CA2330756A1 - Derives indoliques et leur utilisation pour le traitement de maladies malignes et autres induites par des proliferations cellulaires pathologiques - Google Patents
Derives indoliques et leur utilisation pour le traitement de maladies malignes et autres induites par des proliferations cellulaires pathologiques Download PDFInfo
- Publication number
- CA2330756A1 CA2330756A1 CA002330756A CA2330756A CA2330756A1 CA 2330756 A1 CA2330756 A1 CA 2330756A1 CA 002330756 A CA002330756 A CA 002330756A CA 2330756 A CA2330756 A CA 2330756A CA 2330756 A1 CA2330756 A1 CA 2330756A1
- Authority
- CA
- Canada
- Prior art keywords
- cell proliferation
- malignant
- treatment
- pathological cell
- indole derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 **C(*1*)=C(*)c2c1c(*)c(*)c(*)c2* Chemical compound **C(*1*)=C(*)c2c1c(*)c(*)c(*)c2* 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/56—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002496859A CA2496859A1 (fr) | 1998-05-04 | 1999-04-22 | Derives indoliques et leur utilisation pour le traitement de maladies malignes et autres induites par des proliferations cellulaires pathologiques |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19819835 | 1998-05-04 | ||
DE19819835.3 | 1998-05-04 | ||
DE19838506.4 | 1998-08-25 | ||
DE19838506A DE19838506C2 (de) | 1998-05-04 | 1998-08-25 | Indolderivate und deren Verwendung zur Behandlung von malignen und anderen, auf pathologischen Zellproliferationen beruhenden Erkrankungen |
PCT/DE1999/001214 WO1999057117A2 (fr) | 1998-05-04 | 1999-04-22 | Derives indoliques et leur utilisation pour le traitement de maladies malignes et autres induites par des proliferations cellulaires pathologiques |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002496859A Division CA2496859A1 (fr) | 1998-05-04 | 1999-04-22 | Derives indoliques et leur utilisation pour le traitement de maladies malignes et autres induites par des proliferations cellulaires pathologiques |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2330756A1 true CA2330756A1 (fr) | 1999-11-11 |
CA2330756C CA2330756C (fr) | 2007-10-02 |
Family
ID=26045937
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002330756A Expired - Fee Related CA2330756C (fr) | 1998-05-04 | 1999-04-22 | Derives indoliques et leur utilisation pour le traitement de maladies malignes et autres induites par des proliferations cellulaires pathologiques |
Country Status (22)
Country | Link |
---|---|
US (2) | US6407102B1 (fr) |
EP (1) | EP1109785B1 (fr) |
JP (1) | JP2002514572A (fr) |
CN (1) | CN1151127C (fr) |
AT (1) | ATE230394T1 (fr) |
AU (1) | AU752464B2 (fr) |
BG (1) | BG104996A (fr) |
BR (1) | BR9911017A (fr) |
CA (1) | CA2330756C (fr) |
CZ (1) | CZ20003960A3 (fr) |
DE (1) | DE59903921D1 (fr) |
DK (1) | DK1109785T3 (fr) |
ES (1) | ES2190221T3 (fr) |
HK (1) | HK1038354A1 (fr) |
HU (1) | HUP0102563A3 (fr) |
IL (1) | IL139056A0 (fr) |
NO (1) | NO317261B1 (fr) |
NZ (1) | NZ507735A (fr) |
PL (1) | PL346840A1 (fr) |
SK (1) | SK16352000A3 (fr) |
TR (1) | TR200003206T2 (fr) |
