HK1079543A1 - Process for producing cytotoxic lymphocyte - Google Patents

Process for producing cytotoxic lymphocyte

Info

Publication number
HK1079543A1
HK1079543A1 HK05111402.4A HK05111402A HK1079543A1 HK 1079543 A1 HK1079543 A1 HK 1079543A1 HK 05111402 A HK05111402 A HK 05111402A HK 1079543 A1 HK1079543 A1 HK 1079543A1
Authority
HK
Hong Kong
Prior art keywords
cytotoxic lymphocyte
producing cytotoxic
producing
lymphocyte
fibronectin
Prior art date
Application number
HK05111402.4A
Other languages
English (en)
Inventor
Hiroaki Sagawa
Mitsuko Ideno
Ikunoshin Kato
Original Assignee
Takara Bio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takara Bio Inc filed Critical Takara Bio Inc
Publication of HK1079543A1 publication Critical patent/HK1079543A1/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0636T lymphocytes
    • C12N5/0638Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/461Cellular immunotherapy characterised by the cell type used
    • A61K39/4611T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/461Cellular immunotherapy characterised by the cell type used
    • A61K39/4613Natural-killer cells [NK or NK-T]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/464Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643Vertebrate antigens
    • A61K39/4644Cancer antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/464Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/464838Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0636T lymphocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50Cell markers; Cell surface determinants
    • C12N2501/58Adhesion molecules, e.g. ICAM, VCAM, CD18 (ligand), CD11 (ligand), CD49 (ligand)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compounds Of Unknown Constitution (AREA)
HK05111402.4A 2002-03-25 2005-12-12 Process for producing cytotoxic lymphocyte HK1079543A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2002084414 2002-03-25
PCT/JP2003/003575 WO2003080817A1 (en) 2002-03-25 2003-03-25 Process for producing cytotoxic lymphocyte

Publications (1)

Publication Number Publication Date
HK1079543A1 true HK1079543A1 (en) 2006-04-07

Family

ID=28449211

Family Applications (2)

Application Number Title Priority Date Filing Date
HK05111402.4A HK1079543A1 (en) 2002-03-25 2005-12-12 Process for producing cytotoxic lymphocyte
HK10110610.7A HK1144105A1 (en) 2002-03-25 2010-11-15 Process for producing cytotoxic lymphocyte

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK10110610.7A HK1144105A1 (en) 2002-03-25 2010-11-15 Process for producing cytotoxic lymphocyte

Country Status (15)

