HK1040494A1 - 抑制骨內再吸收的方法 - Google Patents

抑制骨內再吸收的方法

Info

Publication number
HK1040494A1
HK1040494A1 HK02102042.2A HK02102042A HK1040494A1 HK 1040494 A1 HK1040494 A1 HK 1040494A1 HK 02102042 A HK02102042 A HK 02102042A HK 1040494 A1 HK1040494 A1 HK 1040494A1
Authority
HK
Hong Kong
Prior art keywords
bone resorption
disclosed
inhibiting bone
methods
etridronate
Prior art date
Application number
HK02102042.2A
Other languages
English (en)
Inventor
G Daifotis Anastasia
C Santora Ii Arthur
John Yates A
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27451690&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1040494(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9717590.5A external-priority patent/GB9717590D0/en
Priority claimed from GBGB9717850.3A external-priority patent/GB9717850D0/en
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of HK1040494A1 publication Critical patent/HK1040494A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)
  • Saccharide Compounds (AREA)
  • Fittings On The Vehicle Exterior For Carrying Loads, And Devices For Holding Or Mounting Articles (AREA)
  • Pit Excavations, Shoring, Fill Or Stabilisation Of Slopes (AREA)
  • Aiming, Guidance, Guns With A Light Source, Armor, Camouflage, And Targets (AREA)
HK02102042.2A 1997-07-22 2002-03-16 抑制骨內再吸收的方法 HK1040494A1 (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US5335197P 1997-07-22 1997-07-22
US5353597P 1997-07-23 1997-07-23
GBGB9717590.5A GB9717590D0 (en) 1997-08-20 1997-08-20 Oral method for treating or preventing abnormal bone resorption
GBGB9717850.3A GB9717850D0 (en) 1997-08-22 1997-08-22 Oral method for treating or preventing abnormal bone resorption

Publications (1)

Publication Number Publication Date
HK1040494A1 true HK1040494A1 (zh) 2002-06-14

Family

ID=27451690

Family Applications (5)

Application Number Title Priority Date Filing Date
HK00102840A HK1024166A1 (en) 1997-07-22 2000-05-12 Method for inhibiting bone resorption
HK02101656.1A HK1042230A1 (zh) 1997-07-22 2002-03-04 抑制骨內再吸收的方法
HK02101869.4A HK1042232A1 (zh) 1997-07-22 2002-03-12 抑制骨內再吸收的方法
HK02102042.2A HK1040494A1 (zh) 1997-07-22 2002-03-16 抑制骨內再吸收的方法
HK02102043.1A HK1040495A1 (zh) 1997-07-22 2002-03-16 抑制骨內再吸收的方法

Family Applications Before (3)

Application Number Title Priority Date Filing Date
HK00102840A HK1024166A1 (en) 1997-07-22 2000-05-12 Method for inhibiting bone resorption
HK02101656.1A HK1042230A1 (zh) 1997-07-22 2002-03-04 抑制骨內再吸收的方法
HK02101869.4A HK1042232A1 (zh) 1997-07-22 2002-03-12 抑制骨內再吸收的方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK02102043.1A HK1040495A1 (zh) 1997-07-22 2002-03-16 抑制骨內再吸收的方法

Country Status (31)

