HK1056549A1 - Double salts offumaric acid with a carnitine and an amino acid and food supplements, dietary supplements and drugs containing same - Google Patents

Double salts offumaric acid with a carnitine and an amino acid and food supplements, dietary supplements and drugs containing same

Info

Publication number: HK1056549A1
Authority: HK; Hong Kong
Prior art keywords: carnitine; supplements; acid; amino acid; offumaric
Prior art date: 2000-06-14

Application number

HK03109000A

Other languages

English (en)

Inventor

Antonietta Buononato

Original Assignee

Sigma Tau Ind Farmaceuti

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-06-14

Filing date

2003-12-11

Publication date

2004-02-20

2003-12-11 Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti

2004-02-20 Publication of HK1056549A1 publication Critical patent/HK1056549A1/xx

Links

235000015872 dietary supplement Nutrition 0.000 title abstract 4
PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 title abstract 2
150000001413 amino acids Chemical class 0.000 title abstract 2
239000003814 drug Substances 0.000 title abstract 2
229940079593 drug Drugs 0.000 title abstract 2
239000002253 acid Substances 0.000 title 1
235000005550 amino acid supplement Nutrition 0.000 title 1
229960004203 carnitine Drugs 0.000 title 1
150000003839 salts Chemical class 0.000 title 1
239000004480 active ingredient Substances 0.000 abstract 1
VZCYOOQTPOCHFL-OWOJBTEDSA-L fumarate(2-) Chemical class [O-]C(=O)\C=C\C([O-])=O VZCYOOQTPOCHFL-OWOJBTEDSA-L 0.000 abstract 1
IGQBPDJNUXPEMT-SNVBAGLBSA-N isovaleryl-L-carnitine Chemical compound CC(C)CC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C IGQBPDJNUXPEMT-SNVBAGLBSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/30—Artificial sweetening agents
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/13—Nucleic acids or derivatives thereof
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/02—Monosaccharides
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Nutrition Science (AREA)
Polymers & Plastics (AREA)
Food Science & Technology (AREA)
General Health & Medical Sciences (AREA)
Mycology (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
General Chemical & Material Sciences (AREA)
Diabetes (AREA)
Hematology (AREA)
Bioinformatics & Cheminformatics (AREA)
Obesity (AREA)
Toxicology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
Medicinal Preparation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Fodder In General (AREA)

HK03109000A 2000-06-14 2003-12-11 Double salts offumaric acid with a carnitine and an amino acid and food supplements, dietary supplements and drugs containing same HK1056549A1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT2000RM000322A IT1317042B1 (it)	2000-06-14	2000-06-14	Fumarati doppi di una carnitina e creatina, e integratori alimentari,dietetici e farmaci che li contengono.

Publications (1)

Publication Number	Publication Date
HK1056549A1 true HK1056549A1 (en)	2004-02-20

Family

ID=11454785

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HK03109000A HK1056549A1 (en)	2000-06-14	2003-12-11	Double salts offumaric acid with a carnitine and an amino acid and food supplements, dietary supplements and drugs containing same

Country Status (20)

Country	Link
US (1)	US6730693B2 (zh)
EP (1)	EP1289931B1 (zh)
JP (1)	JP4430301B2 (zh)
KR (1)	KR100596732B1 (zh)
CN (1)	CN1326832C (zh)
AT (1)	ATE286016T1 (zh)
AU (1)	AU783291B2 (zh)
BR (1)	BR0111579A (zh)
CA (1)	CA2412055C (zh)
CZ (1)	CZ302371B6 (zh)
DE (1)	DE60108122T2 (zh)
DK (1)	DK1289931T3 (zh)
ES (1)	ES2233635T3 (zh)
HK (1)	HK1056549A1 (zh)
HU (1)	HU228837B1 (zh)
IT (1)	IT1317042B1 (zh)
MX (1)	MXPA02012265A (zh)
PL (1)	PL203876B1 (zh)
PT (1)	PT1289931E (zh)
WO (1)	WO2001096281A1 (zh)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20140099364A2 (en)	2004-10-08	2014-04-10	Forward Pharma A/S	Controlled release pharmaceutical compositions comprising a fumaric acid ester
US20080227847A1 (en) *	2005-07-07	2008-09-18	Aditech Pharma Ab	Novel Salts of Fumaric Acid Monoalkylesters and Their Pharmaceutical Use
CN101209975B (zh) *	2006-12-29	2010-12-01	沈阳科硕营养科技有限公司	左旋肉碱富马酸钙及其制备方法与用途
PT2379063E (pt)	2009-01-09	2013-05-03	Forward Pharma As	Formulação farmacêutica compreendendo um ou mais ésteres de ácido fumárico numa matriz de erosão
RS57497B1 (sr)	2013-03-14	2018-10-31	Alkermes Pharma Ireland Ltd	Prolekovi fumarata i njihova upotreba u lečenju raznih bolesti
US8669281B1 (en)	2013-03-14	2014-03-11	Alkermes Pharma Ireland Limited	Prodrugs of fumarates and their use in treating various diseases
EP3110793B1 (en)	2014-02-24	2019-08-21	Alkermes Pharma Ireland Limited	Sulfonamide and sulfinamide prodrugs of fumarates and their use in treating various diseases