Country Link
US (3) US8728811B2 (xx)
EP (3) EP1496109B1 (xx)
JP (1) JP4406566B2 (xx)
KR (2) KR100786054B1 (xx)
CN (3) CN100591760C (xx)
AT (1) ATE491021T1 (xx)
AU (2) AU2003221073B2 (xx)
CA (1) CA2479288C (xx)
DE (1) DE60335253D1 (xx)
EA (1) EA010434B1 (xx)
ES (3) ES2396447T3 (xx)
HK (2) HK1079543A1 (xx)
MX (1) MXPA04009287A (xx)
TW (2) TW201043699A (xx)
WO (1) WO2003080817A1 (xx)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101633907B (zh) 2001-08-15 2012-09-05 宝生物工程株式会社 抗原特异性细胞毒性t细胞的扩大培养方法
ATE491021T1 (de) 2002-03-25 2010-12-15 Takara Bio Inc Verfahren zur produktion eines zytotoxischen lymphozyten
CN1839202B (zh) * 2003-08-22 2012-07-18 宝生物工程株式会社 细胞毒性淋巴细胞的制备方法
GB0409775D0 (en) * 2004-04-30 2004-06-09 Mabtech Ab Assay
KR101279172B1 (ko) 2005-08-17 2013-06-27 다카라 바이오 가부시키가이샤 림프구의 제조 방법
JP4741906B2 (ja) * 2005-08-31 2011-08-10 タカラバイオ株式会社 リンパ球の製造方法
CN101400785B (zh) * 2005-09-30 2013-09-25 宝生物工程株式会社 T细胞群的制备方法
WO2007142300A1 (ja) 2006-06-09 2007-12-13 Takara Bio Inc. リンパ球の製造方法
US8715718B2 (en) * 2006-07-14 2014-05-06 Rutgers, The State University Of New Jersey Extracellular matrix production from nanoscale substrate
US20110158954A1 (en) * 2007-03-09 2011-06-30 Mitsuko Ideno Method for producing gamma delta t cell population
TW200908988A (en) * 2007-05-11 2009-03-01 Takara Bio Inc Therapeutic agent for cancer
US8470966B2 (en) * 2007-08-10 2013-06-25 Protelica, Inc. Universal fibronectin type III binding-domain libraries
US20110027242A1 (en) * 2008-03-27 2011-02-03 Takara Bio Inc. Method for production of transfected cell
EP2471901A4 (en) 2009-08-25 2013-06-26 Takara Bio Inc PROCESS FOR PRODUCING T-CELL POPULATION IN THE PRESENCE OF RETINOIC ACID
EP2476752A4 (en) 2009-09-11 2013-04-03 Takara Bio Inc PROCESS FOR THE PRODUCTION OF NATURAL KILLER CELLS
US8809050B2 (en) * 2009-12-08 2014-08-19 Wilson Wolf Manufacturing Methods of cell culture for adoptive cell therapy
US8956860B2 (en) 2009-12-08 2015-02-17 Juan F. Vera Methods of cell culture for adoptive cell therapy
KR101988895B1 (ko) 2011-05-19 2019-06-13 도레이 카부시키가이샤 면역 유도제
CN115094036A (zh) 2016-04-08 2022-09-23 爱默蕾大学 使用基于细胞的疗法治疗癌症和传染病的方法
WO2018135646A1 (ja) 2017-01-20 2018-07-26 国立大学法人京都大学 CD8α+β+細胞傷害性T細胞の製造方法
CN111655842B (zh) * 2018-01-25 2023-10-20 宝生物工程株式会社 淋巴细胞生产方法
CN115516084A (zh) 2020-03-31 2022-12-23 国立大学法人京都大学 T细胞祖细胞的制造方法

