HK1024864A1 - Preparation of stable formulations of lipid-nucleic acid complexes for efficient in vivo delivery - Google Patents
Preparation of stable formulations of lipid-nucleic acid complexes for efficient in vivo deliveryInfo
- Publication number
- HK1024864A1 HK1024864A1 HK00102585.7A HK00102585A HK1024864A1 HK 1024864 A1 HK1024864 A1 HK 1024864A1 HK 00102585 A HK00102585 A HK 00102585A HK 1024864 A1 HK1024864 A1 HK 1024864A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- lipid
- efficient
- preparation
- nucleic acid
- acid complexes
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
- A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
- A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
- A61K47/6913—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome the liposome being modified on its surface by an antibody
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3057896P | 1996-11-12 | 1996-11-12 | |
PCT/US1997/020690 WO1998020857A1 (en) | 1996-11-12 | 1997-11-10 | Preparation of stable formulations of lipid-nucleic acid complexes for efficient in vivo delivery |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1024864A1 true HK1024864A1 (en) | 2000-10-27 |
Family
ID=21854872
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK00102585.7A HK1024864A1 (en) | 1996-11-12 | 2000-04-28 | Preparation of stable formulations of lipid-nucleic acid complexes for efficient in vivo delivery |
Country Status (10)
Country | Link |
---|---|
US (4) | US6071533A (ja) |
EP (1) | EP0956001B1 (ja) |
JP (2) | JP2001510457A (ja) |
AU (1) | AU729655B2 (ja) |
CA (1) | CA2271325A1 (ja) |
DK (1) | DK0956001T3 (ja) |
ES (1) | ES2392246T3 (ja) |
HK (1) | HK1024864A1 (ja) |
PT (1) | PT956001E (ja) |
WO (1) | WO1998020857A1 (ja) |
Families Citing this family (62)
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US5795587A (en) * | 1995-01-23 | 1998-08-18 | University Of Pittsburgh | Stable lipid-comprising drug delivery complexes and methods for their production |
US6008202A (en) * | 1995-01-23 | 1999-12-28 | University Of Pittsburgh | Stable lipid-comprising drug delivery complexes and methods for their production |
US6210707B1 (en) * | 1996-11-12 | 2001-04-03 | The Regents Of The University Of California | Methods of forming protein-linked lipidic microparticles, and compositions thereof |
ES2392246T3 (es) * | 1996-11-12 | 2012-12-07 | The Regents Of The University Of California | Preparación de formulaciones estables de complejos de lípido-ácido nucleico para el suministro eficaz in vivo |
WO1998046273A2 (en) * | 1997-04-17 | 1998-10-22 | Paola Leone | Delivery system for gene therapy to the brain |
US6749863B1 (en) | 1997-11-19 | 2004-06-15 | Georgetown University | Targeted liposome gene delivery |
AU747597B2 (en) * | 1998-07-20 | 2002-05-16 | Inex Pharmaceuticals Corporation | Liposomal encapsulated nucleic acid-complexes |
US9034329B2 (en) | 1999-02-22 | 2015-05-19 | Georgetown University | Preparation of antibody or an antibody fragment-targeted immunoliposomes for systemic administration of therapeutic or diagnostic agents and uses thereof |
US7780882B2 (en) | 1999-02-22 | 2010-08-24 | Georgetown University | Simplified and improved method for preparing an antibody or an antibody fragment targeted immunoliposome for systemic administration of a therapeutic or diagnostic agent |
JP4799736B2 (ja) | 1999-02-22 | 2011-10-26 | ジョージタウン・ユニバーシティ | 全身性遺伝子送達のための抗体フラグメント標的化イムノリポソーム |
CA2362485A1 (en) * | 1999-03-02 | 2000-09-08 | The Liposome Company, Inc. | Encapsulation of bioactive complexes in liposomes |
AU5161800A (en) * | 1999-05-24 | 2000-12-12 | Board Of Regents, The University Of Texas System | Methods and compositions for non-viral gene therapy for treatment of hyperproliferative diseases |
