A2 (pt) 2011-06-07
BRPI0616054B8 (pt) 2021-05-25
WO2007031187A1 (en) 2007-03-22

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