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8516421D0 (en) 1985-06-28 1985-07-31 Biotechnology Interface Ltd Fibronectins
DE3788796T2 (de) 1986-10-20 1994-05-05 Life Technologies Inc Serumfreies medium zur proliferation von lymphokin-aktivierten töterzellen.
US5019646A (en) 1987-08-25 1991-05-28 Regents Of The University Of Minnesota Polypeptides with fibronectin activity
JP2561131B2 (ja) * 1988-06-30 1996-12-04 寳酒造株式会社 細胞接着活性ポリペプチド
GB8909916D0 (en) 1989-04-29 1989-06-14 Delta Biotechnology Ltd Polypeptides
US5198423A (en) * 1989-05-26 1993-03-30 Takara Shuzo Co., Ltd. Functional polypeptide containing a cell binding domain and a heparin binding domain of fibronectin
GR1001034B (el) 1989-07-21 1993-03-31 Ortho Pharma Corp Μεθοδος διεγερσης του πολλαπλασιασμου λεμφοκυτταρων περιφερειακου αιματος.
US5188959A (en) * 1989-09-28 1993-02-23 Trustees Of Tufts College Extracellular matrix protein adherent t cells
JP3104178B2 (ja) 1990-03-30 2000-10-30 寶酒造株式会社 機能性ポリペプチド
JPH04297494A (ja) * 1991-03-26 1992-10-21 Fuji Photo Film Co Ltd ペプチド誘導体とその用途
JP2729712B2 (ja) 1991-04-23 1998-03-18 寳酒造株式会社 機能性ポリペプチド
JPH07102131B2 (ja) 1991-07-15 1995-11-08 日本石油株式会社 ヒトリンパ球の癌細胞に対する傷害活性を高める方法
JPH06172203A (ja) 1992-12-02 1994-06-21 Takara Shuzo Co Ltd フィブロネクチンレセプター産生異常細胞抑制剤
JPH06306096A (ja) * 1993-02-26 1994-11-01 Fuji Photo Film Co Ltd ペプチド誘導体及びその用途
GB9315810D0 (en) 1993-07-30 1993-09-15 Univ London Stabilised materials
DE4336399A1 (de) 1993-10-26 1995-04-27 Augustinus Dr Med Bader Verfahren zur Verbesserung der Matrixbedingungen bipolar adhärierter Hepatozyten und zur Herstellung eines entsprechend konfigurierten Zellkulturkits
US6821778B1 (en) * 1993-12-01 2004-11-23 The Board Of Trustees Of Leland Stanford Junior University Methods for using dendritic cells to activate gamma/delta-T cell receptor-positive T cells
DE4412794A1 (de) * 1994-04-14 1995-12-14 Univ Ludwigs Albert Verfahren zur Herstellung von dendritischen Zellen, so erhaltene Zellen und Behälter zur Durchführung dieses Verfahrens
GB9413029D0 (en) 1994-06-29 1994-08-17 Common Services Agency Stem cell immobilisation
US5827642A (en) 1994-08-31 1998-10-27 Fred Hutchinson Cancer Research Center Rapid expansion method ("REM") for in vitro propagation of T lymphocytes
US5824547A (en) 1994-11-29 1998-10-20 Takara Shuzo Co., Ltd. Method for production of transfected cells
JPH11506902A (ja) 1994-12-01 1999-06-22 ベス イズレイル ディーコネス メディカル センター インコーポレイテッド イン・ビトロtリンパ球生成系
US7067318B2 (en) * 1995-06-07 2006-06-27 The Regents Of The University Of Michigan Methods for transfecting T cells
ATE292689T1 (de) * 1995-05-04 2005-04-15 Us Navy Verbesserte verfahren zur transfektion der t- zellen
US6692964B1 (en) * 1995-05-04 2004-02-17 The United States Of America As Represented By The Secretary Of The Navy Methods for transfecting T cells
JP3391941B2 (ja) 1995-06-15 2003-03-31 アサヒビール株式会社 余剰汚泥の処理方法
WO1997001194A1 (de) 1995-06-21 1997-01-09 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Elektrochemisches festelektrolyt-zellsystem
JPH0925299A (ja) 1995-07-13 1997-01-28 Sumitomo Electric Ind Ltd Cd44リガンド