EP1754488A1 (en) * | 1999-05-24 | 2007-02-21 | Introgen Therapeutics, Inc. | Methods and compositions for non-viral gene therapy for treatment of hyperproliferative diseases |
US7067111B1 (en) * | 1999-10-25 | 2006-06-27 | Board Of Regents, University Of Texas System | Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging |
US7189705B2 (en) * | 2000-04-20 | 2007-03-13 | The University Of British Columbia | Methods of enhancing SPLP-mediated transfection using endosomal membrane destabilizers |
US10293056B1 (en) | 2000-05-24 | 2019-05-21 | Board Of Regents, The University Of Texas System | Methods and compositions for non-viral gene therapy for treatment of hyperproliferative diseases |
BRPI0111220B8 (pt) | 2000-06-02 | 2021-07-27 | Univ Texas | conjugados de fármacos com etilenodicisteína (ec) |
US6846809B2 (en) * | 2000-09-25 | 2005-01-25 | Board Of Regents, The University Of Texas System | PEI: DNA vector formulations for in vitro and in vivo gene delivery |
US20020146829A1 (en) * | 2000-11-29 | 2002-10-10 | Aventis Pharmaceuticals Products Inc. | Neutral and anionic colloidal particles for gene delivery |
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US20050261214A1 (en) * | 2001-05-15 | 2005-11-24 | Serge Braun | Complexes for transferring substances of interest into a cell |
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US20030049203A1 (en) * | 2001-08-31 | 2003-03-13 | Elmaleh David R. | Targeted nucleic acid constructs and uses related thereto |
US7261875B2 (en) * | 2001-12-21 | 2007-08-28 | Board Of Regents, The University Of Texas System | Dendritic poly (amino acid) carriers and methods of use |
KR100466254B1 (ko) * | 2002-02-25 | 2005-01-14 | 한국과학기술원 | 세포내 전달을 위한 올리고뉴클레오티드와 친수성 고분자로 구성되는 유전자 전달용 접합체, 고분자 전해질 복합 미셀 및 그의 제조방법 |
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EP2316493A3 (en) * | 2002-11-07 | 2011-08-10 | Board of Regents, The University of Texas System | Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging |
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US7678540B2 (en) * | 2003-10-16 | 2010-03-16 | University Of Massachusetts | Template-directed assembly of receptor signaling complexes |
US9050378B2 (en) * | 2003-12-10 | 2015-06-09 | Board Of Regents, The University Of Texas System | N2S2 chelate-targeting ligand conjugates |
US20050261221A1 (en) * | 2004-03-01 | 2005-11-24 | Li Wang | Compositions and methods for enhanced delivery of compounds via transfection complexes |
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JP2008526213A (ja) * | 2004-12-30 | 2008-07-24 | トッド エム. ハウザー, | 自己保護オリゴヌクレオチドを使用する、遺伝子発現を調節するための組成物および方法 |
WO2006080118A1 (ja) * | 2005-01-28 | 2006-08-03 | Kyowa Hakko Kogyo Co., Ltd. | 標的遺伝子の発現を抑制する組成物 |
US20090175930A1 (en) * | 2006-01-11 | 2009-07-09 | Nobuhiro Yagi | Composition Suppressing The Expression of Target Gene in Eyeball and Medicament For Treating of Disease in Eyeball |
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US8758723B2 (en) | 2006-04-19 | 2014-06-24 | The Board Of Regents Of The University Of Texas System | Compositions and methods for cellular imaging and therapy |
JP6105187B2 (ja) | 2006-04-25 | 2017-03-29 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | Cns障害の処置のための成長因子の投与 |
US20070259031A1 (en) * | 2006-04-26 | 2007-11-08 | The Regents Of The University Of California | Compositions and methods for convection enhanced delivery of high molecular weight neurotherapeutics |
KR20140135267A (ko) * | 2006-05-15 | 2014-11-25 | 조지타운 유니버시티 | 치료제 또는 진단제의 전신 투여를 위한 항체- 또는 항체 단편-표적화 면역리포좀 제제 및 그의 용도 |
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US20080213349A1 (en) * | 2006-09-11 | 2008-09-04 | Deepak Ramesh Thakker | Liposome Complexes Containing Pharmaceutical Agents and Methods |
JP5407862B2 (ja) * | 2006-10-04 | 2014-02-05 | サントル・ナシオナル・ドゥ・ラ・ルシェルシュ・シアンティフィーク(セーエヌエールエス) | siRNAおよび脂質性4,5−二置換2−デオキシストレプタミン環アミノグリコシド誘導体を含む組成物ならびにその用途 |