WO (1) | WO1999057117A2 (fr) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR9911017A (pt) | 1998-05-04 | 2001-02-06 | Asta Medica Ag | Derivados de indol e seu emprego para o tratamento de doenças malignas e outras, que se baseiam na proliferação de células patológicas |
DE69922526T2 (de) * | 1998-10-08 | 2005-06-02 | Smithkline Beecham Plc, Brentford | 3-(3-chloro-4-hydroxyphenylamino)-4-(2-nitrophenyl)-1h-pyrrol-2,5-dion als glykogen synthase kinase-3 inhibitor (gsk-3) |
US6719520B2 (en) | 1998-10-08 | 2004-04-13 | Smithkline Beecham Corporation | Method and compounds |
WO2002000641A2 (fr) * | 2000-06-28 | 2002-01-03 | Eli Lilly And Company | Nouveaux inhibiteurs de spla2 |
KR20030031132A (ko) * | 2000-07-28 | 2003-04-18 | 스미또모 세이야꾸 가부시키가이샤 | 피롤 유도체 |
TW557298B (en) * | 2000-08-14 | 2003-10-11 | Ciba Sc Holding Ag | A compound, a photopolymerizible composition, a process for producing coatings and a method for causing a photoinitiator to accumulate at the surface of coatings |
US20030032625A1 (en) * | 2001-03-29 | 2003-02-13 | Topo Target Aps | Succinimide and maleimide derivatives and their use as topoisomerase II catalytic inhibitors |
DE10143079A1 (de) * | 2001-09-03 | 2003-05-15 | Zentaris Ag | Cyclische Indol- und Heteroindolderivate, deren Herstellung und Verwendung als Arzneimittel |
US20050267303A1 (en) * | 2001-09-04 | 2005-12-01 | Zentaris Ag | Cyclic indole and heteroindole derivatives and methods for making and using as pharmaceuticals |
JPWO2003063861A1 (ja) * | 2002-01-30 | 2005-05-26 | 住友製薬株式会社 | 線維化抑制剤 |
US6800655B2 (en) | 2002-08-20 | 2004-10-05 | Sri International | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents |
US7098231B2 (en) | 2003-01-22 | 2006-08-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
US7223785B2 (en) | 2003-01-22 | 2007-05-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
CA2565387A1 (fr) * | 2004-05-03 | 2005-11-17 | Ilypsa, Inc. | Modulation de la lysophosphatidylcholine et traitement des etats induits par un regime alimentaire |
WO2007056279A2 (fr) * | 2005-11-03 | 2007-05-18 | Ilypsa, Inc. | Inhibiteurs de phospholipases, notamment inhibiteurs de phospholipases multivalents, leur utilisation, notamment en tant qu'inhibiteurs de phospholipases localises dans une lumiere |
AU2006311766A1 (en) * | 2005-11-03 | 2007-05-18 | Ilypsa, Inc. | Indole compounds having C4-acidic substituents and use thereof as phospholipase-A2 inhibitors |
AU2006311851A1 (en) * | 2005-11-03 | 2007-05-18 | Ilypsa, Inc. | Azaindole compounds and use thereof as phospholipase-A2 inhibitors |
US7666898B2 (en) * | 2005-11-03 | 2010-02-23 | Ilypsa, Inc. | Multivalent indole compounds and use thereof as phospholipase-A2 inhibitors |
JP2009517341A (ja) * | 2005-11-03 | 2009-04-30 | イリプサ, インコーポレイテッド | C4−アミド置換基を有するインドール化合物およびホスホリパーゼa2インヒビターとしてのその使用 |
US20090142832A1 (en) * | 2007-11-29 | 2009-06-04 | James Dalton | Indoles, Derivatives, and Analogs Thereof and Uses Therefor |
MY162507A (en) | 2009-06-29 | 2017-06-15 | Incyte Holdings Corp | Pyrimidinones as pi3k inhibitors |
CN101704828A (zh) * | 2009-11-04 | 2010-05-12 | 中国科学院昆明植物研究所 | 山橙素类双吲哚化合物,其药物组合物及其制备方法和用途 |
US8680108B2 (en) * | 2009-12-18 | 2014-03-25 | Incyte Corporation | Substituted fused aryl and heteroaryl derivatives as PI3K inhibitors |