EP0852618A1 (en) 1995-07-25 1998-07-15 Celltherapy Inc. Autologous immune cell therapy: cell compositions, methods and applications to treatment of human disease
DE19537494C2 (de) 1995-09-25 1997-10-02 Desitin Arzneimittel Gmbh Kreatin zum Schutz von neuralem Gewebe
WO1997011604A1 (en) 1995-09-29 1997-04-03 Indiana University Foundation Methods for enhanced virus-mediated dna transfer using molecules with virus- and cell-binding domains
CN100390290C (zh) * 1995-11-13 2008-05-28 宝生物工程株式会社 用逆转录病毒将基因转入靶细胞的方法
US6734014B1 (en) * 1996-02-08 2004-05-11 The United States Of America As Represented By The Department Of Health And Human Services Methods and compositions for transforming dendritic cells and activating T cells
EP0904350B1 (en) * 1996-03-04 2010-08-04 Calyx Bio-Ventures Inc. Modified rapid expansion methods ("modified-rem") for in vitro propagation of t lymphocytes
AU726198B2 (en) 1996-03-04 2000-11-02 Targeted Genetics Corporation Modified rapid expansion methods ("modified-REM") for in vitro propagation of T lymphocytes
JPH1029952A (ja) 1996-07-16 1998-02-03 Takara Shuzo Co Ltd ヒト免疫不全ウイルス感染の制御用組成物および制御方法
CA2267288A1 (en) 1996-09-23 1998-03-26 Ontogeny, Inc. Hematopoietic stem cells and methods for generating such cells
AU6140998A (en) 1997-01-31 1998-08-25 Epimmune, Inc. Peptides and peptide-loaded antigen presenting cells for the activation of ctl
JP3591286B2 (ja) 1997-04-24 2004-11-17 セイコーエプソン株式会社 タイミング調整方法、印字装置及び調整パターン作成方法
TWI239352B (en) * 1997-07-23 2005-09-11 Takara Bio Inc Gene transfer method with the use of serum-free medium
EP1047708B1 (en) 1997-12-24 2007-09-26 Bracco International B.V. Peptide chelators that predominately form a single stereoisomeric species upon coordination to a metal center
EP1992640A1 (en) 1997-12-24 2008-11-19 Corixa Corporation Compounds for immunotherapy and diagnosis of breast cancer and methods for their use
JP2002522513A (ja) 1998-08-11 2002-07-23 アメリカ合衆国 哺乳動物細胞を形質導入する方法およびそれに関連する産物
EP1163912B1 (en) 1999-03-23 2007-10-31 Takara Bio Inc. Gene therapeutics
ATE373078T1 (de) 2000-02-24 2007-09-15 Xcyte Therapies Inc Gleichzeitige stimulation und konzentration von zellen
US6797514B2 (en) * 2000-02-24 2004-09-28 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
JP3904374B2 (ja) * 2000-02-29 2007-04-11 独立行政法人科学技術振興機構 キラー活性を増強したリンパ球
AU2001278734A1 (en) * 2000-08-16 2002-02-25 Takara Bio Inc. Method of extensive culture of antigen-specific cytotoxic t cells
KR20040048379A (ko) * 2001-06-01 2004-06-09 싸이트 테라피스 인코포레이티드 T 세포 유도된 조직 복구 및 재생
CN101633907B (zh) * 2001-08-15 2012-09-05 宝生物工程株式会社 抗原特异性细胞毒性t细胞的扩大培养方法
JP4759890B2 (ja) 2001-09-12 2011-08-31 大日本印刷株式会社 パール調印刷物の印刷濃度管理方法
US7745140B2 (en) * 2002-01-03 2010-06-29 The Trustees Of The University Of Pennsylvania Activation and expansion of T-cells using an engineered multivalent signaling platform as a research tool
ATE491021T1 (de) 2002-03-25 2010-12-15 Takara Bio Inc Verfahren zur produktion eines zytotoxischen lymphozyten
WO2004018667A1 (ja) 2002-08-26 2004-03-04 Kirin Beer Kabushiki Kaisha ペプチド及びこれを含む医薬
CN1839202B (zh) 2003-08-22 2012-07-18 宝生物工程株式会社 细胞毒性淋巴细胞的制备方法

