HK1060067A1 - Compositions for antitumour treatment containing ecteinascidin 743 - Google Patents

Compositions for antitumour treatment containing ecteinascidin 743

Info

Publication number: HK1060067A1
Authority: HK; Hong Kong
Prior art keywords: ecteinascidin; compositions; treatment containing; antitumour treatment; antitumour
Prior art date: 2000-11-06

Application number

HK04103120.3A

Other languages

English (en)

Inventor

Naoto Takahashi

Steve Weitman

Incalci Maurizio D

Glynn Thomas Faicloth

Rafaella Giavazzi

Andreas Gescher

Original Assignee

Pharma Mar Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-11-06

Filing date

2004-05-04

Publication date

2004-07-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27399908&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1060067(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2004-05-04 Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa

2004-07-30 Publication of HK1060067A1 publication Critical patent/HK1060067A1/xx

Links

XXPXYPLPSDPERN-UHFFFAOYSA-N Ecteinascidin 743 Natural products COc1cc2C(NCCc2cc1O)C(=O)OCC3N4C(O)C5Cc6cc(C)c(OC)c(O)c6C(C4C(S)c7c(OC(=O)C)c(C)c8OCOc8c37)N5C XXPXYPLPSDPERN-UHFFFAOYSA-N 0.000 title abstract 3
PKVRCIRHQMSYJX-AIFWHQITSA-N trabectedin Chemical compound C([C@@]1(C(OC2)=O)NCCC3=C1C=C(C(=C3)O)OC)S[C@@H]1C3=C(OC(C)=O)C(C)=C4OCOC4=C3[C@H]2N2[C@@H](O)[C@H](CC=3C4=C(O)C(OC)=C(C)C=3)N(C)[C@H]4[C@@H]21 PKVRCIRHQMSYJX-AIFWHQITSA-N 0.000 title abstract 3
229960000977 trabectedin Drugs 0.000 title abstract 3
230000000259 anti-tumor effect Effects 0.000 title 1
239000000203 mixture Substances 0.000 title 1
239000003814 drug Substances 0.000 abstract 2
206010028980 Neoplasm Diseases 0.000 abstract 1
238000002648 combination therapy Methods 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

HK04103120.3A 2000-11-06 2004-05-04 Compositions for antitumour treatment containing ecteinascidin 743 HK1060067A1 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US24623300P	2000-11-06	2000-11-06
US24809500P	2000-11-13	2000-11-13
US34598201P	2001-10-19	2001-10-19
PCT/GB2001/004902 WO2002036135A2 (en)	2000-11-06	2001-11-06	Compositions for antitumour treatment containing ecteinascidin 743

Publications (1)

Publication Number	Publication Date
HK1060067A1 true HK1060067A1 (en)	2004-07-30

Family

ID=27399908

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HK04103120.3A HK1060067A1 (en)	2000-11-06	2004-05-04	Compositions for antitumour treatment containing ecteinascidin 743

Country Status (25)

