HK1099014A1 - Malonamide derivatives blocking the activity of gama-secretase - Google Patents

Malonamide derivatives blocking the activity of gama-secretase

Info

Publication number
HK1099014A1
HK1099014A1 HK07105326.7A HK07105326A HK1099014A1 HK 1099014 A1 HK1099014 A1 HK 1099014A1 HK 07105326 A HK07105326 A HK 07105326A HK 1099014 A1 HK1099014 A1 HK 1099014A1
Authority
HK
Hong Kong
Prior art keywords
gama
secretase
activity
malonamide derivatives
blocking
Prior art date
Application number
HK07105326.7A
Other languages
English (en)
Inventor
Alexander Flohr
Guido Galley
Roland Jakob-Roetne
Eric Argirios Kitas
Jens-Uwe Peters
Wolfgang Wostl
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HK1099014A1 publication Critical patent/HK1099014A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/558—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/20—Dibenz [b, e] azepines; Hydrogenated dibenz [b, e] azepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/14—[b,f]-condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
HK07105326.7A 2003-09-09 2007-05-21 Malonamide derivatives blocking the activity of gama-secretase HK1099014A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03019683 2003-09-09
PCT/EP2004/009700 WO2005023772A1 (en) 2003-09-09 2004-08-31 Malonamide derivatives blocking the activity of gama-secretase

Publications (1)

Publication Number Publication Date
HK1099014A1 true HK1099014A1 (en) 2007-08-03

Family

ID=34224068

Family Applications (1)

Application Number Title Priority Date Filing Date
HK07105326.7A HK1099014A1 (en) 2003-09-09 2007-05-21 Malonamide derivatives blocking the activity of gama-secretase

Country Status (35)

Country Link
US (1) US7160875B2 (ko)
EP (1) EP1711470B1 (ko)
JP (2) JP4571639B2 (ko)
KR (3) KR20070087233A (ko)
CN (1) CN100593539C (ko)
AR (1) AR045609A1 (ko)
AT (1) ATE428698T1 (ko)
AU (1) AU2004270361B2 (ko)
BR (1) BRPI0413533A (ko)
CA (1) CA2537440C (ko)
CO (1) CO5660268A2 (ko)
CR (1) CR8264A (ko)
CY (1) CY1109225T1 (ko)
DE (1) DE602004020680D1 (ko)
DK (1) DK1711470T3 (ko)
EA (1) EA009940B1 (ko)
EC (1) ECSP066414A (ko)
ES (1) ES2322652T3 (ko)
HK (1) HK1099014A1 (ko)
HR (1) HRP20090266T1 (ko)
IL (1) IL173905A (ko)
MA (1) MA28034A1 (ko)
MX (1) MXPA06002562A (ko)
MY (1) MY141308A (ko)
NO (1) NO20061047L (ko)
NZ (1) NZ545538A (ko)
PL (1) PL1711470T3 (ko)
PT (1) PT1711470E (ko)
RS (1) RS20060146A (ko)
SI (1) SI1711470T1 (ko)
TN (1) TNSN06077A1 (ko)
TW (1) TW200519092A (ko)
UA (1) UA83501C2 (ko)
WO (1) WO2005023772A1 (ko)
ZA (1) ZA200601989B (ko)