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0150688B1 (en) *	1983-12-28	1987-04-22	Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.	Salts of l-carnitine and alkanoyl l-carnitines and process for preparing same
FR2635264B1 (fr)	1988-08-12	1992-02-28	Bellon Labor Sa Roger	Compositions pharmaceutiques et/ou dietetiques contenant de la l-carnitine et de la l-lysine
IT1245699B (it) *	1991-05-29	1994-10-14	Sigma Tau Ind Farmaceuti	Derivati della l-carnitina quali agenti terapeutici per il trattamento delle miopatie, della degenarazione neuronale e per inibire la proteolisi
US5994581A (en) *	1998-03-09	1999-11-30	Amt Labs, Inc.	Carnitine creatinate

2000
- 2000-06-14 IT IT2000RM000322A patent/IT1317042B1/it active
2001
- 2001-04-24 ES ES01934310T patent/ES2233635T3/es not_active Expired - Lifetime
- 2001-04-24 WO PCT/IT2001/000199 patent/WO2001096281A1/en active IP Right Grant
- 2001-04-24 PL PL363511A patent/PL203876B1/pl unknown
- 2001-04-24 US US10/297,843 patent/US6730693B2/en not_active Expired - Lifetime
- 2001-04-24 HU HU0301568A patent/HU228837B1/hu unknown
- 2001-04-24 CN CNB018111092A patent/CN1326832C/zh not_active Expired - Lifetime
- 2001-04-24 DE DE60108122T patent/DE60108122T2/de not_active Expired - Lifetime
- 2001-04-24 PT PT01934310T patent/PT1289931E/pt unknown
- 2001-04-24 CA CA002412055A patent/CA2412055C/en not_active Expired - Lifetime
- 2001-04-24 DK DK01934310T patent/DK1289931T3/da active
- 2001-04-24 CZ CZ20023949A patent/CZ302371B6/cs not_active IP Right Cessation
- 2001-04-24 JP JP2002510425A patent/JP4430301B2/ja not_active Expired - Lifetime
- 2001-04-24 BR BR0111579-0A patent/BR0111579A/pt not_active Application Discontinuation
- 2001-04-24 EP EP01934310A patent/EP1289931B1/en not_active Expired - Lifetime
- 2001-04-24 KR KR1020027016899A patent/KR100596732B1/ko active IP Right Grant
- 2001-04-24 AT AT01934310T patent/ATE286016T1/de active
- 2001-04-24 MX MXPA02012265A patent/MXPA02012265A/es active IP Right Grant
- 2001-04-24 AU AU60603/01A patent/AU783291B2/en not_active Expired
2003
- 2003-12-11 HK HK03109000A patent/HK1056549A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
BR0111579A (pt)	2003-03-18
IT1317042B1 (it)	2003-05-26
US6730693B2 (en)	2004-05-04
EP1289931B1 (en)	2004-12-29
KR20030017536A (ko)	2003-03-03
CZ20023949A3 (cs)	2003-04-16
KR100596732B1 (ko)	2006-07-04
EP1289931A1 (en)	2003-03-12
DE60108122D1 (de)	2005-02-03
US20030171417A1 (en)	2003-09-11
CN1436166A (zh)	2003-08-13
WO2001096281A1 (en)	2001-12-20
AU6060301A (en)	2001-12-24
HUP0301568A3 (en)	2004-12-28
PL363511A1 (en)	2004-11-29
ATE286016T1 (de)	2005-01-15
CN1326832C (zh)	2007-07-18
ES2233635T3 (es)	2005-06-16
ITRM20000322A1 (it)	2001-12-14
AU783291B2 (en)	2005-10-13
ITRM20000322A0 (it)	2000-06-14
DE60108122T2 (de)	2005-12-29
JP4430301B2 (ja)	2010-03-10
CA2412055C (en)	2009-02-03
HUP0301568A2 (hu)	2003-08-28
CZ302371B6 (cs)	2011-04-13
CA2412055A1 (en)	2001-12-20
MXPA02012265A (es)	2004-02-27
HU228837B1 (en)	2013-06-28
JP2004503521A (ja)	2004-02-05
PT1289931E (pt)	2005-03-31
PL203876B1 (pl)	2009-11-30
DK1289931T3 (da)	2005-04-25