Country	Link
US (3)	US20040108086A1 (xx)
EP (1)	EP1365808B1 (xx)
JP (2)	JP4391083B2 (xx)
KR (1)	KR100718946B1 (xx)
CN (1)	CN100374162C (xx)
AT (1)	ATE495793T1 (xx)
AU (2)	AU1249902A (xx)
BG (1)	BG107843A (xx)
BR (1)	BR0115162A (xx)
CA (1)	CA2428160C (xx)
CY (1)	CY1112361T1 (xx)
CZ (1)	CZ20031327A3 (xx)
DE (1)	DE60143911D1 (xx)
DK (1)	DK1365808T3 (xx)
EA (1)	EA005564B1 (xx)
HK (1)	HK1060067A1 (xx)
HU (1)	HUP0400648A3 (xx)
IL (1)	IL155781A0 (xx)
MX (1)	MXPA03003975A (xx)
NO (1)	NO329981B1 (xx)
NZ (1)	NZ525730A (xx)
PL (1)	PL361389A1 (xx)
PT (1)	PT1365808E (xx)
SK (1)	SK287901B6 (xx)
WO (1)	WO2002036135A2 (xx)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MY164077A (en)	1999-05-13	2017-11-30	Pharma Mar Sa	Compositions and uses of et743 for treating cancer
MXPA02011319A (es) *	2000-05-15	2003-06-06	Pharma Mar Sa	Analogos antitumorales de ecteinascidina 743.
CA2428160C (en) *	2000-11-06	2009-10-13	Pharma Mar, S.A.	Compositions for antitumor treatment containing ecteinascidin 743
GB0117402D0 (en) *	2001-07-17	2001-09-05	Pharma Mar Sa	New antitumoral derivatives of et-743
HUP0401903A3 (en) *	2001-10-19	2008-07-28	Pharma Mar	Improved use of et-743 in cancer thereapy
GB0202544D0 (en)	2002-02-04	2002-03-20	Pharma Mar Sa	The synthesis of naturally occuring ecteinascidins and related compounds
US20050043233A1 (en) *	2003-04-29	2005-02-24	Boehringer Ingelheim International Gmbh	Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis
GB0312407D0 (en) *	2003-05-29	2003-07-02	Pharma Mar Sau	Treatment
GB0324201D0 (en) *	2003-10-15	2003-11-19	Pharma Mar Sau	Improved antitumoral combinations
RS50692B (sr) *	2003-11-13	2010-06-30	Pharma Mar S.A.U.	Kombinacija et-743 sa prolekovima 5-fluorouracila za lečenje kancera
AU2004291037A1 (en) *	2003-11-14	2005-06-02	Pharma Mar, S.A.	Combination therapy comprising the use of ET-743 and paclitaxel for treating cancer
GB0326486D0 (en) *	2003-11-14	2003-12-17	Pharma Mar Sau	Combination treatment
MX2007000360A (es) *	2004-07-09	2007-06-12	Pharma Mar Sa	Marcadores moleculares de pronostico.
US20080242670A2 (en) *	2004-09-29	2008-10-02	Pharma Mar S.A., Sociedad Unipersonal	Anti-Inflammatory Agents
NZ554765A (en) *	2004-10-26	2010-01-29	Pharma Mar Sa	Pegylated Liposomal Doxorubicin In Combination With Ecteinescidin 743
DE602005001833T2 (de)	2004-10-29	2008-04-17	Pharma Mar S.A., Sociedad Unipersonal	Zusammensetzungen enthaltend Ecteinascidin und einen Disaccharide
GB0522082D0 (en)	2005-10-31	2005-12-07	Pharma Mar Sa	Formulations
DE602006020335D1 (de) *	2005-11-25	2011-04-07	Pharma Mar Sa	Verwendung von parp-1-hemmern
US20100267732A1 (en) *	2007-10-19	2010-10-21	Pharma Mar, S.A.	Prognostic Molecular Markers for ET-743 Treatment
RU2743643C2 (ru) *	2010-11-12	2021-02-20	Фарма Мар, С.А.	Комбинированная терапия противоопухолевым алкалоидом
GB201217439D0 (en) *	2012-09-28	2012-11-14	Topotarget As	Combination therapy
WO2014165818A2 (en)	2013-04-05	2014-10-09	T Cell Therapeutics, Inc.	Compositions and methods for preventing and treating prostate cancer
JOP20190254A1 (ar)	2017-04-27	2019-10-27	Pharma Mar Sa	مركبات مضادة للأورام
US10537585B2 (en)	2017-12-18	2020-01-21	Dexcel Pharma Technologies Ltd.	Compositions comprising dexamethasone
CN109276719A (zh) *	2018-11-01	2019-01-29	中山万汉制药有限公司	含有奥利司他纳米粒与蛋白激酶抑制剂的组合物

Family Cites Families (37)