Country Link
EP (5) EP1151752A3 (zh)
JP (2) JP3479780B2 (zh)
KR (3) KR20030097610A (zh)
CN (3) CN1299689C (zh)
AT (2) ATE209037T1 (zh)
AU (1) AU8493698A (zh)
BG (1) BG66282B1 (zh)
BR (1) BR9810779A (zh)
CA (1) CA2294595C (zh)
CY (2) CY1107535T1 (zh)
DE (6) DE122007000063I1 (zh)
DK (2) DK1175904T3 (zh)
EA (1) EA004544B2 (zh)
EE (1) EE05603B1 (zh)
ES (3) ES2164447T3 (zh)
HK (5) HK1024166A1 (zh)
ID (1) ID24096A (zh)
IL (1) IL133535A0 (zh)
IS (3) IS5315A (zh)
LU (2) LU91222I2 (zh)
NL (2) NL300223I1 (zh)
NO (1) NO20000323L (zh)
NZ (1) NZ501807A (zh)
PL (1) PL195272B1 (zh)
PT (2) PT1175904E (zh)
SG (2) SG139556A1 (zh)
SI (1) SI0998292T1 (zh)
SK (1) SK932000A3 (zh)
TR (1) TR200000145T2 (zh)
UY (1) UY25950A1 (zh)
WO (1) WO1999004773A2 (zh)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3219402B2 (ja) 1998-12-25 2001-10-15 山之内製薬株式会社 多発性骨髄腫の骨病変治療用医薬組成物
WO2000071104A2 (en) * 1999-05-21 2000-11-30 Novartis Ag Use of bisphosphonic acids for treating angiogenesis
CN100349574C (zh) * 1999-07-19 2007-11-21 东丽株式会社 牙周疾病用剂
AU2580001A (en) 1999-12-20 2001-07-03 Merck & Co., Inc. Blister package for pharmaceutical treatment card
IL142515A0 (en) * 1999-12-20 2002-03-10 Merck & Co Inc Pharmaceutical kit
AU2001251432A1 (en) * 2000-04-07 2001-10-23 The Board Of Regents Of The University Of Texas System Unique compositions of zwitterionic phospholipids and bisphosphonates and use ofthe compositions as bisphosphate delivery systems with reduced gi toxicity
ATE304856T1 (de) 2000-06-20 2005-10-15 Novartis Pharma Gmbh Methode zur verabreichung von biphosphonaten
US6638920B2 (en) * 2000-07-21 2003-10-28 Merck & Co., Inc. Compositions and methods of preventing or reducing the risk or incidence of skeletal injuries in horses
SE0101379D0 (sv) 2001-04-18 2001-04-18 Diabact Ab Komposition som hämmar utsöndring av magsyra
BR0209360A (pt) * 2001-05-02 2004-06-08 Novartis Ag Método de administração de bisfosfonatos por inalação no tratamento ou prevenção de reabsorção óssea e osteoporose
ES2532393T3 (es) * 2002-05-10 2015-03-26 F. Hoffmann-La Roche Ag Acidos bisfosfónicos para tratamiento y prevención de osteoporosis
SE0203065D0 (sv) 2002-10-16 2002-10-16 Diabact Ab Gastric acid secretion inhibiting composition
WO2005027921A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and a bisphosphonate
WO2005072747A1 (ja) * 2004-02-02 2005-08-11 Ono Pharmaceutical Co., Ltd. 骨吸収抑制剤
JP2009508834A (ja) * 2005-09-16 2009-03-05 セラマイン リミテッド ビスホスホネート製剤
TR201903835T4 (tr) * 2010-12-06 2019-04-22 Effrx Pharmaceuticals Sa Hızlı çözünme özelliklerine sahip stabil efervesan bifosfonat formülasyonları.
CN106924257B (zh) * 2017-03-14 2019-11-19 湖南赛隆药业有限公司 质子泵抑制剂和抗骨质疏松药的复合物及其用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL84731A0 (en) * 1986-12-19 1988-05-31 Norwich Eaton Pharma Heterocycle-substituted diphosphonic acids and salts and esters and pharmaceutical compositions containing them
SE8704436D0 (sv) * 1987-11-13 1987-11-13 Pm Konsult Handelsbolag Anvendning av antisekretoriska substanser for nya indikationer
ATE122228T1 (de) * 1991-07-01 1995-05-15 Gergely Gerhard Verfahren zur herstellung einer pharmazeutischen zubereitung mit wenigstens zwei verschiedenen wirkstoffen und verwendung einer solchen zubereitung.
KR100274734B1 (ko) * 1991-11-22 2000-12-15 제이코버스 코넬리스 레이서 리제드로네이트 지연-방출성 조성물
US5270365A (en) * 1991-12-17 1993-12-14 Merck & Co., Inc. Prevention and treatment of periodontal disease with alendronate
US5294433A (en) * 1992-04-15 1994-03-15 The Procter & Gamble Company Use of H-2 antagonists for treatment of gingivitis
WO1994000129A1 (en) * 1992-06-30 1994-01-06 Procter & Gamble Pharmaceuticals, Inc. Use of phosphonates for the treatment of osteoporosis
US5431920A (en) * 1993-09-21 1995-07-11 Merck Frosst, Canada, Inc. Enteric coated oral compositions containing bisphosphonic acid antihypercalcemic agents
US5646134A (en) * 1994-04-21 1997-07-08 Merck & Co., Inc. Alendronate therapy to prevent loosening of, or pain associated with, orthopedic implant devices
AU703887B2 (en) * 1995-06-06 1999-04-01 Merck & Co., Inc. Bisphosphonate therapy for bone loss associated with rheumatoid arthritis
AU712710B2 (en) * 1996-05-17 1999-11-11 Merck Sharp & Dohme Corp. Effervescent bisphosphonate formulation

