HK1122276A1 - Isoquinoline derivatives as inhibitors of rho-kinase - Google Patents

Isoquinoline derivatives as inhibitors of rho-kinase

Info

Publication number
HK1122276A1
HK1122276A1 HK08113534.8A HK08113534A HK1122276A1 HK 1122276 A1 HK1122276 A1 HK 1122276A1 HK 08113534 A HK08113534 A HK 08113534A HK 1122276 A1 HK1122276 A1 HK 1122276A1
Authority
HK
Hong Kong
Prior art keywords
rho
kinase
inhibitors
isoquinoline derivatives
isoquinoline
Prior art date
Application number
HK08113534.8A
Other languages
English (en)
Inventor
Oliver Plettenburg
Armin Hofmeister
Dieter Kadereit
Stefan Peukert
Sven Ruf
Kurt Ritter
Matthias Loehn
Yuri Ivashchenko
Peter Monecke
Matthias Dreyer
Aimo Kannt
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of HK1122276A1 publication Critical patent/HK1122276A1/xx

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
HK08113534.8A 2005-06-28 2008-12-12 Isoquinoline derivatives as inhibitors of rho-kinase HK1122276A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05013868 2005-06-28
PCT/EP2006/005648 WO2007000240A1 (en) 2005-06-28 2006-06-13 Isoquinoline derivatives as inhibitors of rho-kinase

Publications (1)

Publication Number Publication Date
HK1122276A1 true HK1122276A1 (en) 2009-05-15

Family

ID=35395794

Family Applications (1)

Application Number Title Priority Date Filing Date
HK08113534.8A HK1122276A1 (en) 2005-06-28 2008-12-12 Isoquinoline derivatives as inhibitors of rho-kinase

Country Status (34)

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US (2) US8501736B2 (xx)
EP (1) EP1899322B1 (xx)
JP (1) JP5097701B2 (xx)
KR (1) KR101327780B1 (xx)
CN (1) CN101213187B (xx)
AR (1) AR054518A1 (xx)
AT (1) ATE441641T1 (xx)
AU (1) AU2006264043B2 (xx)
BR (1) BRPI0613597A2 (xx)
CA (1) CA2611295C (xx)
CY (1) CY1110108T1 (xx)
DE (1) DE602006008945D1 (xx)
DK (1) DK1899322T3 (xx)
DO (1) DOP2006000149A (xx)
ES (1) ES2331853T3 (xx)
GT (1) GT200600273A (xx)
HK (1) HK1122276A1 (xx)
HR (1) HRP20090589T1 (xx)
IL (1) IL188380A (xx)
MA (1) MA29535B1 (xx)
MX (1) MX2008000017A (xx)
MY (1) MY146037A (xx)
NZ (1) NZ565040A (xx)
PA (1) PA8683501A1 (xx)
PE (1) PE20070141A1 (xx)
PL (1) PL1899322T3 (xx)
PT (1) PT1899322E (xx)
RS (1) RS51139B (xx)
RU (1) RU2443688C2 (xx)
SI (1) SI1899322T1 (xx)
TW (1) TWI372756B (xx)
UY (1) UY29641A1 (xx)
WO (1) WO2007000240A1 (xx)
ZA (1) ZA200710001B (xx)

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CN110117278B (zh) * 2018-02-07 2022-07-19 石家庄以岭药业股份有限公司 烷氧基苯并五元(六元)杂环胺类化合物及其药物用途
JP2021527125A (ja) * 2018-06-07 2021-10-11 ディサーム・セラピューティクス・インコーポレイテッドＤｉｓａｒｍ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． Ｓａｒｍ１阻害剤
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UY29641A1 (es) 2007-01-31
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EP1899322A1 (en) 2008-03-19
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IL188380A (en) 2012-02-29
ZA200710001B (en) 2008-11-26
CY1110108T1 (el) 2015-01-14
WO2007000240A1 (en) 2007-01-04
KR101327780B1 (ko) 2013-11-11
MA29535B1 (fr) 2008-06-02
US20110245248A1 (en) 2011-10-06
RU2443688C2 (ru) 2012-02-27
IL188380A0 (en) 2008-04-13
DE602006008945D1 (de) 2009-10-15
BRPI0613597A2 (pt) 2011-01-18
AU2006264043B2 (en) 2012-04-26
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CA2611295C (en) 2014-04-22
AR054518A1 (es) 2007-06-27
US8722671B2 (en) 2014-05-13
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ATE441641T1 (de) 2009-09-15
AU2006264043A1 (en) 2007-01-04
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