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US5256663A (en) *	1986-06-09	1993-10-26	The Board Of Trustees Of The University Of Illinois	Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith
US5149804A (en) *	1990-11-30	1992-09-22	The Board Of Trustees Of The University Of Illinois	Ecteinascidins 736 and 722
US5089273A (en) *	1986-06-09	1992-02-18	Board Of Trustees Of The University Of Illinois	Ecteinascidins 729, 743, 745, 759A, 759B and 770
DE3635711A1 (de) *	1986-10-21	1988-04-28	Knoll Ag	5-nitrobenzo(de)isochinolin-1,3-dione, ihre herstellung und verwendung
FR2697752B1 (fr) *	1992-11-10	1995-04-14	Rhone Poulenc Rorer Sa	Compositions antitumorales contenant des dérivés du taxane.
US5478932A (en) *	1993-12-02	1995-12-26	The Board Of Trustees Of The University Of Illinois	Ecteinascidins
US20040059112A1 (en) *	1994-02-18	2004-03-25	Rinehart Kenneth L.	Ecteinascidins
GB9508195D0 (en) *	1995-04-20	1995-06-07	Univ British Columbia	Novel biologically active compounds and compositions,their use and derivation
US5721362A (en) *	1996-09-18	1998-02-24	President And Fellows Of Harvard College	Process for producing ecteinascidin compounds
US5985876A (en) *	1997-04-15	1999-11-16	Univ Illinois	Nucleophile substituted ecteinascidins and N-oxide ecteinascidins
EP0983082A1 (en) *	1997-05-21	2000-03-08	Genentech, Inc.	Novel administration of thrombopoietin
BR9909488B1 (pt) *	1998-04-06	2011-02-08		ecteinascidinas semi-sintéticas e composição farmacêutica.
EP1077698B1 (en) *	1998-05-11	2005-03-02	Pharma Mar, S.A.	Metabolites of ecteinascidin 743
JP2000081438A (ja) *	1998-06-25	2000-03-21	Sekisui Chem Co Ltd	被験者の癌化学療法による免疫機能低下の測定方法
US6124292A (en) *	1998-09-30	2000-09-26	President And Fellows Of Harvard College	Synthetic analogs of ecteinascidin-743
MY164077A (en) *	1999-05-13	2017-11-30	Pharma Mar Sa	Compositions and uses of et743 for treating cancer
MY130271A (en) *	1999-05-14	2007-06-29	Pharma Mar Sa	Hemisynthetic method and new compounds
US7247892B2 (en) *	2000-04-24	2007-07-24	Taylor Geoff W	Imaging array utilizing thyristor-based pixel elements
MXPA02011319A (es) *	2000-05-15	2003-06-06	Pharma Mar Sa	Analogos antitumorales de ecteinascidina 743.
US7420051B2 (en) *	2000-05-15	2008-09-02	Pharma Mar, S.A.	Synthetic process for the manufacture of an ecteinaschidin compound
JP2004506430A (ja) *	2000-08-11	2004-03-04	シティ・オブ・ホープ	Ｓｘｒによるトランス活性化の抗新生物剤ｅｔ−７４３による阻害
CA2428160C (en) *	2000-11-06	2009-10-13	Pharma Mar, S.A.	Compositions for antitumor treatment containing ecteinascidin 743
US6770653B2 (en) *	2001-03-06	2004-08-03	Bristol-Myers Squibb Company	Method and dosage form for treating tumors by the administration of tegafur, uracil, folinic acid, paclitaxel and carboplatin
JP4391038B2 (ja) *	2001-05-10	2009-12-24	パナソニック株式会社	電気炊飯器
HUP0401903A3 (en) *	2001-10-19	2008-07-28	Pharma Mar	Improved use of et-743 in cancer thereapy
US20040019027A1 (en) *	2002-04-12	2004-01-29	Barry Forman	Method of treating cerebrotendinous xanthomatosis
GB0312407D0 (en) *	2003-05-29	2003-07-02	Pharma Mar Sau	Treatment
GB0324201D0 (en) *	2003-10-15	2003-11-19	Pharma Mar Sau	Improved antitumoral combinations
RS50692B (sr) *	2003-11-13	2010-06-30	Pharma Mar S.A.U.	Kombinacija et-743 sa prolekovima 5-fluorouracila za lečenje kancera
GB0326486D0 (en) *	2003-11-14	2003-12-17	Pharma Mar Sau	Combination treatment
AU2004291037A1 (en) *	2003-11-14	2005-06-02	Pharma Mar, S.A.	Combination therapy comprising the use of ET-743 and paclitaxel for treating cancer
MX2007000360A (es) *	2004-07-09	2007-06-12	Pharma Mar Sa	Marcadores moleculares de pronostico.
US20080242670A2 (en) *	2004-09-29	2008-10-02	Pharma Mar S.A., Sociedad Unipersonal	Anti-Inflammatory Agents
NZ554765A (en) *	2004-10-26	2010-01-29	Pharma Mar Sa	Pegylated Liposomal Doxorubicin In Combination With Ecteinescidin 743
DE602005001833T2 (de) *	2004-10-29	2008-04-17	Pharma Mar S.A., Sociedad Unipersonal	Zusammensetzungen enthaltend Ecteinascidin und einen Disaccharide
DE602006020335D1 (de) *	2005-11-25	2011-04-07	Pharma Mar Sa	Verwendung von parp-1-hemmern
JP2009536956A (ja) *	2006-05-12	2009-10-22	ファルマ・マール・ソシエダード・アノニマ	抗癌治療法