US10925977B2 (en) * | 2006-10-05 | 2021-02-23 | Ceil>Point, LLC | Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications |
EP2136832B1 (en) | 2007-03-26 | 2015-09-02 | General Regeneratives Limited | Methods for promoting protection and regeneration of bone marrow using cxcl9 and anti-cxcl9 antibodies |
EP2175835B1 (en) * | 2007-07-09 | 2016-04-20 | Georgetown University | Methods for generating immune response using cationic-liposome-mediated nucleic acid delivery |
CN102065901B (zh) * | 2008-06-19 | 2013-03-06 | 日本新药株式会社 | 药物载体 |
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PT2760463T (pt) | 2011-09-20 | 2019-02-27 | Univ North Carolina Chapel Hill | Regulação de canais de sódio por proteínas plunc |
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US6113946A (en) * | 1992-04-03 | 2000-09-05 | The Regents Of The University Of California | Self-assembling polynucleotide delivery system comprising dendrimer polycations |
CA2133323C (en) * | 1992-04-03 | 2010-10-26 | Francis C. Szoka, Jr. | Self-assembling polynucleotide delivery system |
FR2722506B1 (fr) * | 1994-07-13 | 1996-08-14 | Rhone Poulenc Rorer Sa | Composition contenant des acides nucleiques, preparation et utilisations |
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WO1996014864A1 (en) * | 1994-11-09 | 1996-05-23 | The Regents Of The University Of California | Immunoliposomes that optimize internalization into target cells |
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JP4338106B2 (ja) * | 1995-06-07 | 2009-10-07 | ライフ テクノロジーズ コーポレーション | ペプチド増強カチオン脂質トランスフェクション |
US5851818A (en) | 1996-05-31 | 1998-12-22 | Sequus Pharmaceuticals, Inc. | Condensed plasmid-liposome complex for transfection |
TW520297B (en) * | 1996-10-11 | 2003-02-11 | Sequus Pharm Inc | Fusogenic liposome composition and method |
ES2392246T3 (es) * | 1996-11-12 | 2012-12-07 | The Regents Of The University Of California | Preparación de formulaciones estables de complejos de lípido-ácido nucleico para el suministro eficaz in vivo |
-
1997
- 1997-11-10 ES ES97949417T patent/ES2392246T3/es not_active Expired - Lifetime
- 1997-11-10 EP EP97949417A patent/EP0956001B1/en not_active Expired - Lifetime
- 1997-11-10 WO PCT/US1997/020690 patent/WO1998020857A1/en active IP Right Grant
- 1997-11-10 DK DK97949417.6T patent/DK0956001T3/da active
- 1997-11-10 AU AU71779/98A patent/AU729655B2/en not_active Ceased
- 1997-11-10 US US08/967,791 patent/US6071533A/en not_active Expired - Lifetime
- 1997-11-10 JP JP52280798A patent/JP2001510457A/ja active Pending
- 1997-11-10 PT PT97949417T patent/PT956001E/pt unknown
- 1997-11-10 CA CA002271325A patent/CA2271325A1/en not_active Abandoned
-
1999
- 1999-10-20 US US09/420,908 patent/US6410049B1/en not_active Expired - Lifetime
-
2000
- 2000-04-28 HK HK00102585.7A patent/HK1024864A1/xx not_active IP Right Cessation
-
2002
- 2002-04-12 US US10/121,962 patent/US6943027B2/en not_active Expired - Lifetime
-
2005
- 2005-04-04 US US11/098,888 patent/US7462603B2/en not_active Expired - Fee Related
-
2008
- 2008-05-21 JP JP2008132745A patent/JP4551464B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0956001B1 (en) | 2012-09-12 |
EP0956001A4 (en) | 2006-03-22 |
WO1998020857A1 (en) | 1998-05-22 |
CA2271325A1 (en) | 1998-05-22 |
US7462603B2 (en) | 2008-12-09 |
EP0956001A1 (en) | 1999-11-17 |
US6943027B2 (en) | 2005-09-13 |
AU729655B2 (en) | 2001-02-08 |
US20020182249A1 (en) | 2002-12-05 |
JP4551464B2 (ja) | 2010-09-29 |
US6071533A (en) | 2000-06-06 |
JP2001510457A (ja) | 2001-07-31 |
DK0956001T3 (da) | 2012-10-22 |
AU7177998A (en) | 1998-06-03 |
PT956001E (pt) | 2012-12-06 |
US20050170509A1 (en) | 2005-08-04 |
JP2008239631A (ja) | 2008-10-09 |
US6410049B1 (en) | 2002-06-25 |
ES2392246T3 (es) | 2012-12-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20161110 |