US8759359B2 (en) * | 2009-12-18 | 2014-06-24 | Incyte Corporation | Substituted heteroaryl fused derivatives as PI3K inhibitors |
CA2796311A1 (fr) | 2010-04-14 | 2011-10-20 | Incyte Corporation | Derives condenses en tant qu'inhibiteurs de pi3k.sigma. |
WO2011163195A1 (fr) | 2010-06-21 | 2011-12-29 | Incyte Corporation | Dérivés condensés de pyrrole en tant qu'inhibiteurs de pi3k |
WO2012087881A1 (fr) | 2010-12-20 | 2012-06-28 | Incyte Corporation | N-(1-(phényl substitué)éthyl)-9h-purin-6-amines en tant qu'inhibiteurs de pi3k |
US9108984B2 (en) | 2011-03-14 | 2015-08-18 | Incyte Corporation | Substituted diamino-pyrimidine and diamino-pyridine derivatives as PI3K inhibitors |
US9126948B2 (en) | 2011-03-25 | 2015-09-08 | Incyte Holdings Corporation | Pyrimidine-4,6-diamine derivatives as PI3K inhibitors |
RS55737B1 (sr) | 2011-09-02 | 2017-07-31 | Incyte Holdings Corp | Heterociklilamini kao inhibitori pi3k |
AR090548A1 (es) | 2012-04-02 | 2014-11-19 | Incyte Corp | Azaheterociclobencilaminas biciclicas como inhibidores de pi3k |
WO2015191677A1 (fr) | 2014-06-11 | 2015-12-17 | Incyte Corporation | Dérivés d'hétéroarylaminoalkylphényle bicycliques à titre d'inhibiteurs de pi3k |
CR20210055A (es) | 2015-02-27 | 2021-04-27 | Incyte Corp | SALES DE IHNIBIDOR DE PI3K Y PROCESOS DE PREPARACIÓN (Divisional 2017-0389) |
WO2016183060A1 (fr) | 2015-05-11 | 2016-11-17 | Incyte Corporation | Procédé de synthèse d'un inhibiteur de phospho-inositide 3-kinases |
US9988401B2 (en) | 2015-05-11 | 2018-06-05 | Incyte Corporation | Crystalline forms of a PI3K inhibitor |
CN106317169B (zh) * | 2015-06-23 | 2019-07-02 | 首都医科大学 | 双吲哚-二肽衍生物,其合成,抗血栓活性和制备抗血栓剂的应用 |
CN109790191B (zh) * | 2016-08-05 | 2022-04-08 | 香港大学 | 铂配合物及其使用方法 |
EA202192575A1 (ru) | 2019-03-21 | 2022-01-14 | Онксео | Соединения dbait в сочетании с ингибиторами киназ для лечения рака |
WO2020245208A1 (fr) | 2019-06-04 | 2020-12-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Utilisation de cd9 en tant que biomarqueur et en tant que biocible dans la glomérulonéphrite ou la glomérulosclérose |
US20220401436A1 (en) | 2019-11-08 | 2022-12-22 | INSERM (Institute National de la Santé et de la Recherche Médicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
WO2021148581A1 (fr) | 2020-01-22 | 2021-07-29 | Onxeo | Nouvelle molécule dbait et son utilisation |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3598583A (en) * | 1968-08-09 | 1971-08-10 | Itek Corp | Indomethylene dye bases and their utilization in photographic processes and compositions |
FR2688220A1 (fr) * | 1992-03-06 | 1993-09-10 | Adir | Nouveaux derives de thiazolidine-2,4-dione, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
AU6581094A (en) * | 1993-04-22 | 1994-11-08 | Nippon Shinyaku Co. Ltd. | Benzofurancarboxylic acid derivative and pharmaceutical composition |
US5656643A (en) | 1993-11-08 | 1997-08-12 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Bis mono-and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
PT817627E (pt) * | 1993-12-23 | 2005-07-29 | Lilly Co Eli | Inibidores da proteina cinase c |
JPH08295688A (ja) * | 1995-04-28 | 1996-11-12 | Sharp Corp | ビスアゾ化合物、その中間体及びそれらの製造方法、並びにビスアゾ化合物を含有する電子写真感光体 |