2001
- 2001-11-06 CA CA002428160A patent/CA2428160C/en not_active Expired - Fee Related
- 2001-11-06 JP JP2002538946A patent/JP4391083B2/ja not_active Expired - Fee Related
- 2001-11-06 EP EP01980710A patent/EP1365808B1/en not_active Revoked
- 2001-11-06 US US10/416,086 patent/US20040108086A1/en not_active Abandoned
- 2001-11-06 BR BR0115162-2A patent/BR0115162A/pt not_active IP Right Cessation
- 2001-11-06 EA EA200300544A patent/EA005564B1/ru not_active IP Right Cessation
- 2001-11-06 DE DE60143911T patent/DE60143911D1/de not_active Expired - Lifetime
- 2001-11-06 CN CNB018218032A patent/CN100374162C/zh not_active Expired - Fee Related
- 2001-11-06 HU HU0400648A patent/HUP0400648A3/hu unknown
- 2001-11-06 PL PL01361389A patent/PL361389A1/xx not_active Application Discontinuation
- 2001-11-06 MX MXPA03003975A patent/MXPA03003975A/es active IP Right Grant
- 2001-11-06 SK SK549-2003A patent/SK287901B6/sk not_active IP Right Cessation
- 2001-11-06 DK DK01980710.6T patent/DK1365808T3/da active
- 2001-11-06 CZ CZ20031327A patent/CZ20031327A3/cs unknown
- 2001-11-06 AT AT01980710T patent/ATE495793T1/de active
- 2001-11-06 PT PT01980710T patent/PT1365808E/pt unknown
- 2001-11-06 AU AU1249902A patent/AU1249902A/xx active Pending
- 2001-11-06 WO PCT/GB2001/004902 patent/WO2002036135A2/en active IP Right Grant
- 2001-11-06 AU AU2002212499A patent/AU2002212499B2/en not_active Ceased
- 2001-11-06 KR KR1020037006228A patent/KR100718946B1/ko not_active IP Right Cessation
- 2001-11-06 NZ NZ525730A patent/NZ525730A/xx not_active IP Right Cessation
- 2001-11-06 IL IL15578101A patent/IL155781A0/xx unknown
2003
- 2003-05-06 NO NO20032027A patent/NO329981B1/no not_active IP Right Cessation
- 2003-05-23 BG BG107843A patent/BG107843A/bg unknown
2004
- 2004-05-04 HK HK04103120.3A patent/HK1060067A1/xx not_active IP Right Cessation
2009
- 2009-02-27 JP JP2009046557A patent/JP2009114212A/ja active Pending
- 2009-09-02 US US12/552,347 patent/US20090324744A1/en not_active Abandoned
2011
- 2011-04-18 CY CY20111100397T patent/CY1112361T1/el unknown
- 2011-12-30 US US13/341,262 patent/US20120107417A1/en not_active Abandoned