Also Published As

Publication number Publication date
EP1175904B8 (en) 2007-05-09
CN1602879A (zh) 2005-04-06
NL300223I1 (nl) 2006-04-03
NZ501807A (en) 2003-02-28
EP1175903A3 (en) 2002-12-18
KR20030097611A (ko) 2003-12-31
EA004544B1 (ru) 2004-06-24
JP3479780B2 (ja) 2003-12-15
WO1999004773A9 (en) 1999-10-28
EP1175904A3 (en) 2002-12-18
BG66282B1 (bg) 2013-01-31
JP2002502433A (ja) 2002-01-22
IL133535A0 (en) 2001-04-30
PT1175904E (pt) 2007-04-30
IS7231A (is) 2004-04-21
EA004544B2 (ru) 2006-12-29
HK1024166A1 (en) 2000-10-05
ES2269014T1 (es) 2007-04-01
EP0998292B1 (en) 2001-11-21
NL300292I1 (nl) 2007-11-01
KR100391732B1 (ko) 2003-07-16
ES2269014T3 (es) 2007-05-01
EP1132088A2 (en) 2001-09-12
EP1132088A3 (en) 2002-04-24
EP1175904A2 (en) 2002-01-30
EE200000040A (et) 2000-10-16
EP0998292A2 (en) 2000-05-10
DK0998292T3 (da) 2002-05-13
SG109478A1 (en) 2005-03-30
ES2164447T3 (es) 2002-02-16
DE122006000009I1 (de) 2006-06-14
EP1175904B1 (en) 2007-03-28
CA2294595C (en) 2001-08-21
EP1151752A2 (en) 2001-11-07
DE69837450D1 (de) 2007-05-10
BR9810779A (pt) 2000-07-25
JP2005068010A (ja) 2005-03-17
DE69837450T2 (de) 2007-08-23
LU91364I2 (fr) 2007-11-12
EA200000151A1 (ru) 2000-10-30
AU8493698A (en) 1999-02-16
CA2294595A1 (en) 1999-02-04
SK932000A3 (en) 2000-09-12
ID24096A (id) 2000-07-06
ATE357921T1 (de) 2007-04-15
CN1166365C (zh) 2004-09-15
TR200000145T2 (tr) 2000-05-22
SI0998292T1 (en) 2002-04-30
PL195272B1 (pl) 2007-08-31
CN1299689C (zh) 2007-02-14
ATE209037T1 (de) 2001-12-15
UY25950A1 (es) 2000-09-29
NO20000323D0 (no) 2000-01-21
DK1175904T3 (da) 2007-05-07
SG139556A1 (en) 2008-02-29
PT998292E (pt) 2002-04-29
WO1999004773A2 (en) 1999-02-04
EP1175903A2 (en) 2002-01-30
IS5315A (is) 1999-12-21
KR20030097610A (ko) 2003-12-31
HK1040495A1 (zh) 2002-06-14
CY1107535T1 (el) 2012-01-25
LU91222I2 (fr) 2006-04-18
CY2007022I2 (el) 2012-01-25
CN1265035A (zh) 2000-08-30
HK1042232A1 (zh) 2002-08-09
CN1602880A (zh) 2005-04-06
NO20000323L (no) 2000-03-20
EE05603B1 (et) 2012-12-17
DE01201911T1 (de) 2007-10-18
DE122007000063I1 (de) 2007-12-20
EP1151752A3 (en) 2002-12-18
HK1042230A1 (zh) 2002-08-09
IS7230A (is) 2004-04-21
DE01201913T1 (de) 2007-02-08
DE69803291D1 (de) 2002-02-21
ES2253136T1 (es) 2006-06-01
DE69803291T2 (de) 2002-08-08
WO1999004773A3 (en) 1999-04-15
BG104093A (en) 2000-10-31
CY2007022I1 (el) 2012-01-25
KR20010022110A (ko) 2001-03-15
PL338635A1 (en) 2000-11-06

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