DE19547263C2 (de) * | 1995-12-07 | 1999-04-29 | Cardiotec Inc | Amidinohydrazone vom Benzo[b]furan abgeleiteter Ketone, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
BR9911017A (pt) | 1998-05-04 | 2001-02-06 | Asta Medica Ag | Derivados de indol e seu emprego para o tratamento de doenças malignas e outras, que se baseiam na proliferação de células patológicas |
-
1999
- 1999-04-22 BR BR9911017-2A patent/BR9911017A/pt not_active IP Right Cessation
- 1999-04-22 IL IL13905699A patent/IL139056A0/xx not_active IP Right Cessation
- 1999-04-22 CN CNB998058033A patent/CN1151127C/zh not_active Expired - Fee Related
- 1999-04-22 AU AU44975/99A patent/AU752464B2/en not_active Ceased
- 1999-04-22 ES ES99927711T patent/ES2190221T3/es not_active Expired - Lifetime
- 1999-04-22 CZ CZ20003960A patent/CZ20003960A3/cs unknown
- 1999-04-22 JP JP2000547087A patent/JP2002514572A/ja not_active Withdrawn
- 1999-04-22 DE DE59903921T patent/DE59903921D1/de not_active Expired - Fee Related
- 1999-04-22 DK DK99927711T patent/DK1109785T3/da active
- 1999-04-22 TR TR2000/03206T patent/TR200003206T2/xx unknown
- 1999-04-22 SK SK1635-2000A patent/SK16352000A3/sk unknown
- 1999-04-22 WO PCT/DE1999/001214 patent/WO1999057117A2/fr not_active Application Discontinuation
- 1999-04-22 EP EP99927711A patent/EP1109785B1/fr not_active Expired - Lifetime
- 1999-04-22 AT AT99927711T patent/ATE230394T1/de not_active IP Right Cessation
- 1999-04-22 CA CA002330756A patent/CA2330756C/fr not_active Expired - Fee Related
- 1999-04-22 PL PL99346840A patent/PL346840A1/xx not_active Application Discontinuation
- 1999-04-22 HU HU0102563A patent/HUP0102563A3/hu unknown
- 1999-05-04 US US09/305,115 patent/US6407102B1/en not_active Expired - Fee Related
-
2000
- 2000-10-24 NZ NZ507735A patent/NZ507735A/xx unknown
- 2000-10-27 NO NO20005448A patent/NO317261B1/no unknown
- 2000-11-28 BG BG104996A patent/BG104996A/xx unknown
-
2001
- 2001-12-27 HK HK01109122A patent/HK1038354A1/xx not_active IP Right Cessation
-
2002
- 2002-05-03 US US10/137,653 patent/US6812243B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO1999057117A2 (fr) | 1999-11-11 |
HK1038354A1 (en) | 2002-03-15 |
AU752464B2 (en) | 2002-09-19 |
EP1109785B1 (fr) | 2003-01-02 |
CN1151127C (zh) | 2004-05-26 |
AU4497599A (en) | 1999-11-23 |
NZ507735A (en) | 2003-04-29 |
NO317261B1 (no) | 2004-09-27 |
IL139056A0 (en) | 2001-11-25 |
US20030008898A1 (en) | 2003-01-09 |
HUP0102563A2 (hu) | 2001-11-28 |
TR200003206T2 (tr) | 2001-07-23 |
NO20005448D0 (no) | 2000-10-27 |
CN1310705A (zh) | 2001-08-29 |
US6812243B2 (en) | 2004-11-02 |
JP2002514572A (ja) | 2002-05-21 |
EP1109785A2 (fr) | 2001-06-27 |
US6407102B1 (en) | 2002-06-18 |
CZ20003960A3 (cs) | 2002-04-17 |
ATE230394T1 (de) | 2003-01-15 |
ES2190221T3 (es) | 2003-07-16 |
BR9911017A (pt) | 2001-02-06 |
NO20005448L (no) | 2000-10-27 |
BG104996A (en) | 2001-07-31 |
DE59903921D1 (de) | 2003-02-06 |
WO1999057117A3 (fr) | 2001-04-12 |
SK16352000A3 (sk) | 2002-07-02 |
DK1109785T3 (da) | 2003-04-22 |
HUP0102563A3 (en) | 2003-04-28 |
CA2330756C (fr) | 2007-10-02 |
PL346840A1 (en) | 2002-02-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |