DK1711470T3 - Malonamidderivater der blokerer aktiviteten af gamma-sekretase - Google Patents

Malonamidderivater der blokerer aktiviteten af gamma-sekretase

Info

Publication number: DK1711470T3
Authority: DK; Denmark
Prior art keywords: activity; block; gamma secretase; malonamide derivatives; malonamide
Prior art date: 2003-09-09

Application number

DK04764665T

Other languages

Danish (da)

English (en)

Inventor

Alexander Flohr

Guido Galley

Roland Jakob-Roetne

Eric Argirios Kitas

Jens-Uwe Peters

Wolfgang Wostl

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-09-09

Filing date

2004-08-31

Publication date

2009-06-08

2004-08-31 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2009-06-08 Application granted granted Critical

2009-06-08 Publication of DK1711470T3 publication Critical patent/DK1711470T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/558—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/20—Dibenz [b, e] azepines; Hydrogenated dibenz [b, e] azepines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D313/14—[b,f]-condensed

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
General Chemical & Material Sciences (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Hydrogenated Pyridines (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Pyrane Compounds (AREA)

DK04764665T 2003-09-09 2004-08-31 Malonamidderivater der blokerer aktiviteten af gamma-sekretase DK1711470T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP03019683		2003-09-09
PCT/EP2004/009700 WO2005023772A1 (en)	2003-09-09	2004-08-31	Malonamide derivatives blocking the activity of gama-secretase

Publications (1)

Publication Number	Publication Date
DK1711470T3 true DK1711470T3 (da)	2009-06-08

Family

ID=34224068

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK04764665T DK1711470T3 (da)	2003-09-09	2004-08-31	Malonamidderivater der blokerer aktiviteten af gamma-sekretase

Country Status (35)

Country	Link
US (1)	US7160875B2 (ko)
EP (1)	EP1711470B1 (ko)
JP (2)	JP4571639B2 (ko)
KR (3)	KR20070087233A (ko)
CN (1)	CN100593539C (ko)
AR (1)	AR045609A1 (ko)
AT (1)	ATE428698T1 (ko)
AU (1)	AU2004270361B2 (ko)
BR (1)	BRPI0413533A (ko)
CA (1)	CA2537440C (ko)
CO (1)	CO5660268A2 (ko)
CR (1)	CR8264A (ko)
CY (1)	CY1109225T1 (ko)
DE (1)	DE602004020680D1 (ko)
DK (1)	DK1711470T3 (ko)
EA (1)	EA009940B1 (ko)
EC (1)	ECSP066414A (ko)
ES (1)	ES2322652T3 (ko)
HK (1)	HK1099014A1 (ko)
HR (1)	HRP20090266T1 (ko)
IL (1)	IL173905A (ko)
MA (1)	MA28034A1 (ko)
MX (1)	MXPA06002562A (ko)
MY (1)	MY141308A (ko)
NO (1)	NO20061047L (ko)
NZ (1)	NZ545538A (ko)
PL (1)	PL1711470T3 (ko)
PT (1)	PT1711470E (ko)
RS (1)	RS20060146A (ko)
SI (1)	SI1711470T1 (ko)
TN (1)	TNSN06077A1 (ko)
TW (1)	TW200519092A (ko)
UA (1)	UA83501C2 (ko)
WO (1)	WO2005023772A1 (ko)
ZA (1)	ZA200601989B (ko)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2004069826A1 (en) *	2003-02-04	2004-08-19	F. Hoffmann-La Roche Ag	Malonamide derivatives as gamma-secretase inhibitors
DK1711470T3 (da) *	2003-09-09	2009-06-08	Hoffmann La Roche	Malonamidderivater der blokerer aktiviteten af gamma-sekretase
AU2004283803B2 (en) *	2003-10-06	2010-06-24	F. Hoffmann-La Roche Ag	Substituted dibenzo-azepine and benzo-diazepine derivatives useful as gamma-secretase inhibitors
US7211573B2 (en)	2004-12-08	2007-05-01	Hoffmann-La Roche Inc.	Malonamide derivatives
ES2398531T3 (es) *	2006-03-27	2013-03-20	F. Hoffmann-La Roche Ag	Derivados de malonamida como inhibidores de gamma secretasa
BRPI0717587A2 (pt) *	2006-09-20	2013-10-29	Hoffmann La Roche	Derivados de 4-oxo-2,3,4,5-tetra-hidro-benzo[b][1,4]diazepina
MX2009007864A (es) *	2007-02-02	2009-07-31	Hoffmann La Roche	Derivados de 6-oxo-6,7-dihidro-5h-dibenzo[b,d]azepin-7-ilo.
EP2121579B1 (en) *	2007-03-15	2011-04-20	F. Hoffmann-La Roche AG	Malonamides as orexin antagonists
US7579464B2 (en) *	2007-05-25	2009-08-25	Hoffmann-La Roche Inc.	Process for preparation of enantiomerically pure compounds
US8741889B2 (en)	2008-01-11	2014-06-03	Hoffmann-La Roche Inc	Method of treating non-small cell lung cancer and colon cancer with gamma-secretase inhibitor
MA33076B1 (fr) *	2008-01-11	2012-03-01	Hoffmann La Roche	Utilisation d'un inhibiteur de la gamma-secretase pour le traitement du cancer
US8309299B2 (en)	2010-05-19	2012-11-13	Hoffmann-La Roche Inc.	Combination therapy and method for assessing resistance to treatment
WO2012040444A2 (en) *	2010-09-24	2012-03-29	Bristol-Myers Squibb Company	Treatment of patients with incipient alzheimer's disease
KR101330184B1 (ko)	2010-10-15	2013-11-15	성균관대학교산학협력단	감마-세크레타제 저해제를 유효성분으로 함유하는 류마티스성 관절염의 예방 또는 치료용 조성물
WO2012050370A2 (ko) *	2010-10-15	2012-04-19	성균관대학교산학협력단	감마-세크레타제 저해제를 유효성분으로 함유하는 류마티스성 관절염의 예방 또는 치료용 조성물
US20120114638A1 (en)	2010-11-08	2012-05-10	John Boylan	Combination therapy
US20120184529A1 (en)	2011-01-14	2012-07-19	Demario Mark D	Combination therapy
US20120225860A1 (en)	2011-03-02	2012-09-06	John Frederick Boylan	Method for administration of a gamma secretase inhibitor
TWI530489B (zh)	2011-03-22	2016-04-21	必治妥美雅史谷比公司	雙（氟烷基）－１，４－苯二氮呯酮化合物
JO3148B1 (ar)	2011-07-27	2017-09-20	Lilly Co Eli	مركب مثبط لإشارات مسار notch
EP2897947B1 (en)	2012-09-21	2016-10-26	Bristol-Myers Squibb Company	Alkyl, fluoroalkyl-1,4-benzodiazepinone compounds
US9187434B2 (en)	2012-09-21	2015-11-17	Bristol-Myers Squibb Company	Substituted 1,5-benzodiazepinones compounds
TWI614238B (zh)	2012-09-21	2018-02-11	必治妥美雅史谷比公司	雙（氟烷基）－１，４－苯并二氮呯酮化合物及其前藥
WO2014047390A1 (en)	2012-09-21	2014-03-27	Bristol-Myers Squibb Company	Tricyclic heterocyclic compounds as notch inhibitors
US9133126B2 (en)	2012-09-21	2015-09-15	Bristol-Myers Squibb Company	Fluoroalkyl dibenzoazepinone compounds
EP2897946B1 (en)	2012-09-21	2016-11-16	Bristol-Myers Squibb Company	N-substituted bis(fluoroalkkyl)-1,4-benzodiazepinone compounds as notch inhibitors
EP2897954B1 (en)	2012-09-21	2016-10-26	Bristol-Myers Squibb Company	Fluoroalkyl-1,4-benzodiazepinone compounds
US9273075B2 (en)	2012-09-21	2016-03-01	Bristol-Myers Squibb Company	Prodrugs of 1,4-benzodiazepinone compounds
CN104822665A (zh)	2012-09-21	2015-08-05	百时美施贵宝公司	用作Notch抑制剂的氟烷基和氟环烷基1,4-苯并二氮杂*酮化合物
WO2014165718A1 (en)	2013-04-04	2014-10-09	Bristol-Myers Squibb Company	Combination therapy for the treatment of proliferative diseases
EP2932966A1 (en)	2014-04-16	2015-10-21	Novartis AG	Gamma secretase inhibitors for treating respiratory diseases
KR102130458B1 (ko) *	2015-10-30	2020-07-08	파이프라인 테라퓨틱스, 아이엔씨.	디벤조 아제핀 화합물 및 귀 질환과 귀 장애 치료에서의 그의 용도
AU2017376109A1 (en)	2016-12-16	2019-07-11	Pipeline Therapeutics, Inc.	Methods of treating cochlear synaptopathy
WO2018201051A1 (en)	2017-04-28	2018-11-01	Novartis Ag	Bcma-targeting agent, and combination therapy with a gamma secretase inhibitor
EP3615055A1 (en)	2017-04-28	2020-03-04	Novartis AG	Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor
EP3668844A1 (en) *	2017-08-15	2020-06-24	Bayer Aktiengesellschaft	4-oxo-2,3,4,5-tetrahydro-1h-1,5-benzodiazepine-7-carboxamides
BR112020024351A2 (pt)	2018-06-01	2021-02-23	Novartis Ag	moléculas de ligação contra bcma e usos das mesmas
US20220332821A1 (en)	2019-06-24	2022-10-20	Novartis Ag	Dosing regimen and combination therapies for multispecific antibodies targeting b-cell maturation antigen
CA3229806A1 (en) *	2021-08-31	2023-03-09	Basf Se	Herbicidal malonamides containing a condensed ring system

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2404273A1 (en) *	2000-04-11	2001-10-18	Bristol-Myers Squibb Pharma Company	Substituted lactams as inhibitors of a.beta. protein production
GB0012671D0 (en) *	2000-05-24	2000-07-19	Merck Sharp & Dohme	Therapeutic agents
WO2004069826A1 (en) *	2003-02-04	2004-08-19	F. Hoffmann-La Roche Ag	Malonamide derivatives as gamma-secretase inhibitors
DK1711470T3 (da) *	2003-09-09	2009-06-08	Hoffmann La Roche	Malonamidderivater der blokerer aktiviteten af gamma-sekretase

2004
- 2004-08-31 DK DK04764665T patent/DK1711470T3/da active
- 2004-08-31 ES ES04764665T patent/ES2322652T3/es active Active
- 2004-08-31 JP JP2006525701A patent/JP4571639B2/ja active Active
- 2004-08-31 MX MXPA06002562A patent/MXPA06002562A/es active IP Right Grant
- 2004-08-31 CA CA2537440A patent/CA2537440C/en not_active Expired - Fee Related
- 2004-08-31 PL PL04764665T patent/PL1711470T3/pl unknown
- 2004-08-31 KR KR1020077017458A patent/KR20070087233A/ko not_active Application Discontinuation
- 2004-08-31 EP EP04764665A patent/EP1711470B1/en active Active
- 2004-08-31 RS YUP-2006/0146A patent/RS20060146A/sr unknown
- 2004-08-31 AU AU2004270361A patent/AU2004270361B2/en not_active Ceased
- 2004-08-31 PT PT04764665T patent/PT1711470E/pt unknown
- 2004-08-31 SI SI200431116T patent/SI1711470T1/sl unknown
- 2004-08-31 EA EA200600503A patent/EA009940B1/ru not_active IP Right Cessation
- 2004-08-31 UA UAA200602854A patent/UA83501C2/uk unknown
- 2004-08-31 WO PCT/EP2004/009700 patent/WO2005023772A1/en active Application Filing
- 2004-08-31 KR KR1020077017457A patent/KR100838852B1/ko active IP Right Grant
- 2004-08-31 KR KR1020067004763A patent/KR100834177B1/ko active IP Right Grant
- 2004-08-31 CN CN200480032641A patent/CN100593539C/zh active Active
- 2004-08-31 DE DE602004020680T patent/DE602004020680D1/de active Active
- 2004-08-31 AT AT04764665T patent/ATE428698T1/de active
- 2004-08-31 BR BRPI0413533-4A patent/BRPI0413533A/pt not_active Application Discontinuation
- 2004-08-31 NZ NZ545538A patent/NZ545538A/en not_active IP Right Cessation
- 2004-09-02 US US10/933,177 patent/US7160875B2/en active Active
- 2004-09-06 TW TW093126876A patent/TW200519092A/zh unknown
- 2004-09-06 MY MYPI20043603A patent/MY141308A/en unknown
- 2004-09-08 AR ARP040103214A patent/AR045609A1/es not_active Application Discontinuation
2006
- 2006-02-23 IL IL173905A patent/IL173905A/en active IP Right Grant
- 2006-02-23 CO CO06018272A patent/CO5660268A2/es not_active Application Discontinuation
- 2006-03-01 CR CR8264A patent/CR8264A/es not_active Application Discontinuation
- 2006-03-03 NO NO20061047A patent/NO20061047L/no not_active Application Discontinuation
- 2006-03-07 TN TNP2006000077A patent/TNSN06077A1/fr unknown
- 2006-03-07 EC EC2006006414A patent/ECSP066414A/es unknown
- 2006-03-08 ZA ZA200601989A patent/ZA200601989B/en unknown
- 2006-03-10 MA MA28867A patent/MA28034A1/fr unknown
2007
- 2007-05-21 HK HK07105326.7A patent/HK1099014A1/xx not_active IP Right Cessation
2009
- 2009-05-12 HR HR20090266T patent/HRP20090266T1/xx unknown
- 2009-07-10 CY CY20091100729T patent/CY1109225T1/el unknown
2010
- 2010-06-18 JP JP2010138970A patent/JP2010229153A/ja active Pending

Also Published As

Publication number	Publication date
TW200519092A (en)	2005-06-16
PT1711470E (pt)	2009-05-21
CR8264A (es)	2008-09-22
DE602004020680D1 (de)	2009-05-28
EP1711470B1 (en)	2009-04-15
KR20070087233A (ko)	2007-08-27
JP2007505063A (ja)	2007-03-08
MA28034A1 (fr)	2006-07-03
AU2004270361B2 (en)	2009-06-25
IL173905A0 (en)	2006-07-05
CN1875005A (zh)	2006-12-06
ES2322652T3 (es)	2009-06-24
US20050054633A1 (en)	2005-03-10
ZA200601989B (en)	2007-05-30
NZ545538A (en)	2008-12-24
CA2537440A1 (en)	2005-03-17
SI1711470T1 (sl)	2009-08-31
RS20060146A (en)	2008-06-05
CN100593539C (zh)	2010-03-10
KR100838852B1 (ko)	2008-06-16
BRPI0413533A (pt)	2006-10-10
ATE428698T1 (de)	2009-05-15
ECSP066414A (es)	2006-09-18
PL1711470T3 (pl)	2009-09-30
EP1711470A1 (en)	2006-10-18
MY141308A (en)	2010-04-16
AR045609A1 (es)	2005-11-02
UA83501C2 (uk)	2008-07-25
JP4571639B2 (ja)	2010-10-27
NO20061047L (no)	2006-04-04
EA200600503A1 (ru)	2006-08-25
CO5660268A2 (es)	2006-07-31
IL173905A (en)	2011-05-31
HRP20090266T1 (en)	2009-06-30
WO2005023772A1 (en)	2005-03-17
HK1099014A1 (en)	2007-08-03
TNSN06077A1 (fr)	2007-10-03
MXPA06002562A (es)	2006-06-20
KR20070087690A (ko)	2007-08-28
KR20060054455A (ko)	2006-05-22
EA009940B1 (ru)	2008-04-28
JP2010229153A (ja)	2010-10-14
CA2537440C (en)	2012-07-10
KR100834177B1 (ko)	2008-05-30
US7160875B2 (en)	2007-01-09
AU2004270361A1 (en)	2005-03-17
CY1109225T1 (el)	2014-07-02

Publication	Publication Date	Title
DK1711470T3 (da)	2009-06-08	Malonamidderivater der blokerer aktiviteten af gamma-sekretase
DE602004015415D1 (de)	2008-09-11	Malonamidderivate als gamma-secretaseinhibitoren
ATE515495T1 (de)	2011-07-15	Gamma sekretase inhibitoren
DE602004015110D1 (de)	2008-08-28	Verbrückte n-arylsulfonylpiperidine als gamma-sekretaseinhibitoren
DE602004020156D1 (de)	2009-05-07	Verwaltung von Rahmenbursts
DE60328426D1 (de)	2009-08-27	Gestaltung der Verschlusselemente
DE602004008303D1 (de)	2007-09-27	Triazolopyrimidinderivate als inhibitoren von glycogensynthasekinase-3
IS2656B (is)	2010-08-15	Nýjar besímídasólafleiður
DK1556385T3 (da)	2010-06-14	Heterocyclocarboxamid-derivater
ATE450506T1 (de)	2009-12-15	Indol-3-schwefelderivate
NO20054136D0 (no)	2005-09-06	Imidazol-4-yl-etynyl-pyridin-derivater
DE602004019294D1 (de)	2009-03-19	Tetrahydronaphthalin- und harnstoffderivate
ATE352550T1 (de)	2007-02-15	Chinazolinderivate
DE602004022180D1 (de)	2009-09-03	Chinazolinderivate
ATE461926T1 (de)	2010-04-15	Substituierte n-arylsulfonylheterocyclische amine als gamma-sekretase-hemmer
NO20054188D0 (no)	2005-09-09	Et arrangement av fagverksstag
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