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* Cited by examiner, † Cited by third party
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WO2004069826A1 (en) * 2003-02-04 2004-08-19 F. Hoffmann-La Roche Ag Malonamide derivatives as gamma-secretase inhibitors
DK1711470T3 (da) * 2003-09-09 2009-06-08 Hoffmann La Roche Malonamidderivater der blokerer aktiviteten af gamma-sekretase
AU2004283803B2 (en) * 2003-10-06 2010-06-24 F. Hoffmann-La Roche Ag Substituted dibenzo-azepine and benzo-diazepine derivatives useful as gamma-secretase inhibitors
US7211573B2 (en) 2004-12-08 2007-05-01 Hoffmann-La Roche Inc. Malonamide derivatives
ES2398531T3 (es) * 2006-03-27 2013-03-20 F. Hoffmann-La Roche Ag Derivados de malonamida como inhibidores de gamma secretasa
BRPI0717587A2 (pt) * 2006-09-20 2013-10-29 Hoffmann La Roche Derivados de 4-oxo-2,3,4,5-tetra-hidro-benzo[b][1,4]diazepina
MX2009007864A (es) * 2007-02-02 2009-07-31 Hoffmann La Roche Derivados de 6-oxo-6,7-dihidro-5h-dibenzo[b,d]azepin-7-ilo.
EP2121579B1 (en) * 2007-03-15 2011-04-20 F. Hoffmann-La Roche AG Malonamides as orexin antagonists
US7579464B2 (en) * 2007-05-25 2009-08-25 Hoffmann-La Roche Inc. Process for preparation of enantiomerically pure compounds
US8741889B2 (en) 2008-01-11 2014-06-03 Hoffmann-La Roche Inc Method of treating non-small cell lung cancer and colon cancer with gamma-secretase inhibitor
MA33076B1 (fr) * 2008-01-11 2012-03-01 Hoffmann La Roche Utilisation d'un inhibiteur de la gamma-secretase pour le traitement du cancer
US8309299B2 (en) 2010-05-19 2012-11-13 Hoffmann-La Roche Inc. Combination therapy and method for assessing resistance to treatment
WO2012040444A2 (en) * 2010-09-24 2012-03-29 Bristol-Myers Squibb Company Treatment of patients with incipient alzheimer's disease
KR101330184B1 (ko) 2010-10-15 2013-11-15 성균관대학교산학협력단 감마-세크레타제 저해제를 유효성분으로 함유하는 류마티스성 관절염의 예방 또는 치료용 조성물
WO2012050370A2 (ko) * 2010-10-15 2012-04-19 성균관대학교산학협력단 감마-세크레타제 저해제를 유효성분으로 함유하는 류마티스성 관절염의 예방 또는 치료용 조성물
US20120114638A1 (en) 2010-11-08 2012-05-10 John Boylan Combination therapy
US20120184529A1 (en) 2011-01-14 2012-07-19 Demario Mark D Combination therapy
US20120225860A1 (en) 2011-03-02 2012-09-06 John Frederick Boylan Method for administration of a gamma secretase inhibitor
TWI530489B (zh) 2011-03-22 2016-04-21 必治妥美雅史谷比公司 雙（氟烷基）－１，４－苯二氮呯酮化合物
JO3148B1 (ar) 2011-07-27 2017-09-20 Lilly Co Eli مركب مثبط لإشارات مسار notch
EP2897947B1 (en) 2012-09-21 2016-10-26 Bristol-Myers Squibb Company Alkyl, fluoroalkyl-1,4-benzodiazepinone compounds
US9187434B2 (en) 2012-09-21 2015-11-17 Bristol-Myers Squibb Company Substituted 1,5-benzodiazepinones compounds
TWI614238B (zh) 2012-09-21 2018-02-11 必治妥美雅史谷比公司 雙（氟烷基）－１，４－苯并二氮呯酮化合物及其前藥
WO2014047390A1 (en) 2012-09-21 2014-03-27 Bristol-Myers Squibb Company Tricyclic heterocyclic compounds as notch inhibitors
US9133126B2 (en) 2012-09-21 2015-09-15 Bristol-Myers Squibb Company Fluoroalkyl dibenzoazepinone compounds
EP2897946B1 (en) 2012-09-21 2016-11-16 Bristol-Myers Squibb Company N-substituted bis(fluoroalkkyl)-1,4-benzodiazepinone compounds as notch inhibitors
EP2897954B1 (en) 2012-09-21 2016-10-26 Bristol-Myers Squibb Company Fluoroalkyl-1,4-benzodiazepinone compounds
US9273075B2 (en) 2012-09-21 2016-03-01 Bristol-Myers Squibb Company Prodrugs of 1,4-benzodiazepinone compounds
CN104822665A (zh) 2012-09-21 2015-08-05 百时美施贵宝公司 用作Notch抑制剂的氟烷基和氟环烷基1,4-苯并二氮杂*酮化合物
WO2014165718A1 (en) 2013-04-04 2014-10-09 Bristol-Myers Squibb Company Combination therapy for the treatment of proliferative diseases
EP2932966A1 (en) 2014-04-16 2015-10-21 Novartis AG Gamma secretase inhibitors for treating respiratory diseases
KR102130458B1 (ko) * 2015-10-30 2020-07-08 파이프라인 테라퓨틱스, 아이엔씨. 디벤조 아제핀 화합물 및 귀 질환과 귀 장애 치료에서의 그의 용도
AU2017376109A1 (en) 2016-12-16 2019-07-11 Pipeline Therapeutics, Inc. Methods of treating cochlear synaptopathy
WO2018201051A1 (en) 2017-04-28 2018-11-01 Novartis Ag Bcma-targeting agent, and combination therapy with a gamma secretase inhibitor
EP3615055A1 (en) 2017-04-28 2020-03-04 Novartis AG Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor
EP3668844A1 (en) * 2017-08-15 2020-06-24 Bayer Aktiengesellschaft 4-oxo-2,3,4,5-tetrahydro-1h-1,5-benzodiazepine-7-carboxamides
BR112020024351A2 (pt) 2018-06-01 2021-02-23 Novartis Ag moléculas de ligação contra bcma e usos das mesmas
US20220332821A1 (en) 2019-06-24 2022-10-20 Novartis Ag Dosing regimen and combination therapies for multispecific antibodies targeting b-cell maturation antigen
CA3229806A1 (en) * 2021-08-31 2023-03-09 Basf Se Herbicidal malonamides containing a condensed ring system

