HK1038354A1 - Indole derivatives and their use in the treatment of malignant and other diseases caused by pathological cell proliferation. - Google Patents

Indole derivatives and their use in the treatment of malignant and other diseases caused by pathological cell proliferation.

Info

Publication number
HK1038354A1
HK1038354A1 HK01109122A HK01109122A HK1038354A1 HK 1038354 A1 HK1038354 A1 HK 1038354A1 HK 01109122 A HK01109122 A HK 01109122A HK 01109122 A HK01109122 A HK 01109122A HK 1038354 A1 HK1038354 A1 HK 1038354A1
Authority
HK
Hong Kong
Prior art keywords
malignant
treatment
cell proliferation
diseases caused
pathological cell
Prior art date
Application number
HK01109122A
Other languages
English (en)
Inventor
Siavosh Mahboobi
Sabine Kuhr
Herwig Pongratz
Alfred Popp
Harald Hufsky
Frank D Bohmer
Steffen Teller
Andrea Uecker
Thomas Beckers
Original Assignee
Asta Medica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19838506A external-priority patent/DE19838506C2/de
Application filed by Asta Medica Ag filed Critical Asta Medica Ag
Publication of HK1038354A1 publication Critical patent/HK1038354A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
HK01109122A 1998-05-04 2001-12-27 Indole derivatives and their use in the treatment of malignant and other diseases caused by pathological cell proliferation. HK1038354A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19819835 1998-05-04
DE19838506A DE19838506C2 (de) 1998-05-04 1998-08-25 Indolderivate und deren Verwendung zur Behandlung von malignen und anderen, auf pathologischen Zellproliferationen beruhenden Erkrankungen
PCT/DE1999/001214 WO1999057117A2 (fr) 1998-05-04 1999-04-22 Derives indoliques et leur utilisation pour le traitement de maladies malignes et autres induites par des proliferations cellulaires pathologiques

Publications (1)

Publication Number Publication Date
HK1038354A1 true HK1038354A1 (en) 2002-03-15

Family

ID=26045937

Family Applications (1)

Application Number Title Priority Date Filing Date
HK01109122A HK1038354A1 (en) 1998-05-04 2001-12-27 Indole derivatives and their use in the treatment of malignant and other diseases caused by pathological cell proliferation.

Country Status (22)

Country Link
US (2) US6407102B1 (fr)
EP (1) EP1109785B1 (fr)
JP (1) JP2002514572A (fr)
CN (1) CN1151127C (fr)
AT (1) ATE230394T1 (fr)
AU (1) AU752464B2 (fr)
BG (1) BG104996A (fr)
BR (1) BR9911017A (fr)
CA (1) CA2330756C (fr)
CZ (1) CZ20003960A3 (fr)
DE (1) DE59903921D1 (fr)
DK (1) DK1109785T3 (fr)
ES (1) ES2190221T3 (fr)
HK (1) HK1038354A1 (fr)
HU (1) HUP0102563A3 (fr)
IL (1) IL139056A0 (fr)
NO (1) NO317261B1 (fr)
NZ (1) NZ507735A (fr)
PL (1) PL346840A1 (fr)
SK (1) SK16352000A3 (fr)
TR (1) TR200003206T2 (fr)
WO (1) WO1999057117A2 (fr)