Also Published As

Publication number	Publication date
NZ525730A (en)	2004-12-24
ATE495793T1 (de)	2011-02-15
EP1365808B1 (en)	2011-01-19
EP1365808A2 (en)	2003-12-03
AU1249902A (en)	2002-05-15
BG107843A (bg)	2004-06-30
EA005564B1 (ru)	2005-04-28
JP2004517056A (ja)	2004-06-10
CA2428160C (en)	2009-10-13
WO2002036135A2 (en)	2002-05-10
NO20032027D0 (no)	2003-05-06
CN1486193A (zh)	2004-03-31
CN100374162C (zh)	2008-03-12
DE60143911D1 (de)	2011-03-03
CZ20031327A3 (cs)	2003-11-12
KR20030048127A (ko)	2003-06-18
IL155781A0 (en)	2003-12-23
JP4391083B2 (ja)	2009-12-24
SK5492003A3 (en)	2004-03-02
BR0115162A (pt)	2003-10-21
SK287901B6 (sk)	2012-03-02
US20040108086A1 (en)	2004-06-10
HUP0400648A2 (hu)	2004-06-28
WO2002036135A3 (en)	2003-04-10
EA200300544A1 (ru)	2003-08-28
MXPA03003975A (es)	2004-02-12
JP2009114212A (ja)	2009-05-28
HUP0400648A3 (en)	2012-09-28
KR100718946B1 (ko)	2007-05-16
NO329981B1 (no)	2011-01-31
NO20032027L (no)	2003-07-04
DK1365808T3 (da)	2011-05-16
PL361389A1 (en)	2004-10-04
AU2002212499B2 (en)	2006-11-02
PT1365808E (pt)	2011-04-08
US20120107417A1 (en)	2012-05-03
CA2428160A1 (en)	2002-05-10
US20090324744A1 (en)	2009-12-31
CY1112361T1 (el)	2015-12-09

Legal Events

Date	Code	Title	Description
2015-05-29	PC	Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)	Effective date: 20141106

Publication	Publication Date	Title
HK1060067A1 (en)	2004-07-30	Compositions for antitumour treatment containing ecteinascidin 743
GEP20063799B (en)	2006-04-25	Tropane derivatives useful in therapy
GEP20053688B (en)	2005-12-12	Substituted-Triazolopyrimidines as Anticancer Agents
MY119403A (en)	2005-05-31	Novel compounds with analgesic effect.
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RS20090083A (xx)	2009-07-15	Nove vrste kompozicija na bazi jedinjenja koja deluju antiholinergijski i beta-mimetika
BR0211228A (pt)	2004-08-10	Composto, composição farmacêutica e seus usos
BG108269A (en)	2004-12-30	Pyrazolopyrimidines as therapeutic agents
FI956014A (fi)	1995-12-14	Nona- ja dekapeptidien käyttö lääkkeen valmistamiseksi AIDS-sairauden hoitoon
MXPA04003674A (es)	2004-07-23	Uso mejorado de compuesto antitumoral en terapia de cancer.
SE9802208D0 (sv)	1998-06-22	Novel compounds
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HK1029932A1 (en)	2001-04-20	Use of mirtazapine for the manufacture of a medicament for treating sleep apneas.
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AU2001246999A1 (en)	2001-10-23	New neurokinin antagonists for use as medicaments
SE9802209D0 (sv)	1998-06-22	Novel compounds
ZA937746B (en)	1994-08-10	Antidepressive therapy
MXPA02012911A (es)	2004-07-30	Compuestos de rutenio (ii) para el uso en terapia del cancer.
GB0027705D0 (en)	2000-12-27	Novel compounds
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SE0004827D0 (sv)	2000-12-22	Therapeutic compounds
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