Legal Events

Date

Code

Title

Description

2004-09-30

AS

Change of ownership

Owner name: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A.

Free format text: FORMER OWNER(S): BIOSALTS S.R.L

2021-05-07

PE

Patent expired

Publication	Publication Date	Title
WO2005123108A3 (en)	2006-05-04	Advanced vitamins and protein based nutritional supplements
AU2003234146A1 (en)	2003-11-03	Food supplements containing 4-hydroxyisoleucine and creatine
WO2001058271A8 (en)	2002-02-14	Nutritional supplements for aged pets
CA2284738A1 (en)	1998-10-08	Nutritional composition for improvements in cell energetics
DE69614681T2 (de)	2002-07-04	Pharmazeutische und/oder diätische zusammensetzungen mit antioxydationswirkung, welche carnosin und verzweigte aminosäure enthalten
DE69726738D1 (de)	2004-01-22	Ernährungsrezept für phenylketonurie-patienten
CY1112660T1 (el)	2016-02-10	Συμπληρωμα διατροφης που παρεχει ενεργεια σε σκελετικους μυες και που προστατευει την καρδιαγγειακη οδο
WO2008122613A3 (de)	2009-06-04	Nahrungsergänzungsmittel enthaltend alpha-ketosäuren
HK1056549A1 (en)	2004-02-20	Double salts offumaric acid with a carnitine and an amino acid and food supplements, dietary supplements and drugs containing same
CY1111186T1 (el)	2015-06-11	Γαλα ή προϊοντα γαλακτος με συμπληρωμα καρνιτινης
MXPA02011465A (es)	2004-02-26	Sal de creatina que tiene eficacia terapeutica y nutricional mejorada y composiciones que contienen la misma.
WO2003049687A3 (en)	2005-12-22	Medicinal compositions & therapeutic methods
PL367812A1 (en)	2005-03-07	Alpha-ketoglutarates of active ingredients and compositions containing same
CA2285490A1 (en)	2001-04-07	Composition for improvement of cellular nutrition and mitochondrial energetics
HUP0302294A2 (hu)	2003-10-28	L-karnitin és alkanoil-L-karnitin taurin-kloriddal és glicin-kloriddal alkotott nem higroszkópos sói és ezeket tartalmazó, orális beadásra alkalmas szilárd készítmények
BR9808461A (pt)	2000-05-23	Método para composições sólidas adequadas para administração oral compreendendo sais não higroscópicos de l-carnitina e alcanoil-l-carnitina com ácido 2-aminoetassulfÈnico.
WO2004092334A3 (en)	2005-01-27	Methods of producing edible fungi containing activated folates and nutritional supplements containing activated folates
BR9808908A (pt)	2000-08-01	Composições sólidas adequadas para administração oral que compreendem l-carnitina ou tartarato de alcanoil-l-carnitina colina
HK1049326A1 (en)	2003-05-09	Non-hygroscopic salts of active ingredients havingtherapeutical and/or nutritional activities and o rally administrable compositions containing same.
WO2005089734A3 (en)	2006-09-08	Creatine salt enhanced nutritional and therapeutic efficacy and compositions containing same
ITRM20010029A0 (it)	2001-01-23	Sali metallici di carnitine utili come integratori dietetici/nutrizionali o come farmaci, composizioni che li contengono e procedimenti per
WO2005107738A3 (en)	2007-06-14	Basic amino acid-methionine hydroxy analog compositions