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CA2404273A1 (en) * 2000-04-11 2001-10-18 Bristol-Myers Squibb Pharma Company Substituted lactams as inhibitors of a.beta. protein production
GB0012671D0 (en) * 2000-05-24 2000-07-19 Merck Sharp & Dohme Therapeutic agents
WO2004069826A1 (en) * 2003-02-04 2004-08-19 F. Hoffmann-La Roche Ag Malonamide derivatives as gamma-secretase inhibitors
DK1711470T3 (da) * 2003-09-09 2009-06-08 Hoffmann La Roche Malonamidderivater der blokerer aktiviteten af gamma-sekretase

Also Published As

Publication number Publication date
TW200519092A (en) 2005-06-16
PT1711470E (pt) 2009-05-21
CR8264A (es) 2008-09-22
DE602004020680D1 (de) 2009-05-28
EP1711470B1 (en) 2009-04-15
KR20070087233A (ko) 2007-08-27
JP2007505063A (ja) 2007-03-08
MA28034A1 (fr) 2006-07-03
AU2004270361B2 (en) 2009-06-25
IL173905A0 (en) 2006-07-05
CN1875005A (zh) 2006-12-06
ES2322652T3 (es) 2009-06-24
US20050054633A1 (en) 2005-03-10
ZA200601989B (en) 2007-05-30
NZ545538A (en) 2008-12-24
CA2537440A1 (en) 2005-03-17
SI1711470T1 (sl) 2009-08-31
RS20060146A (en) 2008-06-05
CN100593539C (zh) 2010-03-10
DK1711470T3 (da) 2009-06-08
KR100838852B1 (ko) 2008-06-16
BRPI0413533A (pt) 2006-10-10
ATE428698T1 (de) 2009-05-15
ECSP066414A (es) 2006-09-18
PL1711470T3 (pl) 2009-09-30
EP1711470A1 (en) 2006-10-18
MY141308A (en) 2010-04-16
AR045609A1 (es) 2005-11-02
UA83501C2 (uk) 2008-07-25
JP4571639B2 (ja) 2010-10-27
NO20061047L (no) 2006-04-04
EA200600503A1 (ru) 2006-08-25
CO5660268A2 (es) 2006-07-31
IL173905A (en) 2011-05-31
HRP20090266T1 (en) 2009-06-30
WO2005023772A1 (en) 2005-03-17
TNSN06077A1 (fr) 2007-10-03
MXPA06002562A (es) 2006-06-20
KR20070087690A (ko) 2007-08-28
KR20060054455A (ko) 2006-05-22
EA009940B1 (ru) 2008-04-28
JP2010229153A (ja) 2010-10-14
CA2537440C (en) 2012-07-10
KR100834177B1 (ko) 2008-05-30
US7160875B2 (en) 2007-01-09
AU2004270361A1 (en) 2005-03-17
CY1109225T1 (el) 2014-07-02

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20140831