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WO2002010131A1 (fr) * 2000-07-28 2002-02-07 Sumitomo Pharmaceuticals Co., Ltd. Derives du pyrrole
TW557298B (en) * 2000-08-14 2003-10-11 Ciba Sc Holding Ag A compound, a photopolymerizible composition, a process for producing coatings and a method for causing a photoinitiator to accumulate at the surface of coatings
US20030032625A1 (en) * 2001-03-29 2003-02-13 Topo Target Aps Succinimide and maleimide derivatives and their use as topoisomerase II catalytic inhibitors
DE10143079A1 (de) * 2001-09-03 2003-05-15 Zentaris Ag Cyclische Indol- und Heteroindolderivate, deren Herstellung und Verwendung als Arzneimittel
US20050267303A1 (en) * 2001-09-04 2005-12-01 Zentaris Ag Cyclic indole and heteroindole derivatives and methods for making and using as pharmaceuticals
EP1479384A1 (fr) * 2002-01-30 2004-11-24 Sumitomo Pharmaceuticals Company, Limited Inhibiteur de fibrose
US6800655B2 (en) 2002-08-20 2004-10-05 Sri International Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents
US7223785B2 (en) 2003-01-22 2007-05-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7098231B2 (en) 2003-01-22 2006-08-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US20050288255A1 (en) * 2004-05-03 2005-12-29 David Hui Modulation of lysophosphatidylcholine and treatment of diet-induced conditions
JP2009514893A (ja) * 2005-11-03 2009-04-09 イリプサ， インコーポレイテッド 多価インドール化合物およびホスホリパーゼａ２インヒビターとしてのその使用
MX2008005660A (es) * 2005-11-03 2008-12-15 Ilypsa Inc Compuestos de indol que tienen sustituyentes c4-amida y uso de los mismos como inhibidores de la fosfolipasa a2.
CA2627353A1 (fr) * 2005-11-03 2007-05-18 Ilypsa, Inc. Composes d'indole presentant des substituants acides c4 et leur utilisation en tant qu'inhibiteurs de phospholipases a2
JP2009514892A (ja) * 2005-11-03 2009-04-09 イリプサ， インコーポレイテッド 多価ホスホリパーゼインヒビターを含むホスホリパーゼインヒビター、および内腔に局在化されるホスホリパーゼインヒビターとしての使用を含むその使用
MX2008005662A (es) * 2005-11-03 2008-12-15 Ilypsa Inc Compuestos de azaindol y uso de los mismos como inhibidores de la fosfolipasa a2.
US20090142832A1 (en) * 2007-11-29 2009-06-04 James Dalton Indoles, Derivatives, and Analogs Thereof and Uses Therefor
TWI490219B (zh) 2009-06-29 2015-07-01 Incyte Corp 作為ｐｉ３ｋ抑制劑之嘧啶酮
CN101704828A (zh) * 2009-11-04 2010-05-12 中国科学院昆明植物研究所 山橙素类双吲哚化合物,其药物组合物及其制备方法和用途
AR079529A1 (es) * 2009-12-18 2012-02-01 Incyte Corp Derivados arilo y heteroarilo sustituidos y fundidos como inhibidores de la pi3k
US8759359B2 (en) * 2009-12-18 2014-06-24 Incyte Corporation Substituted heteroaryl fused derivatives as PI3K inhibitors
EP2558463A1 (fr) 2010-04-14 2013-02-20 Incyte Corporation Dérivés condensés en tant qu'inhibiteurs de i3
WO2011163195A1 (fr) 2010-06-21 2011-12-29 Incyte Corporation Dérivés condensés de pyrrole en tant qu'inhibiteurs de pi3k
TW201249844A (en) 2010-12-20 2012-12-16 Incyte Corp N-(1-(substituted-phenyl)ethyl)-9H-purin-6-amines as PI3K inhibitors
WO2012125629A1 (fr) 2011-03-14 2012-09-20 Incyte Corporation Dérivés diamino-pyrimidines et diamino-pyridines substituées en tant qu'inhibiteurs de pi3k
US9126948B2 (en) 2011-03-25 2015-09-08 Incyte Holdings Corporation Pyrimidine-4,6-diamine derivatives as PI3K inhibitors
TWI543980B (zh) 2011-09-02 2016-08-01 英塞特控股公司 作為ｐｉ３ｋ抑制劑之雜環基胺
AR090548A1 (es) 2012-04-02 2014-11-19 Incyte Corp Azaheterociclobencilaminas biciclicas como inhibidores de pi3k
US10077277B2 (en) 2014-06-11 2018-09-18 Incyte Corporation Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors
LT3831833T (lt) 2015-02-27 2023-02-27 Incyte Holdings Corporation Pi3k inhibitoriaus gamybos būdai
WO2016183060A1 (fr) 2015-05-11 2016-11-17 Incyte Corporation Procédé de synthèse d'un inhibiteur de phospho-inositide 3-kinases
US9988401B2 (en) 2015-05-11 2018-06-05 Incyte Corporation Crystalline forms of a PI3K inhibitor
CN106317169B (zh) * 2015-06-23 2019-07-02 首都医科大学 双吲哚-二肽衍生物,其合成,抗血栓活性和制备抗血栓剂的应用
WO2018024172A1 (fr) * 2016-08-05 2018-02-08 The University Of Hong Kong Complexes de platine et leurs procédés d'utilisation
KR20210142154A (ko) 2019-03-21 2021-11-24 옹쎄오 암 치료를 위한 키나제 억제제와 조합된 dbait 분자
WO2020245208A1 (fr) 2019-06-04 2020-12-10 INSERM (Institut National de la Santé et de la Recherche Médicale) Utilisation de cd9 en tant que biomarqueur et en tant que biocible dans la glomérulonéphrite ou la glomérulosclérose
US20220401436A1 (en) 2019-11-08 2022-12-22 INSERM (Institute National de la Santé et de la Recherche Médicale) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
WO2021148581A1 (fr) 2020-01-22 2021-07-29 Onxeo Nouvelle molécule dbait et son utilisation

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Also Published As

Publication number Publication date
CN1151127C (zh) 2004-05-26
NO20005448D0 (no) 2000-10-27
IL139056A0 (en) 2001-11-25
US6812243B2 (en) 2004-11-02
US6407102B1 (en) 2002-06-18
JP2002514572A (ja) 2002-05-21
TR200003206T2 (tr) 2001-07-23
ES2190221T3 (es) 2003-07-16
ATE230394T1 (de) 2003-01-15
BG104996A (en) 2001-07-31
BR9911017A (pt) 2001-02-06
US20030008898A1 (en) 2003-01-09
WO1999057117A2 (fr) 1999-11-11
AU4497599A (en) 1999-11-23
NZ507735A (en) 2003-04-29
HUP0102563A2 (hu) 2001-11-28
NO20005448L (no) 2000-10-27
WO1999057117A3 (fr) 2001-04-12
PL346840A1 (en) 2002-02-25
NO317261B1 (no) 2004-09-27
CN1310705A (zh) 2001-08-29
CA2330756A1 (fr) 1999-11-11
EP1109785A2 (fr) 2001-06-27
CA2330756C (fr) 2007-10-02
AU752464B2 (en) 2002-09-19
EP1109785B1 (fr) 2003-01-02
SK16352000A3 (sk) 2002-07-02
CZ20003960A3 (cs) 2002-04-17
HUP0102563A3 (en) 2003-04-28
DK1109785T3 (da) 2003-04-22
DE59903921D1 (de) 2003-02-06

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20080422