Also Published As

Publication number Publication date
US8728811B2 (en) 2014-05-20
US20050227354A1 (en) 2005-10-13
EP1496109A1 (en) 2005-01-12
EP1496109B1 (en) 2010-12-08
ES2396447T3 (es) 2013-02-21
ES2397319T3 (es) 2013-03-06
KR20070015620A (ko) 2007-02-05
ATE491021T1 (de) 2010-12-15
CN100591760C (zh) 2010-02-24
TW201043699A (en) 2010-12-16
JPWO2003080817A1 (ja) 2005-07-28
EP2305796A1 (en) 2011-04-06
US20080227204A1 (en) 2008-09-18
EP2305793B1 (en) 2012-10-17
WO2003080817A1 (en) 2003-10-02
US8975070B2 (en) 2015-03-10
CA2479288A1 (en) 2003-10-02
AU2008243221B2 (en) 2011-10-27
KR20040099352A (ko) 2004-11-26
TWI334442B (en) 2010-12-11
DE60335253D1 (de) 2011-01-20
EP2305793A1 (en) 2011-04-06
AU2003221073A1 (en) 2003-10-08
EA200401242A1 (ru) 2005-04-28
AU2008243221A1 (en) 2008-12-04
CN1656215A (zh) 2005-08-17
CA2479288C (en) 2015-02-24
KR100786054B1 (ko) 2007-12-17
AU2003221073B2 (en) 2008-08-21
CN102321579A (zh) 2012-01-18
MXPA04009287A (es) 2005-01-25
TW200400265A (en) 2004-01-01
CN101735981A (zh) 2010-06-16
KR100895231B1 (ko) 2009-05-04
JP4406566B2 (ja) 2010-01-27
CN101735981B (zh) 2013-01-02
EP1496109A4 (en) 2006-07-19
ES2356814T3 (es) 2011-04-13
US20140212972A1 (en) 2014-07-31
EP2305796B1 (en) 2012-10-24
HK1144105A1 (en) 2011-01-28
EA010434B1 (ru) 2008-08-29

Similar Documents

Publication Publication Date Title
HK1144105A1 (en) Process for producing cytotoxic lymphocyte
HK1095606A1 (en) Process for producing cytotoxic lymphocytes
EP1484292A4 (en) GLASS COMPOSITION FOR THE MANUFACTURE OF INORGANIC FIBER, MANUFACTURING METHOD AND PRODUCT MADE OF THE INORGANIC FIBER
IL140419A0 (en) Novel form of irbesartan, methods for obtaining said form and pharmaceutical compositions containing same
ZA200203994B (en) Method of fuel production from Fischer-Tropsch process.
MXPA03010322A (es) PROCEDIMIENTO PARA LA PREPARACIoN DE POLIISOCIANATOS.
ATE304614T1 (de) Verfahren zur herstellung metallisches molybdäns
IL151678A (en) Method for producing asymmetrical 4,6-bis (aryloxy) pyrimidine derivatives
EP1408099A4 (en) TECHNIQUE FOR PRODUCING HYDROCARBON ACCORDING TO THE FISCHER-TROPSCH PROCESS
IL164625A0 (en) Method for producing monoclonal antibodies
AU2002313208A1 (en) Method for producing hydrocarbons by fischer-tropsch process
MXPA03009806A (es) Derivados de piperazino y su uso como inhibidor de fosfodiesterasa de nucleotido ciclico de tipo 4 (pde4).
IL152295A0 (en) Method for producing 2-alkyl-3-chlorophenols
HUP0300902A3 (en) Method for producing bicyclic 1,3-diketones
IL143079A0 (en) Process for the production of cyclene
MXPA03010670A (es) Metodo para producir almidon o productos con almidon a partir de mateias primas vegetales con almidon.
IL133923A0 (en) Method for preparing 3-cyano-2,4-dihalogen-5-fluoro-benzoic acid
AU2002226308A1 (en) Method for producing dnda
IL166374A0 (en) Novel process for producing imidazoÄ1,2-bÜpyridazine derivative
AU2003238198A8 (en) Method for producing 4,6-dichloro-5-fluoropyrimidine
AU2002358557A1 (en) Improved method for the production of biphosphites
GB9805808D0 (en) Process for producing meat products
MXPA05010990A (es) Procedimiento de preparacion del 4, 10beta-diacetoxi-2alfa-benzoiloxi-5beta, 20-epoxi-1,13alfa-dihidroxi-9-oxo-19-norciclopropa[g] tax-11-eno
IL146257A0 (en) Method of producing methoxyimido acetic amide
IL161800A0 (en) Method for the production of desclarithromycin, and intermediateproducts

Legal Events

Date Code Title Description
PE Patent expired

Effective date: 20230327